CN105055475A - Ultramicro wall-breaking smashing method for panax notoginseng - Google Patents

Ultramicro wall-breaking smashing method for panax notoginseng Download PDF

Info

Publication number
CN105055475A
CN105055475A CN201510505753.2A CN201510505753A CN105055475A CN 105055475 A CN105055475 A CN 105055475A CN 201510505753 A CN201510505753 A CN 201510505753A CN 105055475 A CN105055475 A CN 105055475A
Authority
CN
China
Prior art keywords
methionine
powder
radix notoginseng
xylitol
fine powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201510505753.2A
Other languages
Chinese (zh)
Other versions
CN105055475B (en
Inventor
郑红芹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen City Hall Sheng Biotechnology Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510505753.2A priority Critical patent/CN105055475B/en
Publication of CN105055475A publication Critical patent/CN105055475A/en
Application granted granted Critical
Publication of CN105055475B publication Critical patent/CN105055475B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides an ultramicro wall-breaking smashing method for panax notoginseng, and belongs to the field of traditional Chinese medicine. The method is characterized by comprising the following steps: (1) smashing panax notoginseng conventionally, and sieving with a 80 to 100-mesh sieve to obtain panax notoginseng fine powder; (2) uniformly mixing newtol and methionine to obtain newtol-methionine mixed powder, wherein the mass ratio of newtol to methionine is preferably 1:1; (3) uniformly mixing the panax notoginseng fine powder with the newtol-methionine mixed powder to obtain a mixture I, smashing the mixture I with a superfine pulverizer, so as to obtain ultramicro wall-broken panax notoginseng powder of which the average grain diameter is equal to or lower than 2 micron, wherein the mass ratio of the panax notoginseng fine powder to the newtol-methionine mixed powder is preferably (100 to 200):1. Compared with the conventional ultramicro wall-breaking smashing, the method provided by the invention has the advantages that the processing time is short; the flour yield is high; the retention rates and the dissolution rates of ginsenoside and notoginsenoside are high; the average grain diameter is small.

Description

A kind of Radix Notoginseng super-micro wall-broken breaking method
Technical field
The present invention relates to a kind of Radix Notoginseng super-micro wall-broken breaking method, belong to medical art.
Background technology
Radix Notoginseng is the dry root and rhizome of panax araliaceae plant, is conventional rare medicinal herbs, and have the effects such as dissipating blood stasis hemostasis and subduing swelling and relieving pain, its principle active component is ginsenoside and arasaponin, is clinically often used as medicine with powder.
After superfine notoginseng powder is broken, because the specific surface area of particle diameter increases, the dissolution rate of ginsenoside and arasaponin can be increased considerably, thus improve drug effect.Existing Radix Notoginseng super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and ginsenoside and the problem such as arasaponin loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Radix Notoginseng super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Radix Notoginseng super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder;
B: mixed homogeneously with methionine by xylitol, obtains xylitol-methionine mixed powder;
C: mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of xylitol and methionine is preferably 1:1.
The mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is preferably 200 ~ 100:1.
Beneficial effect of the present invention is mainly:
Radix Notoginseng super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, ginsenoside and arasaponin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Radix Notoginseng super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of xylitol, methionine and Radix Notoginseng fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 5g xylitol and 5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 1.
The superfine notoginseng powder related data of table 1 embodiment 1
Embodiment 2
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 2.5g xylitol and 2.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 2.
The superfine notoginseng powder related data of table 2 embodiment 2
Embodiment 3
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 4g xylitol and 4g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 3.
The superfine notoginseng powder related data of table 3 embodiment 3
Comparative example 1
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 10g xylitol and 10g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 4.
The superfine notoginseng powder related data of table 4 comparative example 1
Comparative example 2
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 2g xylitol and 2g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 5.
The superfine notoginseng powder related data of table 5 comparative example 2
Comparative example 3
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 4g xylitol and 6g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 6.
The superfine notoginseng powder related data of table 6 comparative example 3
Comparative example 4
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 6g xylitol and 4g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 7.
The superfine notoginseng powder related data of table 7 comparative example 4
Comparative example 5
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 1.5g xylitol and 3.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 8.
The superfine notoginseng powder related data of table 8 comparative example 5
Comparative example 6
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; By 3.5g xylitol and 1.5g methionine mix homogeneously, obtain xylitol-methionine mixed powder; Mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 9.
The superfine notoginseng powder related data of table 9 comparative example 6
Comparative example 7
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 10.
The superfine notoginseng powder related data of table 10 comparative example 7
Comparative example 8
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Adopt WZJ12J vibration type ultramicro disintegrator to pulverize 5 hours, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 11.
The superfine notoginseng powder related data of table 11 comparative example 8
Comparative example 9
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Mixed homogeneously with 10g xylitol by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 12.
The superfine notoginseng powder related data of table 12 comparative example 9
Comparative example 10
1kg Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder; Mixed homogeneously with 10g methionine by Radix Notoginseng fine powder, adopt WZJ12J vibration type ultramicro disintegrator to pulverize 1 hour, gained powder measures mean diameter, flour extraction, the retention rate of ginsenoside and arasaponin and dissolution rate, the results are shown in Table 13.
The superfine notoginseng powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of xylitol and methionine is preferably 1:1 and the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is preferably 200 ~ 100:1; can realize less than 2 microns micro powder granules, simultaneously flour extraction or ginsenoside and arasaponin retention rate or dissolution rate are all very higher than 95%.Instead of in ratio of the present invention, even if the mass ratio as xylitol and methionine is 1:1, but the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is not 200 ~ 100:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or ginsenoside and arasaponin retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the mass ratio non-1 of xylitol and methionine; 1, even do not add xylitol and methionine, its result shows, and adding xylitol-methionine mixed powder can diminish particle diameter, and do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Radix Notoginseng super-micro wall-broken crushing process, application xylitol-methionine mixed powder is as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, ginsenoside and arasaponin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of xylitol and methionine is 1:1, when the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is 200 ~ 100:1, be key factor, it has best crushing effect, has very large market popularization value.

