CN105111165A - 一种米拉贝隆的制备方法 - Google Patents
一种米拉贝隆的制备方法 Download PDFInfo
- Publication number
- CN105111165A CN105111165A CN201510578796.3A CN201510578796A CN105111165A CN 105111165 A CN105111165 A CN 105111165A CN 201510578796 A CN201510578796 A CN 201510578796A CN 105111165 A CN105111165 A CN 105111165A
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- boc
- amino
- reaction
- mirabegron
- amine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
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CN201510578796.3A CN105111165B (zh) | 2015-09-14 | 2015-09-14 | 一种米拉贝隆的制备方法 |
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CN201510578796.3A CN105111165B (zh) | 2015-09-14 | 2015-09-14 | 一种米拉贝隆的制备方法 |
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CN105111165A true CN105111165A (zh) | 2015-12-02 |
CN105111165B CN105111165B (zh) | 2017-10-31 |
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CN201510578796.3A Active CN105111165B (zh) | 2015-09-14 | 2015-09-14 | 一种米拉贝隆的制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105541750A (zh) * | 2016-03-16 | 2016-05-04 | 湖南方盛制药股份有限公司 | 一种米拉贝隆分析对照品的制备方法 |
CN106083758A (zh) * | 2016-06-20 | 2016-11-09 | 河南师范大学 | 一种米拉贝隆的高效合成方法 |
CN111440126A (zh) * | 2020-04-03 | 2020-07-24 | 湖南复瑞生物医药技术有限责任公司 | 一种米拉贝隆的制备方法 |
CN113816864A (zh) * | 2020-06-18 | 2021-12-21 | 南京正大天晴制药有限公司 | 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法 |
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CN103265457A (zh) * | 2013-05-06 | 2013-08-28 | 苏州永健生物医药有限公司 | 一种(r)-4-氨基苯乙基-(2-羟基-2-苯乙基)-氨基甲酸叔丁酯的合成方法 |
CN103864713A (zh) * | 2014-03-04 | 2014-06-18 | 江西同和药业有限责任公司 | 一种米拉贝隆的制备方法 |
CN103896872A (zh) * | 2014-04-29 | 2014-07-02 | 黑龙江大学 | 米拉贝隆的合成方法 |
CN104016877A (zh) * | 2014-06-13 | 2014-09-03 | 南京海融医药科技有限公司 | 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用 |
WO2014132270A2 (en) * | 2013-02-27 | 2014-09-04 | Msn Laboratories Limited | Process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-{[(2r)-2-hydroxy-2-phenyl ethyl]amino}ethyl)phenyl]acetamide monohydrochloride, its intermediates and polymorph thereof |
WO2015044965A1 (en) * | 2013-09-30 | 2015-04-02 | Megafine Pharma (P) Ltd. | A process for preparation of mirabegron and alpha crystalline form thereof |
CN104892427A (zh) * | 2015-05-25 | 2015-09-09 | 河南师范大学 | 一种对氨基苯乙胺的制备方法 |
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2015
- 2015-09-14 CN CN201510578796.3A patent/CN105111165B/zh active Active
Patent Citations (13)
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EP0068669A1 (en) * | 1981-06-20 | 1983-01-05 | Beecham Group Plc | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application |
US6346532B1 (en) * | 1997-10-17 | 2002-02-12 | Yamanouchi Pharmaceutical Co., Ltd. | Amide derivatives or salts thereof |
US20070123530A1 (en) * | 2002-06-14 | 2007-05-31 | Pascale Gaillard | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
WO2014132270A2 (en) * | 2013-02-27 | 2014-09-04 | Msn Laboratories Limited | Process for the preparation of 2-(2-aminothiazol-4-yl)-n-[4-(2-{[(2r)-2-hydroxy-2-phenyl ethyl]amino}ethyl)phenyl]acetamide monohydrochloride, its intermediates and polymorph thereof |
CN103304511A (zh) * | 2013-04-17 | 2013-09-18 | 苏州永健生物医药有限公司 | 一种米拉贝隆新的合成方法 |
CN103193730A (zh) * | 2013-04-17 | 2013-07-10 | 苏州永健生物医药有限公司 | 一种米拉贝隆的合成方法 |
CN103265457A (zh) * | 2013-05-06 | 2013-08-28 | 苏州永健生物医药有限公司 | 一种(r)-4-氨基苯乙基-(2-羟基-2-苯乙基)-氨基甲酸叔丁酯的合成方法 |
