CN106912943A - The medicine or health food of a kind of strengthen immunity - Google Patents

The medicine or health food of a kind of strengthen immunity Download PDF

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CN106912943A
CN106912943A CN201510995083.7A CN201510995083A CN106912943A CN 106912943 A CN106912943 A CN 106912943A CN 201510995083 A CN201510995083 A CN 201510995083A CN 106912943 A CN106912943 A CN 106912943A
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medicine
parts
radix
health food
strengthen immunity
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牟卫伟
刘艳
刘群
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to the medicine or health food of a kind of strengthen immunity.It is characterized in that containing functional component：The Radix Astragali, Radix Codonopsis, the fruit of Chinese wolfberry, date, Radix Glycyrrhizae.Pharmacological research shows that it has good anti-fatigue effect.

Description

The medicine or health food of a kind of strengthen immunity
Technical field
The present invention relates to a kind of combination of medicinal material, and in particular to a kind of medicine or health care food with strengthen immunity effect Product.
Background technology
Today's society dog-eat-dog, work and study pressure is big, and hypoimmunity is increasingly existing as a kind of universal society As.This just makes us face an important problem：How safely and effectively to strengthen the immunity of body, people is possessed health Constitution and abundant energy ensure high-quality study and work.
The content of the invention
It is an object of the invention to provide a kind of medicine or health food of safely and effectively strengthen immunity.
The medicine or health food of strengthen immunity of the present invention, mainly contain following functional component：The Radix Astragali, party Ginseng, the fruit of Chinese wolfberry, date and Radix Glycyrrhizae.
Wherein, the Radix Astragali, latin name Astragalus membranaceus (Fisch.) Bunge., originates in North China, east more North, the Inner Mongol and northwest, main product are saved in Shanxi, Heilungkiang, Liaoning, Hebei etc., and active ingredient Astragaloside IV has very strong increasing The effects such as strong immunity, antiviral, resisting stress.Modern study shows that the Radix Astragali can strengthen the specific immunity and Fei Te of body Specific immunological, can substantially increase the quantity of red blood cell in blood, it may have antifatigue effect.
Radix Codonopsis is Campanulaceae Radix Codonopsis Codonopsispilosula (Franch.) Nannf., codonopsis pilosula var. modesta CodonopsispilosulaNannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen CodonopsistangshenOliv. dry root.Research shows, the main component lobetyolin of Radix Codonopsis, atractyloide III pair Nervous system has excitation, can strengthen Abwehrkraft des Koepers, and red blood cell and hemoglobin can be increased again；Zinc contained by it can promote Grow and improve sexual function.
The fruit of Chinese wolfberry is plant of Solanaceae lycium barbarum（Lycium barbarum L.）Dry mature fruit.Remembered according to pharmacopeia Fruit of Chinese wolfberry sugariness is carried to put down, can nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, Heat Diabetes, Blood deficiency chlorosis, blurred vision.Modern pharmacological research shows that the fruit of Chinese wolfberry has the pharmacology such as immune enhancing, anti-aging, Kidney and Liver protection Effect.
Date is the dry mature fruit of Rhamnaceae plant jujube ZiziphusjujubaMill..Traditional Chinese medicine thinks, date Sweet, temperature.Returns spleen, stomach.Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.For spleen eating less, weak loose stool, hysteria of womam.Still contain in date Vitamin C, riboflavin（Riboflavine）, thiamine（Thiamine）, carrotene（Carotene）, niacin （Nicotinic acid）Deng multivitamin.In addition, still resinous in date, lymphatic temperament, coumarin derivatives, catechu Phenol（Catechol）, tannin（Tannin）, volatile oil, 36 kinds of trace elements such as 13 kinds of amino acid and calcium, phosphorus, iron, selenium.Date institute The CAMP for containing, is the required composition of human body cell energetic supersession, can strengthen muscular strength, dispelling fatigue, expansion of blood vessels, Increase myocardial contractive power, improve myocardial nutrition, to prevent and treat disease of cardiovascular system play the role of it is good.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The dry root and rhizome of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Traditional Chinese medicine thinks that Radix Glycyrrhizae is sweet, Partial temperature, returns spleen, stomach, the heart, lung channel, function tonifying heart and spleen, relieving spasm to stop pain, mediation property of medicine, purging intense heat and detonicating, profit are used in life with trembling with fear partially, processing Lung cough-relieving.Modern pharmacological research is thought：Radix Glycyrrhizae master is containing glycyrrhizin, liquiritin, steroid mannitol, β-sitosterol, carbohydrate, organic The materials such as acid.Therefore Radix Glycyrrhizae has detoxication, antidiuretic activity, suppresses the gastric acid secretion effect that histamine causes, and has again anti- The effects such as scorching, antianaphylaxis effect.
Present invention selection Radix Astragali tonifying middle-Jiao and Qi, Radix Codonopsis air making-up and spleen enlivening, the fruit of Chinese wolfberry is nourishing liver and kidney, benefiting shrewd head, date invigorating the spleen QI invigorating, nourishing blood and tranquilization adds Radix Glycyrrhizae tonifying heart and spleen, coordinating the drug actions of a prescription again.So that tonifying middle-Jiao and Qi is played jointly, effect of nourishing blood and tranquilization, Fundamentally strengthen the immunity of body.
The optimum extraction process of this medicine or health food：
Weigh the medicinal material of following weight proportion：The Radix Astragali 3, Radix Codonopsis 6, the fruit of Chinese wolfberry 3, date 1, Radix Glycyrrhizae 1, decoct 2 times, Jia 10 for the first time The decocting of amount again is boiled 2 hours, and the decoctings of second plus 8 times amount are boiled 1 hour, collecting decoction, is filtered, and extract solution is concentrated into 50 DEG C When relative density be 1.25 thick paste.
The extract has good strengthen immunity effect.
Related pharmacological experimental data
1st, animal subject
Healthy Kunming mouse, 18 ~ 20 grams of body weight, male and female half and half.
2nd, administering mode
Control group：Distilled water 1mL/10g gastric infusions, twice a day, continuous 30 days；
Experimental group：Optimum proportioning extract 1mL/10g gastric infusions of the present invention, twice a day, continuous 30 days.
3rd, experimental technique
Test method:100 mouse are randomized into five by body weight and test big group, every group 20 (immune one group to carry out NK thin Cytoactive is tested and lymphocyte transformation experiment, and immune two groups carry out the experiment of DTH, spleen index and thymus index, and immune three groups are entered Row antibody-producting cell detection and serum hemolysin are determined, and immune four groups carry out carbon clearance test, and immune five groups carry out macrophage Cell phagocytosis chicken red blood cell experiment.Blank control group and experimental group, every group 10 are provided with each big group of experiment.Put to death after 30 days Mouse, carries out the inspection of indices.
3.1 is immune one group（NK cytoactives, Splenic vein hemodynamics experiment）
Table 1. is immune one group（NK cytoactives, Splenic vein hemodynamics experiment）（±SD）
As seen from the above table, the NK cytoactives of experimental group are significantly higher than control group (p ＜ 0.05), and the OD differences of experimental group also show It is higher than control group (p ＜ 0.05) to write.
3.2 is immune two groups（The experiment of DTH, spleen index and thymus index）
Table 2. is immune two groups（The experiment of DTH, spleen index and thymus index）（±SD）
Result shows that there was no significant difference with spleen index for two groups of thymus indexs of animal；And the left and right ear weight of test group of animals Difference（Swelling）Apparently higher than control group (p ＜ 0.05).
3.3 is immune three groups（Antibody-producting cell and hemolysin are tested）
Table 3. is immune three groups（Antibody-producting cell and hemolysin are tested）（±SD）
Result shows that in antibody-producting cell experiment, the plaque number of experimental group is significantly more than control group (p ＜ 0.01)；Hemolysin In experiment, the antibody product of experimental group is significantly more than control group (p ＜ 0.01).
3.4 is immune four groups（Carbonic clearance is tested）
Table 4. is immune four groups（Carbonic clearance is tested）（±SD）
Result shows, the phagocytic index of experimental group is apparently higher than control group (p ＜ 0.01).
3.5 is immune five groups（Phagocytosis experiment）
Table 5. is immune five groups（Phagocytosis experiment）（±SD）
Result shows that the phagocytic rate and phagocytic index of experimental group are obviously higher than control group（P<0.01）.
4th, experimental summary
Tested more than, show that medicinal material composition of the invention has functions that good strengthen immunity really.
Specific embodiment
Embodiment 1：
Radix Astragali 166.5g, Radix Codonopsis 333g, fruit of Chinese wolfberry 166.5g, date 55.5g, Radix Glycyrrhizae 55.5g are weighed, is decocted 2 times, added for the first time The decocting of 10 times of amounts is boiled 2 hours, and the decocting of second plus 8 times amount is boiled 1 hour, collecting decoction, and extract solution is concentrated into 50 by filtration DEG C when relative density be 1.25 thick paste.Plus dextrin 850g, Steviosin 2g, to pelletize, 75 DEG C of dryings, whole grain is packaged into bag.
Embodiment 2：
Weigh the medicinal material of following weight proportion：The Radix Astragali 3, Radix Codonopsis 6, the fruit of Chinese wolfberry 3, date 1, Radix Glycyrrhizae 1, decoct 2 times, Jia 10 for the first time The decocting of amount again is boiled 2 hours, and the decoctings of second plus 8 times amount are boiled 1 hour, collecting decoction, is filtered, and extract solution is concentrated into 50 DEG C When relative density be 1.25 thick paste.Plus the weight portion of dextrin 15.3, the weight portion of Steviosin 0.04, granulation, 75 DEG C of dryings, whole grain, It is packaged into bag.
Embodiment 3：
Weigh the medicinal material of following weight proportion：The Radix Astragali 3, Radix Codonopsis 3, the fruit of Chinese wolfberry 3, date 1, Radix Glycyrrhizae 1, plus the decocting of 6 times of amounts boil 0.5 Hour, filtration, relative density is 1.10 thick paste when extract solution is concentrated into 50 DEG C, be dry, pulverize, and loads capsule.
Embodiment 4：
Weigh the medicinal material of following weight proportion：The Radix Astragali 9, Radix Codonopsis 15, the fruit of Chinese wolfberry 12, date 10, Radix Glycyrrhizae 10, decoct 3 times, for the first time Plus 10 times of decoctings measured are boiled 2 hours, the decoctings of second plus 8 times amount are boiled 1.5 hours, and it is small that third time adds the decocting of 6 times of amounts to boil 1 When, collecting decoction, filtration, relative density is 1.50 thick paste when extract solution is concentrated into 50 DEG C, adds the weight of polyethylene glycol 20 Part, melting is made dripping pill.

