CN110123972B - Bitter taste-shielding food retention removing and child health care granule as well as preparation method and application thereof - Google Patents
Bitter taste-shielding food retention removing and child health care granule as well as preparation method and application thereof Download PDFInfo
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- CN110123972B CN110123972B CN201910542672.8A CN201910542672A CN110123972B CN 110123972 B CN110123972 B CN 110123972B CN 201910542672 A CN201910542672 A CN 201910542672A CN 110123972 B CN110123972 B CN 110123972B
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a bitter-taste-shielding food-retention-removing and children-strengthening granule and a preparation method thereof, wherein the bitter-taste-shielding food-retention-removing and children-strengthening granule takes medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, betelnut, immature bitter orange and costustoot as raw materials, and ethyl maltol and gamma cyclodextrin are added, so that the bitter taste brought by the traditional Chinese medicine rhizoma picrorhizae is effectively shielded, the food-retention-removing and children-strengthening granule conforms to the compliance of children medication, and the release and detection of medicine components are not influenced.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a food retention removing and children health-care granule capable of shielding bitter taste, and a preparation method and application thereof.
Background
The food retention removing and children health care particle is a traditional Chinese medicine granule, and has the functions and main functions of strengthening stomach, removing food retention and killing parasites. Has good curative effect on the symptoms of infantile indigestion, milk retention, indigestion, dyspepsia and the like. Picrorhiza rhizome in the food stagnation removing and children health care granules has heavier bitter taste and seriously influences the compliance of children in taking medicine.
The bitter taste masking of traditional Chinese medicine has multiple methods, but many methods involve significant changes of preparation processes or influence on the release of medicine components and the effect of the medicine, and a large amount of clinical effects are needed to verify the rationality of process changes.
In view of this, this patent is filed.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the food retention removing and health promoting granules with good bitter taste shielding effect, and the preparation method and the application thereof.
An object of the present invention is to provide a food-retention-eliminating and health-promoting granule for masking bitterness.
The invention also aims to provide two preparation methods of the food retention removing and health care granules for masking bitter taste.
Still another object of the present invention is to provide the use of the food-retention-removing and health-care granules for masking bitter taste.
The bitter taste shielding food retention and health care particle is prepared from the following raw material medicines:
medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange and costustoot, wherein the raw materials also comprise ethyl maltol and gamma-cyclodextrin.
The invention provides a flavoring agent and an embedding agent adding method which can obviously reduce the bitter taste of the food retention removing and child care granules, wherein ethyl maltol is used as the flavoring agent, gamma cyclodextrin can play a role in embedding medicaments, so that the bitter taste of picrorhiza rhizome is slowly released, and the gamma cyclodextrin prevents the food retention removing and child care granules from feeling the bitter taste when passing through the oral cavity, thereby achieving the effect of releasing medicament components in the stomach. The food retention removing and child care granules capable of shielding bitter taste, which are prepared by the invention, meet the regulations of national drug standards.
The bitter taste shielding food retention and health care particle is prepared from the following raw material medicines: 110.6 parts of medicated leaven; 110.6 parts of malt; 44 parts of hawthorn; 110.6 parts of white atractylodes rhizome stir-fried with bran; 110.6 parts of nutmeg; 110.6 parts of rhizoma picrorhizae; 110.6 parts of rangooncreeper fruit; 110.6 of betel nuts; 44 parts of immature bitter orange and 44 parts of costustoot, wherein the addition amount of the ethyl maltol is 2-20mg/100g of picrorhiza rhizome, and the addition amount of the gamma cyclodextrin is 1-10g/100g of picrorhiza rhizome. The addition amount of ethyl maltol and gamma cyclodextrin is determined according to the addition amount of picrorhiza rhizome, 2-20g of ethyl maltol is added in every 100g of picrorhiza rhizome, and 1-10g of gamma cyclodextrin is added in every 100g of picrorhiza rhizome.
The preparation method of the food retention removing and health care granules for shielding bitter taste according to the embodiment of the invention comprises the following steps:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, distilling and extracting volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation, and decocting the mixed solution, the rangooncreeper fruit and the malt together to obtain decoction standby liquid;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, concentrating, adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, and uniformly mixing to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) and (3) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), uniformly mixing, concentrating, adding the mixed clear paste obtained in the step (3), uniformly mixing, concentrating until the relative density is 1.27-1.30, adding sucrose and dextrin, preparing into a granular semi-finished product, drying, spraying the mixed extract oil of nutmeg and elecampane obtained in the step (2), uniformly mixing, and packaging to obtain the bitter-taste-shielded food retention removing and child health care granules.
