CN100467075C - A multidirectional centrifuge type arrangement for continuous separating blood components and method - Google Patents
A multidirectional centrifuge type arrangement for continuous separating blood components and method Download PDFInfo
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- CN100467075C CN100467075C CNB2005100178700A CN200510017870A CN100467075C CN 100467075 C CN100467075 C CN 100467075C CN B2005100178700 A CNB2005100178700 A CN B2005100178700A CN 200510017870 A CN200510017870 A CN 200510017870A CN 100467075 C CN100467075 C CN 100467075C
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Abstract
The invention relates to a segregation device and method of multidirectional continual blood component, which comprises the following steps: gathering blood by gathering needle (10); pushing the blood to the centrifugal container (12, 30) through the pipe route; setting the external blood flow process pipe system in the multidirectional centrifugal rotary device in connection with blood flow path pipe (6) by several control pumps (1); setting the centrifugal container in the rotational hemisphere (16) of centrifugal rotary device. The driving shaft (33) between rotational hemisphere and centrifugal rotary device is fixed to rotate with rotational hemisphere along its own orbital trace. The device transmits the signal from color comparator sensor (4) to corresponding control system after multidirectional centrifugal separating, which shortens the gathering blood time to improve the gathering rate of blood component and is applied in the clinical blood pathological component separation or improves the clinical curative effect in displacement therapy.
Description
Technical field
The present invention relates to the clearance technique field of blood circulation, a kind of multidirectional centrifuge type arrangement for continuous separating blood components.
Background technology
In the medical active procedure, the pathology blood constituent has appearred in people's blood, and clinically to the dispeling or replacement therapy of blood pathology composition, in blood collection procedure, it is centrifugal that blood is carried out gravity, separates various blood constituents.Be with blood of human body, in by the extracorporeal circulation process, extract in the short time and collect single or certain several blood constituent in the blood, the healthy person blood constituent is extracted collect, or the patient carried out the purpose that single blood sampling composition is dispeled, be a kind of technology of promoting rapidly in recent years.
At present, the blood constituent isolation technics of clinical practice has multiple, as the equipment Fewtlcs-3000plus of U.S. Bert company and the separator cell of the HAEMONETIC of Haemanetics Corporation, USA, human body is being carried out in the blood collection procedure, through extracorporeal circulation, utilize unidirectional centrifugation method,, be deposited to corresponding separately aspect the different composition of various proportions in the blood.Draw from aspect separately again and collect corresponding blood constituent, and reach the isolating purpose of blood constituent.
The defective of unidirectional centrifugalize blood constituent method: because the separation of blood constituent is finished in to blood collection procedure.Blood collection and centrifugal blood carry out synchronously, are that blood limit centrifugal blood is gathered on the limit.In blood collection procedure, there is difference the time that blood enters centrifuge container.Be introduced into the blood of centrifuge container, the blood constituent of its various different specific weights, centrifugal through gravity, will be according to proportion large and small, form interface separately.And the blood that enters centrifuge container again will be laminated on the superiors, because the difference of the various one-tenth partial volume of blood size is little.Again because the time to centrifugal blood, in centrifuge container, by on the plane of central shaft at the rotary middle spindle homonymy, the centrifugal force direction that is subjected to of any one particle all is consistent.Cause the different blood constituent of big or small proportion, quite a few motion is arranged, mix and laminate less than corresponding interface.To blood component collection the time, collect less than, cause the blood component collection rate low.The blood component collection rate of individual event centrifugal method, if when gathering the blood constituent of a therapeutic dose, collection rate is about 50%.During collection,, to collecting mouth of pipe extruding, collect to centrifugal external absorption by pipeline again from all around at the interface that each blood constituent forms.Suction force itself is exactly to the blood in centrifugal, has added an external force.This external force is not to come from centrifugal force, makes the blood constituent that is collected, and has formed flowing of blood, and making to have formed does not have several liquid flow circuits.The flowing velocity of each flow circuits is difficult to control, from around to collecting the mouth of pipe, formed countless to the situation of convection current in opposite directions.Again because the difference in specific gravity between each blood constituent is very little, the interface between each blood constituent, original just very not clear, the formed aspect of each blood constituent is quite thin again, flows muddyly so be easy to form, and it is too high to sneak into other components in proportions rates.In the process of collecting blood constituent,, and stop carrying out continuously to corresponding blood component collection because the mixed volume of other blood constituents is too high.Cause the delay of the blood constituent of part needs collection, and collect not exclusively.The blood that viscosity is higher, around flowing velocity on all directions inconsistent, when collecting the composition of respective interface, the interface will be upset relatively, near at the interface, required blood constituent concentration is high more, collection not thorough, the amount of sneaking into other composition increases greatly, so the purity of collecting is relatively poor.
