CN105327239A - Traditional Chinese medicinal composition for treating children anorexia as well as preparation method and application of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for treating children anorexia as well as preparation method and application of traditional Chinese medicinal composition Download PDFInfo
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- CN105327239A CN105327239A CN201410318482.5A CN201410318482A CN105327239A CN 105327239 A CN105327239 A CN 105327239A CN 201410318482 A CN201410318482 A CN 201410318482A CN 105327239 A CN105327239 A CN 105327239A
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Abstract
The invention provides a traditional Chinese medicinal composition for treating children anorexia. The traditional Chinese medicinal composition mainly consists of the following medicinal raw materials: white hyacinth bean, Chinese yam, poria cocos, dark plum, concha ostreae, fructus citri sarcodactyli, fructus hordei germinatus, semen ziziphi spinosae, fructus ziziphi jujubae, arillus longan, fructus alpiniae oxyphyllae, mulberry, fructus crataegi and semen raphani. Furthermore, the traditional Chinese medicinal composition consists of the following medicinal raw materials (in parts by weight): 3-15 parts of white hyacinth bean, 1-10 parts of Chinese yam, 3-15 parts of poria cocos, 1-8 parts of dark plum, 1-8 parts of concha ostreae, 1-8 parts of fructus citri sarcodactyli, 1-8 parts of fructus hordei germinatus, 3-15 parts of semen ziziphi spinosae, 1-8 parts of fructus ziziphi jujubae, 1-8 parts of arillus longan, 1-8 parts of fructus alpiniae oxyphyllae, 1-8 parts of mulberry, 1-8 parts of fructus crataegi and 1-10 parts of semen raphani. The composition disclosed by the invention has functions of tonifying stomach and spleen, boosting immunity and activity of children, tonifying brain and improving intelligence, and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its production and use, be specifically related to a kind of Chinese medicine composition for the treatment of apositia of children and its production and use, belong to field of medicaments.
Background technology
Apositia refers to child's long term inappetence, a kind of disease of even refusing to eat, more common in child.Particularly modern society, because the unreasonable nursing of the head of a family causes children anorexia, refusing to eat, nutrient imbalance disease increases increasingly, causes damage to taste, have impact on the transporting ability of becoming thoroughly decomposed of the spleen and stomach in children.
To the treatment of apositia, generally adopt Chinese and western drugs, but Western medicine not only price is high, some medicines also have side effect.The Chinese prescription of prior art disclosed treatment infantile anorexia is also a lot, but make pharmaceutical preparation as tablet, capsule, pill, granule etc. more, disclosed in Chinese patent application 201210192946.3, form medicine by Radix Pseudostellariae, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Massa Medicata Fermentata, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Endothelium Corneum Gigeriae Galli, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Aurantii Immaturus, Radix Glycyrrhizae; The disclosed medicine be made up of Semen Persicae, Semen Armeniacae Amarum, Fructus Gardeniae, Camphora, Borneolum Syntheticum, Resina Ferulae, Rhizoma Curcumae, Rhizoma Sparganii of Chinese patent application 201310335363.6; The disclosed compositions be made up of Radix Pseudostellariae, stir-fry Semen Vignae Cylindricae, stir-fry Semen Coicis, Fructus Crataegi (parched) core, Semen Raphani (parched), Concha Arcae (calcined), Fructus Aurantii (parched) of Chinese patent application 03111124.6, etc., be all unfavorable for children taking.
The present composition has stomach invigorating, spleen invigorating, strengthens immunization programs for children power and vigor, effect of brain-nourishing intelligence-benefiting.Utilize the present composition to be prepared into child's beverage, not only facilitate material benefit, useful children's health, and preservative free, safe and reliable, mouthfeel is good, be suitable for drinking of children, have huge development prospect.
Summary of the invention
First object of the present invention is to provide a kind of Chinese medicine composition for the treatment of apositia of children.
Second object of the present invention is the preparation method providing said composition.
3rd object of the present invention is to provide the application of said composition in preparation treatment children anorexia disease drug.
