CN105343181A - Superfine wall-breaking pulverization method for fructus swietenia macrophylla - Google Patents
Superfine wall-breaking pulverization method for fructus swietenia macrophylla Download PDFInfo
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- CN105343181A CN105343181A CN201510834468.5A CN201510834468A CN105343181A CN 105343181 A CN105343181 A CN 105343181A CN 201510834468 A CN201510834468 A CN 201510834468A CN 105343181 A CN105343181 A CN 105343181A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention provides a superfine wall-breaking pulverization method for fructus swietenia macrophylla and belongs to the field of traditional Chinese medicine. The superfine wall-breaking pulverization method for the fructus swietenia macrophylla is characterized by including the steps of (1) pulverizing the fructus swietenia macrophylla and sieving the pulverized fructus swietenia macrophylla by a 60-80-mesh sieve so as to obtain fructus swietenia macrophylla powder; (2) uniformly mixing hydroxypropyl-beta-cyclodextrin with medium chain triglyceride in a preferred mass ratio of 8:2 so as to obtain hydroxypropyl-beta-cyclodextrin-medium chain triglyceride mixed powder; (3) uniformly mixing the fructus swietenia macrophylla powder with the hydroxypropyl-beta-cyclodextrin-medium chain triglyceride mixed powder in a preferred mass ratio of 300-200:1. Compared with a conventional superfine wall-breaking pulverization method, the superfine wall-breaking pulverization method for the fructus swietenia macrophylla has the advantages of short preparation time, high powder yield, high fructus swietenia macrophylla flavone retention rate and dissolution rate, small average grain size of the powder and the like.
Description
Technical field
The present invention relates to a kind of to sky fruit super-micro wall-broken breaking method, belong to medical art.
Background technology
Be the fruit of Meliaceae plant to sky fruit tree to sky fruit, be described as " after plant ", have antipyretic, convergence, the effect such as strong, cure mainly diabetes and hypertension, application is normal in powder form.
After sky fruit micronizing, because the specific surface area of particle diameter increases, the dissolution rate to effective ingredient such as sky fruit flavone can be increased considerably, thus improve drug effect.Existing exist that grinding time is long, flour extraction is low and to problems such as sky fruit flavone loss rate are high to sky fruit super-micro wall-broken breaking method.
Summary of the invention
The object of this invention is to provide a kind of to sky fruit super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Of the present invention to sky fruit super-micro wall-broken breaking method, it is characterized in that, concrete steps are as follows:
A: will pulverize to sky fruit, and cross 60 ~ 80 mesh sieves, obtains to sky fruit powder;
B: HP-β-CD mixed homogeneously with medium chain triglyceride, obtains HP-β-CD-medium chain triglyceride mixed powder;
C: will mix homogeneously to sky fruit powder with HP-β-CD-medium chain triglyceride mixed powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of HP-β-CD and medium chain triglyceride is preferably 8:2.
Mass ratio to sky fruit powder and HP-β-CD-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Of the present inventionly have that process time is short, flour extraction is high to sky fruit super-micro wall-broken breaking method, to sky fruit flavone retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Of the present invention unique to sky fruit super-micro wall-broken breaking method, be that the accident in great many of experiments finds, HP-β-CD, medium chain triglyceride and all can not adjust to the order by merging of sky fruit fine powder and ratio.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 8g HP-β-CD and 2g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 1.
Table 1 embodiment 1 to sky fruit superfine powder related data
Embodiment 2
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 12g HP-β-CD and 3g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 2.
Table 2 embodiment 2 to sky fruit superfine powder related data
Embodiment 3
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 9.6g HP-β-CD and 2.4g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 3.
Table 3 embodiment 3 to sky fruit superfine powder related data
Comparative example 1
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 7g HP-β-CD and 1.75g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 4.
Table 4 comparative example 1 to sky fruit superfine powder related data
Comparative example 2
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 13.5g HP-β-CD and 3.375g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 5.
Table 5 comparative example 2 to sky fruit superfine powder related data
Comparative example 3
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; SWFJ micronizing unit will be adopted to pulverize 1 hour to sky fruit powder, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 6.
