CN105106260B - A kind of ginseng super-micro wall-broken breaking method - Google Patents
A kind of ginseng super-micro wall-broken breaking method Download PDFInfo
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- CN105106260B CN105106260B CN201510506862.6A CN201510506862A CN105106260B CN 105106260 B CN105106260 B CN 105106260B CN 201510506862 A CN201510506862 A CN 201510506862A CN 105106260 B CN105106260 B CN 105106260B
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- ginseng
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Abstract
The present invention provides a kind of ginseng super-micro wall-broken breaking methods, belong to the field of Chinese medicines.The ginseng super-micro wall-broken breaking method of the present invention, it is characterised in that include the following steps：（1）Ginseng is routinely crushed, 80 100 mesh sieve is crossed, obtains ginseng fine powder；（2）Mannitol is uniformly mixed with proline, the mass ratio of mannitol and proline is preferably 1:1, obtain mannitol proline mixed powder；（3）Ginseng fine powder is uniformly mixed with mannitol proline mixed powder, ginseng fine powder and the mass ratio of mannitol proline mixed powder are preferably 200~100:1, average grain diameter is crushed to 2 microns using micronizer hereinafter, up to ginseng super-micro wall-broken powder.The ginseng super-micro wall-broken breaking method of the present invention, relatively conventional super-micro wall-broken breaking method have the advantages such as process time is short, flour extraction is high, ginsenoside retention rate and dissolution rate height and powder average particle size are small.
Description
Technical field
The present invention relates to a kind of ginseng super-micro wall-broken breaking methods, belong to pharmaceutical technology field.
Background technology
Ginseng is the dry root and rhizome of Araliaceae, is common rare medicinal herbs, has and improve human immunological competence
The effects that with building up health, principle active component are ginsenoside, and clinic is often used as medicine with powder.
After ginseng submicron powder is broken, since the specific surface area of grain size increases, the dissolution rate of ginsenoside can be increased considerably,
To improve drug effect.That there are grinding times is long for existing ginseng super-micro wall-broken breaking method, flour extraction is low and ginsenoside loss
The problems such as rate is high.
Invention content
The object of the present invention is to provide a kind of ginseng super-micro wall-broken breaking methods, to solve the above technical problems.
For foregoing invention purpose, the present invention provides following technical scheme：
The ginseng super-micro wall-broken breaking method of the present invention, which is characterized in that be as follows：
A：Ginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；
B：Mannitol is uniformly mixed with proline, obtains mannitol-proline mixed powder；
C：Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, ultramicro grinding to average grain diameter to 2 microns with
Under.
The mass ratio of mannitol and proline is preferably 1:1.
Ginseng fine powder and the mass ratio of mannitol-proline mixed powder are preferably 200~100:1.
Beneficial effects of the present invention are mainly：
The present invention ginseng super-micro wall-broken breaking method have process time is short, flour extraction is high, ginsenoside retention rate with
The advantages such as dissolution rate height and powder average particle size are small.The ginseng super-micro wall-broken breaking method of the present invention is unique, is in many experiments
In have been surprisingly found that, mannitol, the order by merging of proline and ginseng fine powder and ratio are unable to adjust.Therefore the present invention uses
Ingredient, ratio and order of addition, be the present invention innovative point.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, but should be noted that the scope of the present invention not by this
Any restrictions of a little examples.
Embodiment 1
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；5g mannitol and 5g proline are mixed
Uniformly, mannitol-proline mixed powder is obtained；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 1.
The ginseng submicron powder related data of 1 embodiment 1 of table
Embodiment 2
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；By 2.5g mannitol and 2.5g proline
It is uniformly mixed, obtains mannitol-proline mixed powder；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 2.
The ginseng submicron powder related data of 2 embodiment 2 of table
Embodiment 3
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；4g mannitol and 4g proline are mixed
Uniformly, mannitol-proline mixed powder is obtained；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder,
It is crushed 1 hour using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter, flour extraction, ginseng
Saponin(e retention rate and ginsenoside dissolution rate, the results are shown in Table 3.
The ginseng submicron powder related data of 3 embodiment 3 of table
Comparative example 1
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；10g mannitol and 10g proline are mixed
It closes uniformly, obtains mannitol-proline mixed powder；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 4.
The ginseng submicron powder related data of 4 comparative example 1 of table
Comparative example 2
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；2g mannitol and 2g proline are mixed
Uniformly, mannitol-proline mixed powder is obtained；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 5.
The ginseng submicron powder related data of 5 comparative example 2 of table
Comparative example 3
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；4g mannitol and 6g proline are mixed
Uniformly, mannitol-proline mixed powder is obtained；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 6.
The ginseng submicron powder related data of 6 comparative example 3 of table
Comparative example 4
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；6g mannitol and 4g proline are mixed
Uniformly, mannitol-proline mixed powder is obtained；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 7.
