CN105294682B - Cdk类小分子抑制剂的化合物及其用途 - Google Patents
Cdk类小分子抑制剂的化合物及其用途 Download PDFInfo
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- CN105294682B CN105294682B CN201510439488.2A CN201510439488A CN105294682B CN 105294682 B CN105294682 B CN 105294682B CN 201510439488 A CN201510439488 A CN 201510439488A CN 105294682 B CN105294682 B CN 105294682B
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- 0 C*1C*CCC1 Chemical compound C*1C*CCC1 0.000 description 27
- HEPOZLAMLKVLEI-UHFFFAOYSA-N CC(C(C(N1C2CCCC2)=[IH])=C(C)c(cn2)c1nc2I)=[IH] Chemical compound CC(C(C(N1C2CCCC2)=[IH])=C(C)c(cn2)c1nc2I)=[IH] HEPOZLAMLKVLEI-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- WUDOTSYRZFWZEV-UHFFFAOYSA-N Cc(cc1)nc(CCN2C)c1C2=O Chemical compound Cc(cc1)nc(CCN2C)c1C2=O WUDOTSYRZFWZEV-UHFFFAOYSA-N 0.000 description 1
- QHLCSKYQFMBTMJ-UHFFFAOYSA-N Cc(nc1)cc2c1[n](C)cc2 Chemical compound Cc(nc1)cc2c1[n](C)cc2 QHLCSKYQFMBTMJ-UHFFFAOYSA-N 0.000 description 1
- LCZUOKDVTBMCMX-UHFFFAOYSA-N Cc1ncc(C)nc1 Chemical compound Cc1ncc(C)nc1 LCZUOKDVTBMCMX-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
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- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
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- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510439488.2A CN105294682B (zh) | 2014-07-26 | 2015-07-23 | Cdk类小分子抑制剂的化合物及其用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410361634 | 2014-07-26 | ||
| CN201410361634X | 2014-07-26 | ||
| CN201510076030 | 2015-02-12 | ||
| CN2015100760305 | 2015-02-12 | ||
| CN201510439488.2A CN105294682B (zh) | 2014-07-26 | 2015-07-23 | Cdk类小分子抑制剂的化合物及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105294682A CN105294682A (zh) | 2016-02-03 |
| CN105294682B true CN105294682B (zh) | 2017-07-07 |
Family
ID=55192593
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510439488.2A Active CN105294682B (zh) | 2014-07-26 | 2015-07-23 | Cdk类小分子抑制剂的化合物及其用途 |
| CN201510439329.2A Active CN105294681B (zh) | 2014-07-26 | 2015-07-23 | Cdk类小分子抑制剂的化合物及其用途 |
| CN201510443167.XA Active CN105294736B (zh) | 2014-07-26 | 2015-07-24 | Cdk类小分子抑制剂的化合物及其用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510439329.2A Active CN105294681B (zh) | 2014-07-26 | 2015-07-23 | Cdk类小分子抑制剂的化合物及其用途 |
| CN201510443167.XA Active CN105294736B (zh) | 2014-07-26 | 2015-07-24 | Cdk类小分子抑制剂的化合物及其用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9828373B2 (https=) |
| EP (1) | EP3172214B1 (https=) |
| JP (1) | JP6631616B2 (https=) |
| KR (1) | KR20170032244A (https=) |
| CN (3) | CN105294682B (https=) |
| AU (1) | AU2015296322B2 (https=) |
| CA (1) | CA2954189A1 (https=) |
| WO (2) | WO2016015598A1 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201800171T1 (it) | 2011-07-29 | 2018-07-17 | Karyopharm Therapeutics Inc | Modulatori di trasporto nucleare contenenti idrazide e loro usi |
| CA2872190C (en) | 2012-05-09 | 2024-06-25 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| DK3492455T3 (da) | 2013-06-21 | 2023-08-14 | Karyopharm Therapeutics Inc | 1,2,4-triazoler som nukleare transportmodulatorer og anvendelse til behandling af specifikke former for cancer |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| US11225492B2 (en) | 2015-12-13 | 2022-01-18 | Hangzhou Innogate Pharma Co., Ltd. | Heterocycles useful as anti-cancer agents |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017161253A1 (en) | 2016-03-18 | 2017-09-21 | Tufts Medical Center | Compositions and methods for treating and preventing metabolic disorders |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| CN105777749A (zh) * | 2016-04-06 | 2016-07-20 | 中国药科大学 | 吡啶并嘧啶类化合物、其制备方法及其用途 |
