CN105148569B - A kind of integration autologous platelet rich gel preparation suit - Google Patents
A kind of integration autologous platelet rich gel preparation suit Download PDFInfo
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- CN105148569B CN105148569B CN201510380314.3A CN201510380314A CN105148569B CN 105148569 B CN105148569 B CN 105148569B CN 201510380314 A CN201510380314 A CN 201510380314A CN 105148569 B CN105148569 B CN 105148569B
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- blood plasma
- storage tube
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- prp
- erythrocyte
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
Abstract
The present invention relates to a kind of integration autologous platelet rich gel preparation suit, including blood plasma storage tube, connecting tube and erythrocyte storage tube closure, connecting tube by one PRP storage tube, locking pipe and erythrocyte storage tube form successively, blood plasma storage tube is threadeded with PRP storage tube, and erythrocyte storage tube is threadeded with erythrocyte storage tube closure；It is provided with blood plasma and extract guiding tube and PRP extraction guiding tube in blood plasma storage tube, the length that PRP extracts guiding tube is more than the length that blood plasma extracts guiding tube, the top of blood plasma storage tube has blood plasma and extracts mouth and PRP extraction mouth, blood plasma is extracted mouth and is connected with blood plasma extraction guiding tube, and PRP is extracted mouth and is connected with PRP extraction guiding tube；It is provided with erythrocyte locking blocking, blood plasma stores the perforate of bottom of the tube and erythrocyte locking blocking matches in locking pipe.It has the advantages that can to complete in integrated apparatus whole extraction process, simple and quick efficiently, be difficult to pollute.
Description
Technical field
The present invention relates to a kind of high concentration platelet rich plasma extraction element, especially integrated autologous platelet rich gel
Preparation is set with, and belongs to medical instruments field.
Background technology
Platelet rich plasma（Platelet Rich Plasma, abbreviation PRP）, it is that autologous whole blood passes through obtained from centrifugation
Containing the hematoblastic blood plasma of high concentration.Platelet containing high concentration in PRP, contains substantial amounts of somatomedin, such as platelet in platelet
Derivative growth factor（PDGF）, transforming growth factor-β (TGF-β), insulin like growth factor（IGF）, epidermal growth factor
（EGF）, VEGF（VEGF）, fibroblast growth factor（FGF）Deng, these somatomedin can accurately from
I navigates to damage location, controls inflammation, and facilitation is played in never cell faced by Tongfang and tissue regeneration, thus accelerating to damage
The repair of tissue, high degree mitigates the formation of scar after the operation.Further, since PRP can carry from patient's self-blood
Take, after extracted enrichment is processed, can be used for the treatment of relevant disease, thus abundance, draw materials conveniently, preparation method simple and
And body can be allowed to absorb, itself PRP is occurred using the problem being also avoided that virus disseminating and immunologic rejection, and therefore PRP is wide
General be applied to various surgical operations, operation on heart and plastic operation, for surgical operation postoperative for repair cell provide creep
Support and somatomedin, promote osteanagenesiss, accelerate soft tissue repair and wound healing, mitigate wound pain；For chronic
Skin ulcer, accelerates skin growth, reduces infection chance；Also it is widely used in medical cosmetology aspect, it is more evenly distributed, smoothing wrinkle is imitated
Really more rapid, lasting.So the extraction quality of PRP is the key factor affecting its function and effect.
PRP can be prepared in operating room under household condition, but must keep aseptic in centrifugal process, and need to be
Do not have to separate under thrombocytolysis or the high concentration of destruction, the PRP result of different PRP instrument preparations is different, also has so far
There is no a kind of preparation method of integral structure, its preparation principle mainly uses various composition sedimentation velocity difference in blood,
So that blood is layered by centrifugation, thus obtain containing hematoblastic blood plasma, and being concentrated further to obtain high concentration using centrifugation
Thrombocyte plasma.The current device that will use a whole set of during separation and Extraction and be made up of parts such as some test tubes, syringes,
Will through multiple injection, centrifugation, extract, operation is relative complex, and if dry part separately use successively, easily cause dirt
Dye.
Content of the invention
The technical problem to be solved is to provide one kind can complete in an integral structure device entirely
Prepared by high concentration platelet rich plasma extraction process, simple and quick integrated autologous platelet rich gel that is efficient, being difficult to pollute
With suit.
The present invention solves above-mentioned being employed technical scheme comprise that：This suit includes blood plasma storage tube, connecting tube and red successively
Cell storage tube closure, wherein connecting tube are managed and erythrocyte storage tube group successively by the PRP storage tube of integrative-structure, locking
Become, blood plasma storage tube is threadeded with PRP storage tube, and erythrocyte storage tube is threadeded with erythrocyte storage tube closure；?
It is provided with blood plasma in blood plasma storage tube and extracts guiding tube and PRP extraction guiding tube, and the length of PRP extraction guiding tube carries more than blood plasma
Take the length of guiding tube, have blood plasma at the top of blood plasma storage tube and extract mouth and PRP extraction mouth, blood plasma is extracted mouth and carried with blood plasma
Guiding tube is taken to be connected, PRP is extracted mouth and is connected with PRP extraction guiding tube；It is provided with erythrocyte locking blocking, blood in locking pipe
The perforate of slurry storage bottom of the tube is matched with erythrocyte locking blocking；Erythrocyte storage tube closure is provided with blood inlet.
Blood plasma storage tube of the present invention is made up of the main part of integrative-structure, transition part and connecting portion, wherein transition
Portion is in tapered vertebra shape, and connecting portion top half is provided with the external screw thread for threadeding, connecting portion the latter half with PRP storage tube
External profile diameter identical with the inner edge diameter of locking pipe, and in connecting portion the latter half, be provided with entrance hole, entrance hole and erythrocyte
Locking blocking matches.
Blood plasma of the present invention extracts the upper end of guiding tube and blood plasma extracts mouth and is connected, and its lower end is located in main part；
PRP extracts the upper end of guiding tube and PRP extracts mouth and is connected, and its lower end is located in the top half of connecting portion.
The outer rim of connecting portion the latter half of the present invention is provided with sealing ring.
Present invention additionally comprises bloodletting tube, bloodletting tube includes flexible pipe, blood ascending pipe and three-way valve, and the injection of flexible pipe, blood
Mouth and blood ascending pipe are interconnected by three-way valve.
It is provided with sealed gum cap at the opening of blood ascending pipe of the present invention.
The top of blood plasma storage tube of the present invention is connected with PRP storage tube closure.
The present invention compared with prior art, has the advantages that：This suit is deposited by PRP storage tube closure, blood plasma
Chu Guan, connecting tube, erythrocyte storage tube closure and bloodletting tube connect composition, in the process extracting high concentration platelet rich plasma
In, using the whole separation process of blood can be completed in an integral structure device it is not necessary to respectively using much scattered
Part, simple to operation, extraction efficiency is high, is difficult to cause pollution, contains higher concentration in prepared platelet rich plasma
Leukocyte, can high degree reduce infection probability.
Brief description
Fig. 1 is the structural representation of blood plasma storage tube in the present invention.
Fig. 2 is the structural representation of connecting tube in the present invention.
Fig. 3 is the structural representation of erythrocyte storage tube closure in the present invention.
Fig. 4 is the structural representation of bloodletting tube in the present invention.
Fig. 5 is the overall structure diagram of the present invention.
Fig. 6 is the schematic diagram when present invention is used cooperatively with syringe.
Fig. 7 is the profile after blood plasma storage tube, connecting tube and the assembling of erythrocyte storage tube closure in the present invention（Blood plasma
All do not tighten between storage tube, connecting tube and erythrocyte storage tube closure）.
Fig. 8 is the profile after blood plasma storage tube, connecting tube and the assembling of erythrocyte storage tube closure in the present invention（Connect
Tighten between pipe and erythrocyte storage tube closure, do not tighten between blood plasma storage tube and connecting tube）.
Fig. 9 is the profile after blood plasma storage tube, connecting tube and the assembling of erythrocyte storage tube closure in the present invention（Connect
Tighten between pipe and erythrocyte storage tube closure, tighten between blood plasma storage tube and connecting tube）.
Specific embodiment
Referring to Fig. 1 Fig. 9, the present embodiment is from top to bottom successively by PRP storage tube closure 4, blood plasma storage tube 1, connection
Pipe 2, erythrocyte storage tube closure 3 and bloodletting tube 5 form.
Connecting tube 2 by integrative-structure PRP storage tube 21, locking pipe 22 and erythrocyte storage tube 23 form successively.Blood plasma
Storage tube 1 is threadeded with PRP storage tube 21, and erythrocyte storage tube 23 is threadeded with erythrocyte storage tube closure 3, PRP
Storage tube closure 4 covers the top in blood plasma storage tube 1.
Blood plasma storage tube 1 is made up of the main part 11 of integrative-structure, transition part 12 and connecting portion 13, and wherein transition part 12 is in
Tapered vertebra shape, connecting portion 13 top half is provided with the external screw thread 16 for threadeding, connecting portion 13 lower half with PRP storage tube 21
Partial external profile diameter is identical with the inner edge diameter of locking pipe 22, and connecting portion 13 is provided with entrance hole 15 in the latter half, and connects
The outer rim of portion 13 the latter half is provided with sealing ring 14.It is provided with blood plasma extraction guiding tube 17 and PRP extracts and draws in blood plasma storage tube 1
Conduit 18, and PRP extracts the length more than blood plasma extraction guiding tube 17 for the length of guiding tube 18.Top in blood plasma storage tube 1
Have blood plasma and extract mouth 19 and PRP extraction mouth 20, blood plasma extracts the upper end of guiding tube 17 and blood plasma extracts mouth 19 and is connected, under it
End is located in main part 11；PRP extracts the upper end of guiding tube 18 and PRP extracts mouth 20 and is connected, and its lower end is located at connecting portion 13
Top half in.It is provided with erythrocyte locking blocking 24 in locking pipe 22.Erythrocyte locking blocking 24 and entrance hole 15 phase
Join, when erythrocyte locking blocking 24 enters in entrance hole 15, the space up and down of the corresponding entrance hole 15 of isolation can be closed.
Erythrocyte storage tube closure 3 is provided with blood inlet 31.
Bloodletting tube 5 includes flexible pipe 51, blood ascending pipe 52 and three-way valve 53, and flexible pipe 51, blood inlet 31 and blood
Ascending pipe 52 is interconnected by three-way valve 53.It is provided with sealed gum cap 54 at the opening of blood ascending pipe 52.
The specifically used step of the present embodiment is as follows：
1st, extract 3cc and contain the anticoagulant of ACD-A, sodium citrate to aseptic 30cc syringe 6, the work of pushing syringe 6
Plug removes the air in syringe 6；
2nd, remove the sealed gum cap 54 at blood ascending pipe 52 opening, syringe 6 is inserted blood ascending pipe 52, rotate three
Port valve 53, makes flexible pipe 51 and blood ascending pipe 52 communicate, now blood inlet 31 not with flexible pipe 51, blood ascending pipe 52 phase
Logical, extract 20cc blood samples of patients to syringe 6 with flexible pipe 51；
3rd, rotate three-way valve 53, so that blood inlet 31 and blood ascending pipe 52 is communicated, now flexible pipe 51 is not noted with blood
Entrance 31, blood ascending pipe 52 communicate, and take off flexible pipe 51, and handss laterally take syringe 6, and another handss vertically take this extraction to fill
Put, swing back and forth and rock at least 20 times, so that the blood in syringe 6 and anticoagulant is sufficiently mixed；
4th, the piston of slowly pushing syringe 6, the mixture of blood and anticoagulant is injected red thin through blood inlet 31
In born of the same parents' storage tube closure 3, connecting tube 2 and blood plasma storage tube 1, take off syringe 6 and three-way valve 53, cover in blood inlet 31
Upper sealed gum cap 54；
5th, weigh the gross weight of this extraction element after step 4 terminates, prepare an identical extraction element, inside note
Enter water, make both gross weights identical, by centrifuge of putting into symmetrical for two extraction elements, rotating speed 3850RPM, 7 minutes time,
After being centrifuged for the first time, blood is divided into three layers, and orlop is the maximum red blood cell layer of sedimentation coefficient, and the superiors are supernatant layer, and two
Person's intersection is platelet rich plasma layer, and undermost red blood cell layer is all located in erythrocyte storage tube 23 substantially；
6th, rotate erythrocyte storage tube closure 3, mutual with erythrocyte storage tube closure 3 and erythrocyte storage tube 23
Tighten further, the upper liquid level of red blood cell layer rises, and when it rises at sealing ring 14, the erythrocyte storage tube that stops operating is close
Capping 3；
7th, rotate blood plasma storage tube 1, so that the top half of connecting portion 13 and PRP storage tube 21 is tightened further, directly mutually
Enter in entrance hole 15 to locking blocking 24, the space-closed up and down of entrance hole 15 is kept apart, now under connecting portion 13
Also fit tightly between half part and PRP storage tube 21, red blood cell layer is enclosed in erythrocyte storage tube 23；
8th, this extraction element after terminating step 7 is placed again into centrifuge, rotating speed 3850RPM, 8 minutes time, and second
After secondary centrifugation, the blood in blood plasma storage tube 1 and PRP storage tube 21 is divided into two-layer, and upper strata is impurity layer, and lower floor is to go further
High concentration platelet rich plasma layer after the removal of impurity；
9th, remove PRP storage tube closure 4, extract mouth 19 with syringe from blood plasma and extract impurity layer, until blood plasma storage
Liquid level in pipe 1 and PRP storage tube 21 drops to the lower end that blood plasma extracts guiding tube 17, then extracts mouth 20 with syringe from PRP
Extract the high concentration platelet rich plasma layer after going the removal of impurity, the high concentration that can extract about 2cc from 20cc blood samples of patients is rich
Thrombocyte plasma.
Claims (7)
1. a kind of integration autologous platelet rich gel preparation suit, is characterized in that：Include blood plasma storage tube successively（1）, even
Adapter（2）With erythrocyte storage tube closure（3）, wherein connecting tube（2）PRP storage tube by integrative-structure（21）, locking pipe
（22）With erythrocyte storage tube（23）Form successively, blood plasma storage tube（1）With PRP storage tube（21）Threaded, erythrocyte is deposited
Chu Guan（23）With erythrocyte storage tube closure（3）Threaded；In blood plasma storage tube（1）Inside it is provided with blood plasma and extract guiding tube
（17）Extract guiding tube with PRP（18）, and PRP extracts guiding tube（18）Length be more than blood plasma extract guiding tube（17）Length
Degree, in blood plasma storage tube（1）Top have blood plasma extract mouth（19）Extract mouth with PRP（20）, blood plasma extraction mouth（19）With blood
Slurry extracts guiding tube（17）It is connected, PRP extracts mouth（20）Extract guiding tube with PRP（18）It is connected；In locking pipe（22）Interior
It is provided with erythrocyte locking blocking（24）, blood plasma storage tube（1）The perforate of bottom and erythrocyte locking blocking（24）Match；Red thin
Born of the same parents' storage tube closure（3）It is provided with blood inlet（31）.
2. integration autologous platelet rich gel preparation suit according to claim 1, is characterized in that：Described blood plasma
Storage tube（1）Main part by integrative-structure（11）, transition part（12）And connecting portion（13）Composition, wherein transition part（12）In gradually
Contracting vertebra shape, connecting portion（13）Top half be provided with for PRP storage tube（21）Threaded external screw thread（16）, connecting portion
（13）The external profile diameter of the latter half and locking pipe（22）Inner edge diameter identical, and connecting portion（13）It is provided with the latter half and lead
Enter hole（15）, entrance hole（15）Lock blocking with erythrocyte（24）Match.
3. integration autologous platelet rich gel preparation suit according to claim 2, is characterized in that：Described blood plasma carries
Take guiding tube（17）Upper end and blood plasma extract mouth（19）It is connected, its lower end is located at main part（11）Interior；PRP extracts guiding tube
（18）Upper end and PRP extract mouth（20）It is connected, its lower end is located at connecting portion（13）Top half in.
4. integration autologous platelet rich gel preparation suit according to claim 2, is characterized in that：Described connecting portion
（13）The outer rim of the latter half is provided with sealing ring（14）.
5. integration autologous platelet rich gel preparation suit according to claim 1, is characterized in that：Also include drawing blood
Pipe（5）, bloodletting tube（5）Including flexible pipe（51）, blood ascending pipe（52）And three-way valve（53）, and flexible pipe（51）, blood inlet
（31）With blood ascending pipe（52）By three-way valve（53）Interconnect.
6. integration autologous platelet rich gel preparation suit according to claim 5, is characterized in that：Described blood note
Enter pipe（52）Opening at be provided with sealed gum cap（54）.
7. integration autologous platelet rich gel preparation suit according to claim 1, is characterized in that：Described blood plasma is deposited
Chu Guan（1）Top be connected with PRP storage tube closure（4）.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510380314.3A CN105148569B (en) | 2015-07-02 | 2015-07-02 | A kind of integration autologous platelet rich gel preparation suit |
| PCT/CN2016/087222 WO2017000851A1 (en) | 2015-07-02 | 2016-06-27 | Integrated autologous platelet-rich gel preparation kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510380314.3A CN105148569B (en) | 2015-07-02 | 2015-07-02 | A kind of integration autologous platelet rich gel preparation suit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105148569A CN105148569A (en) | 2015-12-16 |
| CN105148569B true CN105148569B (en) | 2017-03-01 |
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ID=54789805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510380314.3A Active CN105148569B (en) | 2015-07-02 | 2015-07-02 | A kind of integration autologous platelet rich gel preparation suit |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN105148569B (en) |
| WO (1) | WO2017000851A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148569B (en) * | 2015-07-02 | 2017-03-01 | 周建明 | A kind of integration autologous platelet rich gel preparation suit |
| CN106139290B (en) * | 2016-08-01 | 2018-11-16 | 娄域峰 | Integrated autologous platelet rich plasma preparation suit |
| CN110251995B (en) * | 2019-06-17 | 2021-05-14 | 郭钦 | Economical preparation method of platelet-rich plasma |
| US11660253B2 (en) * | 2019-09-18 | 2023-05-30 | Medisarang Co., Ltd. | Device for extracting platelet rich plasma |
| CN111974475B (en) * | 2020-08-20 | 2021-09-21 | 四川行之智汇知识产权运营有限公司 | Blood component separator |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007000966A1 (en) * | 2005-06-27 | 2007-01-04 | Sekisui Chemical Co., Ltd. | Container for sampleing specimen |
| CN103111097A (en) * | 2011-11-16 | 2013-05-22 | 玛旺干细胞医学生物科技股份有限公司 | Platelet-rich blood plasma acquiring device |
| CN203648142U (en) * | 2013-11-04 | 2014-06-18 | 常州尚泰医疗科技有限公司 | Blood platelet-rich separation and extraction device |
| CN203777714U (en) * | 2013-10-31 | 2014-08-20 | 肖乐义 | Platelet-rich plasma separation enrichment device |
| CN205287726U (en) * | 2015-07-02 | 2016-06-08 | 周建明 | Suit is used in rich blood platelet gel preparation of integration autologous |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566629B (en) * | 2013-11-04 | 2015-05-06 | 常州尚泰医疗科技有限公司 | Method and device for separating and extracting platelet rich blood |
| CN105148569B (en) * | 2015-07-02 | 2017-03-01 | 周建明 | A kind of integration autologous platelet rich gel preparation suit |
-
2015
- 2015-07-02 CN CN201510380314.3A patent/CN105148569B/en active Active
-
2016
- 2016-06-27 WO PCT/CN2016/087222 patent/WO2017000851A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007000966A1 (en) * | 2005-06-27 | 2007-01-04 | Sekisui Chemical Co., Ltd. | Container for sampleing specimen |
| CN103111097A (en) * | 2011-11-16 | 2013-05-22 | 玛旺干细胞医学生物科技股份有限公司 | Platelet-rich blood plasma acquiring device |
| CN203777714U (en) * | 2013-10-31 | 2014-08-20 | 肖乐义 | Platelet-rich plasma separation enrichment device |
| CN203648142U (en) * | 2013-11-04 | 2014-06-18 | 常州尚泰医疗科技有限公司 | Blood platelet-rich separation and extraction device |
| CN205287726U (en) * | 2015-07-02 | 2016-06-08 | 周建明 | Suit is used in rich blood platelet gel preparation of integration autologous |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017000851A1 (en) | 2017-01-05 |
| CN105148569A (en) | 2015-12-16 |
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Effective date of registration: 20180104 Address after: 324113 Zhejiang city of Quzhou province Huiyuan Shanhai Cooperation Zone Jiangshan City Economic Development Zone, Road No. 20 Patentee after: Zhejiang Kangci Medical Technology Co., Ltd. Address before: 324113 Zhejiang city of Quzhou province Huiyuan Shanhai Cooperation Zone Jiangshan City Economic Development Zone, Road No. 20 Patentee before: Zhou Jianming |