CN213217058U - Leukocyte-poor platelet-rich plasma (PRP) preparation set - Google Patents
Leukocyte-poor platelet-rich plasma (PRP) preparation set Download PDFInfo
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- CN213217058U CN213217058U CN202022119061.3U CN202022119061U CN213217058U CN 213217058 U CN213217058 U CN 213217058U CN 202022119061 U CN202022119061 U CN 202022119061U CN 213217058 U CN213217058 U CN 213217058U
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Abstract
The utility model provides a leucocyte-poor platelet-rich plasma (PRP) preparation suit, which comprises a rubber tourniquet, a first injector, a blood taking needle, a second injector, an anticoagulant storage device, a platelet-rich plasma extraction centrifuge tube and a centrifuge; the centrifuge tube includes: the device comprises a centrifugal tube body with a centrifugal tube cavity, a platelet leukocyte-removing filter membrane arranged in the centrifugal tube cavity, a three-way tube arranged on the centrifugal tube body and positioned below the leukocyte-removing filter membrane, and a centrifugal tube cover detachably connected at the tube orifice of the centrifugal tube body; the three-way pipe comprises: an upper longitudinal pipe, a lower longitudinal pipe, and a transverse pipe communicated with the upper longitudinal pipe; one end of the serum transfer pipeline extends into the centrifugal tube cavity for a certain length, the other end of the serum transfer pipeline is connected with the port of the lower longitudinal pipeline, the upper end of the upper longitudinal pipeline is communicated with the lower end of the centrifugal tube cavity, and the three-way pipe is connected with a valve. The PRP extracted by the application is leukocyte-deficient PRP, and has no inflammatory reaction of an organism caused by proinflammatory factors generated by leukocytes.
Description
Technical Field
The utility model relates to the technical field of medical devices, in particular to a leucocyte-poor platelet-rich plasma (PRP) preparation suit.
Background
Platelet Rich Plasma (PRP) refers to a platelet concentrate obtained from whole blood by centrifugation, and contains high-concentration platelets, which can release a large amount of growth factors after activation of platelets to promote healing of the body, and thus is widely used clinically, for example, in sports system injuries (arthritis, synovitis, tennis elbow, etc.), primary operations (open wound healing, internal fixation of wound, etc.), secondary operations (delayed fracture healing, bone nonunion, etc.). At present, the commonly used PRP extraction kit which is already commercialized does not remove leukocytes, so that the extracted PRP contains a large amount of leukocytes, and the proinflammatory factors secreted by the cells can trigger the inflammatory response of the organism, thereby influencing the healing of the organism.
SUMMERY OF THE UTILITY MODEL
The utility model provides a leucocyte-poor platelet-rich plasma (PRP) preparation suit for solve the above-mentioned technical problem that the background art provided.
In order to solve the technical problem, the utility model discloses a preparation kit for plasma (PRP) with poor white blood cells and rich platelets, which comprises a rubber tourniquet, a blood taking needle, a first injector, a second injector, an anticoagulant storage device, a centrifugal tube for extracting plasma with rich platelets and a centrifugal machine, wherein the blood taking needle is detachably connected with the first injector;
the platelet rich plasma draws centrifuging tube includes: the device comprises a centrifugal tube body with a centrifugal tube cavity, a platelet leukocyte-removing filter membrane arranged in the centrifugal tube cavity, a three-way tube arranged on the centrifugal tube body and positioned below the leukocyte-removing filter membrane, and a centrifugal tube cover detachably connected at the tube orifice of the centrifugal tube body;
the three-way pipe comprises: an upper longitudinal pipe and a lower longitudinal pipe, and a transverse pipe connected between the upper longitudinal pipe and the lower longitudinal pipe and communicated with the upper longitudinal pipe; the serum shifts the pipeline, the one end that the serum shifted the pipeline stretches into certain length in the centrifuging tube intracavity, the other end that the serum shifted the pipeline with the port of lower longitudinal pipeline is connected, the upper end and the centrifugation lumen lower extreme intercommunication of going up longitudinal pipeline, the three-way pipe is connected with the valve.
Preferably, the centrifuge comprises:
a host;
the rotating shaft is rotatably arranged in the main machine and is driven by a driving motor in the main machine, and a plurality of rotors are rotatably arranged in the main machine;
the rotor comprises a plurality of rotors, a plurality of first connecting rods and a plurality of connecting rings, wherein the rotors correspond to the first connecting rods one by one;
the centrifuge tube comprises a plurality of centrifuge tubes, a plurality of air inlets and a plurality of air outlets, wherein the centrifuge tubes are provided with rotor centrifugal cavities, and the rotor centrifugal cavities are provided with the platelet-rich plasma extraction centrifuge tubes;
and the rotor centrifugal cavity cover is detachably connected with the outer centrifugal tube and is used for sealing or opening the rotor centrifugal cavity.
Preferably, the first syringe is used for collecting whole blood; the second syringe is used for extracting the bottom layer red blood cells, the surface layer serum and the PRP.
Preferably, the first syringe is a 20ml syringe and the second syringe (4) is a 10ml syringe.
Preferably, the anticoagulant stored in the anticoagulant storage device is a 4% sodium citrate anticoagulant.
Preferably, set up the connecting pipe on the centrifuging tube lid, the outside external screw thread that sets up in connecting pipe upper end, external screw thread department threaded connection has the nut, is used for sealing the connecting pipe.
Preferably, the leukocyte-removing filter is a concentrated platelet-leukocyte-removing polyester filter.
The technical solution of the present invention is further described in detail by the accompanying drawings and examples.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:
fig. 1 is a schematic structural diagram of a combination of some devices before the centrifugal process of the present invention.
Fig. 2 is a schematic structural diagram of a part of the device assembly during the centrifugal process of the set of the present invention.
Fig. 3 is a schematic structural diagram of the centrifuge rotor connected to the rotating shaft, the connecting shaft and the fixing ring.
Fig. 4 is a schematic diagram showing the change of the motion state of the rotor and the rotating shaft of the centrifuge of the present invention.
In the figure: 1. a rubber tourniquet; 2. a blood collection needle; 3. a first syringe; 4. a second syringe; 5. an anticoagulant storage device; 6. a platelet-rich plasma extraction centrifugal tube; 61. centrifuging the tube body; 62. a centrifuge tube cover; 63. a connecting pipe; 7. a centrifuge; 71. a host; 72. a rotating shaft; 73. a first connecting rod; 74. a fixing ring; 75. a connecting shaft; 76. an outer centrifuge tube; 77. a rotor centrifugal chamber cover; 78. a rotor; 8. a three-way pipe; 81. an upper longitudinal conduit; 82. a lower longitudinal duct; 83. a transverse conduit; 9. a serum transfer pipeline.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are presented herein only to illustrate and explain the present invention, and not to limit the present invention.
In addition, the descriptions related to "first", "second", etc. in the present invention are only for description purposes, not specifically referring to the order or sequence, and are not intended to limit the present invention, but only to distinguish the components or operations described in the same technical terms, and are not to be construed as indicating or implying any relative importance or implicit indication of the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions and technical features between the various embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent, and is not within the protection scope of the present invention.
Example 1
The utility model discloses a leucocyte-poor platelet-rich plasma (PRP) preparation set, as shown in figures 1-3,
the blood taking needle comprises a rubber tourniquet 1, a blood taking needle 2, a first injector 3, a second injector 4, an anticoagulant storage device 5, a platelet-rich plasma extraction centrifugal tube 6 and a centrifuge 7, wherein the blood taking needle 2 is detachably connected with the first injector 3; optionally, the blood taking needle may be a butterfly needle;
the platelet-rich plasma extraction centrifuge tube 6 comprises: a centrifuge tube body 61 having a centrifuge tube cavity for receiving blood, a platelet leukocyte-removing filter membrane installed in the centrifuge tube cavity, a three-way tube 8 (specifically, at the lower end of the centrifuge tube body as shown in fig. 1) installed on the centrifuge tube body 61 and located below the leukocyte-removing filter membrane, and a centrifuge tube cover 62 (for sealing the tube opening) detachably connected to the tube opening of the centrifuge tube body 61;
the three-way pipe 8 includes: an upper longitudinal duct 81 and a lower longitudinal duct 82, and a transverse duct 83 connected between the upper longitudinal duct 81 and the lower longitudinal duct 82 and communicating with said upper longitudinal duct; the serum shifts the pipeline 9, the one end of serum shifts the pipeline 9 stretches into certain length in the centrifuging tube intracavity, the other end of serum shifts the pipeline 9 with the port of lower longitudinal pipeline 82 is connected, the upper end and the centrifugal tube chamber lower extreme intercommunication of going up longitudinal pipeline 81, three-way pipe 8 is connected with the valve. Preferably, valves can be respectively arranged at the discharge pipe orifice (port) of the lower longitudinal pipe and the discharge pipe orifice (port) of the transverse pipe;
the rubber tourniquet comprises the following components: the elbow is tied up, so that the vein of the elbow is full, and the venipuncture is facilitated; the blood taking needle is used for venipuncture and drawing blood in a patient body; the first syringe 3 is used for collecting whole blood; the second injector 4 is used for extracting bottom layer red blood cells, surface layer serum and PRP;
wherein, the first syringe 3 can be but is not limited to a 20ml syringe, and the second syringe 4 can be but is not limited to a 10ml syringe;
the anticoagulant stored in the anticoagulant storage device 5 can be, but is not limited to, a 4% sodium citrate anticoagulant used for in vitro anticoagulation of raw plasma;
the platelet-leukocyte-removing filter membrane can be, but is not limited to, a platelet-concentrated leukocyte-removing polyester filter membrane;
the above-described concentrated platelet-leukocyte-removing filter is used for filtering leukocytes from whole blood and retaining platelets.
Preferably, the centrifugal pipe cover 62 is provided with a connecting pipe 63, the outer part of the upper end of the connecting pipe 63 is provided with an external thread, and the external thread is in threaded connection with a nut for sealing the connecting pipe 63; the arrangement of the connecting pipe realizes that when whole blood is injected into the centrifuge tube body through the second syringe, only the screw cap needs to be opened, and the whole centrifuge tube cover does not need to be opened, so that the sealing property is improved; and the second injector is more convenient to connect at the connecting pipe to inject the blood into the ring.
The working principle and the beneficial effects of the technical scheme are as follows: the utility model discloses a set up and remove the leucocyte of platelet leucocyte filter membrane in being arranged in the filtering whole blood to keep the platelet. Solves the problem that the PRP extracted by the current commonly-used PRP extracting suit which is already commercialized contains a large amount of white blood cells because the white blood cells are not removed, and the problem that the healing of the organism is influenced because the proinflammatory factors secreted by the cells can trigger the inflammatory reaction of the organism is shown in the literature.
The blood after centrifugation is sequentially as follows from top to bottom: serum (platelet-poor plasma layer), platelet layer (buffy coat layer), red blood cells; the tee pipe comprises an upper longitudinal pipeline 81, a lower longitudinal pipeline 82 and a transverse pipeline 83 which is connected between the upper longitudinal pipeline 81 and the lower longitudinal pipeline 82 and communicated with the upper longitudinal pipeline; a serum transfer pipeline 9, wherein one end of the serum transfer pipeline 9 extends into the centrifuge tube cavity for a certain length, the other end of the serum transfer pipeline 9 is connected with the port of the lower longitudinal pipeline 82, the upper end of the upper longitudinal pipeline 81 is communicated with the lower end of the centrifuge tube cavity, and the three-way pipe 8 is connected with a valve; different blood components are extracted by opening different pipe orifices of the three-way pipe, the serum transfer pipeline is a flow channel in the three-way pipe, and the serum is discharged only through a discharge pipe orifice at the lower end of the lower longitudinal pipeline through the serum transfer pipeline; the upper end of the upper longitudinal pipeline is communicated with the lower end of the centrifugal tube cavity, and the upper longitudinal pipeline is communicated with (only) the transverse pipeline, so that another flow channel is formed, and the platelet layer and the red blood cells can be discharged from the other flow channel; the technical scheme is convenient for separating serum, a platelet layer (leucocyte layer) and red blood cells.
The technology contained in the present application allows efficient filtering of leukocytes prior to centrifugation, and maximizes platelet retention.
In summary, the present application has the following advantages: 1. PRP extracted by the application is derived from the blood of a patient and is used by the patient, so that the risk of immunological rejection and disease transmission is avoided;
2. the PRP extracted by the application is leukocyte-deficient PRP, and the inflammatory reaction of the organism caused by proinflammatory factors generated by leukocytes is avoided;
3. according to the application, the PRP containing high-concentration platelets is obtained by removing redundant red blood cells and serum, so that a large amount of growth factors can be generated, and the healing of an organism is promoted;
4. the PRP extracted by the method can be combined with thrombin or calcium chloride to form PRP gel which is adhered to a tissue defect to promote local formation of a high-concentration growth factor environment, and provide a support for cell migration, thereby being beneficial to tissue defect repair.
5. The equipment simple manufacture that this application relates to all adopt green material preparation, obvious reduction in production cost.
Example 2
Based on example 1, as shown in FIGS. 2-3
The centrifuge 7 includes:
the host 71;
the rotating shaft 72 is rotatably arranged in the main machine and is driven by a driving motor in the main machine, and a plurality of rotors 78 are rotatably arranged in the main machine 71;
the rotor comprises a plurality of first connecting rods 73 and a plurality of rotors 78, wherein the first connecting rods 73 correspond to the rotors 78 one by one, one end of each first connecting rod 73 is fixedly connected with the rotating shaft 72, a fixing ring 74 is arranged at the other end of each first connecting rod 73, and the rotors 78 are rotatably connected to the inner sides of the fixing rings 74 through connecting shafts 75 arranged in the front and at the back;
a plurality of outer centrifuge tubes 76, wherein the outer centrifuge tubes 76 are provided with rotor 78 centrifugal cavities, and the platelet-rich plasma extraction centrifuge tubes are arranged in the rotor 78 centrifugal cavities;
and a rotor centrifugal cavity cover 77 which is detachably connected with the outer centrifugal tube and is used for closing or opening the rotor 78 centrifugal cavity.
The working principle and the beneficial effects of the technical scheme are as follows: in the initial state, the outer centrifuge tubes are vertically arranged as shown in fig. 4; the driving motor drives the rotating shaft to rotate horizontally, so that an integrated structure which is connected with the rotating shaft and comprises a first connecting rod, a rotor, an outer centrifuge tube and a fixing ring starts to rotate horizontally; meanwhile, in the rotating process, the rotor longitudinally rotates around the connecting shaft due to centrifugal force, and the rotating speed of the driving motor can be set, so that the rotor is located at the horizontal position shown in the figure 4; the combination of horizontal rotation and longitudinal rotation can accelerate whole blood layering;
at present, most PRP extraction kits used at home and abroad adopt secondary centrifugation to extract PRP, and the secondary centrifugation obviously prolongs the operation time and prolongs the in vitro retention time of PRP, thereby influencing the activity of growth factors in PRP. This application adopts single centrifugation technique can obtain PRP through above-mentioned layering of accelerating whole blood, can obviously shorten operating time, reduces the external persistence time of PRP to the at utmost remains the growth factor activity in the PRP.
The rotor centrifugal cavity cover is arranged to seal the rotor centrifugal cavity, so that the safety coefficient during centrifugation can be improved;
preferably, in example 1 or 2, the method for using the leukocyte-deficient platelet-rich plasma (PRP) preparation set comprises:
step 1: obtaining whole blood, comprising:
step 11: using the 20ml syringe to draw 2ml of 4% sodium citrate anticoagulant;
step 12: the rubber tourniquet 1 is tightly tied above the elbow joint of a patient, after the elbow vein is full, the blood taking needle 2 is used for performing venipuncture, the tail part of the blood taking needle 2 is connected with the 20ml syringe which is extracted in the step 11, and 18ml of whole blood is extracted;
step 13: unscrewing a screw cap above the platelet-leukocyte-removing filter membrane, connecting a 20ml syringe in the connecting pipe 63 to enable the whole blood to be filtered by the platelet-leukocyte-removing filter membrane, and meanwhile, inclining the centrifuge tube by 30 degrees to enable the whole blood to flow to the bottom of the tube along the tube wall of the platelet-plasma-rich extraction centrifuge tube;
step 2: blood centrifugal stratification comprising:
put the platelet-rich plasma extraction centrifuge tube that step 1 was accomplished into centrifuge 7's rotor 78's centrifugal cavity (specifically for the centrifugal cavity of outer centrifuge tube), screw up rotor centrifugal cavity lid, adjust centrifugal parameter and be: 1000g, 10min and 4 ℃; after centrifugation, the blood is layered and comprises red blood cells at the bottom layer, a platelet layer in the middle and serum at the uppermost layer;
and step 3: to obtain platelet-rich plasma and to increase the platelet concentration by obtaining concentrated platelet-rich plasma, it is necessary to remove a part of the underlying red blood cells and the surface serum. The method comprises the following steps:
step 31: rotating the valve of the three-way pipe 8, opening the transverse pipeline 83 of the three-way pipe 8, using the 10ml injector to extract the bottom layer red blood cells to the 2ml scale of the centrifugal pipe, namely, reserving 2ml of the bottom layer red blood cells, and closing the transverse pipeline 83;
step 32: then the valve is rotated, the lower longitudinal pipe 82 of the three-way pipe 8 is opened, and the 10ml syringe is used for extracting the upper serum through the serum transfer pipe 9;
step 33: the transverse channel 83 is opened again and the concentrated platelet rich plasma is withdrawn using a 10ml syringe.
The working principle and the beneficial effects of the technical scheme are as follows:
the whole operation process is simple, and the damage to the patient is small;
different blood components are extracted by opening different pipe orifices of the three-way pipe, the serum transfer pipeline is a flow channel in the three-way pipe, and the serum is discharged only through a discharge pipe orifice at the lower end of the lower longitudinal pipeline through the serum transfer pipeline; the upper end of the upper longitudinal pipeline is communicated with the lower end of the centrifugal tube cavity, and the upper longitudinal pipeline is communicated with (only) the transverse pipeline, so that another flow channel is formed, and the platelet layer and the red blood cells can be discharged from the other flow channel; the technical scheme is convenient for separating serum, a platelet layer (leucocyte layer) and red blood cells. The technical scheme is convenient for separation and simple in operation, and is convenient for separating serum, a platelet layer (leucocyte layer) and red blood cells.
It will be apparent to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (7)
1. A leukocyte-poor platelet-rich plasma (PRP) preparation kit is characterized in that,
the blood taking needle comprises a rubber tourniquet (1), a blood taking needle (2), a first injector (3), a second injector (4), an anticoagulant storage device (5), a platelet-rich plasma extraction centrifugal tube (6) and a centrifuge (7), wherein the blood taking needle (2) is detachably connected with the first injector (3);
the platelet-rich plasma extraction centrifuge tube (6) comprises: the device comprises a centrifugal tube body (61) with a centrifugal tube cavity, a platelet leukocyte-removing filter membrane arranged in the centrifugal tube cavity, a three-way pipe (8) arranged on the centrifugal tube body (61) and positioned below the leukocyte-removing filter membrane, and a centrifugal tube cover (62) detachably connected to the tube opening of the centrifugal tube body (61);
the three-way pipe (8) comprises: an upper longitudinal duct (81) and a lower longitudinal duct (82), and a transverse duct (83) connected between the upper longitudinal duct (81) and the lower longitudinal duct (82) and communicating with the upper longitudinal duct; serum shifts pipeline (9), the one end that serum shifted pipeline (9) stretches into certain length in the centrifuging tube intracavity, the other end that serum shifted pipeline (9) with the port of lower vertical pipeline (82) is connected, go up the upper end and the centrifuging tube intracavity lower extreme intercommunication of vertical pipeline (81), three-way pipe (8) are connected with the valve.
2. The kit for preparing a leukocyte-deficient platelet-rich plasma (PRP) according to claim 1,
comprising a centrifuge (7) comprising:
a host (71);
the rotating shaft (72) is rotatably arranged in the main machine (71) and is driven by a driving motor in the main machine (71), and a plurality of rotors (78) are rotatably arranged in the main machine (71);
the rotor structure comprises a plurality of first connecting rods (73), a plurality of rotors (78), a plurality of connecting rods (73), a plurality of connecting rings (74), a plurality of connecting rods (73) and a plurality of connecting rods (78), wherein one end of each first connecting rod (73) is fixedly connected with a rotating shaft (72), the other end of each first connecting rod (73) is provided with a fixing ring (74), and the rotors (78) are rotatably connected to the inner sides of the fixing rings;
the centrifuge tubes (76) are arranged outside the centrifuge tubes (76), the centrifuge tubes (76) are provided with rotor (78) centrifugal cavities, and the platelet-rich plasma extraction centrifuge tubes (6) are arranged in the rotor (78) centrifugal cavities;
and the rotor centrifugal cavity cover (77) is detachably connected with the outer centrifugal tube (76) and is used for closing or opening the rotor (78) centrifugal cavity.
3. The kit for preparing a leukocyte-deficient platelet-rich plasma (PRP) according to claim 1,
the first syringe (3) is used for collecting whole blood; the second syringe (4) is used for extracting the bottom layer red blood cells, the surface layer serum and the PRP.
4. The set for preparing a leukocyte-depleted platelet-rich plasma (PRP) according to claim 1, wherein the first syringe (3) is a 20ml syringe and the second syringe (4) is a 10ml syringe.
5. The kit for preparing a leukocyte-deficient platelet-rich plasma (PRP) according to claim 1,
the anticoagulant stored in the anticoagulant storage device (5) is a 4% sodium citrate anticoagulant.
6. The kit for preparing a leukocyte-deficient platelet-rich plasma (PRP) according to claim 1,
set up connecting pipe (63) on centrifuge tube lid (62), connecting pipe (63) upper end outside sets up the external screw thread, external screw thread department threaded connection has the nut for seal connecting pipe (63).
7. The kit for preparing a platelet Poor and Rich Plasma (PRP) according to claim 1, wherein the leukocyte-reducing filter is a platelet-concentrate, leukocyte-reducing polyester filter.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022119061.3U CN213217058U (en) | 2020-09-24 | 2020-09-24 | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202022119061.3U CN213217058U (en) | 2020-09-24 | 2020-09-24 | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112120712A (en) * | 2020-09-24 | 2020-12-25 | 北京大学第三医院（北京大学第三临床医学院） | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
| CN113976335A (en) * | 2021-10-29 | 2022-01-28 | 丁政 | Centrifugal system for preparing leukocyte-removed platelet-rich plasma and preparation method thereof |
-
2020
- 2020-09-24 CN CN202022119061.3U patent/CN213217058U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112120712A (en) * | 2020-09-24 | 2020-12-25 | 北京大学第三医院（北京大学第三临床医学院） | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
| CN113976335A (en) * | 2021-10-29 | 2022-01-28 | 丁政 | Centrifugal system for preparing leukocyte-removed platelet-rich plasma and preparation method thereof |
| CN113976335B (en) * | 2021-10-29 | 2024-03-29 | 湖南桔志康医疗科技有限公司 | Centrifugal system for manufacturing leukocyte-removed platelet-rich plasma and manufacturing method thereof |
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