CN103386110A - Chinese medicine composition, and preparation method and applications thereof - Google Patents
Chinese medicine composition, and preparation method and applications thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition. The Chinese medicine composition comprises the following raw materials in parts by weight: 3-15 parts of ginseng, 3-15 parts of rhizome zingiberis, 2-10 parts of cortex cinnamomi, 7-35 parts of orange peels, 3-15 parts of rhizome dioscoreae, 5-25 parts of fructus jujubae, 1-20 parts of poria cocos, 1-60 parts of white hyacinth beans, 1-20 parts of citrus chirocarpus, 1-10 parts of semen raphani, 1-120 parts of black tea, 0-150 parts of radix codonopsis, 0-50 parts of American ginseng, 0-50 parts of sweet-scented osmanthus, 0-30 parts of semen myristicae, 0-60 parts of fresh ginger, 0-20 parts of endothelium corneum gigeriae galli, and 0-30 parts of fructus hordei germinatus. The invention further provides a preparation method of the Chinese medicine composition, and applications of the Chinese medicine composition in the fields of medicaments, health-care products, food and the like. The medicaments, health-care products or food are prepared from multiple herbal Chinese medicines which are coordinated in compatibility, take advantages of each other and are safe and effective, so that the good mouthfeel and safety of the products can be guaranteed, the bitter and astringent taste of medicaments can be avoided, and the Chinese medicine composition has the effects of tonifying the spleen, warming up the stomach, and improving the gastrointestinal function.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and application, particularly a kind of have spleen invigorating warming the stomach, the Chinese medicine composition that improves gastrointestinal function, its preparation method with and in the application of medicine, health product, food industry.
Background technology
Along with improving constantly of social development and living standards of the people, health index but descends increasingly, and most people is in sub-health state, and is tending towards multi-population, the situation of rejuvenation.Bad diet, daily life and allegro life cause easily that taste are impaired, give birth in deficiency and coldness, symptom/the disease that shows in modern medicine mostly is the gastroenteropathys such as inappetence, large loose stool are thin, chronic enterogastritis, functional dyspepsia, peptic ulcer, chronic colitis, therefore have the product for the treatment of and recuperating gastrointestinal tract function, its demand is also increasing.
Thereby the health product, the food that have in the market tonify deficiency warming the stomach spleen invigorating adjusting gastrointestinal function are less, are in certain market vacancy state, the present invention is directed to this present situation, develop a kind of warming and invigorating the spleen and stomach that has, and are fit to the product of mass consumption.
Summary of the invention
At first the present invention provides a kind of Chinese medicine composition composition formula, and described Chinese medicine composition is mainly made by the raw material of following weight proportion: Radix Ginseng 3-15 part, Rhizoma Zingiberis 3-15 part, Cortex Cinnamomi 2-10 part, Pericarpium Citri tangerinae 7-35 part, Rhizoma Dioscoreae 3-15 part, Fructus Jujubae 5-25 part, Poria 1-20 part, Semen Lablab Album 1-60 part, Fructus Citri Sarcodactylis 1-20 part, Semen Raphani 1-10 part, black tea 1-120 part, Radix Codonopsis 0-150 part, Radix Panacis Quinquefolii 0-50 part, Flos Osmanthi Fragrantis 0-50 part, Semen Myristicae 0-30 part, Rhizoma Zingiberis Recens 0-60 part, Endothelium Corneum Gigeriae Galli 0-20 part and Fructus Hordei Germinatus 0-30 part.
As a kind of preferred version, described Chinese medicine composition is mainly made by the raw material of following weight proportion: 15 parts of Radix Ginsengs, 15 parts of Rhizoma Zingiberiss, 10 parts of Cortex Cinnamomis, 35 parts of Pericarpium Citri tangerinaes, 15 parts of Rhizoma Dioscoreaes, 25 parts, Fructus Jujubae, 10 parts, Poria, 30 parts of Semen Lablab Albums, 10 parts of Fructus Citri Sarcodactylis, 5 parts of Semen Raphanis, 60 parts of black tea.
A kind of application as described Chinese medicine composition, the present invention also provides a kind of medicine or health food that comprises above-mentioned Chinese medicine composition, the described medicine that contains above-mentioned Chinese medicine composition or health food can also add one or more in following adjuvant or additive: diluent, excipient, lubricant, disintegrating agent and correctives etc., and the dosage form of described medicine or health product can be the dosage forms such as granule, tablet, pill, powder, oral liquid or capsule.
