CN105153313A - 因子viii融合蛋白 - Google Patents
因子viii融合蛋白 Download PDFInfo
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- CN105153313A CN105153313A CN201510524808.4A CN201510524808A CN105153313A CN 105153313 A CN105153313 A CN 105153313A CN 201510524808 A CN201510524808 A CN 201510524808A CN 105153313 A CN105153313 A CN 105153313A
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- 108010029384 tryptophyl-histidine Proteins 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 108010079202 tyrosyl-alanyl-cysteine Proteins 0.000 description 1
- IBIDRSSEHFLGSD-UHFFFAOYSA-N valinyl-arginine Natural products CC(C)C(N)C(=O)NC(C(O)=O)CCCN=C(N)N IBIDRSSEHFLGSD-UHFFFAOYSA-N 0.000 description 1
- 108010052774 valyl-lysyl-glycyl-phenylalanyl-tyrosine Proteins 0.000 description 1
- 108010015385 valyl-prolyl-proline Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153715.7 | 2010-02-16 | ||
| EP10153715 | 2010-02-16 | ||
| US30617710P | 2010-02-19 | 2010-02-19 | |
| US61/306177 | 2010-02-19 | ||
| CN201180009864.4A CN102770450B (zh) | 2010-02-16 | 2011-02-10 | 因子viii融合蛋白 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180009864.4A Division CN102770450B (zh) | 2010-02-16 | 2011-02-10 | 因子viii融合蛋白 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105153313A true CN105153313A (zh) | 2015-12-16 |
Family
ID=42244627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510524808.4A Withdrawn CN105153313A (zh) | 2010-02-16 | 2011-02-10 | 因子viii融合蛋白 |
| CN201180009864.4A Expired - Fee Related CN102770450B (zh) | 2010-02-16 | 2011-02-10 | 因子viii融合蛋白 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180009864.4A Expired - Fee Related CN102770450B (zh) | 2010-02-16 | 2011-02-10 | 因子viii融合蛋白 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9493543B2 (https=) |
| EP (2) | EP2536754A1 (https=) |
| JP (3) | JP2013519699A (https=) |
| CN (2) | CN105153313A (https=) |
| WO (1) | WO2011101284A1 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106279437A (zh) * | 2016-08-19 | 2017-01-04 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN108623695A (zh) * | 2017-03-24 | 2018-10-09 | 中国科学院过程工程研究所 | 一种白蛋白结合肽-人睫状神经营养因子融合蛋白及其制备方法和应用 |
| WO2019219049A1 (zh) * | 2018-05-18 | 2019-11-21 | 北京辅仁瑞辉生物医药研究院有限公司 | 改进的fviii融合蛋白及其应用 |
| CN110950964A (zh) * | 2018-09-26 | 2020-04-03 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
| CN113166271A (zh) * | 2018-05-18 | 2021-07-23 | 郑州晟斯生物科技有限公司 | 具有延长半衰期的融合多肽缀合物 |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| US11472863B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
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| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| US20130040888A1 (en) * | 2010-02-16 | 2013-02-14 | Novo Nordisk A/S | Factor VIII Molecules With Reduced VWF Binding |
| DK2804623T3 (da) * | 2012-01-12 | 2019-11-11 | Bioverativ Therapeutics Inc | Kimære faktor viii-polypeptider og anvendelser deraf |
| CA2864126A1 (en) * | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| EP2841091A1 (en) | 2012-04-24 | 2015-03-04 | Novo Nordisk A/S | Pharmaceutical composition suitable for treatment of haemophilia |
| JP2015515482A (ja) * | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| HRP20200007T1 (hr) | 2012-07-11 | 2020-03-20 | Bioverativ Therapeutics Inc. | Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba |
| JP6618892B2 (ja) | 2013-04-23 | 2019-12-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細菌バイオフィルムの遺伝的リプログラミング |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | 第ｖｉｉｉ因子両性イオンポリマーコンジュゲート |
| AU2015204646B2 (en) | 2014-01-10 | 2020-08-27 | Bioverativ Therapeutics Inc. | Factor VIII chimeric proteins and uses thereof |