Technical solution problem of the present invention is achieved by the following technical solution:
Treat a Chinese medicine composition for apositia of children, this Chinese medicine composition mainly comprises following crude drug: Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, Concha Ostreae, finger citron sliced, Fructus Hordei Germinatus, Semen Ziziphi Spinosae, Fructus Jujubae, Arillus Longan, Fructus Alpiniae Oxyphyllae, Fructus Mori, Fructus Crataegi, Semen Raphani.
Further, this traditional Chinese medicinal composition raw materials consists of (with listed as parts by weight):
Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part.
Further, its crude drug consists of:
Semen Lablab Album 3-12 part, Rhizoma Dioscoreae 1-7 part, Poria 3-12 part, Fructus Mume 1-6 part, Concha Ostreae 1-6 part, finger citron sliced 1-6 part, Fructus Hordei Germinatus 1-6 part, Semen Ziziphi Spinosae 3-12 part, Fructus Jujubae 1-6 part, Arillus Longan 1-6 part, Fructus Alpiniae Oxyphyllae 1-6 part, Fructus Mori 1-6 part, Fructus Crataegi 1-6 part, Semen Raphani 1-7 part.
Further, its crude drug consists of:
Semen Lablab Album 3-8 part, Rhizoma Dioscoreae 1-5 part, Poria 3-8 part, Fructus Mume 1-4 part, Concha Ostreae 1-4 part, finger citron sliced 1-4 part, Fructus Hordei Germinatus 1-4 part, Semen Ziziphi Spinosae 3-8 part, Fructus Jujubae 1-4 part, Arillus Longan 1-4 part, Fructus Alpiniae Oxyphyllae 1-4 part, Fructus Mori 1-4 part, Fructus Crataegi 1-4 part, Semen Raphani 1-5 part.
Further, its crude drug consists of:
Semen Lablab Album 4 parts, Rhizoma Dioscoreae 2 parts, 4 parts, Poria, Fructus Mume 1 part, Concha Ostreae 1 part, finger citron sliced 1 part, 1 part, Fructus Hordei Germinatus, Semen Ziziphi Spinosae 4,1 part, Fructus Jujubae, Arillus Longan 2 parts, Fructus Alpiniae Oxyphyllae 2 parts, Fructus Mori 2 parts, Fructus Crataegi 2 parts, Semen Raphani 2 parts.
Chinese medicine composition of the present invention can extract preparation according to a conventional method, can also be further purified refining, can also add further customary adjuvant routinely preparation process be prepared into health promoting beverage, oral liquid, granule, tablet, capsule, powder.
Described general extraction methods comprises one or more modes in water boiling and extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects;
Described Extraction solvent is water or alcoholic solution; Be the ethanol of 30-80% further; Further be preferably the ethanol of 50-70%;
Described process for purification refine comprises water extract-alcohol precipitation, extraction or through macroporous resin column, silica column purification etc.
The preparation method of Chinese medicine composition of the present invention comprises the steps:
Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;
Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, and continuation water extraction, obtains extracting solution, and concentrating under reduced pressure to obtain final product.
Further, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Described extraction time is 2-10 hour, and extraction time is 1-3 time; Further, extracting method described in step 1,2 is first soak extraction, then reflux, extract; Further, the described soak extraction time is 2-10 hour, and reflux, extract, number of times is 1-3 time, and each extraction time is 0.5-2 hour.
Treat a health promoting beverage for apositia of children, with parts by weight, this beverage supplementary material consists of:
Raw material forms: Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part;
Adjuvant forms: white sugar 200-300 part, sodium carboxymethyl cellulose 0.1-1 part, citric acid 1-10 part, sodium citrate 0.5-1.5 part, essence 1-10 part.
Further, its adjuvant consists of: white sugar 220-290 part, sodium carboxymethyl cellulose 0.15-0.7 part, citric acid 1.5-7 part, sodium citrate 0.6-1.2 part, essence 1.5-7 part;
Further, its adjuvant consists of: white sugar 240-270 part, sodium carboxymethyl cellulose 0.2-0.5 part, citric acid 2-5 part, sodium citrate 0.5-1 part, essence 2-5 part;
Further, its adjuvant consists of: white sugar 260 parts, sodium carboxymethyl cellulose 0.29 part, citric acid 2.9 parts, sodium citrate 0.87 part, 2.32 parts, essence.
This beverage preparation method comprises the steps:
Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;
Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, and continuation water extraction, obtains extracting solution;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount 1-5%, filters, gets filtrate;
Step 4: add adjuvant in proportion, filters, to obtain final product.
Further, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Further, extracting method described in step 1,2 is first soak extraction, then reflux, extract; Further, the described soak extraction time is 2-10 hour, and reflux, extract, number of times is 1-3 time, and each extraction time is 0.5-2 hour.
Further, add water described in step 3 that to be settled to crude drug amount be 1-4%; Further, be 1-2%; Further, crude drug amount is 1%.
Further, the filtrate obtained is filtered to step 4 and carry out pasteurize.
" extracting solution adds water and is settled to crude drug amount 1% " of the present invention refers to, the extracting solution that 10g crude drug obtains after extracting adds water and is settled to 1000ml, and namely crude drug amount is 1%.
The present composition has stomach invigorating, spleen invigorating, strengthens immunization programs for children power and vigor, effect of brain-nourishing intelligence-benefiting.
Detailed description of the invention
The screening of different components treatment apositia of children comparitive study prescription
1 Experimental agents:
Prescription 1: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g;
Prescription 2: Semen Lablab Album 4g, Rhizoma Dioscoreae 10g, Poria 3g, Fructus Mume 1g, Concha Ostreae 2g, finger citron sliced 1g, Fructus Hordei Germinatus 3g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 8g, Fructus Alpiniae Oxyphyllae 3g, Fructus Mori 2g, Fructus Crataegi 1g, Semen Raphani 10g, Cordyceps militaris (L.) Link. 3g;
Prescription 3: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g, Herba Pogostemonis 5g, Pericarpium Citri tangerinae 3g;
Prescription 4: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g, Cordyceps militaris (L.) Link. 6g, Amylum Puerariae Radicis 3g, Rhizoma Zingiberis Recens 4g;
2. preparation method
In proportion by crude drug, Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction; All the other medical materials mix with Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixed extract and medicinal residues, with water extraction, obtain extracting solution.Add customary adjuvant and be prepared into child's beverage.
3 result on trial
Trier 40 children, the age, trier did not like to have a meal at ordinary times, and appetite is not strong between 6-15 year.
Trial method: the child's beverage prepared by prescription 1-4 gives 10 drinking of childrens on probation respectively, noon, each one bottle of evening, 125ml/ bottle, a week on probation.Pay a return visit trial effect with questionnaire form, result is as shown in table 1.
The trial effect of child's beverage prepared by table 1 prescription 1-4
| Product efficacy | Mouthfeel is good | Appetite improves | Untoward reaction |
| Prescription 1 effective percentage | 90％ | 90％ | 0 |
| Prescription 2 effective percentage | 80％ | 60％ | 0 |
| Prescription 3 effective percentage | 80％ | 40％ | 0 |
| Prescription 4 effective percentage | 70％ | 40％ | 0 |
Result shows, prescription 1 improve appetite and mouthfeel good in Be very effective be better than prescription 2,3,4.。
Preparation method is investigated
Prescription: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g;
Preparation method 1:
Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;
Step 2: the extracting solution of Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 and medicinal residues are mixed, with water extraction, obtains extracting solution.
Preparation method 2:
Get crude drug mixing in proportion, with water extraction, obtain extracting solution.
The extracting solution getting preparation method 1.2 adds customary adjuvant respectively and is prepared into child's beverage.
Trial effect:
Child's beverage is prepared respectively by above two kinds of methods
Trier 20 children, the age, trier at ordinary times appetite was not strong between 6-15 year.
Trial method: the guarantor for hired help child prepared by two kinds of distinct methods gives 10 drinking of childrens on probation respectively, noon, each one bottle of evening, 125ml/ bottle, a week on probation.Pay a return visit trial effect with questionnaire form, result is as shown in table 2.
The trial effect of child's beverage that the different preparation method of table 2 obtains
| Product efficacy | Mouthfeel is good | Appetite improves | Untoward reaction |
| Preparation method 1 effective percentage | 90％ | 90％ | 0 |
| Preparation method 2 effective percentage | 80％ | 60％ | 0 |
Result shows: child's beverage that the child's beverage effect effect prepared by preparation method 1 will be prepared apparently higher than preparation method 2.
Embodiment
Embodiment 1
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g;
Adjuvant forms: white sugar 260g, sodium carboxymethyl cellulose 0.29g, citric acid 2.9g, sodium citrate 0.87g, essence 2.32g;
Preparation method:
Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverizes, adds 10 times of water, soak after 2 hours, heating and refluxing extraction half an hour;
Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 10 times of water, soak after 2 hours, the extracting solution obtained after water extraction with step 1 and medicinal residues mix, continue heating and refluxing extraction twice, each 2 hours, filter, merge extractive liquid;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount and reaches 1%;
Step 4: adopt high speed centrifuge to filter medicinal liquid good for standardize solution and obtain clear liquor;
Step 5: add adjuvant in proportion, crosses 1.0um filtering with microporous membrane;
Step 6: adopt pasteurization process, fill, to obtain final product.
Specification: every bottle of 125ml
Usage and dosage: the morning, noon and afternoon respectively once, each 125ml
Embodiment 2
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 3g, Rhizoma Dioscoreae 10g, Poria 3g, Fructus Mume 8g, Concha Ostreae 2g, finger citron sliced 8g, Fructus Hordei Germinatus 2g, Semen Ziziphi Spinosae 15g, Fructus Jujubae 1g, Arillus Longan 8g, Fructus Alpiniae Oxyphyllae 1g, Fructus Mori 8g, Fructus Crataegi 1g, Semen Raphani 10g;
Adjuvant forms: white sugar 200g, sodium carboxymethyl cellulose 1g, citric acid 1g, sodium citrate 1.5g, crystal grape essence 1g;
Preparation method:
Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverizes, adds 12 times of water, soak after 4 hours, supersound extraction half an hour;
Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 12 times of water, soak after 4 hours, the extracting solution obtained after water extraction with step 1 and medicinal residues mix, continue supersound extraction twice, each 1.5 hours, filter, merge extractive liquid;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount and reaches 2%;
Step 4: adopt diatomite filter circulating filtration to obtain clear liquor medicinal liquid good for standardize solution;
Step 5: add adjuvant in proportion, crosses 1.0um filtering with microporous membrane;
Step 6: adopt pasteurization process, fill, to obtain final product.
Specification: every bottle of 125ml
Usage and dosage: the morning, noon and afternoon respectively once, each 125ml
Embodiment 3
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 15g, Rhizoma Dioscoreae 1g, Poria 15g, Fructus Mume 1g, Concha Ostreae 8g, finger citron sliced 1g, Fructus Hordei Germinatus 8g, Semen Ziziphi Spinosae 3g, Fructus Jujubae 8g, Arillus Longan 1g, Fructus Alpiniae Oxyphyllae 8g, Fructus Mori 1g, Fructus Crataegi 8g, Semen Raphani 1g;
Adjuvant forms: white sugar 300g, sodium carboxymethyl cellulose 0.1g, citric acid 10g, sodium citrate 0.5g, strawberry essence 10g;
Preparation method:
Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverize, add 8 times of water, soak after 3 hours, reflux gets half an hour;
Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 8 times of water, soak after 3 hours, the extracting solution obtained after water extraction with step 1 and medicinal residues mix, seepage pressure effects 12 hours, filter, merge extractive liquid;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount and reaches 3%;
Step 4: the medicinal liquid that standardize solution is good adopts high speed centrifuge to filter and obtains clear liquor;
Step 5: add adjuvant in proportion, crosses 1.0um filtering with microporous membrane;
Step 6: adopt pasteurization process, fill, to obtain final product.
Specification: every bottle of 125ml
Usage and dosage: the morning, noon and afternoon respectively once, each 125ml.
Embodiment 4
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 8g, Rhizoma Dioscoreae 2g, Poria 8g, Fructus Mume 2g, Concha Ostreae 4g, finger citron sliced 1g, Fructus Hordei Germinatus 4g, Semen Ziziphi Spinosae 2g, Fructus Jujubae 4g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 4g, Fructus Mori 1g, Fructus Crataegi 4g, Semen Raphani 3g;
Adjuvant forms: white sugar 240g, sodium carboxymethyl cellulose 0.5g, citric acid 2g, sodium citrate 1g, strawberry essence 2g;
Preparation method:
Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverize, add 8 times of water, soak after 3 hours, reflux gets half an hour;
Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 8 times of water, soak after 3 hours, the extracting solution obtained after water extraction with step 1 and medicinal residues mix, seepage pressure effects 12 hours, filter, merge extractive liquid;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount and reaches 3%;
Step 4: adopt diatomite filter circulating filtration to obtain clear liquor medicinal liquid good for standardize solution;
Step 5: add adjuvant in proportion, crosses 1.0um filtering with microporous membrane;
Step 6: adopt pasteurization process, fill, to obtain final product.
Specification: every bottle of 125ml
Usage and dosage: the morning, noon and afternoon respectively once, each 125ml
Embodiment 5
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 4g, Rhizoma Dioscoreae 5g, Poria 3g, Fructus Mume 5g, Concha Ostreae 6g, finger citron sliced 2g, Fructus Hordei Germinatus 8g, Semen Ziziphi Spinosae 3g, Fructus Jujubae 6g, Arillus Longan 7g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 5g, Semen Raphani 5g;
Adjuvant forms: white sugar 270g, sodium carboxymethyl cellulose 0.2g, citric acid 5g, sodium citrate 0.5g, strawberry essence 5g;
Preparation method:
Step 1: get Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae in proportion, pulverize, add 8 times of water, soak after 3 hours, reflux gets half an hour;
Step 2: get Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani in proportion, add 8 times of water, soak after 3 hours, the extracting solution obtained after water extraction with step 1 and medicinal residues mix, seepage pressure effects 12 hours, filter, merge extractive liquid;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount and reaches 3%;
Step 4: the medicinal liquid that standardize solution is good adopts high speed centrifugation machine filter to obtain clear liquor;
Step 5: add adjuvant in proportion, crosses 1.0um filtering with microporous membrane;
Step 6: adopt pasteurization process, fill, to obtain final product.
Specification: every bottle of 125ml
Usage and dosage: the morning, noon and afternoon respectively once, each 125ml
Embodiment 6
Treat a Chinese medicine composition for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 5g, Rhizoma Dioscoreae 7g, Poria 5g, Fructus Mume 6g, Concha Ostreae 3g, finger citron sliced 6g, Fructus Hordei Germinatus 3g, Semen Ziziphi Spinosae 12g, Fructus Jujubae 2g, Arillus Longan 6g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 6g, Fructus Crataegi 1g, Semen Raphani 7g;
Preparation method: get crude drug in proportion, adds 12 times of supersound extraction twice, each 1.5 hours, filters, merging filtrate, and adding water is adjusted to crude drug amount and reaches 1%; Diatomite filter circulating filtration is adopted to obtain clear liquor; Add water to the clear paste that relative density is 1.06 (50 ~ 60 DEG C), add adjuvant, make oral liquid.
Embodiment 7
Treat a Chinese medicine composition for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 12g, Rhizoma Dioscoreae 3g, Poria 12g, Fructus Mume 3g, Concha Ostreae 6g, finger citron sliced 3g, Fructus Hordei Germinatus 6g, Semen Ziziphi Spinosae 5g, Fructus Jujubae 6g, Arillus Longan 3g, Fructus Alpiniae Oxyphyllae 6g, Fructus Mori 3g, Fructus Crataegi 6g, Semen Raphani 3g;
Preparation method:
Get crude drug in proportion, add 10 times of water backflows twice, each 1.5 hours, merge extractive liquid, concentrating under reduced pressure, obtains concentrated solution B; Concentrated solution A, B are mixed, drying under reduced pressure, is ground into fine powder, adds customary adjuvant, mixing; Dry-pressing is granulated, and tabletting, to obtain final product.
