CN105147984A - Pharmaceutical preparation for treating children cough variant asthma - Google Patents
Pharmaceutical preparation for treating children cough variant asthma Download PDFInfo
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- CN105147984A CN105147984A CN201510655328.1A CN201510655328A CN105147984A CN 105147984 A CN105147984 A CN 105147984A CN 201510655328 A CN201510655328 A CN 201510655328A CN 105147984 A CN105147984 A CN 105147984A
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Abstract
The invention belongs to the field of Chinese herbal preparations, and particularly provides a pharmaceutical preparation for treating children cough variant asthma. The pharmaceutical preparation is prepared from the following raw materials in parts by weight: 20 parts of blumea lacera DC, 15 parts of odontites vulgaris Moench, 16 parts of sedum leucocarpum Franch., 25 parts of diphasiastrum complanatum (L.) Holub.[Lycopodium complanatum L., 15 parts of honeysuckle, 18 parts of shizandra berry, 25 parts of radix platycodonis, 20 parts of figwort root, 25 parts of Chinese angelica, 25 parts fo angelica dahurica, 20 parts of mint, 25 parts of radix scutellariae, 20 parts of Chinese pulsatilla root, 15 parts of herba schizonepetae, 25 parts of purple perilla, 20 parts of dwarf lilyturf turber, 25 parts of pardanthus, 15 parts of cape jasmine fruit, and 5 parts of radix glycyrrhizae. The pharmaceutical preparation provided by the invention can treat children cough variant asthma.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of cough variant asthma in childhood: prednison comparing and its preparation method and application.
Background technology
Destroy the integrity of airway mucus epithelium by bringing out air flue infective inflammation after childhood infection Respirovirus, weaken the defence capability of air flue to stimulus object, and cause the inflammatory reaction in air flue, enhance inflammatory cell to the sensitivity of IgE and reactivity, virus can be used as the allergic immune reaction that anaphylactogen causes body, immune stimulatory cell produces too much IgE antibody, this IgE antibody is referred to as again " irritated memory thing ", as (mastocyte on the easy immune defense cells being attached to human body for a long time, eosinophilic granulocyte etc.), Respirovirus and antibacterial to be combined with IgE antibody as anaphylactogen and to form " Ag-Ab " product, this product stimulates mastocyte, the nonspecific inflammatory medium of the supersecretions such as eosinophilic granulocyte, act on partes corporis humani position mucosa to cause: airway contraction, respiratory secretions increases, increase the weight of airway constriction, cause asthma attack or exacerbate asthma.For this reason, be bursting to and develop the needs that more medicines for the treatment of cough variant asthma in childhood: prednison comparing safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cough variant asthma in childhood: prednison comparing disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of cough variant asthma in childhood: prednison comparing, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Blumeae Lacerae 20 parts, Herba Odontitis serotinae 15 parts, Hemerocallis citrina Baroni Herba Sedi Leucocarpi 16 parts, Caulis Entadae 25 parts, Flos Lonicerae 15 parts, Fructus Schisandrae Chinensis 18 parts, Radix Platycodonis 25 parts, Radix Scrophulariae 20 parts, Radix Angelicae Sinensis 25 parts, the Radix Angelicae Dahuricae 25 parts, Herba Menthae 20 parts, Radix Scutellariae 25 parts, the Radix Pulsatillae 20 parts, Herba Schizonepetae 15 parts, Folium Perillae 25 parts, Radix Ophiopogonis 20 parts, Rhizoma Belamcandae 25 parts, Fructus Gardeniae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of cough variant asthma in childhood: prednison comparing, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of cough variant asthma in childhood: prednison comparing, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment cough variant asthma in childhood: prednison comparing medicine being used for the treatment of cough variant asthma in childhood: prednison comparing.
Herba Blumeae Lacerae is the herb that Compositae Herba Blumeae Balsamiferae platymiscium is shown in white yellow BlumealaceraDC..Spring and summer is gathered, and clean chopping is dried, or fresh leaf.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.
Herba Odontitis serotinae, Latin is called OdontitesvulgarisMoench, Scrophulariaceae Bartsia annual herb, high 20-70cm.Herb is lied prostrate by towel and the raw thin bristle of white.Stem top branch, four prismatics.Leaf to life, the alternate on top sometimes; Stockless; Blade lanceolar is to strip lanceolar, and it is raw that fringe closes inflorescence top; The florescence 7-8 month.Heat clearing and damp drying, cooling blood and relieving pain.For hot infectious disease, liver and gall stagnant heat, blood stasis is had a pain.The present invention is with all herbal medicine.
Hemerocallis citrina Baroni Herba Sedi Leucocarpi is Crassulaceae sengreen Hemerocallis citrina Baroni Herba Sedi Leucocarpi SedumleucocarpumFranch., with all herbal medicine.Autumn adopts, and dries or using fresh herb, heat clearing and inflammation relieving, and for hepatitis, otitis media is controlled in external, burn and scald.
Caulis Entadae is herb or the spore of lycopsid bar helictite, Latin plant name: Diphasiastrumcomplanatum (L.) Holub. [LycopodiumcomplanatumL., treatment summer-heat dysentery, Sunstroke generates heat; dysuria, acute toothache, infantile measles; External treatment sores ulceration of skin pyretic toxicity, erysipelas, flies infections skin ulcer, flies Serpentis ovum.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, children's's shape gas does not fill, skin is weak, lung kidney is tender and lovely, excessive QI is easily made repeatedly to attack table, impairment of dispersing and descending function of the lung, air flue contraction is anxious to be sent out as cough, having coughed for a long time is impairment of the kidney, failure of the kidney in receiving QI, must cause eventually and breathe heavily, cough as at the beginning of breathing heavily, breathe heavily for cough very, though cough variant asthma in childhood: prednison comparing is without obvious wheezing symptoms, but with typical asthma has common pathophysiological basis, Herba Blumeae Lacerae of the present invention, Herba Odontitis serotinae, Hemerocallis citrina Baroni Herba Sedi Leucocarpi, Caulis Entadae, Flos Lonicerae, Fructus Schisandrae Chinensis, Radix Platycodonis, Radix Scrophulariae heat-clearing and toxic substances removing, nourishing the lung to arrest cough is monarch drug, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Herba Menthae, Radix Scutellariae, the Radix Pulsatillae, Herba Schizonepetae, Folium Perillae, Radix Ophiopogonis, Rhizoma Belamcandae, Fructus Gardeniae reinforcing spleen and kidney, wind-dispelling heat-dissipating is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, treatment cough variant asthma in childhood: prednison comparing successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Blumeae Lacerae 20g, Herba Odontitis serotinae 15g, Hemerocallis citrina Baroni Herba Sedi Leucocarpi 16g, Caulis Entadae 25g, Flos Lonicerae 15g, Fructus Schisandrae Chinensis 18g, Radix Platycodonis 25g, Radix Scrophulariae 20g, Radix Angelicae Sinensis 25g, Radix Angelicae Dahuricae 25g, Herba Menthae 20g, Radix Scutellariae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Folium Perillae 25g, Radix Ophiopogonis 20g, Rhizoma Belamcandae 25g, Fructus Gardeniae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Blumeae Lacerae 20g, Herba Odontitis serotinae 15g, Hemerocallis citrina Baroni Herba Sedi Leucocarpi 16g, Caulis Entadae 25g, Flos Lonicerae 15g, Fructus Schisandrae Chinensis 18g, Radix Platycodonis 25g, Radix Scrophulariae 20g, Radix Angelicae Sinensis 25g, Radix Angelicae Dahuricae 25g, Herba Menthae 20g, Radix Scutellariae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Folium Perillae 25g, Radix Ophiopogonis 20g, Rhizoma Belamcandae 25g, Fructus Gardeniae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Blumeae Lacerae 20g, Herba Odontitis serotinae 15g, Hemerocallis citrina Baroni Herba Sedi Leucocarpi 16g, Caulis Entadae 25g, Flos Lonicerae 15g, Fructus Schisandrae Chinensis 18g, Radix Platycodonis 25g, Radix Scrophulariae 20g, Radix Angelicae Sinensis 25g, Radix Angelicae Dahuricae 25g, Herba Menthae 20g, Radix Scutellariae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Folium Perillae 25g, Radix Ophiopogonis 20g, Rhizoma Belamcandae 25g, Fructus Gardeniae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment cough variant asthma in childhood: prednison comparing of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation cough variant asthma in childhood: prednison comparing case 50 example, 1 ~ 9 years old age.The shortest person of the course of disease 1 month, most elder reaches 1 year.
4.2 diagnostic criterias: the CVA diagnostic criteria [1] of formulating with reference to national During Prevention of Asthma in Children cooperative groups in 1998. (1) persistent cough or cough recurrent exerbation > January, to be everlasting night or ictal cough in early morning, few expectorant, after motion, meet cold air, smell characteristic odor after cough and increase the weight of.(2) without infecting sign, invalid through long-time antibiotic therapy.(3) trachea expanding agent diagnostic treatment can make cough alleviate.(4) a guy's allergies and family's allergies, Allergic skin test is positive, and air flue is high response feature, and the brinchial provocation test positive can be used as auxiliary diagnosis.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: with reference to " Chinese medical disease Standardization of diagnosis and curative effect ": recovery from illness: treat 1 ~ 2 course for the treatment of, cough, cough up phlegm, the transference cure such as watery nasal discharge, and in 1 year, symptom has no repeatedly; Effective: through treating 2 ~ 3 courses for the treatment of, coughing, coughing up phlegm, watery nasal discharge is clearly better, in 1 year, symptom has repeatedly, again adds and subtracts treatment, and symptom disappears completely, observe 1 year without repeatedly.Invalid: after 3 ~ 4 courses for the treatment of, clinical symptoms is still without improvement, even increases the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 25 | 8 | 16 | 1 | 96 |
| Blank group | 25 | 1 | 0 | 24 | 4 |
Visible, the medicine that the present invention obtains can safe and effective treatment cough variant asthma in childhood: prednison comparing, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of cough variant asthma in childhood: prednison comparing, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Blumeae Lacerae 20 parts, Herba Odontitis serotinae 15 parts, Hemerocallis citrina Baroni Herba Sedi Leucocarpi 16 parts, Caulis Entadae 25 parts, Flos Lonicerae 15 parts, Fructus Schisandrae Chinensis 18 parts, Radix Platycodonis 25 parts, Radix Scrophulariae 20 parts, Radix Angelicae Sinensis 25 parts, the Radix Angelicae Dahuricae 25 parts, Herba Menthae 20 parts, Radix Scutellariae 25 parts, the Radix Pulsatillae 20 parts, Herba Schizonepetae 15 parts, Folium Perillae 25 parts, Radix Ophiopogonis 20 parts, Rhizoma Belamcandae 25 parts, Fructus Gardeniae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of cough variant asthma in childhood: prednison comparing as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of cough variant asthma in childhood: prednison comparing as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment cough variant asthma in childhood: prednison comparing medicine of cough variant asthma in childhood: prednison comparing according to claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102973863A (en) * | 2012-12-28 | 2013-03-20 | 李佃场 | Chinese herbal medicine composition for relieving a cough of children and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102973863A (en) * | 2012-12-28 | 2013-03-20 | 李佃场 | Chinese herbal medicine composition for relieving a cough of children and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 魏肖云等: "汪受传教授从风论治小儿咳嗽变异型哮喘经验", 《中华中医药杂志（员中国医药学报）》 * |
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