CN104014005A - Blood component separating device - Google Patents
Blood component separating device Download PDFInfo
- Publication number
- CN104014005A CN104014005A CN201410192912.3A CN201410192912A CN104014005A CN 104014005 A CN104014005 A CN 104014005A CN 201410192912 A CN201410192912 A CN 201410192912A CN 104014005 A CN104014005 A CN 104014005A
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- CN
- China
- Prior art keywords
- blood
- centrifugal
- bag
- pipe
- collection
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
Abstract
The invention provides a blood component separating device and belongs to the technical field of blood component separation. The blood component separating device can effectively solve the problem of negative factors of one-way centrifugal force of a centrifugal machine in the blood component separating process. The blood component separating device comprises the centrifugal machine, a blood sampling syringe needle and an anticoagulation pipe connected with a blood sampling pipe. A collection branch pipe with an automatic pipeline clamp is connected with a collecting bag, and a drum of a revolution barrel of the centrifugal machine is horizontally arranged. The axis of a motor shaft vertically intersects with the axis of the revolution barrel. The two ends of the axis of the revolution barrel are provided with insertion holes of shafts of autorotation barrels, and connected with the autorotation barrels through bearings. A balancing bag with balancing liquid and a centrifugal blood bag are respectively arranged in the autorotation barrels at the two ends of the revolution barrel. One end of a two-hole pipe is connected with the centrifugal blood bag, and the other end of the two-hole pipe is fixed to the pipeline clamp; one end of the blood sampling pipe in the two-hole pipe is connected with a main blood sampling pipe, and the other end of the blood sampling pipe is connected with the centrifugal blood bag; one end of the collecting pipe in the two-hole pipe is connected with a main collecting pipe, and the other end of the collecting pipe is connected with the centrifugal blood bag. The blood component separating device is mainly used for separating blood components.
Description
Technical field
The invention belongs to blood constituent separation technology field, relate in particular to the isolation technics in blood collection procedure.
Background technology:
At present, blood constituent isolation technics has multiple, as the separator cell of the equipment Fewtlcs-3000plus of U.S. Bert company and the HAEMONETIC of Haemanetics Corporation, USA, human body is being carried out in blood collection procedure, through extracorporeal circulation, utilize unidirectional centrifugal method, by the different composition of various proportion in blood, be deposited to corresponding aspect separately.From aspect separately, draw and collect corresponding blood constituent again, and reach the object to blood constituent separation.And there is defect in unidirectional centrifugalize blood constituent: because the separation of blood constituent completes in to blood collection procedure.Blood collection and centrifugal blood, synchronously carry out, and is that limit gathers blood limit centrifugal blood.In blood collection procedure, there is difference the time that blood enters centrifuge container.Be introduced into the blood of centrifuge container, the blood constituent of its various different specific weights, centrifugal through gravity, large and small by according to proportion, forms interface separately.And enter again the blood of centrifuge container, can be not completely large and small according to proportion, along with being introduced into blood in centrifuge container, the interface separately that forms.Laminating of the blood constituent that some proportion will occur, vary in size, because the difference of the various one-tenth partial volume of blood size is little.This is because when to centrifugal blood, in centrifuge container, by the plane of central shaft at rotary middle spindle homonymy, the centrifugal force direction that is subject to of any one particle is all consistent.Cause the different blood constituent of big or small proportion, have quite a few motion less than corresponding interface, mix and laminate.When to blood component collection, collect less than, cause blood component collection rate low.In centrifugal process, during to corresponding blood component collection, utilize external force (negative pressure) suction force itself, be exactly to the blood in centrifugal, added an external force.This external force makes the blood constituent being collected, and has formed flowing of blood, and has formed without several liquid flow circuits.The flowing velocity of each flow circuits is difficult to control, and from surrounding to collecting the mouth of pipe, has formed countless to the situation of convection current in opposite directions.Again because the difference in specific gravity between each blood constituent is very little, interface between each blood constituent, original just very not clear, the formed aspect of each blood constituent is quite thin again, so be easy to form the muddiness that flows, and the rate of sneaking into other compositions is too high, and separated concentration is low, purity is low, the response rate is low.The blood that viscosity is higher, flowing velocity in surrounding all directions is inconsistent, when collecting the composition of respective interface, interface will be upset relatively, approach interface, required blood constituent concentration is higher, collection not thorough, the amount of sneaking into other composition increases greatly, so the purity of collecting is poor.
In the blood constituent separating technology of application at present, the separation method of Fewtlcs-3000plus, centrifuge container is far away apart from centrifugal shaft, in centrifugal process, cannot rely on the natural pressure in centrifuge container, and corresponding blood constituent is pressed to outside centrifuge container.HAEMONETIL is that fracture connects, and blood extraction tube cannot be stretched to erythrocyte layer.Because blood extracts pipeline, can not synchronize and rotate with centrifuge container, otherwise, the blood in centrifugal process can be stired and make muddy, be difficult to form interface separately.When animal blood is gathered, because of animal physiological reason, to the disposable in vitro blood flow volume of animal, be to have a threshold quantity.According to separated to blood constituent, the necessary requirement to the collecting amount of blood constituent, when separated to blood constituent, need to reach the raw material blood of a great deal of, just can reach the collecting amount to blood constituent again.So gathering blood, while carrying out component separating, need repeatedly repeatedly to gather, centrifugal, collect, also defeated process just can complete the object to blood constituent separation.So said two products, after to the collection each time of desired blood component, blood after centrifugal when the heavy relatively large erythrocyte of contrast is also defeated, erythrocyte is in the bottom of centrifuge container, need to stop the collection of centrifugal blood and centrifugal blood, the special erythrocyte that extracts is also defeated by human body, so form the blood separation process of discontinuity.In addition the separation method of the disclosed a kind of multidirectional centrifuge type arrangement for continuous separating blood components of Chinese patent ZL200510017870.0 and Fewtlcs-3000plus is in centrifugal process, the upset of blood taking bag (is removed instrument for blood collection, during because of high speed rotating, twisted off) are all the driving effects that utilize gear, when centrifuge runs up, it is the main cause of noise and vibrations.Vibrations, can make in to centrifugal blood process, and by various different specific weight blood constituents, formed interface is extremely unstable, are the key factor of impact to the concentration of blood constituent separation, purity, the response rate.
Summary of the invention
The object of this invention is to provide a kind of blood constituent segregation apparatus, it can effectively utilize the centrifugal force of centrifuge and the effect of continuous media self stress reaches multidirectional centrifugal object.
The object of the invention is to be achieved through the following technical solutions: a kind of blood constituent segregation apparatus, comprise centrifuge and blood collection needles and the anticoagulant pipe that is connected blood taking tube, collecting pipe with automatic pipeline card connects collecting bag, the horizontal layout of centrifuge revolution bucket rotating cylinder, the axis square crossing of the axis of motor shaft and revolution bucket, the axis two ends of revolution bucket are provided with the jack from turning barrel axle, by bearing with from turning barrel, be connected, be equipped with the trim bag of trim liquid and centrifugal blood bag be placed in respectively revolution bucket two ends in turning barrel, one end of double-hole tube is connected with centrifugal blood bag, the other end and pipeline fasten, one end of blood taking tube in double-hole tube is connected with blood sampling house steward, and the other end is connected with centrifugal blood bag, and one end of the collecting pipe in double-hole tube is connected with collection house steward, and the other end is connected with centrifugal blood bag.
In the pipeline of described blood taking tube, collection house steward and anticoagulant pipe, be equipped with the fast valve of control.
The described collecting pipe with automatic pipeline card and collecting bag also connect.
By the centrifugal blood bag of disposable blood taking device material, put into centrifuge in turning barrel, by drawing outside centrifugal body away from blood bag end of double-hole tube, double-hole tube is become and arcly turns to 90 degree, and static fixation.
Like this when centrifuge is opened, when revolution bucket horizontally rotates, will be under the combined effect of revolution bucket and double-hole tube from turning barrel, automatic turn-over body formation rotation, thus avoid the distortion of double-hole tube.By gather syringe needle from the blood gathering in animal body through extracorporeal circulation pipeline, by pipeline, deliver to centrifuge blood bag in turning barrel, under multidirectional rotary centrifugal action, the various blood constituents that proportion is different, obtain separation after being divided into aspect separately, by a plurality of pipelines of disposable blood taking device material, drawn outside the blood bag of centrifuge rotation, through several, control fast valve again and compress, control speed and the direction of blood flow, the blood plasma of heterogeneity after high speed centrifugation is collected.