Table 6 comparative example 3 to sky fruit superfine powder related data
Comparative example 4
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; To mix homogeneously with 10g HP-β-CD to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 7.
Table 7 comparative example 4 to sky fruit superfine powder related data
Comparative example 5
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; To mix homogeneously with 10g medium chain triglyceride to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 8.
Table 8 comparative example 5 to sky fruit superfine powder related data
Comparative example 6
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; To mix homogeneously with 15g HP-β-CD to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 9.
Table 9 comparative example 6 to sky fruit superfine powder related data
Comparative example 7
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; To mix homogeneously with 15g medium chain triglyceride to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 10.
Table 10 comparative example 7 to sky fruit superfine powder related data
Comparative example 8
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 9g HP-β-CD and 1g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 11.
Table 11 comparative example 8 to sky fruit superfine powder related data
Comparative example 9
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 7g HP-β-CD and 3g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 12.
Table 12 comparative example 9 to sky fruit superfine powder related data
Comparative example 10
3kg is pulverized to sky fruit, crosses 60 ~ 80 mesh sieves, obtain to sky fruit powder; By 5g HP-β-CD and 5g medium chain triglyceride mix homogeneously, obtain HP-β-CD-medium chain triglyceride mixed powder; To mix homogeneously with HP-β-CD-medium chain triglyceride mixed powder to sky fruit powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, to sky fruit flavone retention rate and dissolution rate, the results are shown in Table 13.
Table 13 comparative example 10 to sky fruit superfine powder related data
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of HP-β-CD and medium chain triglyceride is preferably 8:2; and be preferably 300 ~ 200:1 to the mass ratio of sky fruit powder and HP-β-CD-medium chain triglyceride mixed powder; the pulverizing of less than 2 microns can be realized, simultaneously flour extraction or to sky really flavone retention rate or dissolution rate all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as HP-β-CD and medium chain triglyceride is 8:2, but not 300 ~ 200:1 to the mass ratio of sky fruit powder and HP-β-CD-medium chain triglyceride mixed powder, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, simultaneously flour extraction still to sky really flavone retention rate or dissolution rate all lower than 95%.And comparative example 3-10, the non-8:2 of mass ratio of HP-β-CD and medium chain triglyceride, even do not add HP-β-CD and medium chain triglyceride, its result shows, add HP-β-CD-medium chain triglyceride mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, to in sky fruit super-micro wall-broken crushing process, application HP-β-CD and medium chain triglyceride are as assisted comminution material, significantly can improve crush efficiency, and have flour extraction high, to sky fruit flavone retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of HP-β-CD and medium chain triglyceride is 8:2, when to sky, really the mass ratio of powder and HP-β-CD-medium chain triglyceride mixed powder is 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1., to a sky fruit super-micro wall-broken breaking method, it is characterized in that, concrete steps are as follows:
A: will pulverize to sky fruit, and cross 60 ~ 80 mesh sieves, obtains to sky fruit powder;
B: HP-β-CD mixed homogeneously with medium chain triglyceride, obtains HP-β-CD-medium chain triglyceride mixed powder;
C: will mix homogeneously to sky fruit powder with HP-β-CD-medium chain triglyceride mixed powder, micronizing is to mean diameter to less than 2 microns.
2. according to claim 1 to sky fruit super-micro wall-broken breaking method, it is characterized in that, the mass ratio of HP-β-CD and medium chain triglyceride is 8:2.
3. according to claim 1 to sky fruit super-micro wall-broken breaking method, it is characterized in that, to sky, really the mass ratio of powder and HP-β-CD-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108497392A (en) * | 2018-05-29 | 2018-09-07 | 闫峻峰 | A kind of food preventing hyperglycemia hypertension |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
Non-Patent Citations (1)
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|---|
| 孙文格等: "中药超微粉碎技术及粉体特征的研究进展", 《中国药业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108497392A (en) * | 2018-05-29 | 2018-09-07 | 闫峻峰 | A kind of food preventing hyperglycemia hypertension |
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