CN105343537A - Ultramicro wall-breaking grinding method for rhizoma gymnadeniae - Google Patents
Ultramicro wall-breaking grinding method for rhizoma gymnadeniae Download PDFInfo
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- CN105343537A CN105343537A CN201510830940.8A CN201510830940A CN105343537A CN 105343537 A CN105343537 A CN 105343537A CN 201510830940 A CN201510830940 A CN 201510830940A CN 105343537 A CN105343537 A CN 105343537A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention belongs to the field of medicines and provides an ultramicro wall-breaking grinding method for rhizoma gymnadeniae. The method is characterized by including steps: (1) grinding the rhizoma gymnadeniae, and filtering through a 60-80-mesh screen to obtain rhizoma gymnadeniae powder; (2) well mixing polyvinylpolypyrrolidone with medium chain triglyceride to obtain polyvinylpolypyrrolidone and medium chain triglyceride mixed powder, wherein a mass ratio of the polyvinylpolypyrrolidone to the medium chain triglyceride is 8:2 preferably; (3) well mixing the rhizoma gymnadeniae powder with the polyvinylpolypyrrolidone and medium chain triglyceride mixed powder, wherein a mass ratio of the rhizoma gymnadeniae powder to the polyvinylpolypyrrolidone and medium chain triglyceride mixed powder is 300-200:1 preferably. Compared with a conventional ultramicro wall-breaking grinding method, the ultramicro wall-breaking grinding method for the rhizoma gymnadeniae has the advantages of short processing time, high powder yield, high gastrodin retention rate, high dissolution rate, small average particle size of the powder and the like.
Description
Technical field
The present invention relates to a kind of Rhizoma Gymnadeniae super-micro wall-broken breaking method, belong to medical art.
Background technology
Rhizoma Gymnadeniae is the tuber of orchid Rhizoma Gymnadeniae or gymnadenia crassinervis Finet, is Qinghai-Tibet rare medical material, gains the name because of outer image palm.Have the effects such as nourishing benefit essence and promoting the production of body fluid to quench thirst, application is normal in powder form.
After Rhizoma Gymnadeniae micronizing, because the specific surface area of particle diameter increases, the dissolution rate of the effective ingredient such as gastrodine can be increased considerably, thus improve drug effect.Existing Rhizoma Gymnadeniae super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and the problem such as gastrodine loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Rhizoma Gymnadeniae super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Rhizoma Gymnadeniae super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: pulverized by Rhizoma Gymnadeniae, crosses 60 ~ 80 mesh sieves, obtains Rhizoma Gymnadeniae powder;
B: mixed homogeneously with medium chain triglyceride by polyvinylpolypyrrolidone, obtains polyvinylpolypyrrolidone-medium chain triglyceride mixed powder;
C: mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of polyvinylpolypyrrolidone and medium chain triglyceride is preferably 8:2.
The mass ratio of Rhizoma Gymnadeniae powder and polyvinylpolypyrrolidone-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Rhizoma Gymnadeniae super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, gastrodine retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Rhizoma Gymnadeniae super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of polyvinylpolypyrrolidone, medium chain triglyceride and Rhizoma Gymnadeniae fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 8g polyvinylpolypyrrolidone and 2g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 1.
The Rhizoma Gymnadeniae superfine powder related data of table 1 embodiment 1
Embodiment 2
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 12g polyvinylpolypyrrolidone and 3g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 2.
The Rhizoma Gymnadeniae superfine powder related data of table 2 embodiment 2
Embodiment 3
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 9.6g polyvinylpolypyrrolidone and 2.4g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 3.
The Rhizoma Gymnadeniae superfine powder related data of table 3 embodiment 3
Comparative example 1
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 7g polyvinylpolypyrrolidone and 1.75g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 4.
The Rhizoma Gymnadeniae superfine powder related data of table 4 comparative example 1
Comparative example 2
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 13.5g polyvinylpolypyrrolidone and 3.375g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 5.
The Rhizoma Gymnadeniae superfine powder related data of table 5 comparative example 2
Comparative example 3
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; Adopted by Rhizoma Gymnadeniae powder SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 6.
The Rhizoma Gymnadeniae superfine powder related data of table 6 comparative example 3
Comparative example 4
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; Mixed homogeneously with 10g polyvinylpolypyrrolidone by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 7.
The Rhizoma Gymnadeniae superfine powder related data of table 7 comparative example 4
Comparative example 5
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; Mixed homogeneously with 10g medium chain triglyceride by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 8.
The Rhizoma Gymnadeniae superfine powder related data of table 8 comparative example 5
Comparative example 6
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; Mixed homogeneously with 15g polyvinylpolypyrrolidone by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 9.
The Rhizoma Gymnadeniae superfine powder related data of table 9 comparative example 6
| Project | Mean diameter | Flour extraction | Gastrodine retention rate | Gastrodine dissolution rate |
| (30min) | ||||
| Rhizoma Gymnadeniae superfine powder | 7.5 micron | 82％ | 80％ | 65％ |
Comparative example 7
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; Mixed homogeneously with 15g medium chain triglyceride by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 10.
The Rhizoma Gymnadeniae superfine powder related data of table 10 comparative example 7
Comparative example 8
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 9g polyvinylpolypyrrolidone and 1g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 11.
The Rhizoma Gymnadeniae superfine powder related data of table 11 comparative example 8
Comparative example 9
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 7g polyvinylpolypyrrolidone and 3g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 12.
The Rhizoma Gymnadeniae superfine powder related data of table 12 comparative example 9
Comparative example 10
3kg Rhizoma Gymnadeniae is pulverized, crosses 60 ~ 80 mesh sieves, obtain Rhizoma Gymnadeniae powder; By 5g polyvinylpolypyrrolidone and 5g medium chain triglyceride mix homogeneously, obtain polyvinylpolypyrrolidone-medium chain triglyceride mixed powder; Mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, gastrodine retention rate and dissolution rate, the results are shown in Table 13.
The Rhizoma Gymnadeniae superfine powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of polyvinylpolypyrrolidone and medium chain triglyceride is preferably 8:2; and the mass ratio of Rhizoma Gymnadeniae powder and polyvinylpolypyrrolidone-medium chain triglyceride mixed powder is preferably 300 ~ 200:1; can realize the pulverizing of less than 2 microns, simultaneously flour extraction or gastrodine retention rate or dissolution rate are all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as polyvinylpolypyrrolidone and medium chain triglyceride is 8:2, but the mass ratio of Rhizoma Gymnadeniae powder and polyvinylpolypyrrolidone-medium chain triglyceride mixed powder is not 300 ~ 200:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or gastrodine retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the non-8:2 of mass ratio of polyvinylpolypyrrolidone and medium chain triglyceride, even do not add polyvinylpolypyrrolidone and medium chain triglyceride, its result shows, add polyvinylpolypyrrolidone-medium chain triglyceride mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Rhizoma Gymnadeniae super-micro wall-broken crushing process, application polyvinylpolypyrrolidone and medium chain triglyceride are as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, gastrodine retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of polyvinylpolypyrrolidone and medium chain triglyceride is 8:2, when the mass ratio of Rhizoma Gymnadeniae powder and polyvinylpolypyrrolidone-medium chain triglyceride mixed powder is 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1. a Rhizoma Gymnadeniae super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: pulverized by Rhizoma Gymnadeniae, crosses 60 ~ 80 mesh sieves, obtains Rhizoma Gymnadeniae powder;
B: mixed homogeneously with medium chain triglyceride by polyvinylpolypyrrolidone, obtains polyvinylpolypyrrolidone-medium chain triglyceride mixed powder;
C: mixed homogeneously with polyvinylpolypyrrolidone-medium chain triglyceride mixed powder by Rhizoma Gymnadeniae powder, micronizing is to mean diameter to less than 2 microns.
2. Rhizoma Gymnadeniae super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of polyvinylpolypyrrolidone and medium chain triglyceride is 8:2.
3. Rhizoma Gymnadeniae super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Rhizoma Gymnadeniae powder and polyvinylpolypyrrolidone-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510830940.8A CN105343537A (en) | 2015-11-25 | 2015-11-25 | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae |
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| CN201510830940.8A CN105343537A (en) | 2015-11-25 | 2015-11-25 | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481581A (en) * | 2018-12-12 | 2019-03-19 | 广州白云山汉方现代药业有限公司 | A kind of preparation method of rhizoma gymnadeniae broken wall medicine materical crude slice |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105055475A (en) * | 2015-08-18 | 2015-11-18 | 郑红芹 | Ultramicro wall-breaking smashing method for panax notoginseng |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105055475A (en) * | 2015-08-18 | 2015-11-18 | 郑红芹 | Ultramicro wall-breaking smashing method for panax notoginseng |
Non-Patent Citations (1)
| Title |
|---|
| 巴晓革 等: "微粉中药制剂添加助剂的制备工艺研究", 《齐鲁药事》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481581A (en) * | 2018-12-12 | 2019-03-19 | 广州白云山汉方现代药业有限公司 | A kind of preparation method of rhizoma gymnadeniae broken wall medicine materical crude slice |
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Application publication date: 20160224 |