CN105125871A - Medicine preparation for treating fatty liver - Google Patents
Medicine preparation for treating fatty liver Download PDFInfo
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- CN105125871A CN105125871A CN201510628218.6A CN201510628218A CN105125871A CN 105125871 A CN105125871 A CN 105125871A CN 201510628218 A CN201510628218 A CN 201510628218A CN 105125871 A CN105125871 A CN 105125871A
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Abstract
The invention belongs to the field of a traditional Chinese medicine preparation, and concretely provides a medicine preparation for treating fatty liver. The medicine preparation is prepared from the following ingredients: 25 parts of equisetum, 20 parts of eria graminifolia, 18 parts of spiny amarauth herb or root, 15 parts of dicranostigma leptopodum, 25 parts of honeysuckle, 28 parts of artemisia capillaris, 15 parts of salvia miltiorrhiza, 15 parts of schisandra chinensis, 20 parts of glossy privet fruit, 25 parts of eclipta, 20 parts of golden cypress, 15 parts of folium mori and 5 parts of liquorice. The medicine preparation can be used for treating the fatty liver.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of fatty liver and its preparation method and application.
Background technology
Fatty liver refers to the pathological changes due to overheap fatty in the hepatocyte that a variety of causes causes.The health of the positive serious threat compatriots of fatty liver disease, becomes the second largest hepatopathy being only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.Fatty liver is a kind of common clinical picture, but not one independently disease.The lighter is asymptomatic in its clinical manifestation, and the severe one state of an illness is violent.Generally speaking, fatty liver belongs to reversibility disease, and early diagnosis also treatment in time often can recover normal.For this reason, be bursting to and develop the needs that more medicines for the treatment of fatty liver safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of Fatty Liver Disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of fatty liver, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: Herba Equiseti Arvinsis 25 parts, Eria graminifolia Lindl. 20 parts, Amaranthus spinosus L. 18 parts, rein in the horse back 15 parts, Flos Lonicerae 25 parts, Herba Artemisiae Scopariae 28 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 20 parts, Herba Ecliptae 25 parts, Cortex Phellodendri 20 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of fatty liver, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of fatty liver, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment fatty liver medicament being used for the treatment of fatty liver.
Herba Equiseti Arvinsis, Latin is called Equisetumarvense), herbaceos perennial, Equisetales, Equisetaceae, Equisetum, nature and flavor: bitter, cool.Heat clearing away, removing heat from blood, cough-relieving, diuresis.Control epistaxis, spit blood, spitting of blood, has blood in stool, metrorrhagia, traumatic hemorrhage, cough and asthma, gonorrhea, conjunctivitis.Aerial parts (Herba Equiseti Arvinsis) is bitter, puckery, cool.Clearing away heat and promoting diuresis, hemostasis, suppressing the hyperactive liver improving eyesight, relieving cough and asthma.For nose nephew, enterorrhagia, spitting of blood, hemorrhoid hemorrhage, menorrhagia, stranguria, fracture, cough with asthma, conjunctival congestion and swelling pain.The present invention is with all herbal medicine.
Eria graminifolia Lindl. is the orchid family hair orchid platymiscium Eria graminifolia Lindl. EriagraminifoliaLindl., with all herbal medicine.7 ~ August gathers, and clean cutting is dried.Stomach reinforcing, promotes the production of body fluid.For consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, achlorhydria.
Amaranthus spinosus L. is dry herb or the root of amaranthaceous plant Amaranthusspinosus L. AmaranthusspinosusL..Summer, autumn gather, and removing silt, dries or take advantage of fresh-cut section, dry.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis.For dysentery, enteritis, taste-blindness rate is hemorrhage, hemorrhoidal hemorrhage; Venom is controlled in external, skin eczema, furuncle and phyma pus infections.The present invention is with all herbal medicine.
Reining in the horse back is Scrophulariaceae brooklime Veronica linariifolia VeronicalinariifoliaPall.exLinksubsp.Dilatata (NakaietKitag.) Hong, with ground all herbal medicine.Extract herb when stem and leaf is in great numbers, cutting is dried or using fresh herb.Lung heat clearing, reduces phlegm, cough-relieving, removing toxic substances.For chronic tracheitis, pulmonary suppuration disease, coughs vomiting bloody pus; Hemorrhoid are controlled in external, skin eczema, and rubella is scratched where it itches, furuncle carbuncle skin infection.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, fatty liver is this mainly with qi depression to blood stasis, take dampness-heat in the liver and gallbladder as mark, Herba Equiseti Arvinsis of the present invention, Eria graminifolia Lindl., Amaranthus spinosus L., rein in the horse back, Flos Lonicerae, Herba Artemisiae Scopariae heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating be monarch drug, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Herba Ecliptae, Cortex Phellodendri, Folium Mori blood circulation promoting and blood stasis dispelling are ministerial drug, Radix Glycyrrhizae is adjuvant, full side compatibility mutually, treatment fatty liver successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Equiseti Arvinsis 25g, Eria graminifolia Lindl. 20g, Amaranthus spinosus L. 18g, rein in the horse back 15g, Flos Lonicerae 25g, Herba Artemisiae Scopariae 28g, Radix Salviae Miltiorrhizae 15g, Fructus Schisandrae Chinensis 15g, Fructus Ligustri Lucidi 20g, Herba Ecliptae 25g, Cortex Phellodendri 20g, Folium Mori 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Equiseti Arvinsis 25g, Eria graminifolia Lindl. 20g, Amaranthus spinosus L. 18g, rein in the horse back 15g, Flos Lonicerae 25g, Herba Artemisiae Scopariae 28g, Radix Salviae Miltiorrhizae 15g, Fructus Schisandrae Chinensis 15g, Fructus Ligustri Lucidi 20g, Herba Ecliptae 25g, Cortex Phellodendri 20g, Folium Mori 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Equiseti Arvinsis 25g, Eria graminifolia Lindl. 20g, Amaranthus spinosus L. 18g, rein in the horse back 15g, Flos Lonicerae 25g, Herba Artemisiae Scopariae 28g, Radix Salviae Miltiorrhizae 15g, Fructus Schisandrae Chinensis 15g, Fructus Ligustri Lucidi 20g, Herba Ecliptae 25g, Cortex Phellodendri 20g, Folium Mori 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment fatty liver of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation fatty liver 80 cases, 45 ~ 67 years old age.The shortest person of the course of disease 4 months, most elder reaches 5 years.
4.2 diagnostic criterias: all possess following 1st ~ 5 and the 6th or the 7th any one person and can be diagnosed as non-alcoholic fatty liver disease.1. there is susceptible factor as obesity, type 2 diabetes mellitus, hyperlipemia and women etc.; 2. without history of drinking history or drink and amount to ethanol amount < 40g weekly; 3. viral hepatitis, drug-induced liver disease, Wilson disease, total parenteral nutrition and autoimmune liver disease etc. except; 4., except protopathy clinical manifestation, the symptoms such as weak, dull pain in liver can be there is, hepatosplenomegaly can be accompanied; 5. serum transaminase can raise, and based on ALT, can increase with GGT, ferritin and uric acid etc.; 6. liver histological has typical performance; 7. there is imaging diagnosis foundation.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: cure: cardinal symptom disappearance, hepatomegaly disappears or retraction, and hepatic region is without obvious tenderness or percussion pain, and liver function is normal, and normally, blood fat is tending towards normal or obviously improves, weight loss for ultrasonic echo figure and ultrasonogram.Effective: cardinal symptom disappears substantially, hepatomegaly is recovered to some extent, and ultrasonoscopy is clearly better, and blood fat makes moderate progress, and body weight declines to some extent.Invalid: symptom, sign, chemical examination, ultrasonoscopy and body weight are without changer.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
Treatment group | 40 | 14 | 23 | 3 | 92.5 |
Blank group | 40 | 1 | 1 | 38 | 5 |
Visible, the medicine that the present invention obtains can safe and effective treatment fatty liver, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of fatty liver, it is characterized in that, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: Herba Equiseti Arvinsis 25 parts, Eria graminifolia Lindl. 20 parts, Amaranthus spinosus L. 18 parts, rein in the horse back 15 parts, Flos Lonicerae 25 parts, Herba Artemisiae Scopariae 28 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 20 parts, Herba Ecliptae 25 parts, Cortex Phellodendri 20 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of fatty liver as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of fatty liver as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment fatty liver medicament of fatty liver according to claim 1.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850217A (en) * | 2006-01-28 | 2006-10-25 | 吉林敖东药业集团延吉股份有限公司 | Compounded preparation for treating fatty liver and preparing method |
CN102488850A (en) * | 2011-12-31 | 2012-06-13 | 黄文珍 | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof |
CN104740541A (en) * | 2015-04-21 | 2015-07-01 | 杨波 | Health-care traditional Chinese medicine powder for protecting liver, detoxifying and recovering liver functions |
CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1850217A (en) * | 2006-01-28 | 2006-10-25 | 吉林敖东药业集团延吉股份有限公司 | Compounded preparation for treating fatty liver and preparing method |
CN102488850A (en) * | 2011-12-31 | 2012-06-13 | 黄文珍 | Traditional Chinese medicinal composition for treating alcoholic fatty liver and preparation method thereof |
CN104740541A (en) * | 2015-04-21 | 2015-07-01 | 杨波 | Health-care traditional Chinese medicine powder for protecting liver, detoxifying and recovering liver functions |
CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
Non-Patent Citations (1)
Title |
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廖慧: "许雪君治疗脂肪肝经验", 《湖南中医杂志》 * |
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Application publication date: 20151209 |