Advantage and effect are compared with prior art:
The present invention utilizes self stress-type upset centrifuging, is the key factor that reduces noise, is also one of key factor of avoiding vibrations.Reduce noise and vibrations, most important to collecting blood constituent, can directly cause the raising of the Quality and yield of product, make high collection rate, the high concentration of its product, the generation of high yield.Also can alleviate greatly, reduce animal is being carried out in blood collection procedure, animal is mismatched and brought out a series ofly affects manpower, material consumption (due to the formation of microthrombus, and put disposable blood taking device material and collected half-finished discarded) and product quality, also alleviated artificial labor intensity simultaneously, alleviated the harsh degree requiring gathering blood donors, expand the object requiring gathering blood donors, saved donor, expanded the range of choice to donor.
On the other hand, leukocyte diameter is greater than 8 microns, the about 3-12 micron of red blood cell diameter, hematoblastic diameter is 2-3 micron, rotation and revolution eccentricity direction are 90 degree, if unidirectional centrifugal, to forming the different blood constituent of diameter, mutually superpose so, aspect degree of purity at the various blood constituents of centrifugal rear formation is lower, in the centrifugal situation of multi-direction type of the present invention, can make the multiple blood constituent that diameter or quality are different, in by multidirectional centrifugal process, at the suffered force direction of particle separately, vary in size, the track of motion is respectively had any different, different quality so, the blood constituent of size can better more successfully concentrate on blood constituent aspect separately according to operating on centrifugal force, the formed aspect of each blood constituent that makes it to be centrifuged is more clear, pure, contribute to improve the response rate of blood.
Accompanying drawing explanation
Fig. 1 overall structure schematic diagram of the present invention
Fig. 2 centrifuge of the present invention is from turning barrel position view
Fig. 3 double-hole tube sectional view of the present invention
Embodiment
Below by accompanying drawing, the present invention is described further:
The anticoagulant pipe 17 that the present invention includes centrifuge 3 and blood collection needles 11 and be connected blood taking tube 20, collection arm with automatic pipeline card 22 connects collecting bag 21, centrifuge revolution bucket 3 horizontal layouts, the axis square crossing of the axis of motor shaft 2 and revolution bucket 3, the axis two ends of revolution bucket 3 are provided with the jack 4 from turning barrel axle, by bearing 5 with from turning barrel 8, be connected, be equipped with the trim bag 7 of trim liquid 6 and centrifugal blood bag 9 be placed in respectively revolution bucket 3 two ends in turning barrel 8, one end of double-hole tube 10 is connected with centrifugal blood bag 9, and the other end and pipeline card 13 are fixing; One end of blood taking tube 11 in double-hole tube 10 is connected with blood sampling house steward 14, and the other end is connected with centrifugal blood bag 9, and one end of the collecting pipe 12 in double-hole tube 10 is connected with collection house steward 15, and the other end is connected with centrifugal blood bag 9.
In the pipeline of described blood taking tube 20, collection house steward 15 and anticoagulant pipe 17, be equipped with the fast valve 18 of control.
The described collection arm with automatic pipeline card 22 and collecting bag 21 also connect.
In blood extracorporeal circulation pipeline, by blood collection needles 19, in human or animal body, gather blood, the blood taking tube 11 connecting in double-hole tube 10 by blood sampling house steward 14 is delivered to centrifugal blood bag 9, and in course of conveying, velocity of blood flow is controlled by controlling fast valve 18.Carry out medical disposable material installation, use the empty bag the same with centrifugal blood bag 9 sizes, proportion, full normal saline, be positioned over revolution bucket 3 one end from turning barrel 8 intracavity in order to serve as the trim liquid 6 of centrifugal rotation, and guarantee that sack 7 does not expose rotation bung.By centrifugal blood packed enter the revolution bucket other end from turning barrel 8 intracavity, at the interior clamping of fixed-piping card 13 that double-hole tube 10 is connected with centrifugal support 1, and guarantee that the double-hole tube 10 between fixed-piping card 13 and centrifugal blood bag 9 upper ends is not more than the circular arc state of 30 centimetres in radius.By blood taking tube 11 and anticoagulant pipe 17, connect respectively the fast valve 18 of control.Total collecting pipe 15 is placed in to particle monitoring device, and collection branch pipe(tube) separately, all by corresponding pipeline card, communicates with collecting bag 21 separately.After installing, follow blood collection procedure, close on collecting pipe each automatic pipeline card 22 and control fast valve 18, and open control on anticoagulant pipeline speed valve 18, in centrifugal blood bag, inject anticoagulant, by controlling fast valve 18, control, guarantee to enter centrifugal blood bag 9 after anticoagulant and blood mix in certain proportion, after centrifugal blood bag 9 is full, close the control speed valve 18 on anticoagulant pipeline 17 and blood taking tube.Later stage is in the separation of blood, collection process, open the control speed valve 18 on collecting pipe, under the monitoring of watch-dog, with electromagnetic pulse signal according to the size of granule, automatically open successively the automatic pipeline card 22 on collecting bag pipeline separately, guarantee that the pipeline card on other pipelines closes simultaneously, and then complete collection, separation, the collection work to blood.
