CN105431204A - 用于治疗或预防眼科病的方法 - Google Patents

用于治疗或预防眼科病的方法 Download PDF

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Publication number
CN105431204A
CN105431204A CN201480039516.5A CN201480039516A CN105431204A CN 105431204 A CN105431204 A CN 105431204A CN 201480039516 A CN201480039516 A CN 201480039516A CN 105431204 A CN105431204 A CN 105431204A
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China
Prior art keywords
antagonist
pharmaceutically acceptable
acceptable salt
vegf
agent
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Pending
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CN201480039516.5A
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English (en)
Chinese (zh)
Inventor
萨米尔·帕特尔
哈维·马索松
大卫·古耶尔
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Iveric Bio Inc
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Ophthotech Corp
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Application filed by Ophthotech Corp filed Critical Ophthotech Corp
Priority to CN201910114391.2A priority Critical patent/CN110193009A/zh
Publication of CN105431204A publication Critical patent/CN105431204A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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CN201480039516.5A 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法 Pending CN105431204A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910114391.2A CN110193009A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

Applications Claiming Priority (31)

Application Number Priority Date Filing Date Title
US201361845938P 2013-07-12 2013-07-12
US201361845936P 2013-07-12 2013-07-12
US201361845935P 2013-07-12 2013-07-12
US61/845,938 2013-07-12
US61/845,936 2013-07-12
US61/845,935 2013-07-12
US201361866503P 2013-08-15 2013-08-15
US201361866507P 2013-08-15 2013-08-15
US201361866502P 2013-08-15 2013-08-15
US61/866,502 2013-08-15
US61/866,503 2013-08-15
US61/866,507 2013-08-15
US201361911860P 2013-12-04 2013-12-04
US201361911854P 2013-12-04 2013-12-04
US201361911894P 2013-12-04 2013-12-04
US61/911,854 2013-12-04
US61/911,860 2013-12-04
US61/911,894 2013-12-04
US201461926825P 2014-01-13 2014-01-13
US201461926812P 2014-01-13 2014-01-13
US201461926848P 2014-01-13 2014-01-13
US61/926,812 2014-01-13
US61/926,825 2014-01-13
US61/926,848 2014-01-13
US201461931135P 2014-01-24 2014-01-24
US201461931116P 2014-01-24 2014-01-24
US201461931125P 2014-01-24 2014-01-24
US61/931,125 2014-01-24
US61/931,116 2014-01-24
US61/931,135 2014-01-24
PCT/US2014/046416 WO2015006734A1 (en) 2013-07-12 2014-07-11 Methods for treating or preventing ophthalmological conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910114391.2A Division CN110193009A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

Publications (1)

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CN105431204A true CN105431204A (zh) 2016-03-23

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CN201480039516.5A Pending CN105431204A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法
CN201910114391.2A Pending CN110193009A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

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CN201910114391.2A Pending CN110193009A (zh) 2013-07-12 2014-07-11 用于治疗或预防眼科病的方法

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US (8) US20150017163A1 (enExample)
EP (3) EP3628373A1 (enExample)
JP (5) JP2016531901A (enExample)
KR (3) KR20160030396A (enExample)
CN (2) CN105431204A (enExample)
AU (4) AU2014286996A1 (enExample)
BR (1) BR112016000546A2 (enExample)
CA (2) CA3107182A1 (enExample)
CL (1) CL2016000055A1 (enExample)
DK (1) DK4374873T3 (enExample)
EA (1) EA201690212A8 (enExample)
FI (1) FI4374873T3 (enExample)
HK (1) HK1223319A1 (enExample)
IL (3) IL294463A (enExample)
MX (1) MX2016000364A (enExample)
MY (1) MY199027A (enExample)
PH (1) PH12015502773A1 (enExample)
SG (3) SG10201708882TA (enExample)
WO (1) WO2015006734A1 (enExample)

Cited By (3)

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CN110650624A (zh) * 2017-03-10 2020-01-03 威斯康星州医药大学股份有限公司 用于视网膜疾病的核糖开关调节的基因治疗
CN116327963A (zh) * 2016-11-21 2023-06-27 济世-伊沃泰克生物制品有限公司 一种眼科制剂及其用途
WO2024006902A3 (en) * 2022-06-30 2024-02-01 Iveric Bio, Inc. Sustained release silica hydrogel composites for treating ophthalmological conditions and methods of using same

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KR102149206B1 (ko) 2012-11-08 2020-08-31 세센 바이오, 아이엔씨. 인터루킨-6의 길항제 및 이의 용도
IL294463A (en) 2013-07-12 2022-09-01 Iveric Bio Inc Methods for treating or preventing eye conditions
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
EP4268843B1 (en) 2014-11-07 2025-09-03 F. Hoffmann-La Roche Ltd Improved il-6 antibodies
KR101808234B1 (ko) * 2015-06-23 2017-12-12 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제
PL3384049T3 (pl) * 2015-12-03 2024-01-22 Regeneron Pharmaceuticals, Inc. Sposoby powiązania wariantów genetycznych z wynikiem klinicznym u pacjentów cierpiących na zwyrodnienie plamki związane z wiekiem, leczonych anty-vegf
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
AR107708A1 (es) 2016-02-23 2018-05-23 Eleven Biotherapeutics Inc Formulaciones de antagonista de il-6 y sus usos
PT3795181T (pt) * 2016-06-16 2025-11-05 Adverum Biotechnologies Inc Tratamento de dmi com utilização da variante aav2 com aflibercept
WO2019040397A1 (en) * 2017-08-21 2019-02-28 Ophthotech Corporation METHOD FOR TREATING OR PREVENTING MACULAR DEGENERATION OF THE NEOVASCULAR AGE
WO2019099786A1 (en) * 2017-11-16 2019-05-23 Ophthotech Corporation A method for treating or preventing idiopathic polypoidal choroidal vasculopathy (ipcv)
JP7184894B2 (ja) * 2017-11-27 2022-12-06 ４ディー モレキュラー セラピューティクス インコーポレイテッド アデノ随伴ウイルス変異キャプシドおよび血管新生の阻害のための使用
SMT202200374T1 (it) * 2017-11-30 2022-11-18 Regeneron Pharma Uso di un antagonista del vegf per trattare disturbi angiogenici dell’occhio
MX2020009152A (es) 2018-03-02 2020-11-09 Kodiak Sciences Inc Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos.
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
WO2020041689A1 (en) * 2018-08-23 2020-02-27 Bernstein Eric F Systems, devices and methods for applying anti-vegf compounds and using such compounds to treat skin conditions
WO2021046245A1 (en) * 2019-09-04 2021-03-11 University Of Massachusetts Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof
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