CN105343135A - Superfine wall-breaking pulverization method for ganoderma spore - Google Patents
Superfine wall-breaking pulverization method for ganoderma spore Download PDFInfo
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- CN105343135A CN105343135A CN201510834077.3A CN201510834077A CN105343135A CN 105343135 A CN105343135 A CN 105343135A CN 201510834077 A CN201510834077 A CN 201510834077A CN 105343135 A CN105343135 A CN 105343135A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention provides a superfine wall-breaking pulverization method for ganoderma spore and belongs to the field of traditional Chinese medicine. The superfine wall-breaking pulverization method for the ganoderma spore is characterized by including the steps of (1) pulverizing the ganoderma spore and sieving the pulverized ganoderma spore by a 60-80-mesh sieve so as to obtain ganoderma spore powder; (2) uniformly mixing powdered cellulose with glyceryl behenate in a preferred mass ratio of 6:4 so as to obtain powdered cellulose-glyceryl behenate mixed powder; (3) uniformly mixing the ganoderma spore powder with the powdered cellulose-glyceryl behenate mixed powder in a preferred mass ratio of 300-200:1. Compared with a conventional superfine wall-breaking pulverization method, the superfine wall-breaking pulverization method for the ganoderma spore has the advantages of short preparation time, high powder yield, high ganoderma acid retention rate and dissolution rate, small average grain size of the powder and the like.
Description
Technical field
The present invention relates to a kind of Ganoderma spore super-micro wall-broken breaking method, belong to medical art.
Background technology
Ganoderma spore be Ganoderma in the growth and maturity phase, to be hit by a bullet the extremely small avette sexual cell shot out from Ganoderma lamella.Ganoderma spore can strengthen immune function after taking, the diseases such as prevention and therapy tumor, and application is normal in powder form.
After Ganoderma spore micronizing, because the destruction of outer sporoderm, the specific surface area of particle diameter increase, the dissolution rate of the effective ingredient such as Ganodenic acid A can be increased considerably, thus improve drug effect.Existing Ganoderma spore super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and the problem such as Ganodenic acid A isoreactivity component loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Ganoderma spore super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Ganoderma spore super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: pulverized by Ganoderma spore, crosses 60 ~ 80 mesh sieves, obtains Ganoderma spore powder;
B: mixed homogeneously with Glyceryl Behenate by Powderd cellulose, obtains Powderd cellulose-Glyceryl Behenate mixed powder;
C: mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of Powderd cellulose and Glyceryl Behenate is preferably 6:4.
The mass ratio of Ganoderma spore powder and Powderd cellulose-Glyceryl Behenate mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Ganoderma spore super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, Ganodenic acid A retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Ganoderma spore super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of Powderd cellulose, Glyceryl Behenate and Ganoderma spore fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 6g Powderd cellulose and 4g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 1.
The Ganoderma spore superfine powder related data of table 1 embodiment 1
Embodiment 2
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 9g Powderd cellulose and 6g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 2.
The Ganoderma spore superfine powder related data of table 2 embodiment 2
Embodiment 3
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 7.2g Powderd cellulose and 4.8g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 3.
The Ganoderma spore superfine powder related data of table 3 embodiment 3
Comparative example 1
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 5.7g Powderd cellulose and 3.8g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 4.
The Ganoderma spore superfine powder related data of table 4 comparative example 1
Comparative example 2
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 9.3g Powderd cellulose and 6.2g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 5.
The Ganoderma spore superfine powder related data of table 5 comparative example 2
Comparative example 3
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; Adopted by Ganoderma spore powder SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 6.
The Ganoderma spore superfine powder related data of table 6 comparative example 3
Comparative example 4
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; Mixed homogeneously with 10g Powderd cellulose by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 7.
The Ganoderma spore superfine powder related data of table 7 comparative example 4
Comparative example 5
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; Mixed homogeneously with 10g Glyceryl Behenate by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 8.
The Ganoderma spore superfine powder related data of table 8 comparative example 5
Comparative example 6
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; Mixed homogeneously with 15g Powderd cellulose by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 9.
The Ganoderma spore superfine powder related data of table 9 comparative example 6
Comparative example 7
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; Mixed homogeneously with 15g Glyceryl Behenate by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 10.
The Ganoderma spore superfine powder related data of table 10 comparative example 7
Comparative example 8
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 7g Powderd cellulose and 3g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 11.
The Ganoderma spore superfine powder related data of table 11 comparative example 8
Comparative example 9
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 5g Powderd cellulose and 5g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 12.
The Ganoderma spore superfine powder related data of table 12 comparative example 9
Comparative example 10
3kg Ganoderma spore is pulverized, crosses 60 ~ 80 mesh sieves, obtain Ganoderma spore powder; By 4g Powderd cellulose and 6g Glyceryl Behenate mix homogeneously, obtain Powderd cellulose-Glyceryl Behenate mixed powder; Mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, Ganodenic acid A retention rate and dissolution rate, the results are shown in Table 13.
The Ganoderma spore superfine powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of Powderd cellulose and Glyceryl Behenate is preferably 6:4; and the mass ratio of Ganoderma spore powder and Powderd cellulose-Glyceryl Behenate mixed powder is preferably 300 ~ 200:1; can realize the pulverizing of less than 2 microns, simultaneously flour extraction or Ganodenic acid A retention rate or dissolution rate are all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as Powderd cellulose and Glyceryl Behenate is 6:4, but the mass ratio of Ganoderma spore powder and Powderd cellulose-Glyceryl Behenate mixed powder is not 300 ~ 200:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or Ganodenic acid A retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the non-6:4 of mass ratio of Powderd cellulose and Glyceryl Behenate, even do not add Powderd cellulose and Glyceryl Behenate, its result shows, add Powderd cellulose-Glyceryl Behenate mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 3 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Ganoderma spore super-micro wall-broken crushing process, application Powderd cellulose and Glyceryl Behenate are as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, Ganodenic acid A retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of Powderd cellulose and Glyceryl Behenate is 6:4, when the mass ratio of Ganoderma spore powder and Powderd cellulose-Glyceryl Behenate mixed powder is 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1. a Ganoderma spore super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: pulverized by Ganoderma spore, crosses 60 ~ 80 mesh sieves, obtains Ganoderma spore powder;
B: mixed homogeneously with Glyceryl Behenate by Powderd cellulose, obtains Powderd cellulose-Glyceryl Behenate mixed powder;
C: mixed homogeneously with Powderd cellulose-Glyceryl Behenate mixed powder by Ganoderma spore powder, micronizing is to mean diameter to less than 2 microns.
2. Ganoderma spore super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Powderd cellulose and Glyceryl Behenate is 6:4.
3. Ganoderma spore super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Ganoderma spore powder and Powderd cellulose-Glyceryl Behenate mixed powder is preferably 300 ~ 200:1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381494A (en) * | 2018-11-29 | 2019-02-26 | 四川旭阳药业有限责任公司 | A kind of method for breaking trachytectum of glossy ganoderma |
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| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105055475A (en) * | 2015-08-18 | 2015-11-18 | 郑红芹 | Ultramicro wall-breaking smashing method for panax notoginseng |
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- 2015-11-25 CN CN201510834077.3A patent/CN105343135A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105055475A (en) * | 2015-08-18 | 2015-11-18 | 郑红芹 | Ultramicro wall-breaking smashing method for panax notoginseng |
Non-Patent Citations (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381494A (en) * | 2018-11-29 | 2019-02-26 | 四川旭阳药业有限责任公司 | A kind of method for breaking trachytectum of glossy ganoderma |
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