| CN105968109B (zh) * | 2016-05-13 | 2017-11-17 | 聂红梅 | 一种制备帕博西尼中间体的方法 |
| EP3463453A1 (en) * | 2016-05-23 | 2019-04-10 | Eli Lilly and Company | Combination of pembrolizumab and abemaciclib for the treatment of cancer |
| CN106083844B (zh) * | 2016-06-05 | 2017-11-10 | 陈志明 | 一种制备抗乳腺癌药物帕博西尼中间体的方法 |
| WO2018001270A1 (en) * | 2016-06-30 | 2018-01-04 | Noratech Pharmaceuticals, Inc. | Palbociclib prodrugs and composition thereof |
| CA3040815C (en) | 2016-10-20 | 2021-07-20 | Steven Martin Evans | Anti-proliferative agents for treating pah |
| EP3541389A1 (en) * | 2016-11-16 | 2019-09-25 | Pfizer Inc | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
| LT3546458T (lt) * | 2016-11-28 | 2021-05-10 | Teijin Pharma Limited | ((piridin-2-il)-amino)pirido[3,4-d]pirimidino ir ((piridazin-3-il)-amino)pirido[3,4-d]pirimidino dariniai, kaip cdk4/6 inhibitoriai, skirti gydymui, pvz. reumatoidinio artrito, arteriosklerozės, plaučių fibrozės, smegenų infarkto arba vėžio |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| EP3556758B1 (en) * | 2016-12-16 | 2024-07-17 | Cstone Pharmaceuticals (Suzhou) Co., Ltd. | 1,2-dihydro-1,6-naphthyridin-2-one derivatives as cdk4/6 inhibitors |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| US20190388407A1 (en) | 2017-02-12 | 2019-12-26 | Aiviva Biopharma, Inc. | Multikinase inhibitors of vegf and tfg beta and uses thereof |
| CN108929324A (zh) * | 2017-05-22 | 2018-12-04 | 南开大学 | 新型1,1-环丙基二酰胺衍生物的制备与应用 |
| EP3635132A4 (en) * | 2017-06-07 | 2021-05-26 | Intrexon Corporation | EXPRESSION OF NOVEL CELL MARKERS |
| CN109384767B (zh) * | 2017-08-08 | 2020-05-05 | 江苏恒瑞医药股份有限公司 | 一种吡啶并嘧啶类衍生物的制备方法及其中间体 |
| CN109394767A (zh) * | 2017-12-19 | 2019-03-01 | 清华大学 | 化合物在制备药物中的用途 |
| WO2019161224A1 (en) | 2018-02-15 | 2019-08-22 | GiraFpharma LLC | Heterocyclic compounds as kinase inhibitors |
| EP3786161A4 (en) | 2018-04-24 | 2021-05-05 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd | CDK4 / 6 INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPHIC THEREOF, AND USE OF IT |
| CN110496223B (zh) * | 2018-05-17 | 2021-09-10 | 复旦大学附属肿瘤医院 | 一种治疗非霍奇金氏淋巴瘤的药物组合物 |
| CN108524938B (zh) * | 2018-06-15 | 2020-06-19 | 深圳大学 | Cdk6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用 |
| WO2020006210A1 (en) * | 2018-06-27 | 2020-01-02 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
| BR112021001499A2 (pt) | 2018-07-27 | 2021-04-27 | California Institute Of Technology | inibidores de cdk e usos dos mesmos |
| AU2019321429B2 (en) * | 2018-08-15 | 2022-12-08 | Aiviva Biopharma, Inc. | Multi-kinase inhibitors of VEGF and TGF beta and uses thereof |
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| EP3172214B1 (en) | 2020-05-13 |
| JP6631616B2 (ja) | 2020-01-15 |
| CN105294681B (zh) | 2017-07-07 |
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| EP3172214A4 (en) | 2018-02-07 |
| AU2015296322A1 (en) | 2017-01-12 |
| CN105294736A (zh) | 2016-02-03 |
| CN105294682A (zh) | 2016-02-03 |
| KR20170032244A (ko) | 2017-03-22 |
| CN105294681A (zh) | 2016-02-03 |
| CN105294736B (zh) | 2020-01-14 |
| CA2954189A1 (en) | 2016-02-04 |
| US9828373B2 (en) | 2017-11-28 |
| WO2016015597A1 (en) | 2016-02-04 |
| WO2016015598A1 (en) | 2016-02-04 |
| HK1232223A1 (en) | 2018-01-05 |
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