Claims (5)

1. a kind of medicine or health food with strengthen immunity effect, it is characterised in that contain the Radix Astragali, Radix Codonopsis, matrimony vine Son, date, the taste medicinal material of Radix Glycyrrhizae 5.
2. medicine or health food with strengthen immunity effect according to claim 1, it is characterised in that it contains The weight proportion for having each active ingredient is：Radix Astragali 3-9 parts, Radix Codonopsis 3-15 parts, fruit of Chinese wolfberry 3-12 parts, date 1-10 parts, Radix Glycyrrhizae 1- 10 parts.
3. medicine or health food with strengthen immunity effect according to claim 1 and 2, it is characterised in that its Weight proportion containing each active ingredient is：3 parts of the Radix Astragali, 6 parts of Radix Codonopsis, 3 parts of the fruit of Chinese wolfberry, 1 part of date, 1 part of Radix Glycyrrhizae.
4. the medicine or health food with strengthen immunity effect according to claim 1,2 or 3, it is characterised in that The extraction process of its active ingredient is：Above-mentioned medicinal material is weighed, is decocted 1-3 times, collecting decoction, filtration, when filtrate is concentrated into 50 DEG C Relative density is the thick paste of 1.10-1.50.
5. medicine or health food with strengthen immunity effect according to claim 4, it is characterised in that it has Imitate composition extraction process be：Above-mentioned medicinal material is weighed, is decocted 2 times, add the decoctings of 10 times of amounts to boil for the first time 2 hours, Jia 8 for the second time The decocting of amount again is boiled 1 hour, collecting decoction, filtration, and relative density is 1.25 thick paste when filtrate is concentrated into 50 DEG C.
CN201510995083.7A 2015-12-28 2015-12-28 The medicine or health food of a kind of strengthen immunity Pending CN106912943A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107213283A (en) * 2017-07-21 2017-09-29 臧星 A kind of antifatigue, Yin Yang balancing food and medicament dual-purpose Chinese medicine composition and preparation method thereof
CN107260889A (en) * 2017-07-07 2017-10-20 重庆喜旋生物科技有限公司 A kind of Qihuang Granule and preparation method thereof
CN107568740A (en) * 2017-09-07 2018-01-12 哈尔滨医科大学 A kind of health-care food composition, its preparation method and the purposes in terms of strengthen immunity
CN110141610A (en) * 2019-05-28 2019-08-20 山西大学 A kind of Chinese herbal ointment formula is preparing the application in hepatic
CN113476506A (en) * 2021-07-13 2021-10-08 山西中医药大学 Astragalus root body resistance strengthening tea with function of regulating immunity and preparation method thereof
CN113679770A (en) * 2021-09-27 2021-11-23 山西中医药大学 Composition and medicinal tea for improving immunity and preparation method thereof
CN113730478A (en) * 2021-10-27 2021-12-03 成都西域苁蓉生物科技有限公司 Spleen-tonifying and nerve-soothing wine containing cistanche and preparation method thereof

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107260889A (en) * 2017-07-07 2017-10-20 重庆喜旋生物科技有限公司 A kind of Qihuang Granule and preparation method thereof
CN107213283A (en) * 2017-07-21 2017-09-29 臧星 A kind of antifatigue, Yin Yang balancing food and medicament dual-purpose Chinese medicine composition and preparation method thereof
CN107568740A (en) * 2017-09-07 2018-01-12 哈尔滨医科大学 A kind of health-care food composition, its preparation method and the purposes in terms of strengthen immunity
CN110141610A (en) * 2019-05-28 2019-08-20 山西大学 A kind of Chinese herbal ointment formula is preparing the application in hepatic
CN110141610B (en) * 2019-05-28 2021-07-27 山西大学 Application of traditional Chinese medicine ointment formula in preparation of liver-protecting medicine
CN113476506A (en) * 2021-07-13 2021-10-08 山西中医药大学 Astragalus root body resistance strengthening tea with function of regulating immunity and preparation method thereof
CN116850223A (en) * 2021-07-13 2023-10-10 山西中医药大学 Astragalus mongholicus strengthening tea with immunity regulating function and preparation method thereof
CN113679770A (en) * 2021-09-27 2021-11-23 山西中医药大学 Composition and medicinal tea for improving immunity and preparation method thereof
CN113730478A (en) * 2021-10-27 2021-12-03 成都西域苁蓉生物科技有限公司 Spleen-tonifying and nerve-soothing wine containing cistanche and preparation method thereof

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Application publication date: 20170704