| EP3114138B1 (en) | 2014-03-05 | 2021-11-17 | Pfizer Inc. | Improved muteins of clotting factor viii |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US10238718B2 (en) | 2014-08-04 | 2019-03-26 | Csl Limited | Factor VIII formulation |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| ES2772933T3 (es) | 2015-03-06 | 2020-07-08 | CSL Behring Lengnau AG | Factor de von Willebrand modificado que tiene una semivida mejorada |
| EP3280397A4 (en) | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| WO2016198521A1 (en) * | 2015-06-10 | 2016-12-15 | Novo Nordisk A/S | Fviii fusion proteins |
| CN104926946B (zh) * | 2015-07-13 | 2021-09-17 | 中国科学院广州生物医药与健康研究院 | 具有延长体内半衰期的adamts13-mdtcs融合蛋白及其应用 |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| CN107921103A (zh) | 2015-08-12 | 2018-04-17 | 细胞机械股份有限公司 | 涉及长半衰期凝血复合物的方法和组合物 |
| GB201520021D0 (en) * | 2015-11-13 | 2015-12-30 | Asterion Ltd | Fusion polypeptide |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US11098133B2 (en) | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
| IL319473A (en) | 2016-12-02 | 2025-05-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| CA3059938A1 (en) | 2017-04-14 | 2018-10-18 | Kodiak Sciences Inc. | Complement factor d antagonist antibodies and conjugates thereof |
| GB201706781D0 (en) | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| CN114072420B (zh) | 2019-07-04 | 2024-06-11 | 康诺贝林伦瑙有限公司 | 用于增加凝血因子viii的体外稳定性的截短的血管性血友病因子(vwf) |
| AU2020342349A1 (en) * | 2019-09-02 | 2022-03-03 | Biotest Ag | Factor VIII protein with increased half-life |
| EP3785726A1 (en) | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| JP7680442B2 (ja) | 2019-11-11 | 2025-05-20 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第ｖｉｉｉ因子に対する寛容を誘導するためのポリペプチド |
| TWI787710B (zh) * | 2020-01-20 | 2022-12-21 | 中國大陸商上海藥明生物技術有限公司 | 用於親和層析的新型清洗緩衝液 |
| IL301332A (en) * | 2020-09-23 | 2023-05-01 | Ablevia Biotech Gmbh | Compound for the prevention or treatment of autoantibody-mediated conditions |
| JP2025521136A (ja) * | 2022-05-25 | 2025-07-08 | チアンスー ジェンサイエンス インコーポレイテッド | 半減期が延長されたｆｖｉｉｉ融合タンパク質コンジュゲート及びその応用 |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN106279437A (zh) * | 2016-08-19 | 2017-01-04 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| US11833212B2 (en) | 2016-08-19 | 2023-12-05 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| US11472863B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof |
| US11471513B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Highly glycosylated human blood-clotting factor VIII fusion protein, and manufacturing method and application of same |
| CN108623695A (zh) * | 2017-03-24 | 2018-10-09 | 中国科学院过程工程研究所 | 一种白蛋白结合肽-人睫状神经营养因子融合蛋白及其制备方法和应用 |
| WO2019219049A1 (zh) * | 2018-05-18 | 2019-11-21 | 北京辅仁瑞辉生物医药研究院有限公司 | 改进的fviii融合蛋白及其应用 |
| US20210361775A1 (en) * | 2018-05-18 | 2021-11-25 | Zhengzhou Gensciences Inc | Improved fviii fusion protein and use thereof |
| CN113166271A (zh) * | 2018-05-18 | 2021-07-23 | 郑州晟斯生物科技有限公司 | 具有延长半衰期的融合多肽缀合物 |
| CN113039200A (zh) * | 2018-05-18 | 2021-06-25 | 郑州晟斯生物科技有限公司 | 改进的fviii融合蛋白及其应用 |
| CN113039200B (zh) * | 2018-05-18 | 2023-07-25 | 郑州晟斯生物科技有限公司 | 改进的fviii融合蛋白及其应用 |
| US12440572B2 (en) * | 2018-05-18 | 2025-10-14 | Zhengzhou Gensciences Inc. | FVIII fusion protein and use thereof |
| CN110950964A (zh) * | 2018-09-26 | 2020-04-03 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016084365A (ja) | 2016-05-19 |
| US9493543B2 (en) | 2016-11-15 |
| JP2017190342A (ja) | 2017-10-19 |
| EP2536754A1 (en) | 2012-12-26 |
| JP6185097B2 (ja) | 2017-08-23 |
| CN102770450B (zh) | 2015-12-02 |
| JP2013519699A (ja) | 2013-05-30 |
| US20130040889A1 (en) | 2013-02-14 |
| CN102770450A (zh) | 2012-11-07 |
| WO2011101284A1 (en) | 2011-08-25 |
| US20170015729A1 (en) | 2017-01-19 |
| EP2977055A1 (en) | 2016-01-27 |
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