CN105360824B - A kind of cordyceps drink and preparation method thereof - Google Patents
A kind of cordyceps drink and preparation method thereof Download PDFInfo
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- CN105360824B CN105360824B CN201510776271.0A CN201510776271A CN105360824B CN 105360824 B CN105360824 B CN 105360824B CN 201510776271 A CN201510776271 A CN 201510776271A CN 105360824 B CN105360824 B CN 105360824B
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- water
- added
- cordyceps
- inspissated juice
- taken
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- VXOZCESVZIRHCJ-KGHQQZOUSA-N ergosterol peroxide Chemical compound O1O[C@@]2(C=C3)[C@@H]4CC[C@H]([C@H](C)/C=C/[C@H](C)C(C)C)[C@@]4(C)CC[C@@H]2[C@]2(C)[C@@]13C[C@@H](O)CC2 VXOZCESVZIRHCJ-KGHQQZOUSA-N 0.000 description 1
- VXOZCESVZIRHCJ-KYQKSOQPSA-N ergosterol peroxide Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@@H]2[C@]1(C)CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@@]45OO[C@@]23C=C5 VXOZCESVZIRHCJ-KYQKSOQPSA-N 0.000 description 1
- LESGHGUKCRHTCP-UHFFFAOYSA-N ergosteryl peroxide Natural products C1C(OO)CCC2(C)C(CCC3(C(C(C)C=CC(C)C(C)C)CCC33)C)C3=CC=C21 LESGHGUKCRHTCP-UHFFFAOYSA-N 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A kind of cordyceps drink, is made of following materials by weight percentage：Sweetener 3%-9%, Cordyceps militaris 0.01%-0.04%, arillus longan 0.01%-0.03%, jujube 0.01%-0.03%, fructus lycii 0.01%-0.02%, rhizoma polygonati 0.01%-0.02%, Radix Glycyrrhizae 0.005%-0.015%, surplus is water, which has effects that strengthen immunity.
Description
Technical field
The present invention relates to a kind of preparation methods of beverage, more particularly, to a kind of cordyceps drink with health role.
Background technique
Cordyceps militaris is Ascomycotina, ergot Zoopagales, Clavicipitaceae, Cordyceps type sepecies.Scientific name is
Cordycepsmilitaris also known as northern Chinese caterpillar Fungus, Cordceps militaris etc. have some areas to be also known as the cordyceps sinensis that leaps up, worldwide distribution
Natural resources quantity is seldom.Cordyceps militaris belong to cordyceps sinensis belong to it is not of the same race, as its effective component of help class Chinese medicine and life
The active history for studying existing decades of object, using more and more extensive.It is reported that its health-care efficacy is similar to the winter worm summer
Grass, it is new resource food that the 2009 Nian Yuan Ministry of Public Health, which ratify Cordyceps militaris, becomes the favorable substitutes and new resources of cordyceps sinensis
Food.Cordyceps militaris is by stroma (i.e. careless part) and sclerotium (i.e. the corpse part of worm) complex dimerous, chemistry
Composition is N6- [β-(acetamide formyl) oxygen ethyl] adenosine, cordyceps sinensis cyclic peptide A；It is nucleosides, ergosterol peroxide, polysaccharide, a variety of
Amino acid, electrolytes and minerals.Chinese medicine think it can tonifying lung yin and kidney-replenishing, can adjust simultaneously, Yin Yang balancing.
Kidney deficiency is cured mainly, impotence and seminal emission, soreness of waist and knee joint, eak after being ill, chronic cough is weak, and phthisical cough phlegm blood, spontaneous sweating etc. is unique one kind
The Chinese medicine of yin-yang can be balanced, adjusted simultaneously.Pharmacological action modern science, which proves Cordyceps militaris not only, has special nutritive value, and
And there is apparent medical value.Wherein especially with cordycepic acid, cordycepin, Cordyceps sinensis polysaccharide.The multiple biological activities such as Cordyceps sinensis polysaccharide and SOD
The medical value of substance is the most significant.Cordycepic acid (mannitol) can significantly decrease cranium pressure, promote body metabolism, thus
Cerebral hemorrhage and cerebral thrombosis disease is set to be eased.Cordyceps sinensis polysaccharide is a kind of highly branched galactomannans, it can promote to drench
Bar cell transformation improves the antibody content of serum IgG and the immune function of body, the ability of enhancing body itself anticancer suppression cancer.
Arillus longan is aril also known as the intelligence development, sweet spleen, longan of sapindaceous plant longan.Main product in Guangdong, Fujian,
The ground such as Taiwan, Guangxi, Yunnan, Guizhou, Sichuan.July to October fruit it is ripe when pick, dry or dry, meat stoning is taken to shine to dry and comfortable
It does not glue.Arillus longan is《Pharmacopoeia of People's Republic of China》Official drug, ideal tonic.Chinese medicine thinks, longan is sweet in flavor, property
Temperature.Enter the heart, the spleen channel.It allays excitement with tonifying heart and spleen, blood-nourishing, invigorating the spleen to arrest diarrhea, inducing diuresis to remove edema and other effects.Suitable for physically weak after being ill, blood
The illnesss such as empty sallow, insufficiency of vital energy and blood, neurasthenia, palpitation and severe palpitation, amnesia insomnia.