Another method for preparing the indigestion healthy baby granules for masking bitter taste according to the embodiment of the present invention comprises the following steps:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, distilling and extracting volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation, and decocting the mixed solution, the rangooncreeper fruit and the malt together to obtain decoction standby liquid;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, and concentrating to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), concentrating after uniformly mixing, then adding the mixed clear paste obtained in the step (3), uniformly mixing, then adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, concentrating until the relative density is 1.27-1.30 after uniformly mixing, then adding sucrose and dextrin, preparing into a granular semi-finished product, drying, finally spraying the nutmeg and elecampane mixed extract oil obtained in the step (2), uniformly mixing, and packaging to obtain the food retention removing and health care granules with the bitter taste shielded.
Mixing, heating and concentrating to relative density of 1.27-1.30, wherein the relative density is measured at 80 deg.C.
According to the preparation method of the food retention removing and health care granules for masking bitter taste, in the step (2), the nutmeg and the elecampane are mixed, then 6 times of water by weight is added for distillation extraction of volatile oil for 8 hours, the mixed solution is decocted with the rangooncreeper fruit and the malt twice, the time of each decoction is 2 hours, then the two decoctions are combined and filtered, and a decoction solution for standby is obtained.
According to the preparation method of the food retention removing and health care granules for masking bitter taste, in the step (2), the nutmeg and the elecampane are mixed, then 6 times of water by weight is added for distilling and extracting volatile oil for 8 hours, the mixed solution is decocted with the rangooncreeper fruit and the malt twice, the time of each decoction is 2 hours, then the two decoctions are combined, filtered and concentrated to the relative density of 1.08(90 ℃), after the temperature is cooled to room temperature, ethanol is added to enable the alcohol content to reach 65-70%, the mixture is kept stand for 12-16 hours until the mixture is clear, the filtrate is filtered, the ethanol is recovered and concentrated to the relative density of 1.00-1.05 (60-65 ℃), and a decoction standby solution is obtained.
According to the preparation method of the food retention removing and children health care granules for masking bitter taste in the specific embodiment of the invention, in the step (3), the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange are respectively crushed into coarse powder before being mixed, 5 times of ethanol with the concentration of 60% is added into the mixture to be used as a solvent for percolation, the mixture is subjected to ethanol percolation, and then the ethanol is recovered to form mixed liquid medicine.
According to the preparation method of the food retention removing and health promoting granules for masking bitter taste, in the step (3), the mixed liquid medicine is concentrated to the relative density of 1.00-1.05. Concentrating the mixed liquid medicine until the relative density is 1.00-1.05 at 55-60 ℃; adding ethyl maltol and gamma cyclodextrin, and stirring in a stirrer. The stirrer is a scraper blade type paddle stirrer or a kneader.
According to the preparation method of the food retention removing and health care granules for masking bitter taste, in the step (4), 25% ethanol solution with the weight 3 times that of the medicated leaven is added for mixing, and after percolation, the medicated leaven clear paste is formed by concentration. The percolation in the preparation method of the invention adopts normal temperature percolation.
According to the preparation method of the food retention removing and health care granules for masking bitter taste, in the step (4), 25% ethanol solution with the weight 3 times that of the medicated leaven is added for mixing, the ethanol is recovered after percolation, and the mixture is concentrated to the relative density of 1.00-1.05 at the temperature of 60-65 ℃ to form medicated leaven clear paste.
According to the preparation method of the food retention removing and health care granules capable of shielding bitter taste, according to the specific embodiment of the invention, in the step (5), before the mixed extracted oil of nutmeg and costus root is sprayed, 10 times of anhydrous ethanol is added into the mixed extracted oil of nutmeg and costus root, the mixture is uniformly mixed, the granular semi-finished product is sprayed with the mixed extracted oil of nutmeg and costus root, which is mixed by the anhydrous ethanol, and then the mixture is uniformly mixed again, and the mixture is sealed and packaged, so that the food retention removing and health care granules capable of shielding bitter taste are obtained.
