CN105288233A - Medicinal preparation for treating trigeminal neuralgia - Google Patents

Abstract

The invention specifically provides a medicinal preparation for treating trigeminal neuralgia, which belongs to the field of traditional Chinese medicine preparations. The medicinal preparation is prepared from the following raw materials: 20 parts of all-grass of shiningfruit night-shade, 25 parts of endive root, 22 parts of central China dryoathyrium, 25 parts of root-bark of Cuneateleaf Meliosma, 28 parts of dragon boat raspberry, 22 parts of Silene firma, 26 parts of white peony root, 15 parts of Fructus viticis, 25 parts of Chinese angelica, 28 parts of gastrodia tuer, 15 parts of Hedyotis diffusa, 15 parts of garden burnet, 20 parts of common andrographis herb, 25 parts of mint, 20 parts of lumbricus, 25 parts of achyranthes root, 20 parts of cassia twig, 15 parts of gentian and 5 parts of licorice. The medicinal preparation can treat trigeminal neuralgia.

Description

One is used for the treatment of prosopalgic pharmaceutical preparation

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of prosopalgic pharmaceutical preparation and its preparation method and application.

Background technology

Trigeminal neuralgia is modal cranial nerve diseases, and with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, female is slightly more than man, and sickness rate can increase with the age.Trigeminal neuralgia is multiple is born in middle-aged and elderly people, R)L.The feature of this disease is: in Head And Face nervi trigeminus distributed areas, and morbidity is sent out suddenly, all standing, lightning sample, the sample that lancinates, burns sample, intractable, insufferable severity pain.Speak, wash one's face, brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking.Pain lasts several seconds or several minutes, and pain is periodical attack, and the outbreak intermission is the same with normal person.For this reason, be bursting to develop and manyly treat the needs that prosopalgic medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of trigeminal neuralgia disease.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of prosopalgic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba solani photeinocarpi 20 parts, Radix Lactucae versicoloris 25 parts, Folium Dryoathyrii okuboanii 22 parts, Cortex Meliosmatis Radicis 25 parts, Rubus sieboldi Blume. 28 parts, Herba melandrii firmi 22 parts, the Radix Paeoniae Alba 26 parts, Fructus Viticis 15 parts, Radix Angelicae Sinensis 25 parts, 28 parts, Rhizoma Gastrodiae, Herba Hedyotidis Diffusae 15 parts, Radix Sanguisorbae 15 parts, Herba Andrographis 20 parts, Herba Menthae 25 parts, Pheretima 20 parts, Radix Achyranthis Bidentatae 25 parts, Ramulus Cinnamomi 20 parts, Radix Gentianae 15 parts, 5 parts, Radix Glycyrrhizae.

Describedly be used for the treatment of prosopalgic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.

Describedly be used for the treatment of prosopalgic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

Describedly be used for the treatment of the application of prosopalgic pharmaceutical preparation in preparation treatment trigeminal neuralgia medicine.

Herba solani photeinocarpi is the herb of plant of Solanaceae S. photeinocarpum.

Radix Lactucae versicoloris is the root of the young dish of feverfew rabbit.

Folium Dryoathyrii okuboanii is the leaf of Athyriaceae plant Central China Jie Herba pteridii latiusculi.

Cortex Meliosmatis Radicis is the root bark of Sabiaceae plant cuneateleaf meliosma.

Rubus sieboldi Blume. is the Herb of the rosaceous plant hot pillar certain kind of berries.Latin name: RubussieboldiBlume., hemostasis, invigorates blood circulation, pain relieving, antipyretic diuresis.

