CN1053907C - 生产三环化合物的方法 - Google Patents
生产三环化合物的方法 Download PDFInfo
- Publication number
- CN1053907C CN1053907C CN94190968A CN94190968A CN1053907C CN 1053907 C CN1053907 C CN 1053907C CN 94190968 A CN94190968 A CN 94190968A CN 94190968 A CN94190968 A CN 94190968A CN 1053907 C CN1053907 C CN 1053907C
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- amino
- methyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93101031 | 1993-01-23 | ||
| EP93101031.8 | 1993-01-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1116849A CN1116849A (zh) | 1996-02-14 |
| CN1053907C true CN1053907C (zh) | 2000-06-28 |
Family
ID=8212553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94190968A Expired - Lifetime CN1053907C (zh) | 1993-01-23 | 1994-01-19 | 生产三环化合物的方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5892040A (https=) |
| EP (1) | EP0680482B1 (https=) |
| JP (1) | JP2809509B2 (https=) |
| KR (1) | KR100256461B1 (https=) |
| CN (1) | CN1053907C (https=) |
| AT (1) | ATE151075T1 (https=) |
| AU (1) | AU688301B2 (https=) |
| CA (1) | CA2153984C (https=) |
| DE (1) | DE69402412T2 (https=) |
| DK (1) | DK0680482T3 (https=) |
| ES (1) | ES2100695T3 (https=) |
| GR (1) | GR3023195T3 (https=) |
| NZ (1) | NZ261106A (https=) |
| TW (1) | TW266208B (https=) |
| WO (1) | WO1994017074A1 (https=) |
| ZA (1) | ZA94433B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4329600A1 (de) * | 1993-09-02 | 1995-03-09 | Bayer Ag | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
| CN101020647B (zh) * | 2007-02-14 | 2011-03-30 | 杭州师范学院 | 一种β-环丙胺基丙烯酸(酯)的合成方法 |
| EP2332916A3 (en) * | 2009-11-19 | 2011-08-03 | Krka Tovarna Zdravil, D.D., Novo Mesto | A process for a preparation of marbofloxacin and intermediate thereof |
| CN102060860B (zh) * | 2011-01-07 | 2013-04-10 | 宁波美诺华药业股份有限公司 | 一种马波沙星的制备方法 |
| CN102617595A (zh) * | 2012-03-23 | 2012-08-01 | 江西华士药业有限公司 | 氟喹诺酮类抗菌药马波沙星的制备方法 |
| CN107383058B (zh) * | 2017-08-28 | 2019-07-26 | 海门慧聚药业有限公司 | 马波沙星的制备 |
| CN107522718B (zh) * | 2017-09-14 | 2019-11-08 | 浙江国邦药业有限公司 | 一种马波沙星的合成方法 |
| CN114249749B (zh) * | 2022-01-08 | 2024-03-22 | 天象生物药业邢台有限责任公司 | 一种马波沙星甲酸盐的转化方法 |
| CN116987096B (zh) * | 2023-08-06 | 2025-07-01 | 石家庄学院 | 一种马波沙星的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3409922A1 (de) * | 1984-03-17 | 1985-09-26 | Bayer Ag, 5090 Leverkusen | 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen |
| JPS60204476A (ja) * | 1984-03-29 | 1985-10-16 | 株式会社東芝 | 電子部品の包装容器および包装方法 |
| US4769492A (en) * | 1985-03-13 | 1988-09-06 | Nippon Shokubai Kagaku Kogyo Co., Ltd. | Method for production of 2,3,4,5-tetrafluorobenzoic acid |
| US4782180A (en) * | 1985-09-09 | 1988-11-01 | Warner-Lambert Company | Process for tetrafluorobenzoic acid |
| US4689423A (en) * | 1986-04-01 | 1987-08-25 | Warner-Lambert Company | Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates |
| US4769493A (en) * | 1986-08-18 | 1988-09-06 | Sds Biotech K.K. | Process for producing tetrafluorophthalic acid |
| US4864023A (en) * | 1986-09-12 | 1989-09-05 | Hoffmann-La Roche Inc. | Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives |
| EP0259804B1 (de) * | 1986-09-12 | 1993-11-18 | F. Hoffmann-La Roche Ag | Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte |
| US4831190A (en) * | 1986-12-04 | 1989-05-16 | Ube Industries, Ltd. | Trifluorohydroxyaromatic acid and preparation thereof |
| WO1992015584A1 (en) | 1991-02-28 | 1992-09-17 | Fuzisawa Pharmaceutical Co., Ltd. | Process for producing tricyclic compound or salt thereof |