According to the preparation method of the food retention removing and health care granules for shielding bitter taste, in the step (5), the adding amount ratio of the sucrose to the dextrin is 10: 1.
according to the preparation method of the food retention removing and health care granules for shielding bitter taste, in the step (5), the decoction standby liquid and the medicated leaven clear paste are mixed, uniformly mixed and then vacuum-concentrated for 10 minutes under reduced pressure.
According to the application of the bitter taste-shielding food-eliminating and health-care granules, the bitter taste-shielding food-eliminating and health-care granules are used for preparing medicines or health-care products or foods for invigorating stomach and promoting digestion.
The designer of the invention designs the food retention removing and health care granules for masking bitter taste by specially selecting ethyl maltol and gamma cyclodextrin as important raw materials through long-term exploration and trial and a plurality of experiments and endeavors, improves and innovates continuously by taking the ethyl maltol as a flavoring agent to improve the bitter taste of picrorhiza rhizome and adding the gamma cyclodextrin with the function of embedding medicaments, so that bitter components in the granules are slowly released, the bitter taste cannot be felt when the granules pass through the oral cavity, and the granules are completely released and play the drug effect after entering the stomach.
In the invention, the raw material components and the mixture ratio thereof of the traditional Chinese medicine composition are very critical, after knowing the components and the mixture ratio, the ordinary skilled person in the art can adopt various conventional traditional Chinese medicine effective component extraction methods to extract effective components, such as a decoction method, a water extraction and alcohol precipitation method, a salting-out method, an organic solvent extraction method and the like, and because the extraction methods can obtain main effective components in the traditional Chinese medicine formula, the traditional Chinese medicine composition has certain curative effects on strengthening stomach and promoting digestion.
The usage and dosage of the food retention removing and health care granules for shielding bitter taste of the invention are as follows: 0.75g for three years old or younger, 1.5g for three to seven years old, and 2 times a day.
The invention has the beneficial effects that:
1. the bitter taste-shielding food-retention-removing and child-care granules are added with the corrigent ethyl maltol and the embedding agent gamma cyclodextrin, so that the bitter taste brought by the traditional Chinese medicine rhizoma picrorhizae is effectively shielded, the food-retention-removing and child-care granules conform to the compliance of children medication, and the release and detection of medicine components are not influenced.
2. The food retention removing and health care granules with the bitter taste masked achieve the effect of masking the bitter taste only by adding a flavoring agent and a pharmaceutic adjuvant without changing the basic preparation method process, and are acceptable; the invention adds the flavoring agent and the auxiliary material into the traditional Chinese medicine clear paste before the food retention removing and children health care granule solid is formed, which is a feasible method for masking bitter taste.
3. The food-eliminating and health-care granules for eliminating food retention and protecting children, which can shield bitter taste, can adapt to the requirements of production and drug registration without basically changing the preparation process.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The food retention removing and child health care granules for shielding bitter taste can be prepared by the following steps:
(1) pulverizing semen Myristicae and radix aucklandiae, mixing, adding 6 times of water, extracting volatile oil for 8 hr, and collecting volatile oil;
(2) adding 6 times of weight of water into the distilled and residual mixed solution and mashed rangooncreeper fruit and malt for decocting twice, 2 hours each time, combining the decoctions, filtering, concentrating until the relative density is 1.08(90 ℃), cooling to room temperature, adding ethanol until the alcohol content reaches 65-70%, standing for 12-16 hours until the solution is clear, filtering, recovering ethanol from the filtrate, concentrating until the relative density is 1.00-1.05 (60-65 ℃) to obtain a decoction standby solution for later use;
(3) crushing hawthorn, bran-fried bighead atractylodes rhizome, picrorhiza rhizome, betel nut and immature bitter orange into coarse powder, percolating by using 60% ethanol which is 5 times of the weight of the coarse powder as a solvent according to a fluid extract and extract item lower percolation method (0189 in the general rule of Chinese pharmacopoeia 2015 edition), recovering ethanol from a percolate, and concentrating to a relative density of 1.00-1.05 (55-60 ℃) to obtain a mixed extract for later use;
(4) mashing the medicated leaven, percolating with 25% ethanol which is 3 times of the weight of the medicated leaven as a solvent, filtering the percolate, recovering the ethanol from the percolate, and concentrating to obtain medicated leaven clear paste with the relative density of 1.00-1.05 (60-65 ℃);
(5) mixing the medicated leaven clear paste obtained in the step (4) with the decoction standby liquid obtained in the step (2), concentrating for 10 minutes, adding the mixed clear paste obtained in the step (3), uniformly mixing, adding ethyl maltol and gamma cyclodextrin, fully stirring by a stirrer, and concentrating to relative density of 1.27-1.30 (80 ℃); adding sucrose and dextrin (ratio 10:1), making into granular semi-finished product by extrusion granulator, drying, diluting the volatile oil obtained in step (1) with 10 times of anhydrous ethanol, spraying the volatile oil into the granular semi-finished product, mixing well, and making into 100kg of product to be packaged.