Jujube rich in protein, fat, carbohydrate, carrotene, B family vitamin, vitamin C, citrin and calcium, phosphorus,
The nutritional ingredients such as iron and cyclic adenosine monophosphate.Wherein ascorbic content comes out at the top in fruit, there is the laudatory title of vitamin king,
There is the effect of blood-enriching face-nourishing.Cyclic adenosine monophosphate contained by jujube is the essential component of human body cell energetic supersession, Neng Gouzeng
Strong muscular strength eliminates fatigue, expansion blood vessel, increases myocardial contractive power, improves myocardial nutrition, has to prevention and treatment disease of cardiovascular system good
Good effect；Theory thinks in Chinese medicine, and jujube has the effects that tonic and nourishing, nourishing blood and tranquilization, strengthening the spleen and stomach, and jujube is to Chronic Liver
The illnesss such as inflammation, cirrhosis, anaemia, anaphylactoid purpura have good therapeutic effect；Jujube contains triterpene compound and cyclic adenosine monophosphate, has
Stronger anticancer, anti-allergic effects.Jujube energy moistening herat and lung, tonifying five zang organs, governance wasting, removes stomach addiction gas at cough-relieving, moreover it is possible to An Zhongyang
Spleen, logical nine orifices, helps 12 warps at flat stomach gas.
Fructus lycii, (FRUCTUS LYCII) alias beet red ear pendant ground frame, is the mellow fruit of matrimony vine of solanaceae plant
It is real.It is picked when summer, autumn fruit maturation, removes carpopodium, set after shady place dries in the air to pericarp and corrugate, then be exposed to the sun to crust is stiff, fruit
Meat softness to obtain the final product.Meeting wet weather can be dried with small fire.It is the dual-purpose of drug and food food of Ministry of Public Health's approval with various health care functions.Chinese holly
Qi polysaccharide, glycine betaine is nourishing liver and kidney, benefiting shrewd head.
Rhizoma polygonati (scientific name：Polygonatumsibiricum), also known as：It is polygonatum sibiricum Redoute, yellow chicken dish, pen tube dish, claw ginseng, old
Brave ginger, achickenclaw ginseng.For HUANGJING ZANYU CAPSULE, rhizome it is horizontal walk, cylindric, tubercle expands.Impeller generator, stockless.Medicinal plant has and mends
Spleen, the effect of moistening lung and producing body fluid.
As increasingly fierceness, the modern especially a middle-aged person of the prosperity of social economy, the accelerating rhythm of life, competition want
The dual heavy burden of family and work is born, the factor for influencing human health has changed a lot, the physical strength of long-term excess load,
Mental labour leads to body's immunity decline, so that causing a variety of diseases.
The development of modern medicine, cell biology and molecular biology, make it was recognized that the disorder of immune system not only
A variety of diseases can be generated, and are had with the generation of the frequently-occurring disease of human senility and the elderly such as tumour, hypertension, diabetes close
Relationship is cut, immune function has age_related changes, i.e. the age increases, immune function decline or disorder, as a result atrophy of thymus gland, T
Cell depletion, so as to cause body aging, the lost of life.And the immune function of the elderly can be enhanced in Chinese medicine immunomodulator,
Over the past decade, chemists have obtained multiple compounds from equal helps class Chinese medicine of strengthening the body resistance to consolidate the constitution, can not only promote body
Immune function, and confirm really have very strong immunocompetence.Therefore finding has good immunoregulation effect, with pre-
The drug of a variety of diseases such as anti-and treatment tumour, cardiovascular and cerebrovascular.In order to reach daily health-care effect, it is badly in need of a kind of convenient
And the food of safe and reliable integration of drinking and medicinal herbs.
Summary of the invention
In order to solve the above-mentioned technical problems, the present invention provides a kind of cordyceps drinks to be equipped with using Cordyceps militaris as primary raw material
The rare genuine integration of drinking and medicinal herbs Chinese medicine of arillus longan, jujube, fructus lycii, rhizoma polygonati, Radix Glycyrrhizae multi-flavor develops New-generation healthy drink
Material --- Worm grass oral.Fructus lycii, arillus longan, jujube, rhizoma polygonati are all help class Chinese medicine in side, to human-body sub-health is improved, are improved
Immunity of organisms has a certain effect, and Radix Glycyrrhizae plays mediation property of medicine.
The present invention also provides the preparation method of cordyceps drink, this method adheres to the traditional draft in China and impregnates fresh-keeping extraction
Technique processes meticulously in conjunction with modern film concentration technique, and mouthfeel is excellent, and suitable masses drink.
The present invention is achieved through the following technical solutions：
A kind of cordyceps drink, is made of following materials by weight percentage：
Sweetener 3%-9%
Cordyceps militaris 0.01%-0.04%
Arillus longan 0.01%-0.03%
Jujube 0.01%-0.03%
Fructus lycii 0.01%-0.02%
Rhizoma polygonati 0.01%-0.02%
Radix Glycyrrhizae 0.005%-0.015%, surplus are water.
It is preferred that a kind of cordyceps drink, is made of following materials by weight percentage：
Sweetener 4%-8%
Cordyceps militaris 0.02%-0.04%
Arillus longan 0.01%-0.02%
Jujube 0.01%-0.03%
Fructus lycii 0.01%-0.02%
Rhizoma polygonati 0.01%-0.02%
Radix Glycyrrhizae 0.005%-0.015%, surplus are water.
A kind of best cordyceps drink, is made of the raw material of following weight percentage：
Sweetener 7%
Cordyceps militaris 0.035%
Arillus longan 0.02%
Jujube 0.02%
Fructus lycii 0.01%
Rhizoma polygonati 0.01%
Radix Glycyrrhizae 0.010%, surplus are water.