Herba melandrii firmi is the herb of the sturdy Herba Melandrii Aprici of pinkwort.Latin name: SilenefirmaSieb.EtZucc., gathers during 8 ~ JIUYUE seed maturity, dries.Heat-clearing and toxic substances removing; Diuresis; Regulating menstruation.Cure mainly laryngopharynx swelling and pain; (ear booth) ear comes to a head; Dysuria.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science thinks that trigeminal neuralgia is caused by QI and blood retardance, liver sthenia gastropyrexia upper punch or hyperactivity of YANG due to deficiency of YIN, asthenic fire are disturbed.Herba solani photeinocarpi of the present invention, Radix Lactucae versicoloris, Folium Dryoathyrii okuboanii, Cortex Meliosmatis Radicis, Rubus sieboldi Blume., Herba melandrii firmi, the Radix Paeoniae Alba, Fructus Viticis, Radix Angelicae Sinensis, invigorating blood circulation of Rhizoma Gastrodiae, stasis of blood wind and heat dispersing, relieving spasm to stop pain are monarch drug, Herba Hedyotidis Diffusae, Radix Sanguisorbae, Herba Andrographis, Herba Menthae, Pheretima, Radix Achyranthis Bidentatae, Ramulus Cinnamomi, Radix Gentianae heat-clearing and toxic substances removing, supplementing QI and nourishing YIN, promoting the circulation of QI to relieve pain are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, treatment trigeminal neuralgia successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Herba solani photeinocarpi 20g, Radix Lactucae versicoloris 25g, Folium Dryoathyrii okuboanii 22g, Cortex Meliosmatis Radicis 25g, Rubus sieboldi Blume. 28g, Herba melandrii firmi 22g, Radix Paeoniae Alba 26g, Fructus Viticis 15g, Radix Angelicae Sinensis 25g, Rhizoma Gastrodiae 28g, Herba Hedyotidis Diffusae 15g, Radix Sanguisorbae 15g, Herba Andrographis 20g, Herba Menthae 25g, Pheretima 20g, Radix Achyranthis Bidentatae 25g, Ramulus Cinnamomi 20g, Radix Gentianae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Herba solani photeinocarpi 20g, Radix Lactucae versicoloris 25g, Folium Dryoathyrii okuboanii 22g, Cortex Meliosmatis Radicis 25g, Rubus sieboldi Blume. 28g, Herba melandrii firmi 22g, Radix Paeoniae Alba 26g, Fructus Viticis 15g, Radix Angelicae Sinensis 25g, Rhizoma Gastrodiae 28g, Herba Hedyotidis Diffusae 15g, Radix Sanguisorbae 15g, Herba Andrographis 20g, Herba Menthae 25g, Pheretima 20g, Radix Achyranthis Bidentatae 25g, Ramulus Cinnamomi 20g, Radix Gentianae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get Herba solani photeinocarpi 20g, Radix Lactucae versicoloris 25g, Folium Dryoathyrii okuboanii 22g, Cortex Meliosmatis Radicis 25g, Rubus sieboldi Blume. 28g, Herba melandrii firmi 22g, Radix Paeoniae Alba 26g, Fructus Viticis 15g, Radix Angelicae Sinensis 25g, Rhizoma Gastrodiae 28g, Herba Hedyotidis Diffusae 15g, Radix Sanguisorbae 15g, Herba Andrographis 20g, Herba Menthae 25g, Pheretima 20g, Radix Achyranthis Bidentatae 25g, Ramulus Cinnamomi 20g, Radix Gentianae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, traditional Chinese medicine composition for treating trigeminal neuralgia of the present invention clinical research

4.1 general data: this Chinese medicine composition is applied to clinical observation trigeminal neuralgia case 50 example, 36 ~ 65 years old age.The shortest person of the course of disease 3 months, most elder reaches 4 years, average 2.4 years.

4.2 diagnostic criterias: the standard with reference to the classical trigeminal neuralgia (primary trigeminal neuralgia) of International Headache association (IHS) diagnosis worked out in 1988 is made a definite diagnosis.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: clinical recovery:: panic attacks disappears, and follows up a case by regular visits to and has no recurrence in 3 months; Take a turn for the better: when attack times reduces and (or) shows effect, pain degree alleviates; Invalid: attack times and outbreak pain degree are without alleviating.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	25	8	13	4	84
Blank group	25	1	2	22	12

Visible the present invention has good therapeutic effect to trigeminal neuralgia, and toxic and side effects does not occur treatments period.

Claims (4)

1. one kind is used for the treatment of prosopalgic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba solani photeinocarpi 20 parts, Radix Lactucae versicoloris 25 parts, Folium Dryoathyrii okuboanii 22 parts, Cortex Meliosmatis Radicis 25 parts, Rubus sieboldi Blume. 28 parts, Herba melandrii firmi 22 parts, the Radix Paeoniae Alba 26 parts, Fructus Viticis 15 parts, Radix Angelicae Sinensis 25 parts, 28 parts, Rhizoma Gastrodiae, Herba Hedyotidis Diffusae 15 parts, Radix Sanguisorbae 15 parts, Herba Andrographis 20 parts, Herba Menthae 25 parts, Pheretima 20 parts, Radix Achyranthis Bidentatae 25 parts, Ramulus Cinnamomi 20 parts, Radix Gentianae 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of prosopalgic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of prosopalgic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of prosopalgic pharmaceutical preparation in treatment trigeminal neuralgia medicine according to claim 1.