CN211160246U - Special centrifugal tube subassembly of rich platelet plasma preparation - Google Patents
Special centrifugal tube subassembly of rich platelet plasma preparation Download PDFInfo
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- CN211160246U CN211160246U CN201921774082.XU CN201921774082U CN211160246U CN 211160246 U CN211160246 U CN 211160246U CN 201921774082 U CN201921774082 U CN 201921774082U CN 211160246 U CN211160246 U CN 211160246U
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- needle
- centrifugal tube
- blood taking
- puncture needle
- bottle stopper
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 210000004369 blood Anatomy 0.000 claims abstract description 40
- 239000008280 blood Substances 0.000 claims abstract description 40
- 210000004623 platelet-rich plasma Anatomy 0.000 claims abstract description 36
- 241001411320 Eriogonum inflatum Species 0.000 claims abstract description 13
- 210000003462 vein Anatomy 0.000 claims abstract description 6
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 4
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 4
- 238000000926 separation method Methods 0.000 abstract description 22
- 239000003102 growth factor Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 230000005779 cell damage Effects 0.000 abstract description 2
- 208000037887 cell injury Diseases 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 210000001772 blood platelet Anatomy 0.000 description 2
- 239000007799 cork Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The utility model discloses a special centrifugal tube component for preparing platelet-rich plasma, which is a disposable device and comprises a centrifugal tube, a blood taking needle and a converter; the vein puncture needle end of the blood taking needle is connected with the bottle stopper puncture needle end by a hose, and the bottle stopper puncture needle end of the blood taking needle is provided with a needle holder; the inner cavity of the centrifugal tube is loaded with separation gel, an anticoagulant is loaded above the separation gel, and the inner cavity of the centrifugal tube is in a negative pressure state. The cell removal rate can reach more than 99.5 percent and reach more than 4 times of concentration. The product can extract platelet-rich plasma with proper concentration at one time, thereby avoiding pollution in the preparation process, causing little damage to patients, reducing the workload and danger of medical care personnel and leading the treatment to have qualitative leap. And adopts a one-time separation technology: the cell damage is less, and the operation is simple and convenient; the short separation time results in higher activity of autologous growth factors.
Description
Technical Field
The utility model relates to a special disposable centrifuge tube for preparing Platelet Rich Plasma (PRP) and accessories thereof.
Background
Platelet-rich plasma (PRP), which is Platelet concentrate obtained by centrifugation of autologous whole blood, is used as a Platelet-rich plasma. PRP contains a large number of growth factors and proteins.
In the prior art, PRP is mainly prepared by a plasma separation and replacement method. The plasma separation and replacement method is mainly applied to the collection of blood platelets in a blood bank and the transfusion of clinical components.
However, the preparation method of PRP does not form a uniform standard, and the existing plasma separation and replacement method usually requires multiple extraction processes, which increases the hidden danger of pollution in the preparation process, has complicated operation and long separation time, reduces the activity of autologous growth factors, and increases the workload and the risk of medical care personnel.
SUMMERY OF THE UTILITY MODEL
In order to solve the above drawbacks, the present invention provides a centrifuge tube assembly for preparing platelet rich plasma, which realizes the extraction of platelet rich plasma with a suitable concentration. The utility model discloses the method of using this subassembly preparation PRP is still provided. In order to solve the technical problem, the technical scheme adopted by the utility model is that the special centrifugal tube component for preparing platelet-rich plasma is characterized in that the component is a disposable device and comprises a centrifugal tube, a blood taking needle and a converter; the vein puncture needle end of the blood taking needle is connected with the bottle stopper puncture needle end by a hose, and the bottle stopper puncture needle end of the blood taking needle is provided with a needle holder; the inner cavity of the centrifugal tube is loaded with separation gel, an anticoagulant is loaded above the separation gel, and the inner cavity of the centrifugal tube is in a negative pressure state.
The method for preparing PRP by using the centrifugal tube assembly is characterized by sequentially comprising the following steps:
and 3, extracting PRP: and connecting the converter by using a sterile syringe A, extracting serum, connecting the converter by using a sterile syringe B, and extracting the PRP above the separation gel.
The beneficial effects of the utility model reside in that:
1. the erythrocyte removing rate can reach more than 99.5 percent. Only 8ml of blood is used to extract 1.5ml of platelet-rich plasma with a concentration of more than 4 times. 2. Primary extraction: the product can extract platelet-rich plasma with proper concentration at one time, thereby avoiding pollution in the preparation process, causing little damage to patients, reducing the workload and danger of medical care personnel and leading the treatment to have qualitative leap. And adopts a one-time separation technology: the cell damage is less, and the operation is simple and convenient; the short separation time results in higher activity of autologous growth factors.
In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will be able to make similar modifications without departing from the spirit and scope of the present invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Drawings
FIG. 1 is a schematic diagram of a dedicated centrifuge tube for platelet rich plasma preparation;
FIG. 2 is a schematic structural view of the needle holder;
FIG. 3 is a schematic view of the construction of the lancet;
fig. 4 is a schematic diagram of the converter.
Detailed Description
Referring to the drawings, the specific structure of the utility model is reflected, and the special centrifugal tube component for preparing platelet-rich plasma is a disposable device, which comprises a centrifugal tube 1, a blood taking needle and a converter 6; the 3 end of the vein puncture needle of the blood taking needle is connected with the 4 end of the bottle stopper puncture needle by a hose 5, and the 4 end of the bottle stopper puncture needle of the blood taking needle is provided with a needle holder 2; separation glue 101 is loaded to 1 inner chamber of centrifuging tube, and the anticoagulant (not shown in the figure) is loaded to separation glue 101 top, centrifuging tube 1 is equipped with plug and protective cover, and centrifuging tube 1's inner chamber is negative pressure state. In this embodiment, the blood taking needle is a disposable automatic resilient safety blood taking needle. "Disposable automatic resilient safety blood taking needle" disclosed in patent document No. CN205866753U "
The method for preparing PRP by using the centrifugal tube assembly sequentially comprises the following steps:
and 3, extracting PRP: inserting an injection port of a 5ml sterile syringe A (not shown in the figure) into a connecting port 601 of a converter 6 to connect the converter 6 with a lengthened needle tube, puncturing a needle end of the converter 6 into a rubber plug of a centrifuge tube 1, extracting serum (PPP) layer by layer, replacing the needle end with a 5ml sterile syringe B (not shown in the figure) to connect the converter 6, extracting PRP above separation gel 101, shaking the centrifuge tube 20-30 times to clean the collection tube wall and PRP attached to the separation gel when extracting PRP in the height of about 1cm above the separation gel 101, and inverting the centrifuge tube to extract. And (4) finishing.
1ml of Platelet Rich Plasma (PRP) can be obtained from each disposable PRP preparation special centrifuge tube. The detection shows that the erythrocyte removal rate can reach more than 99.5 percent. Only 8ml of blood is used to extract 1.5ml of platelet-rich plasma with a concentration of more than 4 times. About 4 times the concentration is the clinically recognized concentration with the most therapeutic effect.
Clinical application the utility model discloses after the prp that prepares, open the blood cell activation mode, the rate of release growth factor is: more than 90% is released in 1 hour.
The assembly is subjected to irradiation sterilization by using 25KGy gamma rays, repeated sterilization cannot be performed, the aseptic validity period is 24 months, and the assembly needs to be used within the validity period; the plastic uptake package is adopted, and the sealing performance is good; no pyrogen, no abnormal toxicity, safety, effectiveness and no hemolytic reaction; the product is disposable and is destroyed after being used; PRP must be prepared and used in a timely manner using freshly drawn blood.
The foregoing embodiments are merely for clarity of explanation, and are not to be construed as limiting the present invention. The utility model discloses have known multiple substitution or warp in this technical field, do not deviating from the utility model discloses under the prerequisite of essence meaning, all fall into the utility model discloses a protection scope.
Claims (1)
1. A special centrifuge tube assembly for platelet rich plasma preparation, wherein the assembly is a disposable device comprising a centrifuge tube, a blood collection needle and a converter; the vein puncture needle end of the blood taking needle is connected with the bottle stopper puncture needle end by a hose, and the bottle stopper puncture needle end of the blood taking needle is provided with a needle holder; separating gel is loaded in the inner cavity of the centrifugal tube, anticoagulant is loaded above the separating gel, and the inner cavity of the centrifugal tube is in a negative pressure state; the blood taking needle and the needle holder are connected in the following mode: the external thread on the bottle stopper puncture needle is connected with the internal thread at the port of the needle holder, so that the bottle stopper puncture needle is inserted into the sleeve of the needle holder.
Priority Applications (1)
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CN201921774082.XU CN211160246U (en) | 2019-10-22 | 2019-10-22 | Special centrifugal tube subassembly of rich platelet plasma preparation |
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CN201921774082.XU CN211160246U (en) | 2019-10-22 | 2019-10-22 | Special centrifugal tube subassembly of rich platelet plasma preparation |
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CN211160246U true CN211160246U (en) | 2020-08-04 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113663821A (en) * | 2021-08-20 | 2021-11-19 | 中国人民解放军陆军军医大学第一附属医院 | Separation method of platelet-rich fibrin gel |
-
2019
- 2019-10-22 CN CN201921774082.XU patent/CN211160246U/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113663821A (en) * | 2021-08-20 | 2021-11-19 | 中国人民解放军陆军军医大学第一附属医院 | Separation method of platelet-rich fibrin gel |
CN113663821B (en) * | 2021-08-20 | 2023-08-29 | 中国人民解放军陆军军医大学第一附属医院 | Separation method of platelet-rich fibrin gel |
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Effective date of registration: 20201119 Address after: 410300 99 Jinsha North Road, Liuyang market, Hunan, Changsha Patentee after: LIUYANG SANLI MEDICAL TECHNOLOGY DEVELOPMENT Co.,Ltd. Address before: 410300 Liuyang Sanli medical science and Technology Development Co., Ltd., No. 99, North Jili Jinsha Road, Liuyang City, Changsha City, Hunan Province Patentee before: Chen Pingxuan |