The present invention also provides a kind of preparation methods of cordyceps drink, include the following steps
(1) weight percent raw material is taken：Sweetener 4%-8%, Cordyceps militaris：0.02%-0.04%, arillus longan 0.01%-
0.02%, jujube 0.01%-0.03%, fructus lycii 0.01%-0.02%, rhizoma polygonati 0.01%-0.02%, Radix Glycyrrhizae 0.005%-
0.015%, water is spare；
(2) medicinal material inspissated juice extracts：Take Cordyceps militaris, arillus longan, jujube, fructus lycii, rhizoma polygonati, licorice medicinal materials that boiling is added
Boiling is kept in after obtaining extracting solution I filtering；Boiling water is added in the dregs of a decoction after extracting for the first time, boils, extracting solution II, combined extract I
And II, it is cooled to room temperature hereinafter, coolant liquid is centrifuged, extracting centrifugal liquid is concentrated to get inspissated juice；
(3) product preparing：Inspissated juice 12-20% is taken, heating water sufficiently dissolves；Sweetener is taken, liquid glucose is dissolved in water into, it will
Inspissated juice lysate and liquid glucose are set in blend tank, allotment.
Further preferred preparation method, includes the following steps：
(1) weight percent raw material is taken：Sweetener 4%-8%, Cordyceps militaris 0.02%-0.04%, arillus longan 0.01%-
0.02%, jujube 0.01%-0.03%, fructus lycii 0.01%-0.02%, rhizoma polygonati 0.01%-0.02%, Radix Glycyrrhizae 0.005%-
0.015%, water is spare；
(2) medicinal material inspissated juice extracts：Take Cordyceps militaris, arillus longan, jujube, fructus lycii, rhizoma polygonati, licorice medicinal materials that 10-15 is added
Times boiling boiling, is kept for slightly boiled extractions 0.5-3 hour, is obtained temporary after extracting solution I is filtered；8- is added in the dregs of a decoction after extracting for the first time
12 times of boiling water, boil, and keep 0.5-3 hours slightly boiled, extracting solution II, combined extract I and II, are cooled to room temperature hereinafter, cooling
Liquid centrifugation, extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) to get inspissated juice, and inspissated juice sterilization fills
Dress；
(3) product preparing：Inspissated juice 14-18% is taken, heating water sufficiently dissolves；Sweetener is taken, 30-80% is dissolved in water into
Liquid glucose sets inspissated juice lysate and liquid glucose in blend tank, and water is added to scale.
Still further preferably preparation method includes the following steps：
(1) weight percent raw material is taken：Sweetener 7%, Cordyceps militaris 0.035%, arillus longan 0.02%, jujube 0.02%,
Fructus lycii 0.01%, rhizoma polygonati 0.01%, Radix Glycyrrhizae 0.010%, water is spare；
(2) it takes Cordyceps militaris, arillus longan, jujube, fructus lycii, rhizoma polygonati, licorice medicinal materials that 12 times of boiling boilings are added, keeps slightly boiled and mention
It takes 1 hour, is kept in after obtaining extracting solution I filtering；10 times of boiling water are added in the dregs of a decoction after extracting for the first time, boil, holding slightly boiled 1 is small
When, extracting solution II, combined extract I and II are cooled to 20 DEG C hereinafter, coolant liquid centrifugation (4000-6000r/min), takes centrifugation
Liquid crosses film concentration, and being concentrated into relative density is (15% or more) up to inspissated juice, and at 138 DEG C ± 2 DEG C, 20-36s is killed inspissated juice
Bacterium, filling, filling fluid temperature≤25 DEG C；
(3) product preparing：Inspissated juice 16% is taken, heating water sufficiently dissolves；Sweetener is taken, 60% liquid glucose is dissolved in water into,
Inspissated juice lysate and liquid glucose are set in blend tank, water is added to deploy to scale.
Method of the present invention further includes that the deployed product pop can of step (4), PET bottle or Tetra Pak are filling,
Finished product is obtained after the assay was approved.
Film described in step (2) of the present invention is reverse osmosis membrane, and membrane aperture requires only hydrone to be allowed to pass through.Pass through film mistake
Filter retains the fragrance component of plant beverage to the maximum extent, and the plant beverage flavor produced with the technique is better than using traditional handicraft
The plant beverage of production.
Centrifugation described in step (2) of the present invention uses disk centrifugal separator, 4000-6000r/min.
Cordyceps drink of the present invention may be solid beverage.
Sweetener of the present invention is white granulated sugar, soft white sugar, sucrose, glucose, saccharin sodium, fructose syrup, honey, mountain
Pears alcohol, mannitol, honey element, Aspartame, steviol glycoside, alitame, Radix Glycyrrhizae, antierythrite, xylitol, lactitol, malt
It is one or more kinds of in sugar alcohol, D-mannital.Preferred sweeteners be white granulated sugar, soft white sugar, in sucrose it is a kind of or it is a kind of with
On.
Water of the present invention is process water.
Beneficial effect
Beneficial effects of the present invention are illustrated by following test examples
1 material and method
1.1 sample：Worm grass oral (ingredient and preparation of embodiment), 250ml/ tank is canned, and liquid is stored at room temperature, and human body pushes away
Recommending day dosing is 2 tanks/day, and in terms of adult weight 60kg, recommended amounts are 8.33ml/kg BW.This test is provided dense using producer
Contracting sample (cycles of concentration is 33.9 times) is tested.
1.2 experimental animals and laboratory：SPF grades of Kunming kind female small white mouses, 6~8 week old (weight：18g~22g), by
Guangdong Medical Lab Animal Center provides, quality certification number：SCXK (Guangdong) 2013-0002, certification of fitness number：
44007200021570, pellet is also provided by Guangdong Medical Lab Animal Center；Animal Lab. is barrier environment, is made
Use credit number：SYXK (Guangdong) 2013-0011,20~26 DEG C of room temperature, humidity 40~70%.
The selection of 1.3 dosage handles and gives mode with tested material
1.3.1 dosage selects：This experiment sets basic, normal, high three dosage groups, and dosage is 41.7ml/kg BW, 83.3ml/kg
BW, 250.0ml/kg BW, the dosage for converting as concentrating sample is 1.23ml/kg BW, 2.46ml/kg BW, 7.37ml/kg
BW is equivalent to 5,10,30 times of human body recommended amounts, separately sets negative control group.
1.3.2 tested material handles and gives mode：Concentrating sample 73.7ml is measured when experiment, is configured to pure water
The sample liquid of 200.0ml is used for high dose group animal stomach-filling；50.0ml is taken from high dose group sample liquid, is diluted to pure water
150.0ml is used for middle dose group animal stomach-filling；50.0ml is taken from middle dose group sample liquid, is diluted to pure water
100.0ml is used for low dose group animal stomach-filling.Tested material is given by 0.2ml/10g BW amount stomach-filling animal daily.
1.4 key instruments and reagent：CO2Incubator,DT type cell counter, SOFTmaxPRO microplate reader are ultra-clean
Workbench, spectrophotometer, inverted microscope, microscope, incubator, vernier caliper, RPMI1640 culture medium, sheep red blood cell (SRBC),
MTT and ConA etc..
1.5 test method：After animal is quarantined three days in laboratory conditions, animal is divided into I, II, III, IV batch, every batch of
40 animals are randomly divided into four groups, and every group 10, tested material is given in daily stomach-filling, are increased and decreased to sample amount according to weight weekly and are adjusted,
Experimental period is 4 weeks.
1.5.1 mouse delayed allergy test (vola pedis thickness increases method) (the Ith batch of animal)
Experiment terminate before the 4th day immune animal, with 2% (v/v) sheep red blood cell (SRBC) be injected intraperitoneally 0.2ml sensitized animal, 5
Left back foot plantar thickness is measured after it, and 20% (v/v) sheep red blood cell (SRBC) (the 20 every mouse of μ l/) then is subcutaneously injected at this, injection
It measures within 24 hours left back foot plantar thickness three times afterwards, obtains average value.
1.5.2ConA the mouse spleen lymphocyte conversion test (mtt assay) (the IIth batch of animal) induced
Splenocyte suspension preparation：It is sterile to take spleen, it is placed in the small plate for filling appropriate sterile Hank ' s liquid, gently with embedding son
Spleen is torn up, individual cells suspension is made.Through 200 mesh net filtrations, Hank ' s liquid is washed 3 times, is centrifuged 10min (1000r/ every time
min).Then cell is suspended in the complete culture solution of 2ml, is usedDT cell counter counts splenocyte, adjusts cell
Concentration is 3 × 106A/ml.
Lymphproliferation response：It is divided to two holes to be added in 24 well culture plates cell suspension, every hole 1ml a, hole adds 75 μ l
ConA liquid (is equivalent to 7.5ug/ml), and 5%CO is set as control in another hole2, 37 DEG C of culture 72h.Culture terminates first 4 hours, often
Hole sucks supernatant 0.7ml, 0.7ml serum-free RPMI 1640 culture medium is added, while 50 hole μ l/ MTT (5mg/ml) is added,
Continue to cultivate 4h.After culture, 1ml acid isopropyl alcohol is added in every hole, and piping and druming mixes, and dissolves purple crystal, is divided and is added on 96
In well culture plate, make the Duplicate Samples in 2 holes, OD value is measured with 570nm wavelength.
1.5.3 mice serum hemolysin titer determination (half hemolytic value method) (the Ith batch of animal)
The 4th day immune animal before terminating is tested, the sheep red blood cell (SRBC) 0.2ml of every intraperitoneal injection 2% is extractd after 5 days
Eyeball blood sampling, separation serum are spare.Hemolytic reaction：Serum is diluted 100 times with SA buffer, the serum 1ml after dilution is set
In test tube, 10%SRBC 0.5ml is sequentially added, complement 1ml (presses 1 with SA liquid:8 dilutions), separately set the control tube of not increase serum；
30min in 37 DEG C of incubators is set, ice bath terminates reaction, is centrifuged (2000r/min) 10min, takes supernatant 1ml, add Dou Shi reagent
3ml, while 10%SRBC 0.25ml being taken to add Dou Shi reagent to 4ml, it mixes well；After placing 10min, surveyed respectively at 540nm
Fixed each pipe OD value.
1.5.4 mouse boosting cell antibody tormation test (the IIth batch of animal)
Immune animal：The sheep blood for taking de- fiber is centrifuged (2000r/min) 10min, pressure with brine 3 times every time
Product SRBC is made into the cell suspension of 2% (v/v) with physiological saline, and 0.2ml is injected intraperitoneally in every mouse.
Splenocyte suspension preparation：Mouse cervical dislocation after SRBC is immunized 4 days is put to death, and is taken out spleen, is placed on and fills
In the small plate of Hank ' s liquid, spleen is gently ground, cell suspension is made, through 200 mesh net filtrations, is centrifuged (1000r/min)
10min is washed 2 times with Hank ' s liquid, finally cell is suspended in 5ml RPMI 1640 culture medium, is usedDT cell count
Instrument meter number splenocyte, and cell concentration is adjusted to 5 × 106A/ml.
The measurement of plaque：After surface layer culture medium is dissolved by heating, put 45~50 DEG C of water-baths heat preservation, with equivalent pH7.2~
7.4, Hank ' the s liquid mixing of 2 times of concentration dispenses small test tube, every pipe 0.5ml, then adds 50 μ l 10%SRBC (v/v, use into pipe
SA buffer), 25 μ l splenocyte suspensions mix rapidly, are poured on the slide of own brush agarose thin layer, do parallel plate,
After agar solidification, slide level is buckled and is placed on horse, is put into 1~1.5h of incubation in carbon dioxide incubator, then use SA
The diluted complement (1 of buffer:8) it is added in glass frame groove, after continuing 1~1.5h of incubation, counts hemolysis plaque number.
1.5.5 mouse carbonic clearance test (the IIIth batch of animal)
After the last administration with 1:4 diluted india inks, by every mouse 10g weight 0.1ml tail vein injection, timing immediately,
Interval takes 20 μ l of blood from angular vein clump respectively in 2,10 minutes, and 2ml Na is added2CO3In solution, with spectrophotometer in 600nm
OD value is surveyed at wavelength, uses Na2CO3Solution does blank control, puts to death mouse, takes liver, spleen weighing, calculates phagocytic index.
1.5.6 Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell test (the IVth batch of animal)
The activation of mouse macrophage：2% hematocrit sheeps blood erythrocyte 0.2ml is injected to every mouse peritoneal within experiment first 4 days.
Mouse is put to death with cervical dislocation, intraperitoneal injection adds Hank ' the s liquid 4ml/ of calf serum only, gently rubs abdomen 20 times, to fill
Divide and wash out peritoneal macrophage, stomach wall is then cut off into an osculum, draws abdominal cavity washing lotion 2ml in test tube with rubber head suction pipe.
Abdominal cavity washing lotion 0.5ml is drawn with 1ml sample injector to be added in the test tube for filling 1% chicken red blood cells suspension of 0.5ml, is mixed.With note
Emitter draws 0.5ml mixed liquor, is added in the agar circle of slide.It places in incubator and is incubated for 15~20 minutes for 37 DEG C.Incubation terminates
Non- attached cell is washed out with physiological saline rapidly afterwards, 1 minute is fixed in methanol solution, Giemsa liquid dyes 15 minutes.With
Distilled water flushing is clean, dries, with 40 × microscopic counting phagocytic rate and phagocytic index.Phagocytic rate is every 100 macrophages
In, swallow percentage shared by the macrophage of chicken red blood cell：Phagocytic index is that average each macrophage swallows chicken red blood cell
Number.
1.5.7 NK cytoactive detection (LDH method) (the IIth batch of animal)
The preparation (effector cell) of splenocyte suspension：It is sterile to take spleen, it is placed in the small plate for filling appropriate sterile Hank ' s liquid
In, gently spleen is torn up with tweezers, single cell suspension is made.Through 200 mesh net filtrations, Hank ' s liquid is washed 3 times, is centrifuged every time
10min(1000r/min).Then cell is suspended in the complete culture solution of 2ml, is usedDT cell counter counts spleen
Cell is finally 2 × 10 with 1640 complete culture solution of RPMI adjustment cell concentration7A/ml.
NK cytoactive detection：Taking concentration is 4 × 105The YAC-1 target cell of a/ml and each 100 μ l of effector cell (effect target
Than 50:1) U-shaped 96 well culture plate, is added；Target cell Spontaneous release hole adds target cell and each 100 μ l of culture solution, and target cell is maximum
Relief hole adds target cell and each 100 μ l of 1%NP40；Above-mentioned items are all provided with three multiple holes, in 37 DEG C, 5%CO2It is cultivated in incubator
Then 96 well culture plates are centrifuged 5min with 1500r/min by 4h, every hole is drawn in 100 μ l horizontalization bottom of supernatant, 96 well culture plate, together
When 100 μ l of LDH matrix liquid is added, react 3min, 30 μ l of 1mol/L HCl is added in every hole, and measurement light is close enzyme-linked instrument 492nm at
Angle value.
1.6 test datas statistics：Using variance analysis, homogeneity test of variance, variance are first carried out by the program of variance analysis
Together, F value, F value are calculated<F0.05, conclusion：No significant difference between each group mean；F value >=F0.05, P≤0.05, with multiple experimental groups
The comparative approach two-by-two of mean is counted between a control group；Change appropriate is carried out to the data of abnormal or heterogeneity of variance
Amount conversion, after meeting normal state or variance and requiring together, is counted with the data after conversion；If after variable conversion still not up to just
State or the neat purpose of variance, use rank sum test instead and are counted.
1.7 result judgement
Strengthen immunity function determines：In cellular immune function, humoral immune function, monokaryon-macrophage function, NK
Any two aspect results of four aspects of cell activity are positive, can determine that the given the test agent strengthen immunity function.
1.7.1 cellular immune function result judgement：Two experimental results in cellular immune function assay project are sun
Property or any one experiment two dosage group results it is positive, can determine that cellular immune function assay result is positive.
1.7.2 humoral immune function result judgement：Two experimental results in humoral immune function measurement item are sun
Property or any one experiment two dosage group results it is positive, can determine that humoral immune function measurement result is positive.
1.7.3 monokaryon-macrophage function result judgement：Two realities in mononuclear-macrophage function assay project
Testing result is the positive or two dosage group results positives of any one experiment, can determine that monokaryon-macrophage function result
It is positive.
1.7.4 NK cell activity result judgement：One dosage group result above of NK cytoactive detection experiment is positive,
It can determine that NK cell activity result is positive.
2 results
Influence of 2.1 Worm grass orals to mouse weight：Serum hemolysin and delayed allergy group are shown in Table 1, lymphocyte
Conversion, NK determination of activity, antibody tormation group are shown in Table 2, and carbonic clearance experimental group is shown in Table 3, and phagocytosis chicken red blood cell group is shown in Table 4.Each dosage
Compared with each phase weight of group period weight corresponding with control group, difference there are no significant meaning shows Worm grass oral to the weight of mouse
Growth has no significant effect.
1. Worm grass oral of table to mouse weight influence (the Ith batch of animal, n=10,)
2. Worm grass oral of table to mouse weight influence (the IIth batch of animal, n=10,)
3. Worm grass oral of table to mouse weight influence (the IIIth batch of animal, n=10,)
4. Worm grass oral of table to mouse weight influence (the IVth batch of animal, n=10,)
Influence of 2.2 Worm grass orals to mouse spleen weight and thymic weight：Each dosage group internal organs/weight ratio and control group
Compare, difference there are no significant meaning (being shown in Table 5).Show Worm grass oral to the spleen weight and thymic weight of mouse without obvious shadow
It rings.
5. Worm grass oral of table to mouse thymus, spleen weight influence (n=10,)
Influence of 2.3 Worm grass orals to the delayed allergy of mouse：Middle and high dosage group vola pedis thickens value and is higher than control
Group, difference have significant (being shown in Table 6).Show that Worm grass oral is the positive to the delayed allergy test result of mouse.
6. Worm grass oral of table to mouse delayed allergy influence ()
Influence of 2.4 Worm grass orals to the ConA mouse spleen lymphocyte conversion reaction induced：Each dosage group optical density difference
Compared with the control group, difference there are no significant meaning (being shown in Table 7).Show Worm grass oral to mouse spleen lymphocyte conversion test result
For feminine gender.
7. Worm grass oral of table to mouse spleen lymphocyte conversion reaction influence ()
Influence of 2.5 Worm grass orals to animal subject serum hemolysin half hemolytic value：The serum of low, middle and high dose groups is molten
Sanguinin half hemolytic value is above control group, and difference has significant (being shown in Table 8).Show that Worm grass oral is molten to animal subject serum
Sanguinin test result is the positive.
8. Worm grass oral of table to mice serum hemolysin half hemolytic value influence ()
Influence of 2.6 Worm grass orals to animal subject splenocyte antibody tormation level：The splenocyte antibody tormation of each dosage group
It is horizontal compared with the control group, difference there are no significant meaning (being shown in Table 9).Show Worm grass oral to animal subject splenocyte antibody tormation
Horizontal measurement result is feminine gender.
9. Worm grass oral of table to mouse boosting cell antibody tormation level influence ()
Influence of 2.7 Worm grass orals to mouse carbonic clearance phagocytic function：Each dosage group carbonic clearance phagocytic index and control group ratio
Compared with, difference there are no significant meaning (being shown in Table 10).Show the carbonic clearance phagocytosis test result of Worm grass oral for feminine gender.
10. Worm grass oral of table to mouse carbonic clearance phagocytic function influence ()
Influence of 2.8 Worm grass orals to Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell phagocytic function：The phagocytosis of each dosage group
Percentage conversion value and phagocytic index compared with the control group, difference there are no significant meaning (being shown in Table 11).Show the small of Worm grass oral
It is feminine gender that mouse peritoneal macrophage, which swallows chicken red blood cell test result,.
11. Worm grass oral of table to Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell phagocytic function influence (n=10,)
Phagocytic percentage conversion value：X=Sin‐1(p)1/2
Influence of 2.9 Worm grass orals to animal subject NK cell activity：The NK cell activity of each dosage group compared with the control group,
Difference there are no significant meaning (being shown in Table 12).Show that Worm grass oral is feminine gender to animal subject NK cell activity assays result.
The influence active on NK cells in mice of 12. Worm grass oral of table (n=10,)
NK cell activity conversion value：X=Sin‐1(p)1/2
3 brief summaries
It is oral to SPF Kunming mice to give Worm grass oral concentrating sample respectively daily (cycles of concentration is 33.9 times)
1.23,2.46,7.37ml/kg BW are equivalent to Worm grass oral 41.7ml/kg BW, 83.3ml/kg BW, 250.0ml/kg BW, are
5,10,30 times of Worm grass oral recommended daily dosage, totally 4 weeks, as the result is shown：The mouse delayed allergy of sheep red blood cell (SRBC) induction
Test result is positive, and given the test agent has enhancing cellular immune function effect；Serum is molten after sheep red blood cell (SRBC) immunization of animal subjects
Sanguinin test result is positive, and given the test agent has enhancing body fluid immunity function；Carbonic clearance test and macrophage swallow chicken
Red cell test result is negative, and given the test agent does not have enhancing monocytes/macrophages function；NK cell activity assays yin
Property, given the test agent does not have enhancing NK cell activity effect；The mouse spleen lymphocyte proliferation test result of ConA induction
It is negative；Splenocyte antibody tormation test result is negative after sheep red blood cell (SRBC) immunization of animal subjects.
