CN104435951A - Anti-hypoxia traditional Chinese medicine - Google Patents
Anti-hypoxia traditional Chinese medicine Download PDFInfo
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- CN104435951A CN104435951A CN201410633375.1A CN201410633375A CN104435951A CN 104435951 A CN104435951 A CN 104435951A CN 201410633375 A CN201410633375 A CN 201410633375A CN 104435951 A CN104435951 A CN 104435951A
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses an anti-hypoxia traditional Chinese medicine. The anti-hypoxia traditional Chinese medicine is prepared from the following medicinal raw materials including roots of balsamiferou blumea, roots of wintersweet, fruits of Japense calangal and roots of redflower peasthrub. The anti-hypoxia traditional Chinese medicine is prepared into granules by using a water extraction method and is capable of remarkably improving the anti-hypoxia capability.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of anti-hypoxia Chinese medicine.
Background technology
Oxygen and hypoxia are the most important key factors of vital movement, are the important topics of life sciences basic theories.Long-term hypoxia is the important hidden danger be detrimental to health, and severe patient can threat to life.Therefore, hypoxia causes the heart, brain and respiratory system equivalent damage to become one of 21 century medical circle subject matter anxious to be resolved.
Summary of the invention
For above-mentioned prior art, the object of the present invention is to provide a kind of anti-hypoxia Chinese medicine.
Technical scheme: a kind of Chinese medicine of anti-hypoxia, is extracted by the compatibility of drugs of following weight portion and is prepared from: Radix Blumeae Balsamiferae 12g, Radix Chimonanthi praecocis 12g, Fructus Alpinia Japanicae 12g, Radix Caraganae Roseae 12g, Herba Anaphalidis Margaritaceae 12g, Rhizoma Polygoni Paleachi 12g, Herba Pellioniae 12g, Herba Hyperici Patuli 12g, Herba Passiflorae Cupiformis 12g, Herba Stephaniae Longae 12g, Fructus Querci Liaotungensis 12g, Herba lysimachiae capillipedis 12g, Radix phoebes sheareri 12g, Herba pycnosporae lutescentis 12g.
The application of Chinese medicine in antioxygen medicine of described anti-hypoxia.
Radix Blumeae Balsamiferae is the root of feverfew Herba Blumeae Balsamiferae, has effect of dispel the wind detumescence, promoting blood circulation to remove blood stasis.Latin name: Blumeabalsamifera (L.) DC.
Radix Chimonanthi praecocis is the root of cohosh Radix Chimonanthi praecocis.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Control cystitis, urethritis, furuncle toxic swelling, traumatic injury, impairment caused by overstrain.
Fructus Alpinia Japanicae is the fruit of zingiberaceous plant shellflower.Many places SHENGCAO basis, 4 ~ June of florescence, really 7 ~ October of phase.Pluck when fruit is ripe, dry or oven drying at low temperature.Function cures mainly: dry temperature cold relieving, expectorant preventing the attack (or recurrence) of malaria, spleen invigorating warming the stomach.Stagnant, dyspepsia, vomiting and diarrhoea is interrupted for trusted subordinate's cold type of pain, distension and fullness of the chest and abdomen, expectorant.
Radix Caraganae Roseae is the root of leguminous plant Radix Caraganae Roseae.Spleen invigorating, kidney tonifying, stimulates the menstrual flow, diuresis, treats deficient consumptive fever, cough, stranguria with turbid discharge, sexual impotence, metrorrhagia, leucorrhea, and breast is few, uterine prolapse.
Herba Anaphalidis Margaritaceae is the fragrant blue or green whole herb with root of feverfew.Clearing away heat-fire, dampness.Control haematemesis, dysentery, toothache, acute mastitis, scrofula is stolen.