Embodiment 8
Treat a beverage for apositia of children, prepare as follows:
Crude drug forms: Semen Lablab Album 4g, Rhizoma Dioscoreae 2g, Poria 4g, Fructus Mume 1g, Concha Ostreae 1g, finger citron sliced 1g, Fructus Hordei Germinatus 1g, Semen Ziziphi Spinosae 4g, Fructus Jujubae 1g, Arillus Longan 2g, Fructus Alpiniae Oxyphyllae 2g, Fructus Mori 2g, Fructus Crataegi 2g, Semen Raphani 2g;
Preparation method:
Get crude drug in proportion, add 12 times of soak by water twice, each 2 hours, merge extractive liquid, concentrating under reduced pressure, obtains concentrated solution B; Concentrated solution A, B are mixed, drying under reduced pressure, is ground into fine powder, adds adjuvant, mixing; Dry-pressing is granulated, and to obtain final product.
Effect experimental:
Trier 180 children, in 3-6 year, in 6-10 year, 11-15 year each 60 people, are divided into three groups, often organize and comprise 3-6 year respectively, 6-10 year, 11-15 year each 20 people.Three groups of triers use the product of embodiment 1,2,3 respectively.Child on probation is partially thin at ordinary times, and appetite is not strong, and constipation of getting angry is easily sick.
Test method: the child's beverage prepared by embodiment 1-3 issues trier at random, each one bottle of morning, noon and afternoon, 125ml/ bottle, a week on probation.Trial effect is paid a return visit with questionnaire form.Trial effect is as following table 3:
The trial effect of table 3 embodiment 1-3 product
| Embodiment 1 product | 3-6 year child/people | 6-10 year child/people | 11-15 year child/people | Effective percentage |
| Immunity strengthens | 17 | 16 | 17 | 83.3％ |
| Appetite increases to some extent | 18 | 15 | 17 | 83.3％ |
| Stool is improved | 16 | 18 | 15 | 81.7％ |
| Alive | 16 | 16 | 16 | 80.0％ |
| Total effective rate | 83.75％ | 81.25％ | 78.75 | 81.25％ |
| Embodiment 2 product | 3-6 year child/people | 6-10 year child/people | 11-15 year child/people | Effective percentage |
| Immunity strengthens | 18 | 17 | 16 | 85％ |
| Appetite increases to some extent | 16 | 16 | 15 | 78.3％ |
| Stool is improved | 17 | 16 | 17 | 83.3％ |
| Alive | 16 | 18 | 16 | 83.3％ |
| Total effective rate | 83.75％ | 83.75％ | 80％ | 82.5％ |
| Embodiment 3 product | 3-6 year child/people | 6-10 year child/people | 11-15 year child/people | Effective percentage |
| Immunity strengthens | 18 | 18 | 16 | 83.3％ |
| Appetite increases to some extent | 16 | 17 | 18 | 81.6％ |
| Stool is improved | 17 | 16 | 17 | 83.3％ |
| Alive | 16 | 16 | 17 | 81.6％ |
| Total effective rate | 83.75％ | 83.75％ | 85％ | 82.5％ |
Conclusion: the present invention is suitable for children taking, has and puts on weight, and improves immunization programs for children power, invigorating the stomach and promoting digestion, the effect such as to invigorate.
Claims (10)
1. treat the Chinese medicine composition of apositia of children for one kind, it is characterized in that, this Chinese medicine composition mainly comprises following crude drug: Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, Concha Ostreae, finger citron sliced, Fructus Hordei Germinatus, Semen Ziziphi Spinosae, Fructus Jujubae, Arillus Longan, Fructus Alpiniae Oxyphyllae, Fructus Mori, Fructus Crataegi, Semen Raphani.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:
Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:
Semen Lablab Album 3-12 part, Rhizoma Dioscoreae 1-7 part, Poria 3-12 part, Fructus Mume 1-6 part, Concha Ostreae 1-6 part, finger citron sliced 1-6 part, Fructus Hordei Germinatus 1-6 part, Semen Ziziphi Spinosae 3-12 part, Fructus Jujubae 1-6 part, Arillus Longan 1-6 part, Fructus Alpiniae Oxyphyllae 1-6 part, Fructus Mori 1-6 part, Fructus Crataegi 1-6 part, Semen Raphani 1-7 part.
