CN105055902B - A kind of stem of noble dendrobium super-micro wall-broken breaking method - Google Patents
A kind of stem of noble dendrobium super-micro wall-broken breaking method Download PDFInfo
- Publication number
- CN105055902B CN105055902B CN201510506173.5A CN201510506173A CN105055902B CN 105055902 B CN105055902 B CN 105055902B CN 201510506173 A CN201510506173 A CN 201510506173A CN 105055902 B CN105055902 B CN 105055902B
- Authority
- CN
- China
- Prior art keywords
- powder
- mannitol
- trehalose
- stem
- dendrobe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention provides a kind of stem of noble dendrobium super-micro wall-broken breaking methods, belong to the field of Chinese medicines.The stem of noble dendrobium super-micro wall-broken breaking method of the present invention, it is characterised in that include the following steps：（1）The stem of noble dendrobium is routinely crushed, 50 60 mesh sieve is crossed, obtains dendrobe powder；（2）Trehalose is uniformly mixed with mannitol, the mass ratio of trehalose and mannitol is preferably 3:2, obtain trehalose mannitol mixed powder；（3）Dendrobe powder is uniformly mixed with trehalose mannitol mixed powder, dendrobe powder and the mass ratio of trehalose mannitol mixed powder are preferably 100:1, average grain diameter is crushed to 2 microns using micronizer hereinafter, up to stem of noble dendrobium super-micro wall-broken powder.The stem of noble dendrobium super-micro wall-broken breaking method of the present invention, relatively conventional super-micro wall-broken breaking method is short with process time, flour extraction is high and the advantages such as powder average particle size is small.
Description
Technical field
The present invention relates to a kind of stem of noble dendrobium super-micro wall-broken breaking methods, belong to pharmaceutical technology field.
Background technology
The stem of noble dendrobium is parts of generic medicinal plants, and the kinds such as HERBA DENDROBII, dendrobium candidum, Dendrobium Chrysotoxum Lindl and Dendrobium fimbriatum Hook have significant
Drug effect and health-care effect, clinic are often used as medicine with powder.
After dendrobe ultrafine powder is broken, be conducive to the performance of drug effect and further preparation processing.Existing stem of noble dendrobium super-micro wall-broken powder
Broken method there are grinding times it is long, flour extraction is low and average grain diameter is big the problems such as.
Invention content
The object of the present invention is to provide a kind of stem of noble dendrobium super-micro wall-broken breaking methods, to solve the above technical problems.
For foregoing invention purpose, the present invention provides following technical scheme：
The stem of noble dendrobium super-micro wall-broken breaking method of the present invention, which is characterized in that be as follows：
A：The stem of noble dendrobium is routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；
B：Trehalose is uniformly mixed with mannitol, obtains trehalose-mannitol mixed powder；
C：Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, ultramicro grinding to average grain diameter to 2 microns with
Under.
The mass ratio of trehalose and mannitol is preferably 3:2.
Stem of noble dendrobium fine powder and the mass ratio of trehalose-mannitol mixed powder are preferably 100:1.
Beneficial effects of the present invention are mainly：
The stem of noble dendrobium super-micro wall-broken breaking method of the present invention has process time is short, flour extraction is high and powder average particle size is small etc.
Advantage.The stem of noble dendrobium super-micro wall-broken breaking method of the present invention is unique, is having been surprisingly found that in many experiments, trehalose, mannitol
Order by merging and ratio with dendrobe powder are unable to adjust.Therefore ingredient, ratio and the order of addition that the present invention uses, are this hairs
Bright innovative point.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, but should be noted that the scope of the present invention not by this
Any restrictions of a little examples.
Embodiment 1
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；6g trehaloses and 4g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 1.
The dendrobe ultrafine powder related data of 1 embodiment 1 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 1.1 micron | 96% |
Embodiment 2
1kg dendrobium candidums are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；6g trehaloses and 4g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 2.
The dendrobe ultrafine powder related data of 2 embodiment 2 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium candidum ultrafine powder | 1.2 micron | 97% |
Embodiment 3
1kg Dendrobium Chrysotoxum Lindls are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；6g trehaloses and 4g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 3.
The dendrobe ultrafine powder related data of 3 embodiment 3 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium Chrysotoxum Lindl Ultramicro-powder | 1.1 micron | 97% |
Embodiment 4
1kg Dendrobium fimbriatum Hooks are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；6g trehaloses and 4g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 1 hour, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 4.
The dendrobe ultrafine powder related data of 4 embodiment 4 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium fimbriatum Hook Ultramicro-powder | 1.8 micron | 96% |
Comparative example 1
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；4g trehaloses and 6g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 5.
The dendrobe ultrafine powder related data of 5 comparative example 1 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 2.5 micron | 91% |
Comparative example 2
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；5g trehaloses and 5g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 6.
The dendrobe ultrafine powder related data of 6 comparative example 2 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 2.2 micron | 91% |
Comparative example 3
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；3g trehaloses and 2g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 7.
The dendrobe ultrafine powder related data of 7 comparative example 3 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 3.6 micron | 89% |
Comparative example 4
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；9g trehaloses and 6g mannitol are mixed
Uniformly, trehalose-mannitol mixed powder is obtained；Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, using WZJ12J
Vibration type ultramicro disintegrator crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 8.
The dendrobe ultrafine powder related data of 8 comparative example 4 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 3.1 micron | 92% |
Comparative example 5
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Continue to use WZJ12J oscillatory type ultra micros
Pulverizer crushes 2 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 9.
The dendrobe ultrafine powder related data of 9 comparative example 5 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 12.7 microns | 76% |
Comparative example 6
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Continue to use WZJ12J oscillatory type ultra micros
Pulverizer crushes 5 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 10.
The dendrobe ultrafine powder related data of 10 comparative example 6 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 5.2 micron | 68% |
Comparative example 7
1kg dendrobium candidums are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Continue to use WZJ12J oscillatory type ultra micros
Pulverizer crushes 5 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 11.
The dendrobe ultrafine powder related data of 11 comparative example 7 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium candidum ultrafine powder | 5.9 micron | 65% |
Comparative example 8
1kg Dendrobium Chrysotoxum Lindls are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Continue to use WZJ12J oscillatory type ultra micros
Pulverizer crushes 5 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 12.
The dendrobe ultrafine powder related data of 12 comparative example 8 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium Chrysotoxum Lindl Ultramicro-powder | 5.5 micron | 69% |
Comparative example 9
1kg Dendrobium fimbriatum Hooks are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Continue to use WZJ12J oscillatory type ultra micros
Pulverizer crushes 5 hours, and gained powder measures average grain diameter and flour extraction, the results are shown in Table 13.
The dendrobe ultrafine powder related data of 13 comparative example 9 of table
| Project | Average grain diameter | Flour extraction |
| Dendrobium fimbriatum Hook Ultramicro-powder | 5.8 micron | 71% |
Comparative example 10
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Dendrobe powder is mixed with 10g trehaloses
Uniformly, it is crushed 2 hours using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter and flour extraction, as a result sees
Table 14.
The dendrobe ultrafine powder related data of 14 comparative example 10 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 12.5 microns | 76% |
Comparative example 11
1kg HERBA DENDROBIIs are routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；Dendrobe powder is mixed with 10g mannitol
Uniformly, it is crushed 2 hours using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter and flour extraction, as a result sees
Table 15.
The dendrobe ultrafine powder related data of 15 comparative example 11 of table
| Project | Average grain diameter | Flour extraction |
| HERBA DENDROBII Ultramicro-powder | 13.2 microns | 73% |
The present invention has screened a large amount of prescription, finds：Only in the scope of the present invention, i.e. trehalose and mannitol
Mass ratio is preferably 3:2 and the mass ratio of dendrobe powder and trehalose-mannitol mixed powder be preferably 100:1, it may be implemented 2 microns
Following micro powder granule, while flour extraction is higher than 95%.Rather than in ratio of the present invention, even if such as the quality of trehalose and mannitol
Than being 3:2, but dendrobe powder and the mass ratio of trehalose-mannitol mixed powder are not 100:1, as shown in comparative example 3 and 4, knot
Fruit diameter is more than 2 microns, while flour extraction is less than 95%.And the mass ratio of comparative example 1-2,5-11 trehalose and mannitol non-3:
2, or even it is not added with trehalose and mannitol, the results show that trehalose-mannitol mixed powder, which is added, to become smaller grain size, no
Add rear grain size about at 5 microns or more, indices are not up to standard.
Therefore：As can be seen from the above embodiments, in stem of noble dendrobium super-micro wall-broken crushing process, using trehalose-mannitol
Mixed powder can significantly improve crush efficiency, and small with flour extraction height and powder average particle size as assisted comminution material
Etc. advantages.Wherein when the mass ratio of trehalose and mannitol is 3:2, the mass ratio of dendrobe powder and trehalose-mannitol mixed powder
It is 100:It is key factor when 1, with best crushing effect, there is prodigious market popularization value.
Claims (1)
1. a kind of stem of noble dendrobium super-micro wall-broken breaking method, which is characterized in that be as follows：
A：The stem of noble dendrobium is routinely crushed, 50-60 mesh sieve is crossed, obtains dendrobe powder；
B：Trehalose is uniformly mixed with mannitol, obtains trehalose-mannitol mixed powder；
C：Dendrobe powder is uniformly mixed with trehalose-mannitol mixed powder, ultramicro grinding to average grain diameter is to 2 microns or less；Sea
The mass ratio of algae sugar and mannitol is 3:2；The mass ratio of dendrobe powder and trehalose-mannitol mixed powder is 100:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506173.5A CN105055902B (en) | 2015-08-18 | 2015-08-18 | A kind of stem of noble dendrobium super-micro wall-broken breaking method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506173.5A CN105055902B (en) | 2015-08-18 | 2015-08-18 | A kind of stem of noble dendrobium super-micro wall-broken breaking method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105055902A CN105055902A (en) | 2015-11-18 |
| CN105055902B true CN105055902B (en) | 2018-09-07 |
Family
ID=54485579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510506173.5A Active CN105055902B (en) | 2015-08-18 | 2015-08-18 | A kind of stem of noble dendrobium super-micro wall-broken breaking method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105055902B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434707A (en) * | 2015-11-25 | 2016-03-30 | 苏州普罗达生物科技有限公司 | Superfine wall-breaking crushing method for grape seeds |
| CN105412199A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Rhodiola-rosea ultramicro wall-breaking smashing method |
| CN113801745B (en) * | 2021-10-15 | 2023-12-05 | 广西壮族自治区农业科学院 | Preparation method of rhizoma polygonati refined beer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877395A (en) * | 2014-03-27 | 2014-06-25 | 马荣钢 | Method for preparing dendrobium officinale instant powder |
| CN104069366A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Stock dendrobium officinale preparation and preparation method thereof |
| CN104069367A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Original dendrobium officinale preparation and preparation method thereof |
-
2015
- 2015-08-18 CN CN201510506173.5A patent/CN105055902B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877395A (en) * | 2014-03-27 | 2014-06-25 | 马荣钢 | Method for preparing dendrobium officinale instant powder |
| CN104069366A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Stock dendrobium officinale preparation and preparation method thereof |
| CN104069367A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Original dendrobium officinale preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中药超微粉碎技术及粉体特征的研究进展;孙文格等;《中国药业》;20091120;第18卷(第22期);第75页右边栏第2段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105055902A (en) | 2015-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105030896B (en) | A kind of Radix Salviae Miltiorrhizae super-micro wall-broken breaking method | |
| CN105055475B (en) | A kind of Radix Notoginseng super-micro wall-broken breaking method | |
| CN105055902B (en) | A kind of stem of noble dendrobium super-micro wall-broken breaking method | |
| CN105030865B (en) | A kind of American Ginseng super-micro wall-broken breaking method | |
| CN104224738A (en) | Single traditional Chinese medicine pills and preparation method thereof | |
| CN106582985A (en) | Ultramicro wall breaking and smashing method for rhizomatic traditional Chinese medicine | |
| CN101019898B (en) | Crushing method and preparation of aweto | |
| CN103006742B (en) | Ultramicro mair-cona total-effect preparation and preparation method, dosage form and application thereof | |
| CN105147899A (en) | Preparation for protecting stomach, protecting liver and dissipating effects of alcohol and application of preparation | |
| CN105362720A (en) | Ultra-micro wall-breaking pulverizing method for rhizoma gastrodiae | |
| CN108721341B (en) | Cordyceps militaris superfine powder and processing method thereof | |
| CN106733065A (en) | A kind of Chinese medicine nanometer pulverization method | |
| CN105106260B (en) | A kind of ginseng super-micro wall-broken breaking method | |
| CN105412185A (en) | Ultramicro wall-breaking smashing method for angelica keiskei | |
| CN105412219A (en) | Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves | |
| CN105343135A (en) | Superfine wall-breaking pulverization method for ganoderma spore | |
| CN105343181A (en) | Superfine wall-breaking pulverization method for fructus swietenia macrophylla | |
| CN105343134A (en) | Superfine wall-breaking pulverization method for cordyceps sinensis | |
| CN109954012A (en) | A kind of Chinese medicine nanometer powder solid composite and preparation method thereof | |
| CN103877028A (en) | Process for processing fat-containing fruit seed Chinese herbal medicine ultramicro powder | |
| CN105343153A (en) | Superfine wall-breaking pulverization method for radix astragali | |
| CN105343193A (en) | Superfine wall-breaking pulverization method for orobanche coerulescens | |
| CN105412533A (en) | Fritillaria-praewalskii-maxim-ex-Batal ultramicro wall-breaking smashing method | |
| CN205217043U (en) | Chinese -medicinal material nanometer crushing apparatus | |
| CN106852910A (en) | Micro level Chinese medicine bag（Tea）And preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180625 Address after: 518000 Shenzhen, Guangdong, Luohu District, Guangyuan Road, Luohu District, Shennan East Road, B, block Jinfeng Building, Applicant after: Shenzhen City Hall Sheng Biotechnology Co. Ltd. Address before: 518000 Shenzhen Shennan Road 5015, Guangdong, Luohu District, B 1502-1503, Jinfeng City mansion. Applicant before: Zheng Hongqin |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |