CN105343134A - Superfine wall-breaking pulverization method for cordyceps sinensis - Google Patents
Superfine wall-breaking pulverization method for cordyceps sinensis Download PDFInfo
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- CN105343134A CN105343134A CN201510834165.3A CN201510834165A CN105343134A CN 105343134 A CN105343134 A CN 105343134A CN 201510834165 A CN201510834165 A CN 201510834165A CN 105343134 A CN105343134 A CN 105343134A
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Abstract
The invention provides a superfine wall-breaking pulverization method for cordyceps sinensis and belongs to the field of traditional Chinese medicine. The superfine wall-breaking pulverization method for the cordyceps sinensis is characterized by including the steps of (1) pulverizing the cordyceps sinensis and sieving the pulverized cordyceps sinensis by a 60-80-mesh sieve so as to obtain cordyceps sinensis powder; (2) uniformly mixing alpha-cyclodextrin with medium chain triglyceride in a preferred mass ratio of 8:2 so as to obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; (3) uniformly mixing the cordyceps sinensis powder with the alpha-cyclodextrin-medium chain triglyceride mixed powder in a preferred mass ratio of 300-200:1. Compared with a conventional superfine wall-breaking pulverization method, the superfine wall-breaking pulverization method for the cordyceps sinensis has the advantages of short preparation time, high powder yield, high cordycepic acid retention rate and dissolution rate, small average grain size of the powder and the like.
Description
Technical field
The present invention relates to a kind of Cordyceps super-micro wall-broken breaking method, belong to medical art.
Background technology
Cordyceps has another name called Cordyceps, and be the famous and precious tonic herb of China's usual one among the people, its nutritional labeling, higher than Radix Ginseng, can be used as medicine, also edible, is superior delicacies, has very high nutritive value.Cordyceps can immunity, the nourishing lung and kidney of enhancing body, has obvious inhibitory action to pulmonary carcinoma, hepatocarcinoma etc.All effective in cure to the red blood cell decreased after chronic cough of deficiency lung, asthma, hemoptysis of pulmonary tuberculosis, night sweat, soreness of waist and knee joint of suffering from a deficiency of the kidney, neurasthenia and chemotherapy and radiation clinically, application is normal in powder form.
After Cordyceps micronizing, because the specific surface area of particle diameter increases, the dissolution rate of the effective ingredient such as cordycepic acid can be increased considerably, thus improve drug effect.Existing Cordyceps super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and the problem such as cordycepic acid loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Cordyceps super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Cordyceps super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: pulverized by Cordyceps, crosses 60 ~ 80 mesh sieves, obtains Cordyceps powder;
B: mixed homogeneously with medium chain triglyceride by alpha-cyclodextrin, obtains alpha-cyclodextrin-medium chain triglyceride mixed powder;
C: mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of alpha-cyclodextrin and medium chain triglyceride is preferably 8:2.
The mass ratio of Cordyceps powder and alpha-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Cordyceps super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, cordycepic acid retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Cordyceps super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of alpha-cyclodextrin, medium chain triglyceride and Cordyceps fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 8g alpha-cyclodextrin and 2g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 1.
The Cordyceps superfine powder related data of table 1 embodiment 1
Embodiment 2
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 12g alpha-cyclodextrin and 3g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 2.
The Cordyceps superfine powder related data of table 2 embodiment 2
Embodiment 3
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 9.6g alpha-cyclodextrin and 2.4g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 3.
The Cordyceps superfine powder related data of table 3 embodiment 3
Comparative example 1
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 7g alpha-cyclodextrin and 1.75g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 4.
The Cordyceps superfine powder related data of table 4 comparative example 1
Comparative example 2
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 13.5g alpha-cyclodextrin and 3.375g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 5.
The Cordyceps superfine powder related data of table 5 comparative example 2
Comparative example 3
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; Adopted by Cordyceps powder SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 6.
The Cordyceps superfine powder related data of table 6 comparative example 3
Comparative example 4
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; Mixed homogeneously with 10g alpha-cyclodextrin by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 7.
The Cordyceps superfine powder related data of table 7 comparative example 4
Comparative example 5
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; Mixed homogeneously with 10g medium chain triglyceride by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 8.
The Cordyceps superfine powder related data of table 8 comparative example 5
Comparative example 6
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; Mixed homogeneously with 15g alpha-cyclodextrin by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 9.
The Cordyceps superfine powder related data of table 9 comparative example 6
Comparative example 7
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; Mixed homogeneously with 15g medium chain triglyceride by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 10.
The Cordyceps superfine powder related data of table 10 comparative example 7
Comparative example 8
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 9g alpha-cyclodextrin and 1g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 11.
The Cordyceps superfine powder related data of table 11 comparative example 8
Comparative example 9
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 7g alpha-cyclodextrin and 3g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 12.
The Cordyceps superfine powder related data of table 12 comparative example 9
Comparative example 10
3kg Cordyceps is pulverized, crosses 60 ~ 80 mesh sieves, obtain Cordyceps powder; By 5g alpha-cyclodextrin and 5g medium chain triglyceride mix homogeneously, obtain alpha-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, cordycepic acid retention rate and dissolution rate, the results are shown in Table 13.
The Cordyceps superfine powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of alpha-cyclodextrin and medium chain triglyceride is preferably 8:2; and the mass ratio of Cordyceps powder and alpha-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1; can realize the pulverizing of less than 2 microns, simultaneously flour extraction or cordycepic acid retention rate or dissolution rate are all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as alpha-cyclodextrin and medium chain triglyceride is 8:2, but the mass ratio of Cordyceps powder and alpha-cyclodextrin-medium chain triglyceride mixed powder is not 300 ~ 200:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or cordycepic acid retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the non-8:2 of mass ratio of alpha-cyclodextrin and medium chain triglyceride, even do not add alpha-cyclodextrin and medium chain triglyceride, its result shows, add alpha-cyclodextrin-medium chain triglyceride mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Cordyceps super-micro wall-broken crushing process, application alpha-cyclodextrin and medium chain triglyceride are as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, cordycepic acid retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of alpha-cyclodextrin and medium chain triglyceride is 8:2, when the mass ratio of Cordyceps powder and alpha-cyclodextrin-medium chain triglyceride mixed powder is 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1. a Cordyceps super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: pulverized by Cordyceps, crosses 60 ~ 80 mesh sieves, obtains Cordyceps powder;
B: mixed homogeneously with medium chain triglyceride by alpha-cyclodextrin, obtains alpha-cyclodextrin-medium chain triglyceride mixed powder;
C: mixed homogeneously with alpha-cyclodextrin-medium chain triglyceride mixed powder by Cordyceps powder, micronizing is to mean diameter to less than 2 microns.
2. Cordyceps super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of alpha-cyclodextrin and medium chain triglyceride is 8:2.
3. Cordyceps super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of Cordyceps powder and alpha-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
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| CN111956737A (en) * | 2020-09-08 | 2020-11-20 | 聂汉 | Traditional Chinese medicine for nourishing eyes, preparation method and Chinese-style eye nourishing equipment |
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| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
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| 孙文格等: "中药超微粉碎技术及粉体特征的研究进展", 《中国药业》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111956737A (en) * | 2020-09-08 | 2020-11-20 | 聂汉 | Traditional Chinese medicine for nourishing eyes, preparation method and Chinese-style eye nourishing equipment |
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