The blood constituent separating technology of using all is methods of utilizing individual event centrifugalize blood constituent at present, because erythrocyte proportion is relatively large, erythrocyte will be in the lowermost layer of centrifuge container when centrifugal.As the separation method of Fewtlcs-3000plus, centrifuge container is far away apart from centrifugal shaft, in centrifugal process, can't rely on the natural pressure in the centrifuge container, and corresponding blood constituent is pressed to outside the centrifuge container.HAEMONETIL is that fracture connects, and the blood extraction tube can't be stretched to the erythrocyte layer.Because of blood extracts pipeline, can not rotate synchronously with centrifuge container, otherwise, the blood in the centrifugal process can be stired and make muddy, be difficult to form interface separately.When blood of human body is gathered,, be that a threshold quantity is arranged to the stripped blood flow volume of people's body disposable because of the Human Physiology reason.Again according to blood constituent is separated, the necessary requirement to the collecting amount of blood constituent when blood constituent is separated, need reach the raw material blood of a great deal of, just can reach the collecting amount to blood constituent.So gathering blood, when carrying out component separating, repeatedly collection repeatedly, process centrifugal, that collect, also fail just can be finished the isolating index of blood constituent or reach therapeutic purposes.So said two products, after collection each time to desired blood component, the heavy relatively large erythrocyte of contrast carries out the blood after centrifugal when also defeated, erythrocyte is in the bottom of centrifuge container, needs are stopped the collection of centrifugal blood and centrifugal blood, extract erythrocyte specially and also be defeated by human body.So form the blood separation process of discontinuity.
Summary of the invention
For solving blood is carried out the defective that unidirectional centrifugal method exists, purpose of the present invention provides a kind of multidirectional centrifuge type arrangement for continuous separating blood components, make it can shorten the blood collection time, raising is to the collection rate of blood constituent, be used for clinical dispeling or replacement therapy to blood pathology composition, improve clinical efficacy, increase the emergency capability of blood constituent clinical supply.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components comprises: blood extracorporeal circulation system, multidirectional centrifugal slewing; It connects centrifuge container by gathering syringe needle by pipeline; Blood flow process tubing places multidirectional centrifugal slewing; Blood flow process pipeline is controlled fast pump pressure stressed joint by in the centrifugal slewing several; Centrifuge container places the rotation hemisphere of centrifugal slewing, and the main drive shaft of rotation hemisphere and centrifugal slewing is fixedly connected, and in the time of with the rotation of driving shaft, rotation hemisphere has the track track of its rotation; Through multidirectional rotating centrifugal separate blood composition by the colour comparatour pick off with the signal of sensing to corresponding control system, centrifuge container one outfan is by pipeline coordinator blood collecting bag, another outfan connects the blood air bag by pipeline, and the blood air bag connects the feedback syringe needle by pipeline.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components, whole sealed tube route pipeline one end of blood extracorporeal circulation system connects gathers syringe needle, gather syringe needle by flexible pipe and manually the pipeline card 1. with the anti-soft pipe connection of doubting the agent bag that prevents blood coagulation, be mixed with anti-blood inlet pipe of doubting blood conduit connection centrifuge container inwall one side of agent, opposite side at its centrifuge container inwall has the erythrocyte outlet, and the outlet of erythrocyte pipe is communicated with component blood collecting bag and blood air bag; The collection blood constituent blood outlet of centrifuge container center is communicated with component blood collecting bag and blood air bag; 2. blood air bag outfan is communicated to the blood recovery syringe needle by pipeline through manual pipeline card.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components, multidirectional centrifugal slewing is a ball formula centrifuge container separation equipment, driving shaft by the rotation hemisphere of motor output shaft and separation equipment is fixedly connected, the driving shaft of rotation hemisphere is hollow structure, pass hollow actuating shaft two spring bearings are arranged, pass spring bearing one gear shaft is arranged, respectively there is a rolling bevel gear at the two ends of gear shaft, there is the travelling gear that is meshed and is connected with rotation hemisphere gear at the middle part of back shaft, the rolling bevel gear at gear shaft two ends is meshed with the annular bevel gear of bottom and is connected, and annular bevel gear is fixed on the support; There is a support ring driving shaft upper end of rotation hemisphere, and a side of support ring has spring bearing, and spring bearing is by supporting the fixedly connected rotation hemisphere of the axis of rotation; Its centrifuge container places in the centrifugal hemisphere of rotation, and is fixed in the centrifugal hemisphere of rotation by active card; The opposite side of support ring is being fixed the hanging ring that blood conduit is pricked in a tube bank, there is a fixing loudspeaker ring top of hanging ring, fixedly the loudspeaker ring is connected on the fixed mesa, fixedly a colour comparatour pick off is arranged at the top of loudspeaker ring, transducing signal through the colorimetric analysis instrument with control blood flow to being connected with the circuitry of flow velocity.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components, multidirectional centrifugal slewing is a disc type centrifuge container separation equipment, be connected with belt pulley by motor output shaft, the belt sleeve of belt pulley is contained in the belt grooves of driving shaft of rotation hemisphere, in the bottom of the driving shaft of rotation hemisphere one bearing base is arranged; Have on the top of the driving shaft of rotation hemisphere one with the angled eccentric bearing block of horizontal plane, taper roll bearing is arranged in the bearing block, the hollow axis of rotation of rotation hemisphere bottom is fixed in the taper roll bearing; One side of rotation hemisphere driving shaft upper end fixedly connected a suspension arm, last fixedly connected the pipeline hanging ring of suspension arm; Rotation hemisphere driving shaft upper end opposite side connects a rolling bevel gear by gear shaft through bearing, an annular bevel gear is arranged at the bottom of rolling bevel gear, the rolling bevel gear is meshed with annular bevel gear, fixed support is arranged at annular bevel gear bottom, the top of rolling bevel gear also has a rotation hemisphere gear, and the rolling bevel gear is meshed with it; Top in the rotation hemisphere has slip-knot to link then disc type centrifuge container; Near the centre bit colour comparatour pick off is arranged in the rotation hemisphere, the colour comparatour pick off is fixed on the colour comparatour support bar, the colour comparatour support bar is fixedly connected on the support, the colour comparatour sensor signal through the colorimetric analysis instrument with control blood flow to being connected with the circuitry of flow velocity.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components, its blood conduit bundle that is placed on the centrifuge container has " S " type counter-rotating bent angle of preventing its distortion; " S " type counter-rotating bent angle of distortion is with loudspeaker ring and pipeline hanging ring respectively by two corners of conduit bundles.
Described a kind of multidirectional centrifuge type arrangement for continuous separating blood components, centrifugation apparatus are provided with several blood flow control speed pumps that blood conduit is rolled and pushes.
Owing to adopt as above technical scheme, the present invention has following superiority:
This a kind of multidirectional centrifuge type arrangement for continuous separating blood components is mainly used in blood plasma, platelet, leukocyte, stem cell, erythrocyticly singly adopts separation.Adopt the difference in specific gravity of the various compositions of blood, it is centrifugal to carry out multidirectional gravity simultaneously, finish mask work to one or more compositions of blood, eliminated whole airtight pipeline when running up, part pipeline distortion problem, because on the integral tube confined path, blood collection pipeline and blood recovery pipeline all need static; Centrifuge container in the pipeline is a hard material, and the pipeline that is connected is a soft material, under the situation that centrifuge container runs up, formed separately pipeline direction of rotation when rotation and revolution, soft pipeline can stand up automatically with the distortion on two rightabouts, and pipeline just can not be distorted yet.Can carry out continual continuous separation, shorten the blood collection time, alleviate the labor intensity of operator, increase the emergency capability of blood constituent demand.Isolated blood constituent purity height, collection rate height.Adopt in the application of dispeling art or replacement the patient being carried out pathologic blood constituent list,, improved clinical efficacy significantly better than dispeling or the curative effect of replacement of discontinuous manner.
This a kind of multidirectional centrifuge type arrangement for continuous separating blood components under the situation of high speed rotating, perform the trim of the dynamic equilibrium of rotation, and it is comparatively complete to collect corresponding blood constituent, and the purity height.Realized and continually to have carried out the blood constituent mask work continuously, shortened working hours; Under the situation of blood interaction, the blood constituent that can not form different specific weight laminates mutually, and the identical blood constituent of proportion is concentrated relatively thoroughly, collects also relatively thoroughly, so to the collection of corresponding blood constituent, higher collection rate is arranged.Under the situation that does not have active force beyond the centrifugal force, the blood constituent to central point is concentrated can not form muddiness, and the degree of purity of collecting corresponding blood constituent is than higher.
The centrifugal globe internal diameter is the part of centrifugal globe for 31 centimetres, 200 milliliters of internal volumes.The angle of the axis of rotation and hollow shaft is 15 °, and rotating speed is 1350 rev/mins.Testing two examples altogether, all is to collect platelet.
A case stamen dawn, woman, 42 years old, blood testing; Platelet 181 * 10
9/ L, leukocyte 8 * 10
9/ L, packed cell volume 41%, hemoglobin 13.4g/L.
Platelet rich plasma 160ml is received in amount of blood collected 1600ml, collection, contains platelet 2.04 * 10
11Individual, leukocyte 5.5 * 10
5Individual.Collection rate 70.1%.Donate blood back 24 hours to the Zhang Xiaorui blood testing, platelet count 178 * 10
9Individual/L, the equal no change of other every indexs.
Two Weis of case are to chapter, man, 33 years old, blood testing; Platelet 122 * 10
9Individual/L, hemoglobin 15.6g/L, packed cell volume 46%, leukocyte 5.5 * 10
9Individual/L.
Amount of blood collected 2000ml collects platelet rich plasma 168ml, contains platelet amount 1.81 * 10
11Individual, leukocyte 2.1 * 10
5Individual.Collection rate 75.4%.Donate blood back 24 hours to Wei to the chapter blood testing, platelet meter 124 * 10
9Individual/L, the equal no change of other every indexs.
More than two examples, illustrate that this equipment improves greatly to hematoblastic collection rate.In the collected platelet, leukocytic pollution rate reduces greatly, can reach clinical quality standard.To the harmless effect of blood donor.
Description of drawings
Fig. 1 is a kind of multidirectional centrifuge type seriality blood component collection separate blood flow system figure;
Fig. 2 is the isolating ball formula of a multidirectional centrifuge type seriality blood constituent centrifuge container device structure sketch map;
Fig. 3 is the isolating disc type centrifuge container of a multidirectional centrifuge type seriality blood constituent device structure sketch map;
Shown in the figure: 1-control fast pump; 2-automatically pipe clamps; 3-manually pipe clamps; 4 colour comparatour pick offs; 5-tube bank is pricked; 6-pipeline; 7-anti-agent the bag of doubting; 8-component blood collecting bag; 9-blood air bag; 10-collection syringe needle; 11-feedback syringe needle; 12-ball formula centrifuge container; 13-blood inlet pipe; 14-component blood outlet; 15-erythrocyte outlet; 16-rotation hemisphere; 17-support axis of rotation; 18-rotation hemisphere gear; 19-spring bearing; 20-support ring; 21-excessively gears; 22-rolling bevel gear; 23-annular fixed gear; 24-motor; 25-pipeline hanging ring; 26-slip-knot card; 27-loudspeaker ring; 28-support; 29-fixed station; 30-disc type centrifuge container; 31-taper roll bearing; 32-gear shaft; 33-driving shaft; 34-colour comparatour bar; 35-belt grooves; 36-belt; 37-belt pulley.
The specific embodiment one
As shown in fig. 1: this a kind of multidirectional centrifugal arrangement for continuous separating blood components, in blood extracorporeal circulation pipeline, it delivers to centrifuge container 12,30 by gathering the blood that syringe needle 10 is gathered in the human body by pipeline; Extracorporeal blood flow process tubing is placed multidirectional centrifugal slewing; Blood flow process pipeline 6 is controlled fast pump 1 by in the centrifugal slewing several and is compressed connection; Centrifuge container places the rotation hemisphere 16 of centrifugal slewing, and the main drive shaft 33 of rotation hemisphere and centrifugal slewing is fixedly connected, and in the time of with the rotation of main drive shaft, rotation hemisphere has the track track of its rotation; By colour comparatour pick off 4 transducing signal is transferred to corresponding control system through multidirectional rotating centrifugal separate blood composition, blood plasma after the centrifugalize, platelet, leukocyte, erythrocyte blood constituent is different classes of by it, a part is collected 8 li of component blood collecting bags, and another part is temporary in blood air bag 9 back warps feedback syringe needle 11 and also is defeated by human body again; To having blood plasma, platelet, leukocyte, the erythrocyte of pathology composition in the component blood collecting bag, dispel; Can supply with other people to the blood plasma, platelet, leukocyte, the erythrocyte that have the blood constituent that part wants his person domestic demand in the component blood collecting bag and carry out infusion, be used for the treatment of the ill personnel that lack corresponding blood constituent.Its whole airtight pipeline one end is the collection syringe needle 10 that connects blood of human body, gather syringe needle by pipeline 6 and manually the pipeline card 1. 3 with the anti-soft pipe connection of doubting agent bag 7 that prevents blood coagulation, be mixed with anti-blood inlet pipe 13 of doubting blood conduit connection centrifuge container inwall one side of agent, opposite side at its centrifuge container inwall has erythrocyte outlet 15, and the outlet of erythrocyte pipe is communicated with component blood collecting bag 8 and blood air bag 9; The collection blood constituent blood outlet 14 of centrifuge container center is communicated with component blood collecting bag and blood air bag; 2. the mixing blood constituent that comes out in the blood air bag is communicated to blood recovery syringe needle 11 through manual pipeline card.
As shown in Figure 2: this a kind of multidirectional centrifuge type arrangement for continuous separating blood components is a ball formula centrifuge container separation equipment, driving shaft 33 by the rotation hemisphere of motor 24 output shafts and separation equipment is fixedly connected, the driving shaft of rotation hemisphere is hollow structure, pass hollow actuating shaft two spring bearings 19 are arranged, passing spring bearing has a gear shaft 32, and respectively there is a rolling bevel gear 22 at the two ends of gear shaft; The gear shaft middle part is provided with the travelling gear 21 that is meshed and is connected with rotation hemisphere gear 18, and the rolling bevel gear at gear shaft two ends is meshed with the annular bevel gear 23 of bottom and is connected, and annular bevel gear is fixed on the support 28; There is a support ring 20 the driving shaft upper end of rotation hemisphere, and a side of support ring has spring bearing 19, and spring bearing is by supporting the axis of rotation 17 fixedly connected rotation hemisphere 16; Its ball formula centrifuge container 12 places in the centrifugal hemisphere of rotation, and is fixed on the centrifugal hemisphere of rotation by slip-knot card 26; The opposite side of support ring is being fixed the hanging ring 25 that 5 blood conduits are pricked in a tube bank, the top of hanging ring has one to make blood conduit not produce the fixedly loudspeaker ring 27 of distortion, and the top of loudspeaker ring also is provided with a colour comparatour pick off 4 facing to blood conduit and is connected on the fixed station 29; The colour comparatour pick off links to each other with the colorimetric analysis instrument.
This multidirectional centrifuge type seriality blood constituent ball formula centrifuge container separation equipment, when revolution face becomes an angle of 90 degrees with rotation face, to blood in centrifuge container in the centrifugal process, each particle of centrifuge container inner blood be subjected to force direction different, the blood constituent direction of motion of each particle is changing at any time in the centrifuge container, stressed and the direction of motion of the conversion that blood does not stop in container has formed the approximate spiral helicine motion mode of each particle of blood; Total direction of motion is to rotate the tangential direction of making a concerted effort towards two; Being total force direction that is subjected to, all is towards the centrifuge container outside; In centrifugal process, no matter earlier, after enter the blood of centrifuge container, be engraved in the motor process when in centrifuge container all being; Under action of centrifugal force, the blood constituent that proportion is identical, all can dissociate moves on the corresponding separately aspect, no matter successively enter the blood of centrifugal globe, can not cause the different blood constituent of proportion to mix and laminate; So blood is through centrifugal, the blood constituent that each proportion is different in that aspect is concentrated relatively fully separately, can reach the response rate higher to blood constituent.
The specific embodiment two
As shown in Figure 3: this a kind of multidirectional centrifuge type arrangement for continuous separating blood components is a disc type centrifuge container separation equipment, be connected with belt pulley 37 by motor 24 output shafts, belt 36 on the belt pulley is sleeved on 35 li of the belt grooves of the driving shaft of rotation hemisphere, in the bottom of the driving shaft 33 of rotation hemisphere one spring bearing, 19 bases is arranged; Be provided with on the top of the driving shaft of rotation hemisphere one with 31 of the angled eccentric taper roll bearings of horizontal plane, rotation hemisphere 16 supports the axis of rotation 17 through hollow shape and is fixed in the taper roll bearing; One side of rotation hemisphere driving shaft upper end fixedly connected a suspension arm support ring 20, last fixedly connected the pipeline hanging ring 25 of suspension arm support ring; Rotation hemisphere driving shaft upper end opposite side connects a rolling bevel gear 22 by gear shaft 32 through bearing 19, an annular bevel gear 23 is arranged at the bottom of rolling bevel gear, the rolling bevel gear is meshed with annular fixedly bevel gear, and annular bevel gear bottom is connected on the fixed support 28; The top of rolling bevel gear is meshed with the annular rotation hemisphere gear 18 of rotation hemisphere bottom; Top in the rotation hemisphere has slip-knot card 26 connecting disc type centrifuge container 30; Be equipped with a colour comparatour pick off 4 near the centre bit in the rotation hemisphere, the colour comparatour pick off is fixed on the colour comparatour bar 34, and the colour comparatour bar is fixedly connected on the support 28, and the colour comparatour pick off is connected with the colorimetric analysis controller.
