CN105055475A - Ultramicro wall-breaking smashing method for panax notoginseng - Google Patents
Ultramicro wall-breaking smashing method for panax notoginseng Download PDFInfo
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- CN105055475A CN105055475A CN201510505753.2A CN201510505753A CN105055475A CN 105055475 A CN105055475 A CN 105055475A CN 201510505753 A CN201510505753 A CN 201510505753A CN 105055475 A CN105055475 A CN 105055475A
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- Prior art keywords
- methionine
- powder
- radix notoginseng
- xylitol
- fine powder
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- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 82
- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 69
- 239000011812 mixed powder Substances 0.000 claims abstract description 32
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 22
- 229930182817 methionine Natural products 0.000 claims abstract description 22
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 20
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 20
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 20
- 229960002675 xylitol Drugs 0.000 claims description 20
- 235000010447 xylitol Nutrition 0.000 claims description 20
- 239000000811 xylitol Substances 0.000 claims description 20
- 229940089161 ginsenoside Drugs 0.000 abstract description 21
- 229930182494 ginsenoside Natural products 0.000 abstract description 21
- 238000004090 dissolution Methods 0.000 abstract description 19
- 235000013312 flour Nutrition 0.000 abstract description 19
- 230000014759 maintenance of location Effects 0.000 abstract description 18
- 239000000203 mixture Substances 0.000 abstract description 12
- 239000003814 drug Substances 0.000 abstract description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 2
- 235000013339 cereals Nutrition 0.000 abstract 2
- 229930189092 Notoginsenoside Natural products 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 22
- 238000000605 extraction Methods 0.000 description 18
- 239000002245 particle Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 241000208343 Panax Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an ultramicro wall-breaking smashing method for panax notoginseng, and belongs to the field of traditional Chinese medicine. The method is characterized by comprising the following steps: (1) smashing panax notoginseng conventionally, and sieving with a 80 to 100-mesh sieve to obtain panax notoginseng fine powder; (2) uniformly mixing newtol and methionine to obtain newtol-methionine mixed powder, wherein the mass ratio of newtol to methionine is preferably 1:1; (3) uniformly mixing the panax notoginseng fine powder with the newtol-methionine mixed powder to obtain a mixture I, smashing the mixture I with a superfine pulverizer, so as to obtain ultramicro wall-broken panax notoginseng powder of which the average grain diameter is equal to or lower than 2 micron, wherein the mass ratio of the panax notoginseng fine powder to the newtol-methionine mixed powder is preferably (100 to 200):1. Compared with the conventional ultramicro wall-breaking smashing, the method provided by the invention has the advantages that the processing time is short; the flour yield is high; the retention rates and the dissolution rates of ginsenoside and notoginsenoside are high; the average grain diameter is small.
Description
Technical field
The present invention relates to a kind of Radix Notoginseng super-micro wall-broken breaking method, belong to medical art.
Background technology
Radix Notoginseng is the dry root and rhizome of panax araliaceae plant, is conventional rare medicinal herbs, and have the effects such as dissipating blood stasis hemostasis and subduing swelling and relieving pain, its principle active component is ginsenoside and arasaponin, is clinically often used as medicine with powder.
After superfine notoginseng powder is broken, because the specific surface area of particle diameter increases, the dissolution rate of ginsenoside and arasaponin can be increased considerably, thus improve drug effect.Existing Radix Notoginseng super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and ginsenoside and the problem such as arasaponin loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Radix Notoginseng super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Radix Notoginseng super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder;
B: mixed homogeneously with methionine by xylitol, obtains xylitol-methionine mixed powder;
C: mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of xylitol and methionine is preferably 1:1.
The mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is preferably 200 ~ 100:1.
Beneficial effect of the present invention is mainly:
Radix Notoginseng super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, ginsenoside and arasaponin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Radix Notoginseng super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of xylitol, methionine and Radix Notoginseng fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 5g xylitol and 5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 1.
The superfine notoginseng powder related data of table 1 embodiment 1
Embodiment 2
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 2.5g xylitol and 2.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 2.
The superfine notoginseng powder related data of table 2 embodiment 2
Embodiment 3
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 4g xylitol and 4g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 3.
The superfine notoginseng powder related data of table 3 embodiment 3
Comparative example 1
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 10g xylitol and 10g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 4.
The superfine notoginseng powder related data of table 4 comparative example 1
Comparative example 2
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 2g xylitol and 2g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 5.
The superfine notoginseng powder related data of table 5 comparative example 2
Comparative example 3
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 4g xylitol and 6g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 6.
The superfine notoginseng powder related data of table 6 comparative example 3
Comparative example 4
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 6g xylitol and 4g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 7.
The superfine notoginseng powder related data of table 7 comparative example 4
Comparative example 5
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 1.5g xylitol and 3.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 8.
The superfine notoginseng powder related data of table 8 comparative example 5
Comparative example 6
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 3.5g xylitol and 1.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 9.
The superfine notoginseng powder related data of table 9 comparative example 6
Comparative example 7
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 10.
The superfine notoginseng powder related data of table 10 comparative example 7
Comparative example 8
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Adopt WZJ12J vibration type ultramicro disintegrator to pulverize 5 hours, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 11.
The superfine notoginseng powder related data of table 11 comparative example 8
Comparative example 9
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Mixed homogeneously with 10g xylitol by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 12.
The superfine notoginseng powder related data of table 12 comparative example 9
Comparative example 10
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Mixed homogeneously with 10g methionine by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 13.
The superfine notoginseng powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of xylitol and methionine is preferably 1:1 and the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is preferably 200 ~ 100:1; can realize less than 2 microns micro powder granules, simultaneously flour extraction or ginsenoside and arasaponin retention rate or dissolution rate are all very higher than 95%.Instead of in ratio of the present invention, even if the mass ratio as xylitol and methionine is 1:1, but the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is not 200 ~ 100:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or ginsenoside and arasaponin retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the mass ratio non-1 of xylitol and methionine; 1, even do not add xylitol and methionine, its result shows, and adding xylitol-methionine mixed powder can diminish particle diameter, and do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Radix Notoginseng super-micro wall-broken crushing process, application xylitol-methionine mixed powder is as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, ginsenoside and arasaponin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of xylitol and methionine is 1:1, when the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is 200 ~ 100:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1. a Radix Notoginseng super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder;
B: mixed homogeneously with methionine by xylitol, obtains xylitol-methionine mixed powder;
C: mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, micronizing is to mean diameter to less than 2 microns.
2. Radix Notoginseng super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of xylitol and methionine is 1:1.
3. Radix Notoginseng super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is 200 ~ 100:1.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105327033A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Saffron superfine wall-breaking grinding method |
| CN105326871A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Ultrafine wall-breaking smashing method for moringa seeds |
| CN105343135A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Superfine wall-breaking pulverization method for ganoderma spore |
| CN105343537A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae |
| CN105412219A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves |
| CN105412169A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for eurycoma longifolia roots |
| CN108310030A (en) * | 2018-03-19 | 2018-07-24 | 上海健康医学院 | A kind of nanometer of broken wall Radix Notoginseng powder capsule and preparation method thereof |
| CN111358760A (en) * | 2020-05-13 | 2020-07-03 | 扬子江药业集团广州海瑞药业有限公司 | Ticagrelor tablet pharmaceutical composition and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327033A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Saffron superfine wall-breaking grinding method |
| CN105326871A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Ultrafine wall-breaking smashing method for moringa seeds |
| CN105343135A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Superfine wall-breaking pulverization method for ganoderma spore |
| CN105343537A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae |
| CN105412219A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves |
| CN105412169A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for eurycoma longifolia roots |
| CN108310030A (en) * | 2018-03-19 | 2018-07-24 | 上海健康医学院 | A kind of nanometer of broken wall Radix Notoginseng powder capsule and preparation method thereof |
| CN111358760A (en) * | 2020-05-13 | 2020-07-03 | 扬子江药业集团广州海瑞药业有限公司 | Ticagrelor tablet pharmaceutical composition and preparation method thereof |
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