Claims (3)
1. a blood constituent segregation apparatus, comprise centrifuge and blood collection needles (19) and the anticoagulant pipe (17) that is connected blood taking tube (20), collection arm with automatic pipeline card (22) connects collecting bag (21), it is characterized in that: the horizontal layout of centrifuge revolution bucket (3) rotating cylinder, the axis square crossing of the axis of motor shaft (2) and revolution bucket (3), the axis two ends of revolution bucket (3) are provided with the jack (4) from turning barrel axle, by bearing (5) with from turning barrel (8), be connected, be equipped with the trim bag (7) of trim liquid (6) and centrifugal blood bag (9) be placed in respectively revolution bucket (3) two ends in turning barrel (8), one end of double-hole tube (10) is connected with centrifugal blood bag (9), the other end and pipeline card (13) are fixing, one end of blood taking tube (11) in double-hole tube (10) is connected with blood sampling house steward (14), the other end is connected with centrifugal blood bag (9), one end of collecting pipe (12) in double-hole tube (10) is connected with collection house steward (15), and the other end is connected with centrifugal blood bag (9).
2. a kind of blood constituent segregation apparatus according to claim 1, is characterized in that: in the pipeline of described blood taking tube (20), collection house steward (15) and anticoagulant pipe (17), be equipped with control fast valve (18).
3. a kind of blood constituent segregation apparatus according to claim 1, is characterized in that: the described collection arm with automatic pipeline card (22) and collecting bag (21) also connect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192912.3A CN104014005A (en) | 2014-05-08 | 2014-05-08 | Blood component separating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192912.3A CN104014005A (en) | 2014-05-08 | 2014-05-08 | Blood component separating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104014005A true CN104014005A (en) | 2014-09-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410192912.3A Pending CN104014005A (en) | 2014-05-08 | 2014-05-08 | Blood component separating device |
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| CN (1) | CN104014005A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187923A (en) * | 2018-01-04 | 2018-06-22 | 北京市春立正达医疗器械股份有限公司 | A kind of centrifugal blood component for centrifuge |
| CN112063507A (en) * | 2020-09-30 | 2020-12-11 | 金西盟(天津)人工智能有限责任公司 | Automatic blood component balancing and separating device and method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736497A (en) * | 2005-08-09 | 2006-02-22 | 郭经纬 | A multidirectional centrifuge type arrangement for continuous separating blood components and method |
| CN102527525A (en) * | 2012-02-07 | 2012-07-04 | 郭经纬 | Full-automatic balancing rotary centrifugal separation method and full-automatic centrifugal separator |
| CN203108671U (en) * | 2012-12-31 | 2013-08-07 | 王克诚 | Revolution and rotation planet differential centrifugal |
| CN203291967U (en) * | 2013-02-01 | 2013-11-20 | 北京倍肯恒业科技发展有限责任公司 | Plane high-speed centrifuge |
-
2014
- 2014-05-08 CN CN201410192912.3A patent/CN104014005A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736497A (en) * | 2005-08-09 | 2006-02-22 | 郭经纬 | A multidirectional centrifuge type arrangement for continuous separating blood components and method |
| CN102527525A (en) * | 2012-02-07 | 2012-07-04 | 郭经纬 | Full-automatic balancing rotary centrifugal separation method and full-automatic centrifugal separator |
| CN203108671U (en) * | 2012-12-31 | 2013-08-07 | 王克诚 | Revolution and rotation planet differential centrifugal |
| CN203291967U (en) * | 2013-02-01 | 2013-11-20 | 北京倍肯恒业科技发展有限责任公司 | Plane high-speed centrifuge |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108187923A (en) * | 2018-01-04 | 2018-06-22 | 北京市春立正达医疗器械股份有限公司 | A kind of centrifugal blood component for centrifuge |
| CN108187923B (en) * | 2018-01-04 | 2024-04-02 | 北京市春立正达医疗器械股份有限公司 | Blood centrifugation assembly for centrifugal machine |
| CN112063507A (en) * | 2020-09-30 | 2020-12-11 | 金西盟(天津)人工智能有限责任公司 | Automatic blood component balancing and separating device and method |
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Application publication date: 20140903 |
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