Example 1
The embodiment provides a food retention removing and children health care particle for shielding bitter taste, which comprises the following raw material components:
11.06kg of medicated leaven, 11.06kg of malt, 4.4kg of hawthorn, 11.06kg of bran-fried bighead atractylodes rhizome, 11.06kg of nutmeg, 11.06kg of rhizoma picrorhizae, 11.06kg of rangooncreeper fruit, 11.06kg of betel nut, 4.4kg of immature bitter orange and 4.4kg of costustoot; 90kg of sucrose and dextrin (ratio 10:1), 12g of ethyl maltol and 4kg of gamma cyclodextrin.
The preparation method of the food retention removing and health care granules for shielding bitter taste comprises the following steps:
(1) pulverizing semen Myristicae and radix aucklandiae, mixing, extracting volatile oil with 6 times of water for 8 hr, and collecting volatile oil;
(2) distilling, decocting the rest mixed solution and mashed rangooncreeper fruit and malt with 6 times of weight of water twice, each time for 2 hours, mixing decoctions, filtering, concentrating until the relative density is 1.08(90 ℃), cooling to room temperature, adding ethanol until the ethanol content reaches 70%, standing for 12 hours until the ethanol content is clear, filtering, recovering ethanol from the filtrate, and concentrating until the relative density is 1.05(60 ℃) to obtain a decoction for later use;
(3) pulverizing fructus crataegi, bran-parched Atractylodis rhizoma, rhizoma picrorhizae, Arecae semen, and fructus Aurantii Immaturus into coarse powder, percolating with 5 times of 60% ethanol as solvent according to percolation method (0189 in 2015 version of Chinese pharmacopoeia) under fluid extract and extract item, recovering ethanol from percolate, concentrating to relative density of 1.05(60 deg.C), adding ethyl maltol and gamma cyclodextrin, and stirring thoroughly to obtain mixed fluid extract;
(4) mashing Massa Medicata Fermentata, percolating with 3 times of 25% ethanol as solvent, filtering percolate, recovering ethanol, and concentrating to relative density of 1.05(65 deg.C) to obtain Massa Medicata Fermentata fluid extract;
(5) mixing the Massa Medicata Fermentata fluid extract obtained in step (4) with the decoction solution obtained in step (2), concentrating for 10 min, adding the mixed fluid extract obtained in step (3), mixing, and concentrating to relative density of 1.30(80 deg.C); adding sucrose and dextrin (ratio 10:1) to obtain granular semi-finished product, drying, diluting the volatile oil obtained in step (1) with 10 times of anhydrous ethanol, spraying the volatile oil into the granular semi-finished product, and mixing to obtain 100.2kg of the food retention removing and health promoting granules for packaging with masked bitter taste.
Comparative example 1
The only difference between comparative example 1 and example 1 is that the starting material does not contain ethyl maltol and gamma cyclodextrin, and ethyl maltol and gamma cyclodextrin are not added during the preparation process.
The bitter taste masking indigestible healthy children granules obtained in example 1 and comparative example 1 were subjected to a bitter taste sensory test, respectively:
the test was performed by 20 persons (8 men and 12 women) and evaluated in the form of questionnaires.