This multidirectional centrifuge type seriality blood constituent disc type centrifuge container separation equipment, its blood tube bank bundle 5 that is placed on the centrifuge container has " S " types counter-rotating bent angle of preventing its distortion; " S " type counter-rotating bent angle of distortion is with loudspeaker ring 27 respectively by two corners of conduit bundles and pipeline hanging ring 25 forms; On centrifugation apparatus, have several blood flow controls speed pump 1, when the fast pump rolling disc rotation of control, utilize scroll wheel on the circumference, to reach the control of blood flow to, flow velocity to the blood conduit extruding of rolling; The interior radius of its centrifuge container is a wheelbase of collecting respective liquid, and wheelbase Yu is long, complete, the purity Yu's height of various compositions collection Yu of blood.
The control system of this multidirectional centrifuge type arrangement for continuous separating blood components, by the colorimetric analysis instrument granular size, concentration, air in the blood are implemented monitoring and send corresponding signal through automatic control system and corresponding control software and systems soft ware, to the setting of the calculating of various corresponding blood constituent fractional doses, equipment operation, program, rotary speed and direction, control speed pump and the instruction of the opening and closing of pipe clamp automatically of each motor, to the control of each parts and working procedure, to reach the flow direction and the flow velocity of control blood.
More than two kinds of multidirectional centrifuge type arrangement for continuous separating blood components when using, before gathering blood, one pipeline equipment at first is installed in multidirectional centrifuge type seriality blood constituent equipment, the feedback pipeline after the blood air bag 9 is not installed in the fast pump V1 of control for the time being; When the indication starting device, control fast pump I entry into service, other respectively control fast pump, the automatic pipeline card all is in closed condition; After treating that promoting the circulation of blood liquid is gathered syringe needle 10 punctures, indication beginning again, i.e. system's entry into service.
When system turned round, at first swivel becket began to rotate, automatic pipeline card 2 and control fast pump II, III and start simultaneously and open, and speed is identical.Centrifugal in blood automatic stream ball formula centrifuge container 12 or the disc type centrifuge container, air is also along with being transferred in the blood air bag; The colorimetric analysis instrument will detect ball formula or disc type centrifuge container central spot constantly, according to the result who is monitored, send corresponding signal to corresponding software; After software processes, send instruction, the running of control entire equipment; After treating long-pending full centrifugal globe of blood or centrifugal pan, just can in the blood air bag, shift from the centrifugal globe central point; By the time collection is deposited blood volume when a certain amount of in the blood plasma air bag, manually feed back the puncture of blood again; After finishing the puncture that feeds back syringe needle 11, open manual pipeline folder 23 immediately, start the fast pump V of control simultaneously and rotate, this time control speed pump V gathers blood in the blood air bag; Operator push the pipeline after the blood plasma air bag simultaneously, assist ducted air emptying, make blood gush full blood plasma air bag feedback pipeline afterwards; When the blood of feedback pipeline extraction, after blood converges in the blood plasma air bag, operator will indicate the fast pump V of control to turn to backward rotation rapidly, and its velocity of rotation is equal to the fast pump II of control; The equipment operation of external circulating system will move according to the program that configures in advance, and will be promptly different according to required collection blood constituent, and indication is carried out according to corresponding program, and equipment is just controlled voluntarily and respectively controlled fast pump, the operation of pipeline, control system automatically; Generally all be ascending according to blood specific gravity, promptly blood plasma, platelet, leukocyte, erythrocyte, young erythrocytic sequencing are collected in the blood component collection bag a certain section blood constituent.