Another kind application as described Chinese medicine composition, the present invention also provides a kind of food that comprises above-mentioned Chinese medicine composition, and the described food that contains above-mentioned Chinese medicine composition also can add one or more in following adjuvant or additive: acidity regulator, anticaking agents, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, colour fixative, enzyme preparation, flavour enhancer, nutrition enhancer, antiseptic, sweeting agent, thickening agent and spice etc.; And described food form can be graininess or Powdered alternative tea, beverage, cake or confection etc.
Correspondence the invention provides a kind of preparation method of medicine, health food or food of described Chinese medicine composition, and this preparation method comprises the steps:
(1) described raw material water or ethanol water are extracted, with extracting liquid filtering, concentrated;
(2) spray drying, optionally add adjuvant or additive, pelletizing forming, packaging sterilizing.
As preferred implementation, after described step (1) can be described raw material is soaked 1 hour, heating extraction 1-4 time, each 1-2 hour, the 8-10 that each amount of water is described raw material doubly measures, with extracting solution merging, filtration, cold preservation, standing, the centrifugal impurity of removing, concentrated.
As preferred implementation, described state step (1) and also can be described raw material is added ethanol water and soaks 1 hour after, heating extraction 1-4 time, each 1-2 hour, the 5-7 that adds the ethanol water amount at every turn and be described raw material doubly measures, with extracting liquid filtering, merging, cold preservation, standing, filter, reclaim ethanol, concentrated; Wherein, as preferred embodiment, the concentration of described ethanol water is 70%(v/v).
As another kind of preferred implementation, described step (2) comprises, spray drying obtains former powder, add certain proportion brown sugar, white sugar, dextrin fine powder, its Central Plains powder and brown sugar ratio are 1:0-4, and former powder and white sugar ratio are 1:0-4, former powder and dextrin ratio are 1:0.5-1.5, granulation, packing, sterilizing.
The present invention also provide a kind of comprise described Chinese medicine composition preparation method, this preparation method comprises the steps:
(1) will pulverize and sieve after the described raw material removal of impurity successively;
(2) randomly add adjuvant or additive, the packing or low temperature cure rear packing, sterilizing after and get final product; Wherein said low temperature cures preferably and carries out under 80-150 ℃.
Perhaps, this preparation method comprises the steps:
(1) described raw material water or ethanol water are extracted, with extracting liquid filtering, concentrated;
(2) add water and other adjuvants, mix homogeneously, cold preservation is standing, filters, and adds beverage correctives commonly used and other adjuvants, fine straining, fill, sterilizing.
In side, Rhizoma Zingiberis, Cortex Cinnamomi are monarch, and the large heat of Da Xin, return through taste, the logical cold relieving of temperature, and invigorating YANG presses down cloudy.Enter spleen take Radix Ginseng, Fructus Jujubae, Rhizoma Dioscoreae as minister, Gan Wen, invigorating the spleen and replenishing QI, the foundation of acquired constitution is mended in training, and gas is prosperous and positive also multiple.Spleen is wet soil, and middle void is not transported, and must give birth to damp, take Pericarpium Citri tangerinae, Poria, Semen Lablab Album, Fructus Citri Sarcodactylis as assistant, and damp eliminating spleen invigorating, strong fortune Central Region, institute's happiness of throwing spleen.Semen Raphani, the black tea de-swelling that helps digestion, help gastro-intestinal digestion, promote appetite, use for making medicine, the scalable spleen and stomach function.
Therefore, medicine provided by the invention, health product or food adopt plurality of Chinese, and compatibility is coordinated mutually, respectively get the chief, safe and effective, guaranteed good taste and the safety of product, avoided the pained abnormal smells from the patient of medicine, had simultaneously the spleen invigorating warming the stomach, improve the effect of gastrointestinal function.The present invention adopts the pure natural raw material, and raw material is easy to get, and has no side effect, and has market prospect preferably.The modern pharmacology test shows, the gut hormone index can disclose from microcosmic point the relevant gastrointestinal motility mechanism of syndrome of spleen-deficiency, can give " syndrome of spleen-deficiency " of Traditional Chinese Medicine with the modern science implication, and can be tcm clinical practice and effectively treat syndrome of spleen-deficiency gut hormone evaluation index and foundation are provided.Experiment shows, medicine provided by the invention, health product or food can obviously improve MOTIVITY IN RAT MODEL the stool character, comprise the level of the gut hormone of gastrin (GAS), motilin (MTL), somatostatin (SS).