The granules for removing food retention and invigorating effects obtained in comparative example 1 were dissolved in 1.10g of purified water 50ml, and then the solution was diluted with 2.4% sucrose solution in various proportions, and the granules for removing food retention and invigorating effects for masking bitter taste obtained in example 1 of the present invention were dissolved in 1.10g of purified water 50ml, and then the bitter taste sensory comparison was performed, wherein the granules for removing food retention and invigorating effects for masking bitter taste obtained in example 1 and the granules for removing food retention and invigorating effects obtained in comparative example 1 were diluted by a bitter equivalent weight, and the results of questionnaire are shown in table 1:
TABLE 1 sensory comparison of bitterness between example 1 and comparative example 1
The results show that the bitter taste of the indigestion healthy baby granules prepared in example 1 is reduced by about 50 times compared with the bitter taste of the indigestion healthy baby granules prepared in comparative example 1, and the compliance of children in taking medicines is obviously improved.
Content determination test:
the picroside content of the bitter taste-masked health granules obtained in example 1 and the bitter taste-masked health granules obtained in comparative example 1 were measured by high performance liquid chromatography (chinese pharmacopoeia 2015 edition general regulation 0512), respectively, and the results are shown in table 2:
TABLE 2 comparison of picroside content in the products of example 1 and comparative example 1
| Picroside I | Picroside II | Picroside content | |
| Example 1 the product obtained | 1.23mg/g | 2.80mg/g | 4.03mg/g |
| Product obtained in comparative example 1 | 1.22mg/g | 2.73mg/g | 3.95mg/g |
The results show that there was no significant difference between the picroside content of the bitter taste masked indigestible baby granules obtained in example 1 compared with the non-bitter taste masked indigestible baby granules obtained in comparative example 1 (based on the total amount of picroside i and picroside ii). Content determination tests show that the release of the picroside medicine in the food-eliminating and health-care granules subjected to bitter taste masking treatment is not influenced by bitter taste masking modification.
Example 2
The embodiment provides a food retention removing and children health care particle for shielding bitter taste, which comprises the following raw material components:
11.06kg of medicated leaven, 11.06kg of malt, 4.4kg of hawthorn, 11.06kg of bran-fried bighead atractylodes rhizome, 11.06kg of nutmeg, 11.06kg of rhizoma picrorhizae, 11.06kg of rangooncreeper fruit, 11.06kg of betel nut, 4.4kg of immature bitter orange and 4.4kg of costustoot; 90kg of sucrose and dextrin (ratio 10:1), 20g of ethyl maltol and 10kg of gamma cyclodextrin.
Example 3
The embodiment provides a food retention removing and children health care particle for shielding bitter taste, which comprises the following raw material components:
11.06kg of medicated leaven, 11.06kg of malt, 4.4kg of hawthorn, 11.06kg of bran-fried bighead atractylodes rhizome, 11.06kg of nutmeg, 11.06kg of rhizoma picrorhizae, 11.06kg of rangooncreeper fruit, 11.06kg of betel nut, 4.4kg of immature bitter orange and 4.4kg of costustoot; 90kg of sucrose and dextrin (ratio 10:1), 12g of ethyl maltol and 5kg of gamma cyclodextrin.
The food retention removing and child health care granules for shielding bitter taste are prepared by the following steps:
(1) pulverizing semen Myristicae and radix aucklandiae, mixing, adding 5 times of water, extracting volatile oil for 9 hr, and collecting volatile oil;
(2) distilling, decocting the rest mixed solution and mashed rangooncreeper fruit and malt with 7 times of weight of water twice, each time for 2 hours, mixing decoctions, filtering, concentrating until the relative density is 1.08(90 ℃), cooling to room temperature, adding ethanol until the ethanol content reaches 65%, standing for 16 hours until the ethanol content is clear, filtering, recovering ethanol from the filtrate, and concentrating until the relative density is 1.05(60 ℃) to obtain a decoction for later use;
(3) pulverizing fructus crataegi, bran-parched Atractylodis rhizoma, rhizoma picrorhizae, Arecae semen, and fructus Aurantii Immaturus into coarse powder, percolating with 5 times of 60% ethanol as solvent according to percolation method (0189 in the pharmacopoeia 2015 edition) of fluid extract and extract, recovering ethanol from percolate, and concentrating to relative density of 1.00(60 deg.C) to obtain mixed fluid extract;
(4) mashing Massa Medicata Fermentata, percolating with 25% ethanol 3 times the weight of Massa Medicata Fermentata as solvent, filtering percolate, recovering ethanol, and concentrating to relative density of 1.00(65 deg.C) to obtain Massa Medicata Fermentata fluid extract;
(5) mixing the Massa Medicata Fermentata fluid extract obtained in step (4) with the decoction solution obtained in step (2), concentrating for 10 min, adding the mixed fluid extract obtained in step (3), mixing, adding ethyl maltol and gamma cyclodextrin, stirring thoroughly with a stirrer, concentrating to relative density of 1.27(80 deg.C); adding sucrose and dextrin (ratio 10:1) to obtain granular semi-finished product, drying, diluting the volatile oil obtained in step (1) with 10 times of anhydrous ethanol, spraying the volatile oil into the granular semi-finished product, and mixing to obtain 100.3kg of the food retention removing and health promoting granules for packaging with masked bitter taste.
Comparative example 3
The only difference between comparative example 3 and example 3 is that the starting material does not contain ethyl maltol and gamma cyclodextrin, and ethyl maltol and gamma cyclodextrin are not added during the preparation process.
The bitter taste masking indigestible healthy children granules obtained in example 3 and comparative example 3 were subjected to a bitter taste sensory test, respectively:
the test was performed by 20 persons (8 men and 12 women) and evaluated in the form of questionnaires.
The granules for removing food retention and invigorating effects obtained in comparative example 3 were dissolved in 1.10g of purified water 50ml, and then the solution was diluted with 2.4% sucrose solution in various proportions, and the granules for removing food retention and invigorating effects for masking bitter taste obtained in example 3 of the present invention were dissolved in 1.10g of purified water 50ml, and then the bitter taste sensory comparison was performed, and the granules for removing food retention and invigorating effects for masking bitter taste obtained in example 3 and the granules for removing food retention and invigorating effects obtained in comparative example 3 were diluted by a bitterness equivalent, and the results of questionnaire are shown in table 3:
table 3 sensory comparison of bitterness of example 3 with comparative example 3
The results show that the bitter taste of the indigestible granule with masked bitter taste prepared in example 3 is reduced by about 20-50 times compared with the indigestible granule without masked bitter taste prepared in comparative example 3, and the compliance of children in taking medicine is remarkably improved, and the bitter taste masking effect is slightly inferior to that of the indigestible granule prepared in example 1, in the case of adding ethyl maltol and gamma cyclodextrin.
Content determination test:
the picroside content of the bitter taste-masked health granules obtained in example 3 and the food-eliminating health granules obtained in comparative example 3 were measured by high performance liquid chromatography (chinese pharmacopoeia 2015 edition general regulation 0512), respectively, and the results are shown in table 4:
table 4 comparison of picroside content in the products of example 3 and comparative example 3
| Picroside I | Picroside II | Picroside content | |
| Example 3 the product obtained | 1.26mg/g | 2.81mg/g | 4.07mg/g |
| Product obtained in comparative example 3 | 1.24mg/g | 2.75mg/g | 3.99mg/g |
Assay test results show that the release of picroside drug from the bitter masked xiaojian granules of example 3 is not affected by the bitter masking modification.
Example 4
The embodiment provides a food retention removing and children health care particle for shielding bitter taste, which comprises the following raw material components:
11.06kg of medicated leaven, 11.06kg of malt, 4.4kg of hawthorn, 11.06kg of bran-fried bighead atractylodes rhizome, 11.06kg of nutmeg, 11.06kg of rhizoma picrorhizae, 11.06kg of rangooncreeper fruit, 11.06kg of betel nut, 4.4kg of immature bitter orange and 4.4kg of costustoot; 90kg of sucrose and dextrin (ratio 10:1), 10g of ethyl maltol and 6kg of gamma cyclodextrin.