-
1994
- 1994-01-19 JP JP6516654A patent/JP2809509B2/ja not_active Expired - Lifetime
- 1994-01-19 US US08/492,039 patent/US5892040A/en not_active Expired - Lifetime
- 1994-01-19 DK DK94905666.7T patent/DK0680482T3/da active
- 1994-01-19 CA CA002153984A patent/CA2153984C/en not_active Expired - Lifetime
- 1994-01-19 AT AT94905666T patent/ATE151075T1/de active
- 1994-01-19 NZ NZ261106A patent/NZ261106A/en not_active IP Right Cessation
- 1994-01-19 ES ES94905666T patent/ES2100695T3/es not_active Expired - Lifetime
- 1994-01-19 CN CN94190968A patent/CN1053907C/zh not_active Expired - Lifetime
- 1994-01-19 DE DE69402412T patent/DE69402412T2/de not_active Expired - Lifetime
- 1994-01-19 AU AU59696/94A patent/AU688301B2/en not_active Expired
- 1994-01-19 EP EP94905666A patent/EP0680482B1/en not_active Expired - Lifetime
- 1994-01-19 KR KR1019950702906A patent/KR100256461B1/ko not_active Expired - Lifetime
- 1994-01-19 WO PCT/EP1994/000147 patent/WO1994017074A1/en not_active Ceased
- 1994-01-21 ZA ZA94433A patent/ZA94433B/xx unknown
- 1994-07-04 TW TW083106088A patent/TW266208B/zh not_active IP Right Cessation
-
1997
- 1997-04-21 GR GR970400856T patent/GR3023195T3/el unknown
Non-Patent Citations (1)
| Title |
|---|
| LIEBIGS ANN CHEM 1987.1.1 SYNTHESE VON 1-AMINO-4-CHIOLON-3-CARBONSAUREN * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0680482A1 (en) | 1995-11-08 |
| CN1116849A (zh) | 1996-02-14 |
| JPH08502756A (ja) | 1996-03-26 |
| ES2100695T3 (es) | 1997-06-16 |
| AU688301B2 (en) | 1998-03-12 |
| CA2153984A1 (en) | 1994-08-04 |
| ZA94433B (en) | 1995-07-21 |
| TW266208B (https=) | 1995-12-21 |
| DE69402412T2 (de) | 1997-07-10 |
| JP2809509B2 (ja) | 1998-10-08 |
| EP0680482B1 (en) | 1997-04-02 |
| KR100256461B1 (ko) | 2000-05-15 |
| DK0680482T3 (da) | 1997-05-05 |
| GR3023195T3 (en) | 1997-07-30 |
| DE69402412D1 (de) | 1997-05-07 |
| ATE151075T1 (de) | 1997-04-15 |
| NZ261106A (en) | 1997-06-24 |
| AU5969694A (en) | 1994-08-15 |
| CA2153984C (en) | 2008-08-05 |
| WO1994017074A1 (en) | 1994-08-04 |
| US5892040A (en) | 1999-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Weilong pharmaceutical Assignor: PFIZER Inc. Contract fulfillment period: 2007.4.19 to 2014.1.19 Contract record no.: 2008990000040 Denomination of invention: Process for the manufacture of a tricyclic compound Granted publication date: 20000628 License type: Exclusive license Record date: 20080305 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENCE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.4.19 TO 2014.1.19 Name of requester: WEILONG MEDICINE FACTORY Effective date: 20080305 |
|
| ASS | Succession or assignment of patent right |
Owner name: AH USA 42 LLC Free format text: FORMER OWNER: SMITHKLINE BEECHAM PLC Effective date: 20130814 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C56 | Change in the name or address of the patentee |
Owner name: SHUOTENG CO., LTD. Free format text: FORMER NAME: AH USA 42 LLC |
|
| CP01 | Change in the name or title of a patent holder |
Address after: American New York Patentee after: Pfizer Inc. Address before: American New York Patentee before: Ah USA 42 LLC |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130814 Address after: American New York Patentee after: Ah USA 42 LLC Address before: American New York Patentee before: PFIZER Inc. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20140119 Granted publication date: 20000628 |