Rhizoma Polygoni Paleachi is the rhizome of polygonaceae plant Rhizoma Polygoni Paleachi.Loose blood hemostasis, therapeutic method to keep the adverse QI flowing downwards pain relieving.Control chronic gastritis, taste-blindness rate, food stagnation, lump in the abdomen, menoxenia, edema, traumatic injury, traumatic hemorrhage.
Herba Pellioniae is Urticaceae Herba Pellioniae platymiscium Herba Pellioniae Pellionia radicans (Sieb.et Zucc.) Wedd., with all herbal medicine.The spring and summer autumn gathers, using fresh herb or dry.Blood stasis dispelling, detumescence, removing toxic substances, pain relieving.Swell and ache for dampening, toothache, furuncle, venom.
Herba Hyperici Patuli is Hypericaceae hypericum Herba Hyperici Patuli Hypericum patulum Thunb., with all herbal medicine.Summer adopts browse, and autumn fruit picking is real, and Herb can be adopted the whole year, using fresh herb or dry.Heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing, antipruritic.Herb: upper respiratory tract infection, hepatitis, dysentery, nephritis.Really: metrorrhagia, epistaxis.Leaf: skin pruritus is controlled in external, impetigo.Root: ascarifuge.
Herba Passiflorae Cupiformis is the herb of Passifloraceae plant phyllotheca Herba Passiflorae Caeruleae, removing toxic substances, and hemostasis, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., analgesia.Control furuncle, injury by sword or axe is hemorrhage, eruptive disease abdominal distention cave, hematuria, nebulousurine, hemiplegia.
Herba Stephaniae Longae is Menispermaceae stephania plant Herba Stephaniae Longae Stephania longa Lour., is used as medicine with Herb.The whole year can adopt, and dries or using fresh herb.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For pyelonephritis, cystitis, chronic nephritis, enteritis, dysentery, venom; Carbuncle furuncle infections is controlled in external, suppurative otitis media.
Herba pycnosporae lutescentis is the herb of the close sub-bean of leguminous plant.Latin is called Desmodium heterophyllum (Willd.) DC., is used as medicine with Herb.Relieving stranguria by diuresis, dissipating blood stasis for subsidence of swelling.Cure mainly urinary system calculus, traumatic injury congestive edema, traumatic hemorrhage.
Herba lysimachiae capillipedis is the herb that Primulaceae Lysimachia plant carefully obstructs Herba lysimachiae capillipedis Lysimachia capillipes Hemsl..Xia Qiu gathers, and dries in the shade.Dispel the wind, cough-relieving, regulating menstruation.For cold cough, tracheitis, asthma, menoxenia, neurasthenia.
Radix phoebes sheareri is the root of canella Cortex phoebes sheareri, have invigorate blood circulation, blood stasis dispelling, circulation of qi promoting, the effect such as detumescence, can the diseases such as traumatic injury be treated or hasten parturition.
Fructus Querci Liaotungensis is the fruit of Fagaceae Quercus liaotungensis.Invigorating the spleen to arrest diarrhea, astringing to arrest bleeding.Control insufficiency of the spleen diarrhoea, bleeding hemorrhoids, proctoptosis.
Beneficial effect: energy anti-hypoxia of the present invention.
Detailed description of the invention
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of granule of the present invention
Get Radix Blumeae Balsamiferae 12g, Radix Chimonanthi praecocis 12g, Fructus Alpinia Japanicae 12g, Radix Caraganae Roseae 12g, Herba Anaphalidis Margaritaceae 12g, Rhizoma Polygoni Paleachi 12g, Herba Pellioniae 12g, Herba Hyperici Patuli 12g, Herba Passiflorae Cupiformis 12g, Herba Stephaniae Longae 12g, Fructus Querci Liaotungensis 12g, Herba lysimachiae capillipedis 12g, Radix phoebes sheareri 12g, Herba pycnosporae lutescentis 12g medical material, decoct with water 2 times, add the water yield of medical material weight 10 times at every turn, each decoction 2 hours, filter, when being concentrated to 65 DEG C, relative density is the extractum of 1.15, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 110 DEG C, leaving air temp is 85 DEG C, temperature of charge is 85 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5ml/s), add starch, granulate, make granule.
Embodiment 2: mice normal pressure asphyxia anoxia is tested
1, method:
60 kunming mices, body weight (20 ± 2) g.Be divided into 4 groups at random, gastric infusion.1st group gives 0.3% sodium carboxymethyl cellulose (CMC-Na) solution, and the 2nd group gives propranolol hydrochloride 0.03gKg
-1, pro group.3rd, 4 groups give containing CMC-Na solution of the present invention respectively, and concentration is respectively 5,10gKg
-1.After administration 50min, be placed in wide mouthed bottle and cover tightly bottle stopper (placing 5g sodica calx in bottle).Take respiratory arrest as mark, the record mouse survival time.
2, result:
Compared with Vehicle controls group, the present invention 5,10gKg
-1make the time-to-live of mice under atmospheric closed condition extend 29.46% and 41.57% respectively, difference has significance (P<0.01, P<0.05).
Embodiment 3: mice hypobaric hypoxia is tested
1, method:
40 kunming mices, body weight (20 ± 2) g.Be divided into 4 groups at random, gastric infusion.Administration group gives the present invention, and concentration is respectively 5,10gKg
-1, matched group gives 0.3%CMC-Na solution, and gavage volume is 2mlKg
-1.After 50min, administration group and matched group respectively get 5, put into decompressor, stop decompression when 26.7Kpa (be equivalent to height above sea level and be about 10000m), keep this pressure constant, when animal dead 50%, stop decompression immediately, slowly put into air, take out animal, record each group of dead and viable count, repetitive operation is to having tested.
2, result:
The present invention 5,10gKg
-1make the survival rate of mice under hypobaric hypoxia condition be increased to 70%, 80% by 30%, 20% of matched group, difference has significance (P<0.05).
Conclusion: the present invention can significantly improve survival rate and the time-to-live of asphyxia anoxia and acute decompression hypoxia mice, illustrates that the present invention has oxygen lack resistant function.
Claims (2)
1. the Chinese medicine of an anti-hypoxia, it is characterized in that, extracted by the compatibility of drugs of following weight portion and be prepared from: Radix Blumeae Balsamiferae 12g, Radix Chimonanthi praecocis 12g, Fructus Alpinia Japanicae 12g, Radix Caraganae Roseae 12g, Herba Anaphalidis Margaritaceae 12g, Rhizoma Polygoni Paleachi 12g, Herba Pellioniae 12g, Herba Hyperici Patuli 12g, Herba Passiflorae Cupiformis 12g, Herba Stephaniae Longae 12g, Fructus Querci Liaotungensis 12g, Herba lysimachiae capillipedis 12g, Radix phoebes sheareri 12g, Herba pycnosporae lutescentis 12g.
2. the application of Chinese medicine in antioxygen medicine of anti-hypoxia as claimed in claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112656826A (en) * | 2021-01-29 | 2021-04-16 | 上海和黄药业有限公司 | Myocardial cell hypoxia injury medicine and preparation method and application thereof |
| CN112675207A (en) * | 2021-01-13 | 2021-04-20 | 上海和黄药业有限公司 | Medicine suitable for protecting nerve cells and preparation and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112675207A (en) * | 2021-01-13 | 2021-04-20 | 上海和黄药业有限公司 | Medicine suitable for protecting nerve cells and preparation and application thereof |
| CN112656826A (en) * | 2021-01-29 | 2021-04-16 | 上海和黄药业有限公司 | Myocardial cell hypoxia injury medicine and preparation method and application thereof |
| CN112656826B (en) * | 2021-01-29 | 2022-03-11 | 上海和黄药业有限公司 | Myocardial cell hypoxia injury medicine and preparation method and application thereof |
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Application publication date: 20150325 |