CN103232352A (zh) * | 2013-05-11 | 2013-08-07 | 苏州永健生物医药有限公司 | (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯 |
WO2015044965A1 (en) * | 2013-09-30 | 2015-04-02 | Megafine Pharma (P) Ltd. | A process for preparation of mirabegron and alpha crystalline form thereof |
CN103864713A (zh) * | 2014-03-04 | 2014-06-18 | 江西同和药业有限责任公司 | 一种米拉贝隆的制备方法 |
CN103896872A (zh) * | 2014-04-29 | 2014-07-02 | 黑龙江大学 | 米拉贝隆的合成方法 |
CN104016877A (zh) * | 2014-06-13 | 2014-09-03 | 南京海融医药科技有限公司 | 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用 |
CN104892427A (zh) * | 2015-05-25 | 2015-09-09 | 河南师范大学 | 一种对氨基苯乙胺的制备方法 |
Non-Patent Citations (7)
Title |
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BRIAN M ADGER ET AL: "Selective reduction of nitroarylalkylnitriles with hydrazine and a metal catalyst", 《TETRAHEDRON LETTERS》 * |
GREENE T.W.等: "《有机合成中的保护基》", 31 October 2004, 华东理工大学出版社 * |
RIE NISHIKAWA-SHIMONO ET AL: "Isoquinoline derivatives as potent CRTH2 receptor antagonists: Design, Synthesis and SAR", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
RIE NISHIKAWA-SHIMONO ET AL: "Isoquinoline derivatives as potent CRTH2 receptor antagonists: Synthesis and SAR", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
姚其正: "《药物合成反应》", 30 September 2012, 中国医药科技出版社 * |
毛龙飞 等: "米拉贝隆的合成研究", 《化学研究与应用》 * |
王永红等: "《综合化学实验》", 31 August 2009, 浙江大学出版社 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105541750A (zh) * | 2016-03-16 | 2016-05-04 | 湖南方盛制药股份有限公司 | 一种米拉贝隆分析对照品的制备方法 |
CN106083758A (zh) * | 2016-06-20 | 2016-11-09 | 河南师范大学 | 一种米拉贝隆的高效合成方法 |
CN106083758B (zh) * | 2016-06-20 | 2018-08-21 | 河南师范大学 | 一种米拉贝隆的高效合成方法 |
CN111440126A (zh) * | 2020-04-03 | 2020-07-24 | 湖南复瑞生物医药技术有限责任公司 | 一种米拉贝隆的制备方法 |
CN111440126B (zh) * | 2020-04-03 | 2023-11-28 | 湖南复瑞生物医药技术有限责任公司 | 一种米拉贝隆的制备方法 |
CN113816864A (zh) * | 2020-06-18 | 2021-12-21 | 南京正大天晴制药有限公司 | 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法 |
CN113816864B (zh) * | 2020-06-18 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法 |
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CN105111165B (zh) | 2017-10-31 |
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Effective date of registration: 20170901 Address after: 072153 Hebei city of Baoding province Mancheng District Fang Shun Qiao Xiang Tai Ping Zhuang Applicant after: Baoding Bo Yang Biotechnology Co., Ltd. Address before: 453007 Xinxiang East Road, Makino District, Henan, No. 46 Applicant before: Henan Normal University |
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CB03 | Change of inventor or designer information | ||
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Inventor after: Shao Xinguang Inventor after: Chen Jianjun Inventor after: Mao Longfei Inventor before: Li Wei Inventor before: Mao Shen Inventor before: Mao Longfei Inventor before: Jiang Yuqin Inventor before: Zhang Yingui Inventor before: Yuan Lishuang Inventor before: Xu Guiqing Inventor before: Dong Wenpei Inventor before: Jiang Tao |
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CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Wei Inventor after: Zhang Yingui Inventor after: Mao Shen Inventor after: Shao Xinguang Inventor after: Mao Longfei Inventor after: Jiang Yuqin Inventor after: Chen Jianjun Inventor after: Xu Guiqing Inventor after: Dong Wenpei Inventor after: Jiang Tao Inventor before: Shao Xinguang Inventor before: Chen Jianjun Inventor before: Mao Longfei |
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