The specific embodiment
For technical scheme of the present invention more easily is understood, the present invention is further elaborated below in conjunction with specific embodiment, embodiment described herein is only part embodiment of the present invention, but not whole implementation of the present invention, described embodiment only has exemplary, rather than the exhaustive of technical scheme of the present invention is limited.Without departing from the inventive concept of the premise; all those of ordinary skills do not make creative work with regard to thinkable other embodiment; and other simple replacement to technical solution of the present invention and various common variation, all belong to protection scope of the present invention.Described method is conventional method if no special instructions.Described raw material all can obtain from open commercial sources if no special instructions.
Embodiment 1
Get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g carry out the removal of impurity successively, and it is crushed to 24 orders, be divided into 100 teabag unit quantities, the tea bag of packing into, sterilizing, obtain the teabag of Chinese medicine composition of the present invention.
Embodiment 2
get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 10 times of water gagings and soaked 1 hour, heating decocts 3 times, each 1 hour, add for the first time 10 times of amounts of water, add 8 times of amounts of water rear twice, merge three times extracting liquid filtering, standing 24 hours of filtrate cold preservation, get supernatant, the high speed centrifugation remove impurity, after filtrate is concentrated into relative density 1.2, spray drying obtains former powder, add certain proportion brown sugar (1:1), white sugar (1:3), dextrin (1:1) fine powder, mix homogeneously, press the granule common process, the dried granule that is crushed to, packing, sterilizing.
Embodiment 3
get Radix Ginseng 15 g, Rhizoma Zingiberis 15g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 70%(v/v) ethanol water soaked 1 hour, heating and refluxing extraction 3 times, each 1 hour, add for the first time 7 times of amounts, add 5 times of amounts rear twice, filter, merge three times filtrate, standing 24 hours of filtrate cold preservation, get supernatant, the high speed centrifugation remove impurity, heating recovery ethanol is to nothing alcohol flavor, be concentrated into certain density, spray drying, obtain former powder, add certain proportion brown sugar (1:1), white sugar (1:3), dextrin (1:1) fine powder, mix homogeneously, press the granule common process, the dried granule that is crushed to, packing, sterilizing.
Embodiment 4
get Radix Ginseng 15 g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35 g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30 g, Fructus Citri Sarcodactylis 10 g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material was soaked 1 hour, heating decocts 3 times, each 1 hour, add 10 times of amounts of water at every turn, merge three extracting solution and with the 120-200 mesh sieve, filter, filtrate decompression is concentrated into thick extractum, add a certain amount of ethanol water, mix homogeneously, the standing 24-48 hour of cold preservation, get supernatant, high speed centrifugation, remove impurity, the filtrate heating recovery is to without alcohol, distinguishing the flavor of, be concentrated into certain density, add a certain amount of citric acid, the tea beverage such as acesulfame potassium correctives commonly used and other adjuvants, mix homogeneously, fine straining, fill, sterilizing, obtain beverage.
Embodiment 5
get Radix Ginseng 15g, Rhizoma Zingiberis 15 g, Cortex Cinnamomi 10 g, Pericarpium Citri tangerinae 35g, Rhizoma Dioscoreae 15 g, Poria 10 g, Semen Lablab Album 30g, Fructus Citri Sarcodactylis 10g, Semen Raphani 5 g, Fructus Jujubae 25 g, black tea 60 g, above medical material adds 70%(v/v) ethanol water soaked 1 hour, heating and refluxing extraction 3 times, each 1 hour, add for the first time 7 times of amounts, add 5 times of amounts rear twice, filter, merge three times filtrate, the standing 24-48 hour of filtrate cold preservation, get supernatant, the high speed centrifugation remove impurity, reclaim ethanol to nothing alcohol flavor, be evaporated to certain density, add water and other adjuvants, mix homogeneously, the standing 24-48 hour of cold preservation, get supernatant, high speed centrifugation, remove impurity, add a certain amount of citric acid, the tea beverage such as acesulfame potassium correctives commonly used and other adjuvants, mix homogeneously, fine straining, fill, sterilizing, obtain beverage.
Embodiment 6
Pharmacological evaluation: get 50 of SD rats, be divided at random 5 groups: Normal group, model of spleen deficiency group, group 1(give the teabag of embodiment 1), group 2(gives the granule of embodiment 2), group 3(gives the beverage of embodiment 3), each organizes 10, wherein according to document (Wang Honghai, Xie Ming. the variation ［ J ］ of model of spleen-asthenia hemorheology of rat and TXB2,6-Keto-PGF1 α. Beijing University of Chinese Medicine's journal, 2007,30 (11): 761-765) method copies the insufficiency of the spleen animal model of rat.After 10 days, rat is carried out gavage, every gavage 10mL/kg, observed its general character and measured motilin in its venous blood (MTL), somatostatin (SS) and gastrin (GAS) level after continuous 15 days every day.Result shows 3 groups of rats taking in product of the present invention, the general symptom that it is insufficiency of the spleen is (withered by hair, tiredly sleeping have a liking for saliva, activity obviously reduces, limbs fatigue, abdominal distention is obvious, just does or loose stool less, and crissum is filthy) be improved significantly, with the model of spleen deficiency group, significant difference (P＜0. 05, P＜0. 01) is arranged relatively.The physiochemical indice aspect, rat stomach therbligs (MTL) content has the trend of rising, but with model group, compares nonsignificance; Rat stomach secretin (GAS) content obviously improves, and is 59.19 ± 6.93,58.36 ± 7.52, and 62.25 ± 7.11, compared significant difference (P＜0. 05) with model group 46.02 ± 12.11; Rat plasma somatostatin (SS) content significantly rises, and is 96.28 ± 15.16,98.45 ± 14.15, and 101.02 ± 13.22, with model group 73.76 ± 16.98, significant difference (P＜0. 05) is arranged relatively.By upper data as can be known, product provided by the invention can obviously improve the rat stomach intestinal function.
Claims (10)
1. a Chinese medicine composition, mainly made by the raw material of following weight proportion: Radix Ginseng 3-15 part, Rhizoma Zingiberis 3-15 part, Cortex Cinnamomi 2-10 part, Pericarpium Citri tangerinae 7-35 part, Rhizoma Dioscoreae 3-15 part, Fructus Jujubae 5-25 part, Poria 1-20 part, Semen Lablab Album 1-60 part, Fructus Citri Sarcodactylis 1-20 part, Semen Raphani 1-10 part, black tea 1-120 part, Radix Codonopsis 0-150 part, Radix Panacis Quinquefolii 0-50 part, Flos Osmanthi Fragrantis 0-50 part, Semen Myristicae 0-30 part, Rhizoma Zingiberis Recens 0-60 part, Endothelium Corneum Gigeriae Galli 0-20 part and Fructus Hordei Germinatus 0-30 part.
2. Chinese medicine composition according to claim 1, it is characterized by, mainly by the raw material of following weight proportion, made: 60 parts of 15 parts of Radix Ginsengs, 15 parts of Rhizoma Zingiberiss, 10 parts of Cortex Cinnamomis, 35 parts of Pericarpium Citri tangerinaes, 15 parts of Rhizoma Dioscoreaes, 10 parts, Poria, 30 parts of Semen Lablab Albums, 10 parts of Fructus Citri Sarcodactylis, 5 parts of Semen Raphanis, 25 parts, Fructus Jujubae and black tea.
3. medicine or health food that comprises the described Chinese medicine composition of claim 2, it is characterized by, described medicine or health food also comprise one or more in following adjuvant or additive: diluent, excipient, lubricant, disintegrating agent and correctives, and the dosage form of described medicine is granule, tablet, pill, powder, oral liquid or capsule.
4. food that comprises the described Chinese medicine composition of claim 2, it is characterized by, described food also comprises one or more in following adjuvant or additive: acidity regulator, anticaking agents, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, colour fixative, enzyme preparation, flavour enhancer, nutrition enhancer, antiseptic, sweeting agent, thickening agent and spice, and described food comprises graininess or Powdered alternative tea, beverage, cake or confection.
5. the preparation method of a described medicine, health food or food, is characterized by, and comprises the steps:
(1) described raw material water or ethanol water are extracted, with extracting liquid filtering, concentrated;
(2) spray drying, optionally add adjuvant or additive, pelletizing forming, packaging sterilizing.
6. the preparation method of medicine, health food or food according to claim 5, it is characterized by: described step (1) is for after soaking 1 hour with described raw material, heating extraction 1-4 time, each 1-2 hour, the 8-10 that each amount of water is described raw material doubly measures, with extracting solution merging, filtration, cold preservation, standing, the centrifugal impurity of removing, concentrated.
7. the preparation method of medicine, health food or food according to claim 5, it is characterized by: the described step (1) of stating is for adding described raw material the ethanol water immersion after 1 hour, heating extraction 1-4 time, each 1-2 hour, the 5-7 that adds the ethanol water amount at every turn and be described raw material doubly measures, with extracting liquid filtering, merging, cold preservation, standing, filter, reclaim ethanol, concentrated; Wherein, the concentration of described ethanol water is 70%(v/v).
8. the preparation method of medicine, health food or food according to claim 5, it is characterized by, the former powder of described step (2) for spray drying is obtained, add certain proportion brown sugar, white sugar, dextrin fine powder, its Central Plains powder and brown sugar ratio are 1:0-4, and former powder and white sugar ratio are 1:0-4, former powder and dextrin ratio are 1:0.5-1.5, granulation, packing, sterilizing.
9. the preparation method of food according to claim 4, is characterized by, and comprises the steps:
(1) will pulverize and sieve after the described raw material removal of impurity successively;
(2) randomly add adjuvant or additive, the packing or low temperature cure rear packing, sterilizing after and get final product; Wherein said low temperature cures preferably and carries out under 80-150 ℃.
10. the preparation method of food according to claim 4, is characterized by, and comprises the steps:
(1) described raw material water or ethanol water are extracted, with extracting liquid filtering, concentrated;
(2) add water and other adjuvants, mix homogeneously, cold preservation is standing, filters, and adds beverage correctives commonly used and other adjuvants, fine straining, fill, sterilizing.
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| CN104256611A (en) * | 2014-10-11 | 2015-01-07 | 王�琦 | Food for improving constitution of qi deficiency and preparation technology of food |
| CN105327239A (en) * | 2014-07-04 | 2016-02-17 | 浙江爱生药业有限公司 | Traditional Chinese medicinal composition for treating children anorexia as well as preparation method and application of traditional Chinese medicinal composition |
| CN105327238A (en) * | 2014-07-04 | 2016-02-17 | 浙江爱生药业有限公司 | Traditional Chinese medicinal composition for tonifying spleen and stomach as well as preparation method and application of traditional Chinese medicinal composition |
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| CN110506880A (en) * | 2019-09-16 | 2019-11-29 | 美利新(天津)生物科技有限公司 | A kind of solid beverage with warm stomach function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103705827A (en) * | 2014-01-14 | 2014-04-09 | 刘高胜 | medicated food additive capable of improving intestines and stomach digestion environment |
| CN105327239A (en) * | 2014-07-04 | 2016-02-17 | 浙江爱生药业有限公司 | Traditional Chinese medicinal composition for treating children anorexia as well as preparation method and application of traditional Chinese medicinal composition |
| CN105327238A (en) * | 2014-07-04 | 2016-02-17 | 浙江爱生药业有限公司 | Traditional Chinese medicinal composition for tonifying spleen and stomach as well as preparation method and application of traditional Chinese medicinal composition |
| CN105327239B (en) * | 2014-07-04 | 2019-02-22 | 浙江爱生药业有限公司 | A kind of Chinese medicine composition and its preparation method and application for treating apositia of children |
| CN105327238B (en) * | 2014-07-04 | 2019-02-22 | 浙江爱生药业有限公司 | A kind of Chinese medicine composition of strengthening spleen and nourishing stomach and its preparation method and application |
| CN104256611A (en) * | 2014-10-11 | 2015-01-07 | 王�琦 | Food for improving constitution of qi deficiency and preparation technology of food |
| CN104256611B (en) * | 2014-10-11 | 2016-10-05 | 王�琦 | A kind of food improving Qi deficiency physique and preparation technology thereof |
| CN105660917A (en) * | 2016-02-04 | 2016-06-15 | 上海中晋堂健康科技有限公司 | Warming tea plant beverage |
| CN105707314A (en) * | 2016-02-18 | 2016-06-29 | 上海中晋堂健康科技有限公司 | Body-warming tea plant drink |
| CN106070882A (en) * | 2016-06-22 | 2016-11-09 | 黄辉健 | A kind of Herba Dendrobii dried ginger tea and preparation method thereof |
| CN107752026A (en) * | 2017-09-11 | 2018-03-06 | 厦门医学院 | Improve the fermented tea functional food of functions of intestines and stomach |
| CN110506880A (en) * | 2019-09-16 | 2019-11-29 | 美利新(天津)生物科技有限公司 | A kind of solid beverage with warm stomach function |
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