CN105209055A - 用人生长激素类似物治疗小儿生长激素缺乏症 - Google Patents

用人生长激素类似物治疗小儿生长激素缺乏症 Download PDF

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Publication number
CN105209055A
CN105209055A CN201480011475.9A CN201480011475A CN105209055A CN 105209055 A CN105209055 A CN 105209055A CN 201480011475 A CN201480011475 A CN 201480011475A CN 105209055 A CN105209055 A CN 105209055A
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CN
China
Prior art keywords
days
hgh
xten
bolus dose
fusion rotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480011475.9A
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English (en)
Chinese (zh)
Inventor
J·L·克莱兰
乔治·M·布莱特
埃里克·汉弗里斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amunix Inc
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Amunix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amunix Inc filed Critical Amunix Inc
Publication of CN105209055A publication Critical patent/CN105209055A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201480011475.9A 2013-03-11 2014-03-10 用人生长激素类似物治疗小儿生长激素缺乏症 Pending CN105209055A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201361776618P 2013-03-11 2013-03-11
US61/776,618 2013-03-11
US201361810786P 2013-04-11 2013-04-11
US61/810,786 2013-04-11
US201361835002P 2013-06-14 2013-06-14
US61/835,002 2013-06-14
US201361880701P 2013-09-20 2013-09-20
US61/880,701 2013-09-20
US201361911731P 2013-12-04 2013-12-04
US61/911,731 2013-12-04
US201461931987P 2014-01-27 2014-01-27
US61/931,987 2014-01-27
US201461948457P 2014-03-05 2014-03-05
US61/948,457 2014-03-05
PCT/US2014/022850 WO2014164568A1 (en) 2013-03-11 2014-03-10 Treatment of pediatric growth hormone deficiency with human growth hormone analogues

Publications (1)

Publication Number Publication Date
CN105209055A true CN105209055A (zh) 2015-12-30

Family

ID=51658905

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011475.9A Pending CN105209055A (zh) 2013-03-11 2014-03-10 用人生长激素类似物治疗小儿生长激素缺乏症

Country Status (16)

Country Link
US (1) US20160158321A1 (enExample)
EP (1) EP2968451A4 (enExample)
JP (3) JP2016514132A (enExample)
KR (1) KR20150124955A (enExample)
CN (1) CN105209055A (enExample)
AU (1) AU2014249258A1 (enExample)
BR (1) BR112015022257A8 (enExample)
CA (1) CA2900949A1 (enExample)
CL (1) CL2015002456A1 (enExample)
EA (1) EA201591529A1 (enExample)
HK (1) HK1216617A1 (enExample)
IL (1) IL240392A0 (enExample)
MX (1) MX2015012175A (enExample)
PH (1) PH12015502063A1 (enExample)
SG (1) SG11201506732YA (enExample)
WO (1) WO2014164568A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152816A (zh) * 2016-02-17 2019-01-04 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
CN110177567A (zh) * 2016-08-30 2019-08-27 株式会社吉耐森 含有hGH融合蛋白的治疗生长激素缺乏症的药物组合物
CN111684283A (zh) * 2017-12-19 2020-09-18 阿特纳赞塔里斯有限公司 通过含马昔瑞林的组合物评估人生长激素缺乏症的方法
CN114258492A (zh) * 2020-07-22 2022-03-29 阿特纳赞塔里斯有限公司 一种通过使用马昔瑞林诊断儿科患者中生长激素缺乏症的筛选方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
WO2016109823A1 (en) * 2015-01-02 2016-07-07 Amunix Operation Inc. Treatment of pediatric growth hormone deficiency with human growth hormone analogues
AU2016214265A1 (en) 2015-02-03 2017-08-17 Apple Inc. Family sleep monitoring system
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
AU2018393111B2 (en) 2017-12-21 2025-07-10 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
US11903683B2 (en) 2018-08-03 2024-02-20 Chelak Medical Solutions Inc Non-barometric determination of hemodynamic effects of cardiac arrhythmias using signals sensed by an implantable device
RU2753191C2 (ru) * 2019-09-26 2021-08-12 Федеральное государственное бюджетное учреждение науки Институт Биологии Развития им. Н.К. Кольцова Российской Академии Наук Новый рекомбинантный аналог гормона роста пролонгированного действия
WO2021136223A1 (en) 2019-12-31 2021-07-08 Beijing Ql Biopharmaceutical Co., Ltd. Fusion proteins of glp-1 and gdf15 and conjugates thereof
CN113728013B (zh) 2020-01-11 2022-06-14 北京质肽生物医药科技有限公司 Glp-1和fgf21的融合蛋白的缀合物
KR102599111B1 (ko) * 2020-01-31 2023-11-07 울산대학교 산학협력단 인슐린유사성장인자-1 융합단백질 및 이의 용도
KR20230083294A (ko) 2020-09-30 2023-06-09 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 폴리펩타이드 접합체 및 사용 방법
CA3252113A1 (en) 2022-03-30 2023-10-05 Beijing Ql Biopharmaceutical Co., Ltd. Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239554A1 (en) * 2009-02-03 2010-09-23 Amunix Inc. a Delaware Corporation Extended recombinant polypeptides and compositions comprising same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2544982T3 (es) * 2009-09-02 2015-09-07 Merck Serono S.A. Método para predecir el nivel de respuesta al crecimiento
BR112014030404A2 (pt) * 2012-06-05 2017-06-27 Amunix Operating Inc proteína de fusão hgh-xten e seu uso no tratamento da deficiência de hormônio do crescimento