4. Chinese medicine composition as claimed in claim 3, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:
Semen Lablab Album 3-8 part, Rhizoma Dioscoreae 1-5 part, Poria 3-8 part, Fructus Mume 1-4 part, Concha Ostreae 1-4 part, finger citron sliced 1-4 part, Fructus Hordei Germinatus 1-4 part, Semen Ziziphi Spinosae 3-8 part, Fructus Jujubae 1-4 part, Arillus Longan 1-4 part, Fructus Alpiniae Oxyphyllae 1-4 part, Fructus Mori 1-4 part, Fructus Crataegi 1-4 part, Semen Raphani 1-5 part.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that, with parts by weight, this traditional Chinese medicinal composition raw materials consists of:
Semen Lablab Album 4 parts, Rhizoma Dioscoreae 2 parts, 4 parts, Poria, Fructus Mume 1 part, Concha Ostreae 1 part, finger citron sliced 1 part, 1 part, Fructus Hordei Germinatus, Semen Ziziphi Spinosae 4,1 part, Fructus Jujubae, Arillus Longan 2 parts, Fructus Alpiniae Oxyphyllae 2 parts, Fructus Mori 2 parts, Fructus Crataegi 2 parts, Semen Raphani 2 parts.
6. Chinese medicine composition as described in any one of claim 1-5, is characterized in that, described compositions is prepared into health promoting beverage, oral liquid, granule, tablet, capsule, powder according to a conventional method.
7. the preparation method of Chinese medicine composition as described in any one of claim 1-5, it is characterized in that, the preparation method of this Chinese medicine composition comprises:
Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;
Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, and continuation water extraction, obtains extracting solution, and concentrating under reduced pressure to obtain final product.
8. preparation method as claimed in claim 7, is characterized in that, extracting method described in step 1,2 is decoct one or more modes in extraction, reflux, extract, soak extraction, supersound extraction or seepage pressure effects; Described extraction time is 2-10 hour, and extraction time is 1-3 time.
9. the application of Chinese medicine composition in the health product or medicine of preparation treatment apositia of children as described in any one of claim 1-5.
10. treat a health promoting beverage for apositia of children, it is characterized in that, described health promoting beverage is prepared as follows:
With parts by weight, raw material forms: Semen Lablab Album 3-15 part, Rhizoma Dioscoreae 1-10 part, Poria 3-15 part, Fructus Mume 1-8 part, Concha Ostreae 1-8 part, finger citron sliced 1-8 part, Fructus Hordei Germinatus 1-8 part, Semen Ziziphi Spinosae 3-15 part, Fructus Jujubae 1-8 part, Arillus Longan 1-8 part, Fructus Alpiniae Oxyphyllae 1-8 part, Fructus Mori 1-8 part, Fructus Crataegi 1-8 part, Semen Raphani 1-10 part;
Adjuvant forms: white sugar 200-300 part, sodium carboxymethyl cellulose 0.1-1 part, citric acid 1-10 part, sodium citrate 0.5-1.5 part, essence 1-10 part.
Preparation method:
Step 1: Concha Ostreae, Semen Ziziphi Spinosae, Fructus Alpiniae Oxyphyllae mixing, with water extraction;
Step 2: the extracting solution that Semen Lablab Album, Rhizoma Dioscoreae, Poria, Fructus Mume, finger citron sliced, Fructus Hordei Germinatus, Fructus Jujubae, Arillus Longan, Fructus Mori, Fructus Crataegi, Semen Raphani and step 1 obtain after water extraction and medicinal residues mix, and continuation water extraction, obtains extracting solution;
Step 3: extracting solution step 2 obtained adds water and is settled to crude drug amount 1-5%, filters, gets filtrate;
Step 4: add adjuvant in proportion, filters, to obtain final product.
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