The preparation method of the food retention removing and health care granules for shielding bitter taste comprises the following steps:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, distilling and extracting volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation, and decocting the mixed solution, the rangooncreeper fruit and the malt together to obtain decoction standby liquid;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding 60% ethanol into the mixture as a solvent, percolating the mixture through the ethanol, recovering the ethanol to form mixed liquid medicine, concentrating, adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, and uniformly mixing by using a scraper blade type paddle stirrer to form mixed clear paste;
(4) adding 25% ethanol solution with the weight 3 times that of the medicated leaven weighed in the step (1) into the medicated leaven, mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), uniformly mixing, concentrating, then adding the mixed clear paste obtained in the step (3), uniformly mixing, concentrating to a relative density of 1.29 measured at 80 ℃, then adding sucrose and dextrin, preparing into a granular semi-finished product, drying, finally spraying the mixed extract oil of nutmeg and elecampane obtained in the step (2) diluted by 10 times of anhydrous ethanol, uniformly mixing, and packaging to obtain the bitter-shielded food retention removing and health care granules.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. The bitter-taste-shielding food retention removing and health promoting granules are prepared from the following raw material medicines in parts by weight: 110.6 parts of medicated leaven; 110.6 parts of malt; 44 parts of hawthorn; 110.6 parts of white atractylodes rhizome stir-fried with bran; 110.6 parts of nutmeg; 110.6 parts of rhizoma picrorhizae; 110.6 parts of rangooncreeper fruit; 110.6 of betel nuts; 44 parts of immature bitter orange and 44 parts of costustoot, and is characterized in that the raw materials also comprise ethyl maltol and gamma cyclodextrin, wherein the addition amount of the ethyl maltol is 2-20mg/100g of picrorhiza rhizome, and the addition amount of the gamma cyclodextrin is 1-10g/100g of picrorhiza rhizome; the preparation method comprises the following steps:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, and distilling to extract volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation; decocting the mixed solution, fructus quisqualis and fructus Hordei Germinatus to obtain decoction;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, concentrating, adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, and uniformly mixing to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) and (3) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), uniformly mixing, concentrating, adding the mixed clear paste obtained in the step (3), uniformly mixing, concentrating until the relative density is 1.27-1.30, adding sucrose and dextrin, preparing into a granular semi-finished product, drying, spraying the mixed extract oil of nutmeg and elecampane obtained in the step (2), uniformly mixing, and packaging to obtain the bitter-taste-shielded food retention removing and child health care granules.
2. The bitter-taste-shielding food retention removing and health promoting granules are prepared from the following raw material medicines in parts by weight: 110.6 parts of medicated leaven; 110.6 parts of malt; 44 parts of hawthorn; 110.6 parts of white atractylodes rhizome stir-fried with bran; 110.6 parts of nutmeg; 110.6 parts of rhizoma picrorhizae; 110.6 parts of rangooncreeper fruit; 110.6 of betel nuts; 44 parts of immature bitter orange and 44 parts of costustoot, and is characterized in that the raw materials also comprise ethyl maltol and gamma cyclodextrin, wherein the addition amount of the ethyl maltol is 2-20mg/100g of picrorhiza rhizome, and the addition amount of the gamma cyclodextrin is 1-10g/100g of picrorhiza rhizome; the preparation method comprises the following steps:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, distilling and extracting volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation, and decocting the mixed solution, the rangooncreeper fruit and the malt together to obtain decoction standby liquid;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, and concentrating to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), concentrating after uniformly mixing, then adding the mixed clear paste obtained in the step (3), uniformly mixing, then adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, concentrating until the relative density is 1.27-1.30 after uniformly mixing, then adding sucrose and dextrin, preparing into a granular semi-finished product, drying, finally spraying the nutmeg and elecampane mixed extract oil obtained in the step (2), uniformly mixing, and packaging to obtain the food retention removing and health care granules with the bitter taste shielded.
3. A method of making a bitter masked XIAO JI JIAN ER KE LI of claim 1 comprising the steps of:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, and distilling to extract volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation; decocting the mixed solution, fructus quisqualis and fructus Hordei Germinatus to obtain decoction;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, concentrating, adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, and uniformly mixing to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) and (3) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), uniformly mixing, concentrating, adding the mixed clear paste obtained in the step (3), uniformly mixing, concentrating until the relative density is 1.27-1.30, adding sucrose and dextrin, preparing into a granular semi-finished product, drying, spraying the mixed extract oil of nutmeg and elecampane obtained in the step (2), uniformly mixing, and packaging to obtain the bitter-taste-shielded food retention removing and child health care granules.
4. A method of making a bitter masked XIAO JI JIAN ER KE LI of claim 2 comprising the steps of:
(1) weighing medicated leaven, malt, hawthorn, bran-fried bighead atractylodes rhizome, nutmeg, rhizoma picrorhizae, rangooncreeper fruit, areca seed, immature bitter orange, costustoot, ethyl maltol and gamma-cyclodextrin according to the weight ratio;
(2) mixing the nutmeg weighed in the step (1) and the elecampane, adding 6 times of water by weight, distilling and extracting volatile oil for 8 hours to obtain mixed extracted oil of the nutmeg and the elecampane and mixed solution remained after distillation, and decocting the mixed solution, the rangooncreeper fruit and the malt together to obtain decoction standby liquid;
(3) mixing the hawthorn, the bran-fried bighead atractylodes rhizome, the rhizoma picrorhizae, the betel nut and the immature bitter orange weighed in the step (1), adding ethanol into the mixture as a solvent, percolating the mixture with ethanol, recovering the ethanol to form mixed liquid medicine, and concentrating to form mixed clear paste;
(4) adding 3 times of ethanol solution into the medicated leaven weighed in the step (1), mixing, and concentrating after percolation to form medicated leaven clear paste;
(5) mixing the decoction standby liquid obtained in the step (2) with the medicated leaven clear paste obtained in the step (4), concentrating after uniformly mixing, then adding the mixed clear paste obtained in the step (3), uniformly mixing, then adding ethyl maltol and gamma cyclodextrin into the mixed liquid medicine, concentrating until the relative density is 1.27-1.30 after uniformly mixing, then adding sucrose and dextrin, preparing into a granular semi-finished product, drying, finally spraying the nutmeg and elecampane mixed extract oil obtained in the step (2), uniformly mixing, and packaging to obtain the food retention removing and health care granules with the bitter taste shielded.
5. The method for preparing XIAO JI JIAN ER KE LI (food stagnation eliminating and health promoting granule) according to claim 3 or 4, wherein in the step (2), the nutmeg and the aucklandia root are mixed, and then distilled with 6 times of water for 8 hours, the mixed solution is decocted with the quisqualis fruit and the malt twice, each time is 2 hours, then the two decoctions are combined and filtered to obtain the decoction for use.
6. The method for preparing XIAOJIJIANER granule for masking bitter taste as claimed in claim 3 or 4, wherein in step (3), fructus crataegi, rhizoma Atractylodis Macrocephalae parched with bran, rhizoma picrorhizae, semen Arecae and fructus Aurantii Immaturus are pulverized into coarse powder respectively before mixing, 5 times of 60% ethanol is added into the mixture as solvent for percolation, and the mixture is percolated with ethanol and then ethanol is recovered to form mixed medicinal liquid; and concentrating the mixed liquid medicine to the relative density of 1.00-1.05.
7. The method for preparing the granules for removing food retention and invigorating children according to claim 3 or 4, wherein in the step (4), the 25% ethanol solution with 3 times of the weight of the medicated leaven is added for mixing, and after percolation, the mixture is concentrated to form medicated leaven clear paste.
8. The method for preparing the food-retention-removing and health-care granule for masking bitter taste according to claim 3 or 4, wherein in the step (5), before the mixed extracted oil of nutmeg and elecampane is sprayed, 10 times of anhydrous ethanol is added into the mixed extracted oil of nutmeg and elecampane, the mixture is uniformly mixed, the granular semi-finished product is sprayed with the mixed extracted oil of nutmeg and elecampane which is mixed by the anhydrous ethanol, the mixture is uniformly mixed again, and the mixture is sealed and packaged to obtain the food-retention-removing and health-care granule for masking bitter taste.
9. The method for preparing a granule for removing food retention and invigorating kidney as claimed in claim 3 or 4, wherein the ratio of the sucrose to the dextrin in step (5) is 10: 1.
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| CN107233331A (en) * | 2017-07-28 | 2017-10-10 | 昆明邦宇制药有限公司 | A kind of berberine granula subtilis and preparation method thereof |
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| CN102085321A (en) * | 2009-12-02 | 2011-06-08 | 彭伟洪 | Drug dripping pill with effects of promoting digestion and eliminating retention |
| CN107233331A (en) * | 2017-07-28 | 2017-10-10 | 昆明邦宇制药有限公司 | A kind of berberine granula subtilis and preparation method thereof |
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