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239554A1 (en) * 2009-02-03 2010-09-23 Amunix Inc. a Delaware Corporation Extended recombinant polypeptides and compositions comprising same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109152816A (zh) * 2016-02-17 2019-01-04 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
CN109152816B (zh) * 2016-02-17 2022-08-16 株式会社吉耐森 用于治疗生长激素缺乏症的包含重组hgh的药物组合物
US12233113B2 (en) 2016-02-17 2025-02-25 Genexine, Inc. Pharmaceutical composition comprising recombinant hGH for the treatment of growth hormone deficiency
CN110177567A (zh) * 2016-08-30 2019-08-27 株式会社吉耐森 含有hGH融合蛋白的治疗生长激素缺乏症的药物组合物
US12427186B2 (en) 2016-08-30 2025-09-30 Genexine, Inc. Method for treating growth hormone deficiency employing hGH fusion protein
CN111684283A (zh) * 2017-12-19 2020-09-18 阿特纳赞塔里斯有限公司 通过含马昔瑞林的组合物评估人生长激素缺乏症的方法
CN111684283B (zh) * 2017-12-19 2024-02-09 阿特纳赞塔里斯有限公司 通过含马昔瑞林的组合物评估人生长激素缺乏症的方法
CN114258492A (zh) * 2020-07-22 2022-03-29 阿特纳赞塔里斯有限公司 一种通过使用马昔瑞林诊断儿科患者中生长激素缺乏症的筛选方法

Also Published As

Publication number Publication date
SG11201506732YA (en) 2015-09-29
EP2968451A4 (en) 2017-01-04
EP2968451A1 (en) 2016-01-20
KR20150124955A (ko) 2015-11-06
IL240392A0 (en) 2015-09-24
CL2015002456A1 (es) 2016-05-27
JP2019056013A (ja) 2019-04-11
HK1216617A1 (zh) 2016-11-25
US20160158321A1 (en) 2016-06-09
PH12015502063A1 (en) 2016-01-25
WO2014164568A1 (en) 2014-10-09
JP2017101074A (ja) 2017-06-08
MX2015012175A (es) 2016-01-12
JP2016514132A (ja) 2016-05-19
CA2900949A1 (en) 2014-10-09
BR112015022257A8 (pt) 2018-01-23
EA201591529A1 (ru) 2016-04-29
AU2014249258A1 (en) 2015-08-27
BR112015022257A2 (pt) 2017-10-10

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Application publication date: 20151230

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