Foundation《Health food is examined and assessment technique specification》The judgement of strengthen immunity functional evaluation standard, Worm grass oral have
Strengthen immunity function
The cordyceps drink that formula and technique through the invention is prepared keeps lower apparent viscosity, to make mouthfeel
Exquisiteness, mellow, tasty and refreshing plant beverage have completely new peculiar flavour, and good mouthfeel not only meets the mark of national tea beverage
Standard also has certain health-care effect, to human-body sub-health is improved, improves immunity of organisms and has a certain effect.
The composition of composition and embodiment in scope of the presently claimed invention can be according to actual production, simultaneously
Zoom in or out ratio.
Specific embodiment
Specific embodiment is used only to illustrate the content of present invention, is not to claims of the invention
It further limits.
Embodiment 1
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；White granulated sugar 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 2
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 14kg is taken, is heated
Water sufficiently dissolves；White granulated sugar 90kg is taken, 80% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 3
Take Cordyceps militaris 0.4kg, arillus longan 0.3kg, jujube 0.3kg, fructus lycii 0.2kg, rhizoma polygonati 0.2kg, Radix Glycyrrhizae 0.15kg
15 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 0.5 hour, keep in after obtaining extracting solution I filtering；The dregs of a decoction after extracting for the first time
12 times of boiling water of middle addition, boil, and are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II are cooled to 20 DEG C hereinafter, cold
But liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, be concentrated into relative density be (15% or more) to obtain the final product
Inspissated juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 18kg is taken, is added
Hot water sufficiently dissolves；White granulated sugar 80kg is taken, 70% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank,
Water is added to deploy to 1 ton, it is filling with pop can, PET bottle or Tetra Pak, finished product is obtained after the assay was approved.
Embodiment 4
Take Cordyceps militaris 0.2kg, arillus longan 0.1kg, jujube 0.1kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.05kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；White granulated sugar 40kg is taken, 30% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 5
Take Cordyceps militaris 0.4kg, arillus longan 0.2kg, jujube 0.3kg, fructus lycii 0.2kg, rhizoma polygonati 0.2kg, Radix Glycyrrhizae 0.15kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；White granulated sugar 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 6
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；Maltose 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 7
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；Glucose 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 8
Take Cordyceps militaris 0.1kg, arillus longan 0.1kg, jujube 0.1kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.05kg
8 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 3 hours, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 16kg is taken, is heated
Water sufficiently dissolves；White granulated sugar 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 9
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 12kg is taken, is heated
Water sufficiently dissolves；Soft white sugar 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, added
Water is deployed to 1 ton, filling with pop can, PET bottle or Tetra Pak, obtains finished product after the assay was approved.
Embodiment 10
Take Cordyceps militaris 0.35kg, arillus longan 0.2kg, jujube 0.2kg, fructus lycii 0.1kg, rhizoma polygonati 0.1kg, Radix Glycyrrhizae 0.1kg
12 times of boiling boilings are added in medicinal material, keep slightly boiled and extract 1 hour, keep in after obtaining extracting solution I filtering；In the dregs of a decoction after extracting for the first time
10 times of boiling water are added, boil, are kept for slightly boiled 1 hour, extracting solution II, combined extract I and II, are cooled to 20 DEG C hereinafter, cooling
Liquid disk centrifugal (4000-6000r/min), extracting centrifugal liquid cross film concentration, and being concentrated into relative density is (15% or more) up to dense
Contracting juice, inspissated juice is at 138 DEG C ± 2 DEG C, and 20-36s is sterilized, filling, filling fluid temperature≤25 DEG C：Inspissated juice 20kg is taken, is heated
Water sufficiently dissolves；Sucrose 70kg is taken, 60% liquid glucose is dissolved in water into, inspissated juice lysate and liquid glucose are set in blend tank, water is added
Allotment is filling with pop can, PET bottle or Tetra Pak to 1 ton, obtains finished product after the assay was approved.
Claims (7)
1. a kind of cordyceps drink, which is characterized in that the cordyceps drink is obtained by following preparation methods：
(1) weight percent raw material is taken：Sweetener 7%, Cordyceps militaris 0.035%, arillus longan 0.02%, jujube 0.02%, fructus lycii
Sub 0.01%, rhizoma polygonati 0.01%, Radix Glycyrrhizae 0.010%, water is spare；
(2) it takes Cordyceps militaris, arillus longan, jujube, fructus lycii, rhizoma polygonati, licorice medicinal materials that 12 times of boiling boilings are added, keeps slightly boiled and extract 1
Hour, it is kept in after obtaining extracting solution I filtering；10 times of boiling water are added in the dregs of a decoction after extracting for the first time, boil, are kept for slightly boiled 1 hour,
Extracting solution II, combined extract I and II are cooled to 20 DEG C hereinafter, coolant liquid is centrifuged, and extracting centrifugal liquid crosses film concentration, is concentrated into phase
It is 15% or more up to inspissated juice to density, for inspissated juice at 138 DEG C ± 2 DEG C, 20-36s sterilization is filling, filling fluid temperature≤
25℃；
(3) product preparing：Inspissated juice 16% is taken, heating water sufficiently dissolves；Sweetener is taken, 60% liquid glucose is dissolved in water into, it will be dense
Contracting juice lysate and liquid glucose are set in blend tank, and water is added to deploy to scale.
2. cordyceps drink as described in claim 1, it is characterised in that：The sweetener be white granulated sugar, soft white sugar, sucrose,
It is glucose, saccharin sodium, fructose syrup, honey, sorbierite, mannitol, honey element, Aspartame, steviol glycoside, alitame, sweet
It is grass, antierythrite, xylitol, lactitol, maltitol, one or more kinds of in D-mannital.
3. cordyceps drink as described in claim 1, it is characterised in that：The sweetener is white granulated sugar, in soft white sugar, sucrose
It is one or more kinds of.
4. a kind of preparation method of cordyceps drink, which is characterized in that include the following steps：
(1) weight percent raw material is taken：Sweetener 7%, Cordyceps militaris 0.035%, arillus longan 0.02%, jujube 0.02%, fructus lycii
Sub 0.01%, rhizoma polygonati 0.01%, Radix Glycyrrhizae 0.010%, water is spare；
(2) it takes Cordyceps militaris, arillus longan, jujube, fructus lycii, rhizoma polygonati, licorice medicinal materials that 12 times of boiling boilings are added, keeps slightly boiled and extract 1
Hour, it is kept in after obtaining extracting solution I filtering；10 times of boiling water are added in the dregs of a decoction after extracting for the first time, boil, are kept for slightly boiled 1 hour,
Extracting solution II, combined extract I and II are cooled to 20 DEG C hereinafter, coolant liquid is centrifuged, and extracting centrifugal liquid crosses film concentration, is concentrated into phase
It is 15% or more up to inspissated juice to density, for inspissated juice at 138 DEG C ± 2 DEG C, 20-36s sterilization is filling, filling fluid temperature≤
25℃；
(3) product preparing：Inspissated juice 16% is taken, heating water sufficiently dissolves；Sweetener is taken, 60% liquid glucose is dissolved in water into, it will be dense
Contracting juice lysate and liquid glucose are set in blend tank, and water is added to deploy to scale.
5. preparation method as claimed in claim 4, which is characterized in that including the deployed product pop can of step (4),
PET bottle or Tetra Pak are filling, obtain finished product after the assay was approved.
6. preparation method as claimed in claim 4, which is characterized in that film described in step (2) is reverse osmosis membrane；Described
Centrifugation uses disk centrifugal.
7. application of the cordyceps drink described in claim 1 on preparation enhancing cell or humoral immunity health care product or food.
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| CN105747046B (en) * | 2016-03-11 | 2019-05-07 | 辽宁隆维生物科技有限公司 | A kind of Cordyceps militaris liquid drink and preparation method thereof |
| CN108013269A (en) * | 2016-11-02 | 2018-05-11 | 浙江泛亚生物医药股份有限公司 | A kind of cicada fungus siberian solomonseal beverage and preparation method thereof |
| CN107304398A (en) * | 2017-05-09 | 2017-10-31 | 张帆 | A kind of preparation technology for the Cordyceps militaris magma product for improving immunity |
| CN109463754A (en) * | 2018-10-20 | 2019-03-15 | 广州王老吉药业股份有限公司 | A kind of Chinese medicine composition is preparing the purposes in antioxidant food or health care product |
| CN109222082A (en) * | 2018-10-20 | 2019-01-18 | 广州王老吉药业股份有限公司 | A kind of Chinese medicine composition is preparing the purposes in antifatigue food or health care product |
| CN109463504A (en) * | 2018-12-27 | 2019-03-15 | 山西省农业科学院食用菌研究所 | A kind of cordyceps flower function tea beverage and preparation method thereof |
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| CN101991154A (en) * | 2009-08-21 | 2011-03-30 | 康美药业股份有限公司 | Vegetable beverage formulation and manufacturing method thereof |
| CN102524888A (en) * | 2012-01-04 | 2012-07-04 | 任文武 | Method for preparing Cordyceps militaris sugar-free beverage by microwave extraction |
| CN103462022A (en) * | 2013-09-24 | 2013-12-25 | 郑剑峰 | Cordyceps militaris nourishing paste and preparation method thereof |
| CN104068443A (en) * | 2014-06-10 | 2014-10-01 | 南京泽朗农业发展有限公司 | Solid beverage and preparation method thereof |
| CN104397291A (en) * | 2014-12-04 | 2015-03-11 | 广州王老吉大健康产业有限公司 | Preparation method of concentrated juice of herbal tea |
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| TW201132290A (en) * | 2010-03-24 | 2011-10-01 | Abundant Seedling Biotech Corp | Method of manufacturing extraction fluid of Agaricus blazei Murill |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991154A (en) * | 2009-08-21 | 2011-03-30 | 康美药业股份有限公司 | Vegetable beverage formulation and manufacturing method thereof |
| CN102524888A (en) * | 2012-01-04 | 2012-07-04 | 任文武 | Method for preparing Cordyceps militaris sugar-free beverage by microwave extraction |
| CN103462022A (en) * | 2013-09-24 | 2013-12-25 | 郑剑峰 | Cordyceps militaris nourishing paste and preparation method thereof |
| CN104068443A (en) * | 2014-06-10 | 2014-10-01 | 南京泽朗农业发展有限公司 | Solid beverage and preparation method thereof |
| CN104397291A (en) * | 2014-12-04 | 2015-03-11 | 广州王老吉大健康产业有限公司 | Preparation method of concentrated juice of herbal tea |
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