The ginseng submicron powder related data of 7 comparative example 4 of table
Comparative example 5
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；By 1.5g mannitol and 3.5g proline
It is uniformly mixed, obtains mannitol-proline mixed powder；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 8.
The ginseng submicron powder related data of 8 comparative example 5 of table
Comparative example 6
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；By 3.5g mannitol and 1.5g proline
It is uniformly mixed, obtains mannitol-proline mixed powder；Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside retention rate and
Ginsenoside dissolution rate, the results are shown in Table 9.
The ginseng submicron powder related data of 9 comparative example 6 of table
Comparative example 7
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；Using WZJ12J oscillatory type ultramicro grindings
Machine crushes 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside retention rate and ginsenoside dissolution rate, as a result
It is shown in Table 10.
The ginseng submicron powder related data of 10 comparative example 7 of table
Comparative example 8
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；Using WZJ12J oscillatory type ultramicro grindings
Machine crushes 3 hours, and gained powder measures average grain diameter, flour extraction, ginsenoside retention rate and ginsenoside dissolution rate, as a result
It is shown in Table 11.
The ginseng submicron powder related data of 11 comparative example 8 of table
Comparative example 9
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；Ginseng fine powder is mixed with 10g mannitol
Uniformly, using WZJ12J vibration type ultramicro disintegrators crush 1 hour, gained powder measure average grain diameter, flour extraction,
Ginsenoside retention rate and ginsenoside dissolution rate, the results are shown in Table 12.
The ginseng submicron powder related data of 12 comparative example 9 of table
Comparative example 10
1kg ginsengs are routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；Ginseng fine powder is mixed with 10g proline
Uniformly, it is crushed 1 hour using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter, flour extraction, ginsenoside
Retention rate and ginsenoside dissolution rate, the results are shown in Table 13.
The ginseng submicron powder related data of 13 comparative example 10 of table
The present invention has screened a large amount of prescription, finds：Only in the scope of the present invention, i.e. mannitol and proline
Mass ratio is preferably 1:1 and the mass ratio of ginseng fine powder and mannitol-proline mixed powder be preferably 200~100:1, Ke Yishi
Existing 2 microns or less micro powder granules, while no matter flour extraction or ginsenoside retention rate or dissolution rate are all very higher than 95%.Without
It is in ratio of the present invention, even if if the mass ratio of mannitol and proline is 1:1, but ginseng fine powder and mannitol-proline are mixed
The mass ratio for closing powder is not 200~100:1, as shown in comparative example 1 and 2, result grain size is more than 2 microns, while flour extraction is also
It is that ginsenoside retention rate or dissolution rate are below 95%.And the mass ratio non-1 of comparative example 3-10, mannitol and proline；1,
It even is not added with mannitol and proline, the results show that mannitol-proline mixed powder, which is added, to become smaller grain size, is not added with
For grain size about at 5 microns, indices are not up to standard afterwards.
Therefore：As can be seen from the above embodiments, in ginseng super-micro wall-broken crushing process, using mannitol-proline
Mixed powder can significantly improve crush efficiency as assisted comminution material, and with flour extraction high, ginsenoside retention rate with
The advantages such as dissolution rate height and powder average particle size are small.Wherein when the mass ratio of mannitol and proline is 1:1, ginseng fine powder with it is sweet
The mass ratio for revealing alcohol-proline mixed powder is 200~100:It is key factor when 1, with best crushing effect, has very
Big market popularization value.
Claims (1)
1. a kind of ginseng super-micro wall-broken breaking method, which is characterized in that be as follows：
A：Ginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains ginseng fine powder；
B：Mannitol is uniformly mixed with proline, obtains mannitol-proline mixed powder；
C：Ginseng fine powder is uniformly mixed with mannitol-proline mixed powder, ultramicro grinding to average grain diameter is to 2 microns or less；
The mass ratio of the mannitol and proline is 1:1；The mass ratio of the ginseng fine powder and mannitol-proline mixed powder
It is 200~100:1.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828619A (en) * | 2010-05-12 | 2010-09-15 | 吉林农业大学 | Ginseng instant tea |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828619A (en) * | 2010-05-12 | 2010-09-15 | 吉林农业大学 | Ginseng instant tea |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中药超微粉碎技术及粉体特征的研究进展;孙文格等;《中国药业》;20091120;第18卷(第22期);第75页右边栏第2段 * |
| 超微粉碎对人参中皂苷测定量的影响;张晶等;《食品科学》;20090915;第30卷(第18期);第96页"1.1 材料与试剂"部分，第98页右边栏倒数第3-2段 * |
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Effective date of registration: 20180725 Address after: 518000 Shenzhen, Guangdong, Luohu District, Guangyuan Road, Luohu District, Shennan East Road, B, block Jinfeng Building, Applicant after: Shenzhen City Hall Sheng Biotechnology Co. Ltd. Address before: 518000 Shenzhen Shennan Road 5015, Guangdong, Luohu District, B 1502-1503, Jinfeng City mansion. Applicant before: Zheng Hongqin |
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