CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

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Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
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China
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
idd
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Expired - Fee Related
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CN201380068062.XA
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English (en)
Chinese (zh)
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CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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Priority to CN201810282054.XA priority Critical patent/CN108250264A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

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CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Country Status (22)

Country Link
US (2) US9777038B2 (https=)
EP (1) EP2912013B1 (https=)
JP (1) JP6272888B2 (https=)
KR (1) KR102068381B1 (https=)
CN (2) CN105102425B (https=)
AU (1) AU2013334122B2 (https=)
BR (1) BR112015009395A2 (https=)
CA (1) CA2889592A1 (https=)
CY (1) CY1119731T1 (https=)
DK (1) DK2912013T3 (https=)
ES (1) ES2655034T3 (https=)
HK (1) HK1253301A1 (https=)
HU (1) HUE036887T2 (https=)
IL (1) IL238454B (https=)
MX (1) MX361653B (https=)
NO (1) NO2968302T3 (https=)
NZ (2) NZ707389A (https=)
PL (1) PL2912013T3 (https=)
PT (1) PT2912013T (https=)
SG (1) SG11201503247UA (https=)
SM (1) SMT201700602T1 (https=)
WO (1) WO2014066819A1 (https=)

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SG11201503247UA (en) 2012-10-26 2015-06-29 Intercept Pharmaceuticals Inc Process for preparing bile acid derivatives
SMT202000070T1 (it) * 2014-05-29 2020-03-13 Bar Pharmaceuticals S R L Derivati del colano per l'uso del trattamento e/o la prevenzione di malattie mediate da fxr e tgr5/gpbar1
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
KR102546748B1 (ko) 2014-11-19 2023-06-22 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드
KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
CN107207559B (zh) 2014-11-19 2019-10-25 Nzp英国有限公司 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
TW201628625A (zh) 2015-02-06 2016-08-16 英特賽普醫藥品公司 組合療法醫藥組成物
AU2016325619A1 (en) 2015-09-24 2018-04-12 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation bile acid derivatives
AU2016350690C1 (en) * 2015-11-06 2020-04-23 Intercept Pharmaceuticals, Inc. Methods for the preparation of obeticholic acid and derivatives thereof
US20200262865A1 (en) * 2016-02-15 2020-08-20 Alexander Khoruts Compositions and methods for treating clostridium associated diseases
WO2017180577A1 (en) 2016-04-13 2017-10-19 Intercept Pharmaceuticals, Inc. Methods of treating cancer
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
KR20190057108A (ko) * 2016-09-30 2019-05-27 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체의 결정형
CA3070837A1 (en) * 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
WO2019020067A1 (zh) * 2017-07-26 2019-01-31 正大天晴药业集团股份有限公司 甾体类衍生物fxr激动剂的制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN114144185A (zh) 2019-05-30 2022-03-04 英特塞普特医药品公司 用于治疗胆汁淤积性肝病的包含fxr激动剂和贝特类的药物组合物
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
IL295825A (en) 2020-02-28 2022-10-01 Kallyope Inc gpr40 agonists
WO2021236617A1 (en) 2020-05-19 2021-11-25 Kallyope, Inc. Ampk activators
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators
CN116249536A (zh) 2020-09-18 2023-06-09 首尔大学校产学协力团 牛磺脱氧胆酸钠的批量生产方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

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US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
ES2248581T3 (es) 2001-03-12 2006-03-16 Intercept Pharmaceuticals, Inc. Esteroides como agonistas de fxr.
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
US7932244B2 (en) * 2006-06-27 2011-04-26 Intercept Pharmaceuticals, Inc. Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
ES2774368T3 (es) * 2008-11-19 2020-07-20 Intercept Pharmaceuticals Inc Moduladores de TGR5 y métodos de uso de los mismos
SG11201503247UA (en) 2012-10-26 2015-06-29 Intercept Pharmaceuticals Inc Process for preparing bile acid derivatives

Patent Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

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Title
An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis;Norinder, Jakob等;《 Organic Letters》;20071231;第9卷(第24期);第5095-5098页 *
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
JP6272888B2 (ja) 2018-01-31
HK1253301A1 (zh) 2019-06-14
DK2912013T3 (en) 2018-01-15
BR112015009395A2 (pt) 2017-07-04
JP2015533852A (ja) 2015-11-26
US9777038B2 (en) 2017-10-03
SMT201700602T1 (it) 2018-03-08
CY1119731T1 (el) 2018-06-27
ES2655034T3 (es) 2018-02-16
US20180079776A1 (en) 2018-03-22
AU2013334122A1 (en) 2015-05-14
KR102068381B1 (ko) 2020-01-20
KR20150074062A (ko) 2015-07-01
CN108250264A (zh) 2018-07-06
MX2015005286A (es) 2015-10-29
US20150291653A1 (en) 2015-10-15
WO2014066819A1 (en) 2014-05-01
PL2912013T3 (pl) 2018-05-30
CN105102425A (zh) 2015-11-25
PT2912013T (pt) 2018-01-03
NO2968302T3 (https=) 2018-02-03
NZ745013A (en) 2019-08-30
IL238454A0 (en) 2015-06-30
CA2889592A1 (en) 2014-05-01
EP2912013A4 (en) 2016-06-01
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
EP2912013A1 (en) 2015-09-02
AU2013334122B2 (en) 2017-11-02
SG11201503247UA (en) 2015-06-29
US10202414B2 (en) 2019-02-12
NZ707389A (en) 2018-08-31
MX361653B (es) 2018-12-13
IL238454B (en) 2018-11-29
EP2912013B1 (en) 2017-10-11

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