CN101259156A - Arenaria kansuensis solid state formulation and preparation thereof - Google Patents
Arenaria kansuensis solid state formulation and preparation thereof Download PDFInfo
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- CN101259156A CN101259156A CNA2008100442868A CN200810044286A CN101259156A CN 101259156 A CN101259156 A CN 101259156A CN A2008100442868 A CNA2008100442868 A CN A2008100442868A CN 200810044286 A CN200810044286 A CN 200810044286A CN 101259156 A CN101259156 A CN 101259156A
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Abstract
The invention discloses a solid preparation for arenaria kansuensis maxim. The invention is manufactured by mixing the extract of the arenaria mansuensis maxim as a main material along with honey, excipient and water as auxiliary material. The arenaria kansuensis maxim is one of the Gansu sandwort or ovivalvule sandwort. Meanwhile, the invention also discloses a method for manufacturing the solid preparation. After being strictly tested and tried out, the weight percentage of proper compositions of the solid preparation and an effective technological process are obtained. The weight percentage is as following: (1)30 to 35 percent of the extract of the arenaria mansuensis maxim (a dissolvable solid is more than 23 percent); (2) 1 to 4 percent of the honey; (3) 10 to 50 percent of the excipient and (4) the rest is the water. Due to the weight percentage of the proper compositions and the effective technological process obtained from the strict test and the try-out, the solid preparation with the nutrition needed by the human body can be manufactured. The solid preparation of nutrition can nourish bodies, strengthen immune system, suppress cancer cells and cure diseases. In addition, the solid preparation is the product which has good health-care effect and no side effect.
Description
Technical field
The invention belongs to medicine, particularly Chinese medicine solid formulation the invention still further relates to the preparation method of such solid formulation.
Background technology
People know that Ganoderma is the rarity in China's medical treatment treasure-house, the treasure that the mankind dream of.Since ancient times, Ganoderma is considered as come back to life, prolong life not old " human world Herba mesonae chinensis " by compatriots always, enjoys the good reputation of " kings of ten thousand medicines ".Before more than 2000 years, that Emperor Qin just thinks is alive for evermore, hold the affairs of state forever, the elixir of once sending someone to seek; It is thereafter, among the people that just to spread Ganoderma be the miraculous cure that can make people's " food become an immortal, can control all kinds of diseases and ailments ".Certainly from the science viewpoint, alive for evermore is impossible, can control all kinds of diseases and ailments and exaggerate rather; But modern medicine study proves that this is a kind of strengthening the body resistance that has really, strengthening by means of tonics, invigorating the spleen and replenishing QI, the precious health product of life lengthening.It has and protects the liver, detoxifcation, heart tonifying, calmness, antitussive, eliminates the phlegm, blood pressure lowering, blood fat reducing, presses down tumor, antioxidation and remove many-sided biological activitys such as free radical.Just because of it has these functions, many people blindly use, because improper use or contained ratio are improper, not only cause wastage of material, fall flat on the contrary not very, also can influence healthy sometimes.It is very poor that general light is taken pure Herba arenariae kansuensis mouthfeel, and people are difficult to accept.
Summary of the invention
The present invention seeks to make and a kind ofly can overcome the medicine that above-mentioned shortcoming can conveniently be used again, with the All Pure Nature medicine of building up people's health.
Another purpose of the present invention also is to design the preparation method that this solid formulation is made in a kind of simple and easy to do being used for.
Modern medicine study proof Herba arenariae kansuensis is rich in ganoderan, alkaloid, Ganoderma germanium, several amino acids, vitamin, coumarin and trace element ... etc. over one hundred kind of precious active ingredient.The kind of it self contained these precious compositions and the ratio that cooperatively interacts, and all very good to the integrally-regulated effect of human body.The present invention adopts following technical scheme to realize for achieving the above object.
XUELINGZHI GUTAI ZHIJI is with after a kind of contained active component extraction Saponin is made concentrated solution in Gansu sandwort, the ovum lobe sandwort, makes the required dosage form of solid-state drug by process again.Usually the one-tenth assign group of solid dosage becomes to be made as: Herba arenariae kansuensis abstract, Mel, excipient and water are formed.Described Herba arenariae kansuensis abstract is to extract the active ingredient extract that makes with decocting in water.Usually soluble solid is＞23% in the extract.Described excipient is a kind of or 2 kinds in dextrin, starch, the sucrose etc.Water is drinking water.