Claims (3)

1. a Radix Notoginseng super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: Radix Notoginseng routine is pulverized, crosses 80-100 mesh sieve, obtain Radix Notoginseng fine powder;
B: mixed homogeneously with methionine by xylitol, obtains xylitol-methionine mixed powder;
C: mixed homogeneously with xylitol-methionine mixed powder by Radix Notoginseng fine powder, micronizing is to mean diameter to less than 2 microns.
2. Radix Notoginseng super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of xylitol and methionine is 1:1.
3. Radix Notoginseng super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is 200 ~ 100:1.
CN201510505753.2A 2015-08-18 2015-08-18 A kind of Radix Notoginseng super-micro wall-broken breaking method Active CN105055475B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510505753.2A CN105055475B (en) 2015-08-18 2015-08-18 A kind of Radix Notoginseng super-micro wall-broken breaking method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510505753.2A CN105055475B (en) 2015-08-18 2015-08-18 A kind of Radix Notoginseng super-micro wall-broken breaking method

Publications (2)

Publication Number Publication Date
CN105055475A true CN105055475A (en) 2015-11-18
CN105055475B CN105055475B (en) 2018-09-21

Family

ID=54485157

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510505753.2A Active CN105055475B (en) 2015-08-18 2015-08-18 A kind of Radix Notoginseng super-micro wall-broken breaking method

Country Status (1)

Country Link
CN (1) CN105055475B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105326871A (en) * 2015-11-25 2016-02-17 苏州普罗达生物科技有限公司 Ultrafine wall-breaking smashing method for moringa seeds
CN105327033A (en) * 2015-11-25 2016-02-17 苏州普罗达生物科技有限公司 Saffron superfine wall-breaking grinding method
CN105343537A (en) * 2015-11-25 2016-02-24 苏州普罗达生物科技有限公司 Ultramicro wall-breaking grinding method for rhizoma gymnadeniae
CN105343135A (en) * 2015-11-25 2016-02-24 苏州普罗达生物科技有限公司 Superfine wall-breaking pulverization method for ganoderma spore
CN105412169A (en) * 2015-11-25 2016-03-23 苏州普罗达生物科技有限公司 Ultramicro wall-breaking smashing method for eurycoma longifolia roots
CN105412219A (en) * 2015-11-25 2016-03-23 苏州普罗达生物科技有限公司 Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves
CN108310030A (en) * 2018-03-19 2018-07-24 上海健康医学院 A kind of nanometer of broken wall Radix Notoginseng powder capsule and preparation method thereof
CN111358760A (en) * 2020-05-13 2020-07-03 扬子江药业集团广州海瑞药业有限公司 Ticagrelor tablet pharmaceutical composition and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102423026A (en) * 2011-11-28 2012-04-25 黄珊珊 Micronized Stahlianthus involucratus jelly

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102423026A (en) * 2011-11-28 2012-04-25 黄珊珊 Micronized Stahlianthus involucratus jelly

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙文格等: "中药超微粉碎技术及粉体特征的研究进展", 《中国药业》 *
山东省食品药品监督管理局: "《山东省中药饮片炮制规范(上册)》", 31 January 2013, 山东科学技术出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105326871A (en) * 2015-11-25 2016-02-17 苏州普罗达生物科技有限公司 Ultrafine wall-breaking smashing method for moringa seeds
CN105327033A (en) * 2015-11-25 2016-02-17 苏州普罗达生物科技有限公司 Saffron superfine wall-breaking grinding method
CN105343537A (en) * 2015-11-25 2016-02-24 苏州普罗达生物科技有限公司 Ultramicro wall-breaking grinding method for rhizoma gymnadeniae
CN105343135A (en) * 2015-11-25 2016-02-24 苏州普罗达生物科技有限公司 Superfine wall-breaking pulverization method for ganoderma spore
CN105412169A (en) * 2015-11-25 2016-03-23 苏州普罗达生物科技有限公司 Ultramicro wall-breaking smashing method for eurycoma longifolia roots
CN105412219A (en) * 2015-11-25 2016-03-23 苏州普罗达生物科技有限公司 Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves
CN108310030A (en) * 2018-03-19 2018-07-24 上海健康医学院 A kind of nanometer of broken wall Radix Notoginseng powder capsule and preparation method thereof
CN111358760A (en) * 2020-05-13 2020-07-03 扬子江药业集团广州海瑞药业有限公司 Ticagrelor tablet pharmaceutical composition and preparation method thereof

Also Published As

Publication number Publication date
CN105055475B (en) 2018-09-21

Similar Documents

Publication Publication Date Title
CN105030896B (en) A kind of Radix Salviae Miltiorrhizae super-micro wall-broken breaking method
CN105055475A (en) Ultramicro wall-breaking smashing method for panax notoginseng
CN105030865B (en) A kind of American Ginseng super-micro wall-broken breaking method
CN106582985A (en) Ultramicro wall breaking and smashing method for rhizomatic traditional Chinese medicine
TWI549700B (en) Panax notoginseng broken wall preparation
CN105055902B (en) A kind of stem of noble dendrobium super-micro wall-broken breaking method
CN104622960A (en) Compound salviae miltiorrhizae condensed pill and preparation method thereof
CN101019898B (en) Crushing method and preparation of aweto
CN105362720A (en) Ultra-micro wall-breaking pulverizing method for rhizoma gastrodiae
CN105343153A (en) Superfine wall-breaking pulverization method for radix astragali
CN105343135A (en) Superfine wall-breaking pulverization method for ganoderma spore
CN105106260B (en) A kind of ginseng super-micro wall-broken breaking method
CN104801410A (en) Process for machining plant type traditional Chinese medicine ultra-micro powder
CN105343134A (en) Superfine wall-breaking pulverization method for cordyceps sinensis
CN105343181A (en) Superfine wall-breaking pulverization method for fructus swietenia macrophylla
CN106733065A (en) A kind of Chinese medicine nanometer pulverization method
CN105412185A (en) Ultramicro wall-breaking smashing method for angelica keiskei
CN105343537A (en) Ultramicro wall-breaking grinding method for rhizoma gymnadeniae
CN105326866A (en) Method for carrying out superfine wall breaking and smashing on boletus
CN105412219A (en) Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves
CN105343161A (en) Ultramicro wall-breaking grinding method for semen juglandis
CN105434707A (en) Superfine wall-breaking crushing method for grape seeds
CN105362302A (en) Ultra-micro wall-breaking pulverizing method for cordyceps militaris
CN106727892A (en) A kind of compound taxol preparation and preparation method thereof
CN1205983C (en) Method for making capsule for promoting blood-circulation and relieving pain

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20180814

Address after: 518000 Shenzhen, Guangdong, Luohu District, Guangyuan Road, Luohu District, Shennan East Road, B, block Jinfeng Building,

Applicant after: Shenzhen City Hall Sheng Biotechnology Co. Ltd.

Address before: 518000 Shenzhen Shennan Road 5015, Guangdong, Luohu District, B 1502-1503, Jinfeng City mansion.

Applicant before: Zheng Hongqin

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant