CN104146244B - Not old careless oral liquid of a kind of wilsonii and preparation method thereof - Google Patents
Not old careless oral liquid of a kind of wilsonii and preparation method thereof Download PDFInfo
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- CN104146244B CN104146244B CN201410331066.9A CN201410331066A CN104146244B CN 104146244 B CN104146244 B CN 104146244B CN 201410331066 A CN201410331066 A CN 201410331066A CN 104146244 B CN104146244 B CN 104146244B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses the not old careless oral liquid of a kind of wilsonii, comprise the raw material of following weight fraction: Radix Et Caulis Acanthopanacis Senticosi seed 300 ~ 500 parts, not old grass 80 ~ 120 parts, 600 ~ 800 parts, water and lime tree royal jelly 80 ~ 120 parts, be by Radix Et Caulis Acanthopanacis Senticosi seed, not old grass, drying → broken wall Ultramicro-powder → alcohol steep → enrichment process is prepared into wilsonii, not old grass extracts cream; Add high-quality Changbai Mountain mineral water and appropriate lime tree royal jelly to stir evenly and obtain.This oral liquid has improvement metabolism, promotes nutrient absorption, strengthens immune function of human body, antifatigue, anti-ageing, the effects such as trophic nerve.The not old careless oral liquid preparation technology of wilsonii of the present invention is simple, and suitability for industrialized is produced.
Description
Technical field
The present invention relates to technical field of health care food.More specifically, not old careless oral liquid of a kind of wilsonii and preparation method thereof is related to.
Background technology
At present, the disease such as hypertension, high fat of blood, cerebral thrombus, neurasthenia, early ageing has had generality, serious harm is healthy, even cause the life-threatening major diseases such as diabetes, cerebral thrombus, myocardial infarction, tumour, leukaemia, caused thus and prevention from suffering from the diseases and treatment are paid much attention to.Put prevention first and extensively praised highly always, therefore, develop high-end health food, regulate sub-health population in time, auxiliary alleviation sufferer illness, is of great immediate significance.
Motherland's medicine and pharmacology are of extensive knowledge and profound scholarship, and Chinese medicine is of a great variety, and Changbaishan area, northeast wilsonii is the good medicine of health care.Namely wilsonii is regarded as having from ancient times and adds the good medicine that essence mends marrow and anti-aging effects, and Compendium of Material Medica claims wilsonii, good with the five leaf persons of accompanying each other, therefore named slender acanthopanax, has another name called five flowers.Slender acanthopanax controls rheumatism, strengthens the bone, and its merit is deeply good.And northern wilsonii, best in quality, there is good effect to adrenal gland, disease ability of resisting can be strengthened; Eleutheroside can improve acuity and physics endurance, siberian Ginseng P.E display can irritation cell immunity, Cure of depression, cerebral thrombus, high fat of blood, hypertension, coronary heart disease, diabetes, leukopenia etc., also helpful to the AIDS treatment of commitment; The not old grass in Changbai Mountain is distinctive plant, and not old grass has another name called broomrape, angiosperm, the orchid family, grows on the cliff or steep cliff of height above sea level 1300-2000 rice, now realizes artificial culture.All herbal medicine, containing the super kinases of a large amount of CR, the special effect have tonifying kidney and strengthening yang, relaxing bowel, cure mainly impotence due to deficiency of the kidney, waist knee skelagia, the dry constipation of intestines and cystitis etc., popular legend has effect alive for evermore, and " not old grass " gains the name thus; The differentiation of thousands of years gone through by Changbai Mountain royal jelly, gain the name in the Qing Dynasty, for imperial palace tribute, the woodsy extraordinary royal jelly of natural linden on Changbai Mountain, mainly containing protein, fat, carbohydrate, vitamin A, Cobastab l, vitamin B2, abundant folic acid, pantothenic acid and inositol.Also have similar acetylcholine sample material, and the amino acid of multiple human body needs and bio-hormone etc.Royal jelly is rich in estrogen for beauty treatment, menopause symptom, weak after being ill; Infantile malnutrition; Old body declines; Leukopenia; Unresolved and chronic hepatitis; Duodenal ulcer; Bronchial astehma; Diabetes; Blood disease; Mental disease; Essential uterine bleeding; Irregular menstruation; Functional sterility and baldness etc.