Herba arenariae kansuensis has another name called Herba Cassiopes selaginoidis, is hundred perennial cushion draft, mainly originates in ground such as Tibet, Sichuan, Qinghai, Gansu, is distributed in the grassy marshland and crack of stone in high mountain snow line area of 4000～5000m aboundresources usually.This Herba arenariae kansuensis is a Caryophyllaceae sandwort plant, claims the Tibetan medicine sandwort again, is the natural wild plant in plateau, and that takes usually has a Gansu sandwort Arenaria kansuensis Maxim.Herb with ovum lobe sandwort Arenaria kansuensis maxim.var.ovatipetata Tsui. the taste of Herba Arenariae Kansuensis extract is very pained, but it is owing to be rich in polysaccharide, Saponin, alkaloid and several amino acids, vitamin, coumarin, Ganoderma germanium, trace element etc., energy strengthening body resistance, health-care effect with immunomodulating and inhibition tumor, so become the primary raw material among the present invention program, usually require among the every 100ml of Herba arenariae kansuensis total saponin content more than 45mg, just can reach and improve immunity and building body, the effect of the pain that gets rid of illness.
Mouthfeel when taking in order to improve the present invention so aligned with Mel, also is added with excipient in addition, and all the other are drinking water, and the set of dispense of producing XUELINGZHI GUTAI ZHIJI than (percentage by weight) is:
1, Herba Arenariae Kansuensis extract (soluble solid＞23%) 30-35%
2, Mel 2-6%
3, excipient 10-50%
4, water surplus
For realizing technical solution of the present invention, carry out its preparation by the preparation method of the XUELINGZHI GUTAI ZHIJI that provides below:
1, Herba arenariae kansuensis is ground into the fritter of 2～5cm, gets extracting solution with 10 times of water gaging decoction filtering for the first time, described decocting in water is that its drinking water is 10 times of amounts to Herba arenariae kansuensis; Decoction is 1.5 hours; 1 hour after-filtration of 8 times of water gagings decoctions with the Herba arenariae kansuensis slag after the filter for the first time gets secondary raffinate for the second time;
2, merge extracted twice liquid concentrate extract.Usually concentrate be with vacuum method concentrate extract powder; Effective with vacuum method than other method.
3, the extract after will concentrating mixes with excipient and water and obtains the uniform distribution material;
4, preparation makes powder with medicinal wet granulation or boiling granulating mode usually; According in like manner, available medicinal method further is processed into various solid formulations such as granule, tablet, pill and capsule.
Embodiment
The present invention is according to the made XUELINGZHI GUTAI ZHIJI of Herba Arenariae Kansuensis extract of different proportion grouping, use 2003 02 month Ministry of Public Health to 23 " assay methods of total Saponin in the health food " of " health food check and assessment technique standard " to the present invention in every group of content, divide from low to high low in the Senior Three point measure wherein the total Saponin of labeled component (in the ginsenoside Re, mg/100ml) content.The present invention divides I, II, III group, and every group of I group is 10%, 14%, 19%; The II group is 21%, 25%, 29%; The III group is measured its result such as table one on 31%, 33%, 35% 3:
Table one:
By table one, as can be known, the content of the total Saponin of significant composition is different in the Herba Arenariae Kansuensis extract of different proportion; The Herba Arenariae Kansuensis extract ratio is when 30%-35%, and total saponin content is the highest.Meet the present invention desirable＞requirement of 45mg/100ml.Owing to contain multiple bioactive substances such as flavone, Saponin, alkaloid, several amino acids, coumarin, polysaccharide, Ganoderma germanium, trace element in the Herba arenariae kansuensis, with the significant composition of total Saponin, then can reflect the inherent quality situation of XUELINGZHI GUTAI ZHIJI as XUELINGZHI GUTAI ZHIJI.
Always in the XUELINGZHI GUTAI ZHIJI that Saponin is high, effective ingredient is more, and human body can be higher to the absorbance of active ingredient, and the utilization rate of XUELINGZHI GUTAI ZHIJI is better, thereby reaches raising immunity, the All Pure Nature solid formulation product that is of illnesses and fitness.
The present invention uses for convenient, also Herba Arenariae Kansuensis extract can be dried according to common method pharmaceutically and granulate to such an extent that solid dosages such as solid-state version powder, tablet, pill, capsule, granule are for people to use.
Although with reference to the present invention the disclosed XUELINGZHI GUTAI ZHIJI that relates to has been carried out special description, those skilled in the art can understand, and are not departing under the scope and spirit situation of the present invention, can carry out all conspicuous modification of form or details to it.Therefore above the description is illustrative and nonrestrictive, do not breaking away under the spirit and scope of the invention all variations and revising all in protection scope of the present invention.
Claims (3)
1, a kind of XUELINGZHI GUTAI ZHIJI is characterized in that its component adopts Herba Arenariae Kansuensis extract and Mel, excipient and water to make; Described Herba arenariae kansuensis adopts in Gansu sandwort, the ovum lobe sandwort a kind of; Described excipient with in dextrin, starch, the sucrose one or more, water is drinking water.
2,, it is characterized in that the percentage by weight of each raw material in the component is according to the described XUELINGZHI GUTAI ZHIJI of claim 1:
(1) Herba Arenariae Kansuensis extract (soluble solid＞23%) 30-35%
(2) Mel 1-4%
(3) excipient 10-50%
(4) water surplus
3, according to the preparation method of claim 1,2 described a kind of XUELINGZHI GUTAI ZHIJI, it is characterized in that forming by following steps:
(1) Herba arenariae kansuensis is ground into the fritter of 2～5cm, gets extracting solution with 10 times of water gaging decoction filtering for the first time, described decocting in water is that its water is 10 times of amounts to Herba arenariae kansuensis; Decoction is 1.5 hours; Fry in shallow oil 1 hour after-filtration with 8 times of water gagings of the Herba arenariae kansuensis slag after the filter for the first time for the second time and get extracting solution for the second time;
(2) merge extracted twice liquid concentrate extract; Usually concentrate be with vacuum method concentrate extract powder;
(3) extract after will concentrating mixes with excipient and water, obtains the uniform distribution material;
(4) preparation: make powder with medicinal wet granulation or boiling granulating mode usually; According in like manner, available medicinal method further is processed into the various solid formulation of granule, tablet, pill and capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100442868A CN101259156A (en) | 2008-04-25 | 2008-04-25 | Arenaria kansuensis solid state formulation and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100442868A CN101259156A (en) | 2008-04-25 | 2008-04-25 | Arenaria kansuensis solid state formulation and preparation thereof |
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| CN101259156A true CN101259156A (en) | 2008-09-10 |
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| CNA2008100442868A Pending CN101259156A (en) | 2008-04-25 | 2008-04-25 | Arenaria kansuensis solid state formulation and preparation thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012056900A (en) * | 2010-09-10 | 2012-03-22 | Nippon Menaade Keshohin Kk | Antimutagenic agent |
| CN103622010A (en) * | 2013-11-01 | 2014-03-12 | 马卫军 | Method for preparing maca grains |
| CN103815406A (en) * | 2014-03-13 | 2014-05-28 | 浙江森芝宝生物科技有限公司 | Ganoderma lucidum, spore and cordyceps composition and preparation method thereof |
-
2008
- 2008-04-25 CN CNA2008100442868A patent/CN101259156A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012056900A (en) * | 2010-09-10 | 2012-03-22 | Nippon Menaade Keshohin Kk | Antimutagenic agent |
| CN103622010A (en) * | 2013-11-01 | 2014-03-12 | 马卫军 | Method for preparing maca grains |
| CN103815406A (en) * | 2014-03-13 | 2014-05-28 | 浙江森芝宝生物科技有限公司 | Ganoderma lucidum, spore and cordyceps composition and preparation method thereof |
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Open date: 20080910 |