JP2016514132A - ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 - Google Patents

ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 Download PDF

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JP2016514132A
JP2016514132A JP2016501088A JP2016501088A JP2016514132A JP 2016514132 A JP2016514132 A JP 2016514132A JP 2016501088 A JP2016501088 A JP 2016501088A JP 2016501088 A JP2016501088 A JP 2016501088A JP 2016514132 A JP2016514132 A JP 2016514132A
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days
hgh
xten
fusion protein
bolus dose
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JP2016514132A5 (enExample
Inventor
ジェフリー エル． クリーランド，
ジェフリー エル． クリーランド，
ジョージ エム． ブライト，
ジョージ エム． ブライト，
エリック ハンフリーズ，
エリック ハンフリーズ，
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アムニクス オペレーティング インコーポレイテッド
アムニクス オペレーティング インコーポレイテッド
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Publication of JP2016514132A publication Critical patent/JP2016514132A/ja
Publication of JP2016514132A5 publication Critical patent/JP2016514132A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2016501088A 2013-03-11 2014-03-10 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 Withdrawn JP2016514132A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201361776618P 2013-03-11 2013-03-11
US61/776,618 2013-03-11
US201361810786P 2013-04-11 2013-04-11
US61/810,786 2013-04-11
US201361835002P 2013-06-14 2013-06-14
US61/835,002 2013-06-14
US201361880701P 2013-09-20 2013-09-20
US61/880,701 2013-09-20
US201361911731P 2013-12-04 2013-12-04
US61/911,731 2013-12-04
US201461931987P 2014-01-27 2014-01-27
US61/931,987 2014-01-27
US201461948457P 2014-03-05 2014-03-05
US61/948,457 2014-03-05
PCT/US2014/022850 WO2014164568A1 (en) 2013-03-11 2014-03-10 Treatment of pediatric growth hormone deficiency with human growth hormone analogues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017039625A Division JP2017101074A (ja) 2013-03-11 2017-03-02 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療

Publications (2)

Publication Number Publication Date
JP2016514132A true JP2016514132A (ja) 2016-05-19
JP2016514132A5 JP2016514132A5 (enExample) 2017-04-06

Family

ID=51658905

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016501088A Withdrawn JP2016514132A (ja) 2013-03-11 2014-03-10 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療
JP2017039625A Withdrawn JP2017101074A (ja) 2013-03-11 2017-03-02 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療
JP2019005944A Pending JP2019056013A (ja) 2013-03-11 2019-01-17 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017039625A Withdrawn JP2017101074A (ja) 2013-03-11 2017-03-02 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療
JP2019005944A Pending JP2019056013A (ja) 2013-03-11 2019-01-17 ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療

Country Status (16)

Country Link
US (1) US20160158321A1 (enExample)
EP (1) EP2968451A4 (enExample)
JP (3) JP2016514132A (enExample)
KR (1) KR20150124955A (enExample)
CN (1) CN105209055A (enExample)
AU (1) AU2014249258A1 (enExample)
BR (1) BR112015022257A8 (enExample)
CA (1) CA2900949A1 (enExample)
CL (1) CL2015002456A1 (enExample)
EA (1) EA201591529A1 (enExample)
HK (1) HK1216617A1 (enExample)
IL (1) IL240392A0 (enExample)
MX (1) MX2015012175A (enExample)
PH (1) PH12015502063A1 (enExample)
SG (1) SG11201506732YA (enExample)
WO (1) WO2014164568A1 (enExample)

Cited By (1)

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JP2019533004A (ja) * 2016-08-30 2019-11-14 ジェネクシン・インコーポレイテッドＧｅｎｅｘｉｎｅ， Ｉｎｃ． ｈＧＨ融合タンパク質を含有する、成長ホルモン欠乏症を治療するための医薬組成物

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US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
WO2016109823A1 (en) * 2015-01-02 2016-07-07 Amunix Operation Inc. Treatment of pediatric growth hormone deficiency with human growth hormone analogues
EP3229671A4 (en) 2015-02-03 2018-04-04 Apple Inc. Family sleep monitoring system
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
RU2732113C2 (ru) 2016-02-17 2020-09-11 Дженексин, Инк. Фармацевтическая композиция, включающая рекомбинантный гормон роста человека для лечения дефицита гормона роста
US10288629B1 (en) * 2017-12-19 2019-05-14 Aeterna Zentaris, Inc. Method of assessing growth hormone deficiency in humans by a macimorelin containing composition
WO2019126576A1 (en) 2017-12-21 2019-06-27 Amunix Pharmaceuticals, Inc. Release segments and binding compositions comprising same
US11903683B2 (en) 2018-08-03 2024-02-20 Chelak Medical Solutions Inc Non-barometric determination of hemodynamic effects of cardiac arrhythmias using signals sensed by an implantable device
RU2753191C2 (ru) * 2019-09-26 2021-08-12 Федеральное государственное бюджетное учреждение науки Институт Биологии Развития им. Н.К. Кольцова Российской Академии Наук Новый рекомбинантный аналог гормона роста пролонгированного действия
CN116925237A (zh) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Glp-1和gdf15的融合蛋白以及其缀合物
CN113728013B (zh) 2020-01-11 2022-06-14 北京质肽生物医药科技有限公司 Glp-1和fgf21的融合蛋白的缀合物
KR102599111B1 (ko) * 2020-01-31 2023-11-07 울산대학교 산학협력단 인슐린유사성장인자-1 융합단백질 및 이의 용도
CA3185680A1 (en) * 2020-07-22 2022-01-27 Nicola Ammer A screening method for diagnosing growth hormone deficiency in pediatric patients by using macimorelin
CN115925994B (zh) 2020-09-30 2023-09-22 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
JP2025512832A (ja) 2022-03-30 2025-04-22 ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド ポリペプチドコンジュゲートの液体医薬組成物およびその使用の方法

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PL2393828T3 (pl) * 2009-02-03 2017-06-30 Amunix Operating Inc. Wydłużone rekombinowane polipeptydy i zawierające je kompozycje
ES2544982T3 (es) * 2009-09-02 2015-09-07 Merck Serono S.A. Método para predecir el nivel de respuesta al crecimiento
CA2875827A1 (en) * 2012-06-05 2013-12-12 Amunix Operating Inc. Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency

Non-Patent Citations (2)

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"Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healt", GUIDANCE FOR INDUSTRY, JPN7017003267, July 2005 (2005-07-01), ISSN: 0003658070 *
CLELAND, J.L. ET AL.: "A novel human growth hormone XTEN construct(VRS-317) for once-a-month subcutaneous administration", GROWTH HORMONE & IGF RESEARCH, vol. Vol.20, Supp.1, JPN6017038604, 2010, pages 5, ISSN: 0003658069 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019533004A (ja) * 2016-08-30 2019-11-14 ジェネクシン・インコーポレイテッドＧｅｎｅｘｉｎｅ， Ｉｎｃ． ｈＧＨ融合タンパク質を含有する、成長ホルモン欠乏症を治療するための医薬組成物
US12427186B2 (en) 2016-08-30 2025-09-30 Genexine, Inc. Method for treating growth hormone deficiency employing hGH fusion protein

Also Published As

Publication number Publication date
WO2014164568A1 (en) 2014-10-09
US20160158321A1 (en) 2016-06-09
SG11201506732YA (en) 2015-09-29
KR20150124955A (ko) 2015-11-06
BR112015022257A2 (pt) 2017-10-10
HK1216617A1 (zh) 2016-11-25
JP2017101074A (ja) 2017-06-08
EP2968451A1 (en) 2016-01-20
EA201591529A1 (ru) 2016-04-29
PH12015502063A1 (en) 2016-01-25
AU2014249258A1 (en) 2015-08-27
CA2900949A1 (en) 2014-10-09
EP2968451A4 (en) 2017-01-04
JP2019056013A (ja) 2019-04-11
BR112015022257A8 (pt) 2018-01-23
MX2015012175A (es) 2016-01-12
CN105209055A (zh) 2015-12-30
IL240392A0 (en) 2015-09-24
CL2015002456A1 (es) 2016-05-27

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