But, the product that effect of old for wilsonii grass can be given full play to needing at present to provide a kind of mouthfeel good and preparation method.
Summary of the invention
First technical problem that the present invention will solve is to provide the not old careless oral liquid of a kind of wilsonii, and this oral liquid has improvement metabolism, promotes nutrient absorption, strengthens immune function of human body, antifatigue, anti-ageing, the effects such as trophic nerve.
Second technical problem that the present invention will solve is to provide the preparation method of the not old careless oral liquid of a kind of wilsonii, and the method preparation technology is simple, and suitability for industrialized is produced.
For solving above-mentioned first technical problem, the present invention adopts following technical proposals:
The not old careless oral liquid of a kind of wilsonii, comprises the raw material of following weight fraction: Radix Et Caulis Acanthopanacis Senticosi seed 300 ~ 500 parts, not old grass 80 ~ 120 parts, 600 ~ 800 parts, water and lime tree royal jelly 80 ~ 120 parts.
Preferably, described wet concentration is from Changbai Mountain mineral water; Described lime tree royal jelly is selected from Changbai Mountain lime tree royal jelly.
For solving above-mentioned second technical problem, the present invention adopts following technical proposals:
A preparation method for the not old careless oral liquid of wilsonii, comprises following preparation process:
(1) being ground into granularity with broken wall equipment after 300 ~ 500 parts of Radix Et Caulis Acanthopanacis Senticosi seeds and 80 ~ 120 parts of not old grass being dried by mass fraction is the Ultramicro-powder that 1000 ~ 1500 object Radix Et Caulis Acanthopanacis Senticosi seeds mix with not old grass;
(2) Ultramicro-powder that step (1) obtains is added in multi-functional extraction thickener group extractor, add the ethanol that concentration is 60-80%, amount of alcohol added is 8 ~ 10 times of Ultramicro-powder quality, unlatching extractor heats, extract was heated to boiling after 20 ~ 30 minutes, with the extract suction concentration tank of suction filtering tube by 20-40%;
Unlatching concentration tank and heating system make concentrate temperature be 70 ~ 85 DEG C, and vacuum is-0.05 ~-0.08MPa, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, in cream, moisture content is 25 ~ 30%;
(3) add pure water 600 ~ 800 parts, lime tree royal jelly 80 ~ 120 parts in the slender acanthopanax seed obtained in step (2), not old careless cream, after stirring in mixer, obtain the not old careless oral liquid of product wilsonii.
Preferably, the indirect steam produced when step (2) described concentration tank concentrates becomes condensate liquid through condenser and cooler and is back to extractor and re-uses as solvent, solvent is from top to bottom by bottom Ultramicro-powder to extractor, soluble component in Ultramicro-powder is dissolved in extractor internal solvent, extract is through suction filtering tube suction concentration tank, the concentrated indirect steam produced is delivered to again extractor and is done novel solvent, formation solvent refluxing extracts, proceed until complete stripping and extracting liquid colourless concentrate, the colourless liquid in extractor reclaims for reusing next time.
Beneficial effect of the present invention is as follows:
In the not old careless oral liquid of wilsonii of the present invention, isofraxidin is up to 66.57%, and eleutheroside content can reach more than 65%, and Radix Et Caulis Acanthopanacis Senticosi polysaccharide content is up to 73.9%; The present invention utilizes rupture of membranes wall breaking technology that cell membrane is smashed to allow effective component discharge, not old careless CR super kinases content 2,000,000 unit, and absorptivity can up to 95%; Add super nutritive food royal jelly and the mineral water of fresh high active ingredient, pure natural, preservative free, highly extract raw material beneficiating ingredient, avoid the waste of the existing mode of production to valuable ingredient of traditional Chinese medicine drug effect, also reduce production cost simultaneously, and benefit health products and eat crowd.
Detailed description of the invention
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.It will be appreciated by those skilled in the art that specifically described content is illustrative and nonrestrictive, should not limit the scope of the invention with this below.
Embodiment 1
(1) being ground into granularity with broken wall equipment after 300g Radix Et Caulis Acanthopanacis Senticosi seed and the not old grass of 80g being dried by mass fraction is the Ultramicro-powder that 1000 object Radix Et Caulis Acanthopanacis Senticosi seeds mix with not old grass;
(2) Ultramicro-powder that step (1) obtains is added in multi-functional extraction thickener group extractor, add the ethanol that concentration is 60%, amount of alcohol added is 8 times of Ultramicro-powder quality, unlatching extractor heats, extract was heated to boiling after 20 minutes, with suction filtering tube by the extract suction concentration tank of 20%;
Unlatching concentration tank and heating system make concentrate temperature be 70 DEG C, and vacuum is-0.05 ~-0.08MPa, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, in cream, moisture content is 25%;
(3) add Changbai Mountain mineral water 600g, lime tree royal jelly 80g in the slender acanthopanax seed obtained in step (2), not old careless cream, after stirring in mixer, obtain the not old careless oral liquid of product wilsonii.
The oral liquid obtained to example 1 carries out antifatigue and immunity test, with KM small white mouse for feeding experimental subjects, is provided by preclinical medicine institute of Jilin University animal experimental center, the healthy mouse of 22-24g 16, each 8 of male and female, divide four groups, two female two heros are one group.First group of every day feeds a 2ml; Second group of every day feeds twice, each 2ml; 3rd group of every day feeds twice, each 5ml; Will not feed for 4th group.In (20 ± 3) DEG C constant temperature indoor feeding 20 days.
One, anti-fatigue test
1, swimming with a load attached to the body
Four groups of mouse are tied up using lead as heavy burden by 10% of body weight at afterbody, then mouse is placed in depth of water 30cm, the circular channels of water temperature 25 DEG C swims; From mouse sinks under the water 10 seconds, record each mouse swimming time, more each group, with the difference of control group, is seen the following form:
2, running test
Four groups of mouse are placed in rotary experimental animal cage, record mouse running time and and rest number of times, the results are shown in following table:
Two, immunity experiment
To the influenza virus of four groups of injected in mice 0.1ml after Section 1 experiment, observe the performance of mouse, the results are shown in following table:
Embodiment 2
(1) being ground into granularity with broken wall equipment after 500 parts of Radix Et Caulis Acanthopanacis Senticosi seeds and 120 parts of not old grass being dried by mass fraction is the Ultramicro-powder that 1500 object Radix Et Caulis Acanthopanacis Senticosi seeds mix with not old grass;
(2) Ultramicro-powder that step (1) obtains is added in multi-functional extraction thickener group extractor, add the ethanol that concentration is 80%, amount of alcohol added is 10 times of Ultramicro-powder quality, unlatching extractor heats, extract was heated to boiling after 30 minutes, with suction filtering tube by the extract suction concentration tank of 40%;
Unlatching concentration tank and heating system make concentrate temperature be 85 DEG C, and vacuum is-0.08MPa, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, in cream, moisture content is 30%;
(3) add mineral water 800 parts, lime tree royal jelly 120 parts in the slender acanthopanax seed obtained in step (2), not old careless cream, after stirring in mixer, obtain the not old careless oral liquid of product wilsonii.
Carry out component content test to the not old careless oral liquid of the product wilsonii of embodiment 2, wherein Determination of isofraxidin is 66.57%, and eleutheroside content is 68%, and Radix Et Caulis Acanthopanacis Senticosi polysaccharide content is 73.9%; Not old careless CR super kinases content 2,000,000 unit, absorptivity is 95%.
Embodiment 3
(1) being ground into granularity with broken wall equipment after 400 parts of Radix Et Caulis Acanthopanacis Senticosi seeds and 100 parts of not old grass being dried by mass fraction is the Ultramicro-powder that 1200 object Radix Et Caulis Acanthopanacis Senticosi seeds mix with not old grass;
(2) Ultramicro-powder that step (1) obtains is added in multi-functional extraction thickener group extractor, add the ethanol that concentration is 70%, amount of alcohol added is 8 ~ 10 times of Ultramicro-powder quality, unlatching extractor heats, extract was heated to boiling after 25 minutes, with suction filtering tube by the extract suction concentration tank of 30%;
Unlatching concentration tank and heating system make concentrate temperature be 80 DEG C, and vacuum is-0.06MPa, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, in cream, moisture content is 28%;
(3) add pure water 700 parts, lime tree royal jelly 100 parts in the slender acanthopanax seed obtained in step (2), not old careless cream, after stirring in mixer, obtain the not old careless oral liquid of product wilsonii.
Test the not old careless oral liquid of the product wilsonii of embodiment 3, wherein Determination of isofraxidin is 67%, and eleutheroside content is 65%, and Radix Et Caulis Acanthopanacis Senticosi polysaccharide content is 74%; Not old careless CR super kinases content 2,000,000 unit, absorptivity is 95%.
Embodiment 4
Step 1: Radix Et Caulis Acanthopanacis Senticosi seed, not old careless 800g after clear water washing are proceeded to Chinese herbal medicine drying baker, mass percent is Radix Et Caulis Acanthopanacis Senticosi seed 80%, not old grass 20% is dried, again material is inserted broken wall equipment (Jinan Yin Run YR-8 type), after 50 minutes, be ground into granularity 1000-1500 object Ultramicro-powder 500-600g;
Step 2: utilize multi-functional herbal medicine to extract concentrated unit and extract concentrated (Shanghai brightness exhibition HZ-TNG), take out step 1 Ultramicro-powder and insert in extractor, add the ethanol that 8-10 times of concentration are 66%.Open extractor heating system, make extract be heated to boiling after 20-30 minute, with suction filtering tube by the extract suction concentration tank of 1/3rd.Close extractor directly to unite and chuck hot water, open concentration tank directly to unite and make inspissated juice temperature remain on about 80 DEG C with heating system, vacuum remains on-0.05 to-0.08MPA, the indirect steam produced time concentrated becomes condensate liquid through condenser and cooler and is back to extractor and does novel solvent and add, novel solvent is from top to bottom by bottom Ultramicro-powder to extractor, soluble component in Ultramicro-powder is dissolved in extractor internal solvent, extract is through suction filtering tube suction concentration tank, the concentrated indirect steam produced is delivered to again extractor and is done novel solvent, form novel solvent refluxing extraction, proceed until stripping (extracting liquid colourless) is concentrated completely, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, moisture in cream is 25-30%, colourless liquid in extractor can be next multiplexing.
Step 3: step 2 gained slender acanthopanax seed, not old careless cream are added high-quality Changbai Mountain mineral spring pure water, Changbai Mountain lime tree royal jelly, filling in 10ml sterile glass vials after stirring in mixer.Mass percent is slender acanthopanax seed and not old careless cream 40%, purified water 50%, royal jelly 10%.
Embodiment 5
Identical with embodiment 4 method, difference is that mass percent is slender acanthopanax seed, not old careless cream 35%, purified water 50%, royal jelly 15%.
Product embodiment 5 prepared is to sub-health population; 10 adults of physique deviation take, eating method and amount: every day 2 times, each 1 bottle.
After one month, all reflect that this oral liquid mouthfeel is good, effectively can improve metabolism, promote nutrient absorption, promote hematopoiesis, strengthen immune function of human body, antifatigue, anti-ageing, trophic nerve, balancing blood fat, blood pressure, blood sugar, get well.
Comparative example 1
With embodiment 1, its difference is only: it is 1000 object Radix Et Caulis Acanthopanacis Senticosi seed Ultramicro-powders that step (1) is ground into granularity with broken wall equipment after being dried by 380g Radix Et Caulis Acanthopanacis Senticosi seed by mass fraction.
Comparative example 2
With embodiment 1, its difference is only: step (1) is ground into broken wall equipment the Ultramicro-powder that granularity is the not old grass mixing of 1000 objects after being dried by not old for 380g grass by mass fraction.
The product of comparative example 1,2 and embodiment 1 is used for sub-health population; 10 adults of physique deviation take, eating method and amount: every day 2 times, each 1 bottle.
The products taste of embodiment 1 is good, effectively can improve metabolism, promotes nutrient absorption, promotes hematopoiesis, and strengthen immune function of human body, antifatigue, anti-ageing, trophic nerve, balancing blood fat, blood pressure, blood sugar, get well.
The products taste of comparative example 1,2 is general, and sub-health state does not improve.
The consumption of product increasing comparative example 1,2 is every day 3 times, each 2 bottles, only can balancing blood fat, blood pressure, blood sugar, and to enhancing immune function of human body, antifatigue, anti-ageing, trophic nerve does not have clear improvement.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give exhaustive to all embodiments, every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (1)
1. the not old careless oral liquid of wilsonii, is characterized in that, be made up of the raw material of following parts by weight: Radix Et Caulis Acanthopanacis Senticosi seed 300 ~ 500 parts, not old grass 80 ~ 120 parts, 600 ~ 800 parts, water and lime tree royal jelly 80 ~ 120 parts;
Described wet concentration is from Changbai Mountain mineral water; Described lime tree royal jelly is selected from Changbai Mountain lime tree royal jelly;
The preparation method of described oral liquid comprises the steps:
(1) being ground into granularity with broken wall equipment after 300 ~ 500 parts of Radix Et Caulis Acanthopanacis Senticosi seeds and 80 ~ 120 parts of not old grass being dried by mass fraction is the Ultramicro-powder that 1000 ~ 1500 object Radix Et Caulis Acanthopanacis Senticosi seeds mix with not old grass;
(2) Ultramicro-powder that step (1) obtains is added in multi-functional extraction thickener group extractor, add the ethanol that concentration is 60-80%, amount of alcohol added is 8 ~ 10 times of Ultramicro-powder quality, unlatching extractor heats, extract was heated to boiling after 20 ~ 30 minutes, with the extract suction concentration tank of suction filtering tube by 20-40%;
Unlatching concentration tank and heating system make concentrate temperature be 70 ~ 85 DEG C, and vacuum is-0.05 ~-0.08MPa, until be condensed into Radix Et Caulis Acanthopanacis Senticosi seed, not old careless cream, in cream, moisture content is 25 ~ 30%;
(3) add 600 ~ 800 parts, water, lime tree royal jelly 80 ~ 120 parts in the Radix Et Caulis Acanthopanacis Senticosi seed obtained in step (2), not old careless cream, after stirring in mixer, obtain the not old careless oral liquid of product wilsonii;
Wherein, the indirect steam produced when step (2) described concentration tank concentrates becomes condensate liquid through condenser and cooler and is back to extractor and re-uses as solvent, solvent is from top to bottom by bottom Ultramicro-powder to extractor, soluble component in Ultramicro-powder is dissolved in extractor internal solvent, extract is through suction filtering tube suction concentration tank, the concentrated indirect steam produced is delivered to again extractor and is done novel solvent, formation solvent refluxing extracts, proceed until complete stripping and extracting liquid colourless concentrate, the colourless liquid in extractor reclaims for reusing next time.
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| 东北双参蜂王浆口服液新工艺实验研究;郑秀芹 等;《牡丹江医学院学报》;19930228;第14卷(第2期);第110页第2-3节 * |
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