When desired blood component is begun to collect, to control fast pump III and close immediately automatically, automatic pipeline card 1 is opened immediately, and composition blood will be advanced in the component blood collecting bag 8 by the pressure in centrifugal globe or the centrifugal pan; Detect the granule of super scope when the colorimetric analysis instrument, when reaching finite concentration, the ball formula or the disc type centrifuge container centre bit of the blood constituent absorption mouth of pipe 14 are described, occupied by the composition of next aspect, this moment, control system will indicate automatic pipeline card 1 to close, control fast pump III immediately to open immediately, blood is shifted in the blood plasma air bag; When the colorimetric analysis instrument monitors erythrocyte or erythrocyte when reaching finite concentration, this moment, erythrocyte was full of, control fast pump IV and 3 unlatchings of automatic pipeline card, erythrocyte is shifted in the blood plasma air bag, the control velocity of blood flow equals to control the speed of fast pump II constantly, close the fast pump III of control simultaneously, be to calculate according to circulation volume such duration of runs, be circulating load be less than the packed cell volume ratio of donating blood add 1 multiply by again in ball formula or the disc type centrifuge container actual when holding blood volume, control fast pump III and open, control fast pump IV and close; The blood plasma of centre bit is transferred again in the blood plasma air bag, begins new one immediately and takes turns blood collection, collection process; With regard to carry out repeatedly by this way, repeatedly process, can finish the aequum of collecting blood constituent.
When finishing the collecting amount of desired blood component, program gives the alarm, and this moment, program can be in running simultaneously at the fast pump I of control, II, IV, V, and automatic pipeline card 3 is opened, control fast pump III and be under the closed condition and turn round, whole system has formed simple blood extracorporeal circulation situation; Operator's end operation is finished blood separation work.
Claims (6)
1, a kind of multidirectional centrifuge type arrangement for continuous separating blood components is characterized in that: comprising: blood extracorporeal circulation system, multidirectional centrifugal slewing; It connects centrifuge container (12,30) by gathering syringe needle (10) by pipeline; Blood flow process tubing places multidirectional centrifugal slewing; Blood flow process pipeline (6) is controlled fast pump (1) by in the centrifugal slewing several and is compressed connection; Centrifuge container places the rotation hemisphere (16) of centrifugal slewing, and the main drive shaft of rotation hemisphere and centrifugal slewing (33) is fixedly connected, and in the time of with the rotation of driving shaft, rotation hemisphere has the track track of its rotation; By colour comparatour pick off (4) signal of sensing is transferred to corresponding control system through multidirectional rotating centrifugal separate blood composition, centrifuge container (12) one outfans are by pipeline coordinator blood collecting bag (8), another outfan connects blood air bag (9) by pipeline, and blood air bag (9) connects feedback syringe needle (11) by pipeline.
2, a kind of multidirectional centrifuge type arrangement for continuous separating blood components according to claim 1, it is characterized in that: an end of the whole airtight pipeline of blood extracorporeal circulation system connects gathers syringe needle (10), gather syringe needle by flexible pipe (6) and the first manual pipeline card (3) and the anti-soft pipe connection of doubting agent bag (7) that prevents blood coagulation, be mixed with anti-blood inlet pipe (13) of doubting blood conduit connection centrifuge container inwall one side of agent, opposite side at its centrifuge container inwall has erythrocyte outlet (15), and the outlet of erythrocyte pipe is communicated with component blood collecting bag (8) and blood air bag (9); The collection blood constituent blood outlet (14) of centrifuge container center is communicated with component blood collecting bag and blood air bag; Blood air bag outfan links through the second manual pipeline by pipeline and leads to the blood recovery syringe needle.
3, a kind of multidirectional centrifuge type arrangement for continuous separating blood components according to claim 1 is characterized in that: centrifugation apparatus is provided with several blood flow control speed pumps (1) that blood conduit (6) is rolled and pushes.
4, a kind of multidirectional centrifuge type arrangement for continuous separating blood components according to claim 1, it is characterized in that: multidirectional centrifugal slewing is a ball formula centrifuge container separation equipment, driving shaft (33) by the rotation hemisphere of motor (24) output shaft and separation equipment is fixedly connected, the driving shaft of rotation hemisphere is hollow structure, pass hollow actuating shaft two spring bearings (19) are arranged, passing spring bearing has a gear shaft (32), and respectively there is a rolling bevel gear (22) at the two ends of gear shaft; The gear shaft middle part is provided with the travelling gear (21) that is meshed and is connected with rotation hemisphere gear (18), and the rolling bevel gear at gear shaft two ends is meshed with the annular bevel gear (23) of bottom and is connected, and annular bevel gear is fixed on the support (28); There is a support ring (20) the driving shaft upper end of rotation hemisphere, and a side of support ring has spring bearing (19), and spring bearing is by supporting the axis of rotation (17) fixedly connected rotation hemisphere (16); Its ball formula centrifuge container (12) places in the centrifugal hemisphere of rotation, and is fixed on the centrifugal hemisphere of rotation by slip-knot card (26); The opposite side of support ring is being fixed the hanging ring (25) that blood conduit is pricked in a tube bank, the top of hanging ring has one to make blood conduit not produce the fixedly loudspeaker ring (27) of distortion, and the top of loudspeaker ring also is provided with a colour comparatour pick off (4) facing to blood conduit and is connected on the fixed station (29); The colour comparatour pick off through the colorimetric analysis instrument with control blood flow to being connected with the circuitry of flow velocity.
5, a kind of multidirectional centrifuge type arrangement for continuous separating blood components according to claim 1, it is characterized in that: multidirectional centrifugal slewing is a disc type centrifuge container separation equipment, be connected with belt pulley (37) by motor (24) output shaft, the belt sleeve of belt pulley (37) is contained in belt grooves (35) lining of the driving shaft of rotation hemisphere, in the bottom of the driving shaft (33) of rotation hemisphere one spring bearing (19) base is arranged; Be provided with on the top of the driving shaft of rotation hemisphere one with the angled eccentric taper roll bearing of horizontal plane (31) seat, rotation hemisphere (16) supports the axis of rotation (17) through hollow shape and is fixed in the taper roll bearing; One side of rotation hemisphere driving shaft upper end fixedly connected a suspension arm support ring (20), fixedly connected pipeline hanging ring (25) on the suspension arm support ring; Rotation hemisphere driving shaft upper end opposite side connects a rolling bevel gear (22) by gear shaft (32) through bearing (19), fixedly bevel gear (23) of an annular is arranged at the bottom of rolling bevel gear, the rolling bevel gear is meshed with annular fixedly bevel gear, and annular bevel gear bottom is connected on the fixed support (28); The top of rolling bevel gear is meshed with the annular rotation hemisphere gear (18) of rotation hemisphere bottom; Top in the rotation hemisphere has slip-knot card (26) connecting disc type centrifuge container (30); Be equipped with a colour comparatour pick off (4) near the centre bit in the rotation hemisphere, the colour comparatour pick off is fixed on the colour comparatour support bar (34), the colour comparatour support bar is fixedly connected on the support (28), the colour comparatour pick off through the colorimetric analysis instrument with control blood flow to being connected with the circuitry of flow velocity.
6, a kind of multidirectional centrifuge type arrangement for continuous separating blood components according to claim 5 is characterized in that: " S " type counter-rotating bent angle that (5) have anti-its distortion is pricked in its blood tube bank that is placed on the centrifuge container; " S " type counter-rotating bent angle of distortion is with loudspeaker ring (27) and pipeline hanging ring (25) respectively by two corners of conduit bundles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100178700A CN100467075C (en) | 2005-08-09 | 2005-08-09 | A multidirectional centrifuge type arrangement for continuous separating blood components and method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100178700A CN100467075C (en) | 2005-08-09 | 2005-08-09 | A multidirectional centrifuge type arrangement for continuous separating blood components and method |
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| CN1736497A CN1736497A (en) | 2006-02-22 |
| CN100467075C true CN100467075C (en) | 2009-03-11 |
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| CNB2005100178700A Expired - Fee Related CN100467075C (en) | 2005-08-09 | 2005-08-09 | A multidirectional centrifuge type arrangement for continuous separating blood components and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101298008B (en) * | 2008-01-14 | 2012-10-03 | 经建中 | Pipe coil structure applied on mixed liquid continuous centrifugal separation system |
| MX341634B (en) | 2010-03-18 | 2016-08-08 | Syngen Inc | System for purifying certain cell populations in blood or bone marrow by depleting others. |
| EP2500095A1 (en) | 2011-03-15 | 2012-09-19 | Siemens Healthcare Diagnostics Products GmbH | Method and devices for determining the platelet function in a centrifugal analyser |
| CN104014005A (en) * | 2014-05-08 | 2014-09-03 | 西南交通大学 | Blood component separating device |
| CN109876495B (en) * | 2019-03-27 | 2024-03-19 | 刘忠英 | Component separating device |
| CN117505098B (en) * | 2023-12-29 | 2024-04-30 | 天津芥子生物技术有限公司 | Control method and system for multidimensional track position adjustment and track system |
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