CN102920762A - High-absorptivity ginseng powder and preparation method thereof - Google Patents

High-absorptivity ginseng powder and preparation method thereof Download PDF

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Publication number
CN102920762A
CN102920762A CN2012104758512A CN201210475851A CN102920762A CN 102920762 A CN102920762 A CN 102920762A CN 2012104758512 A CN2012104758512 A CN 2012104758512A CN 201210475851 A CN201210475851 A CN 201210475851A CN 102920762 A CN102920762 A CN 102920762A
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Prior art keywords
radix ginseng
ginseng powder
powder
ginseng
preparation
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钟永祥
钟接贵
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FUJIAN SHANG XIANG PHARMACEUTICAL Co Ltd
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FUJIAN SHANG XIANG PHARMACEUTICAL Co Ltd
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Abstract

The invention relates to high-absorptivity ginseng powder and a preparation method thereof. The ginseng powder provided by the invention is prepared from the following ingredients in percentage by total weight: 50-70% of ginseng and 30-50% of beta-cyclodextrin through the steps of cleaning the ginseng, drying over a fire, crushing, homogenizing, drying and packaging a finished product. Compared with the traditional technique, the preparation method provided by the invention has the beneficial effects that the ginseng is higher in absorptivity and better in taste, the bitter taste of the ginseng is reduced, and the natural fragrance of the ginseng is remained.

Description

A kind of high absorption Radix Ginseng powder and preparation method thereof
One. technical field
The present invention relates to a kind of pharmaceutical technology field, especially a kind of high absorption Radix Ginseng powder and preparation method thereof.
Two. background technology
Radix Ginseng mainly contains the materials such as ginsenoside, peptide and aminoacid, vitamin, is fabulous tonic of all times.At present, various processing and eating method are arranged.The Radix Ginseng powder has common Radix Ginseng powder and ultra micro efflorescence Radix Ginseng powder, and common Radix Ginseng powder's absorbance is low, and ultra micro efflorescence Radix Ginseng powder absorbance is higher.But Radix Ginseng main active ginsenoside's water solublity is relatively poor, and absorbance still has much room for improvement; And, these two kinds of Radix Ginseng powder that technique is made, bitter in the mouth, Radix Ginseng natural aromatic composition is lost more, and mouthfeel is not good enough.
(it is the product that starch generates through the acidolysis cyclisation that β-cyclodextrin is called for short β-CD) to cyclodextrin.It can the various compound molecules of envelope, increase by the stability of inclusion complex to photo-thermal, oxygen, change by the physicochemical property of envelope material.Cycloheptaamylose have height selectivity, do not have toxicity, for edibility, non-hygroscopic property, chemical stability is good and be easy to the advantage such as separation.
The application of Benexate Hydrochloride on pharmaceutics: the stability that improves medicine; Make hygroscopy, volatility or liquid medicine powdered; Increase the dissolubility of insoluble drugs; Improve the bioavailability of medicine; Reduce toxic and side effects, the zest of medicine, cover bad smell; Regulate rate of releasing drug.
Test shows, beta-schardinger dextrin-is 353.20g.L-1 to sl. sol. ginsenoside Rg1's dissolubility in water; Ginsenoside Rh2 and β-CD can spontaneous formation clathrates in aqueous solution, make its dissolubility increase nearly 80 times.
Three. summary of the invention
The preparation method that the purpose of this invention is to provide a kind of high absorption Radix Ginseng powder overcomes the problems such as the absorbance that prior art exists is not high, mouthfeel is not good.
The present invention adopts following technical method to realize:
Radix Ginseng powder of the present invention is by the Radix Ginseng of following composition: gross weight 50%-70%, the cycloheptaamylose of 30%-50%.
The best proportioning of Radix Ginseng powder of the present invention is: the Radix Ginseng of gross weight 60%, 40% cycloheptaamylose.
The present invention is prepared from through following steps:
(1) Radix Ginseng is cleaned, is dried: dry to moisture 3-5%;
(2) pulverize: the Radix Ginseng of oven dry, be ground into first 80 purpose fine powders, be ground into 3000-5000 purpose superfine powder with super micron mill again;
(3) homogenate: with Radix Ginseng powder, cycloheptaamylose, add the water of solid-to-liquid ratio 1:15-20 by prescription, stir and carry out homogenate with colloid mill after 10-20 minute;
(4) drying: with the homogenate suspension in 60-85 ℃ of spray drying;
(5) finished product packing.
Compare with traditional process, the invention has the beneficial effects as follows:
1, by the enclose solubilization of cycloheptaamylose to Radix Ginseng active substance ginsenoside, absorbance is higher.
2, reduced the bitterness of Radix Ginseng, kept the natural aromatic of Radix Ginseng, mouthfeel is better.
Four. the specific embodiment
Below in conjunction with specific embodiment the present invention is elaborated.
(1) with 6 kilograms of Radix Ginsengs, clean, 55 ℃ of dryings are 4 hours in the circulation baking oven, to moisture 4%;
(2) use first Universalpulverizer 80 coarse pulverizations, be ground into 3500-4000 purpose superfine powder with super micron mill again, this super micron mill model HMB-701, the great space development in science and technology in BeiJing ZhongKe company limited is produced;
(3) 4 kilograms of cycloheptaamylose powder and ginseng submicron powder are added 17 kg of water, stir after 15 minutes, cross colloid mill 2 times, this colloid mill model JML80, Shanghai section labor plant equipment company limited is produced;
(4) with the homogenate suspension in 60-85 ℃ of spray drying, what use is that model is the high-speed centrifugal sprayer of GZ-25, Wuxi City weather-drying instrument factory is produced;
(5) get 9.7 kilograms of finished products, enter packing, sell supervisor.
Radix Ginseng powder and the common process Radix Ginseng powder absorbance this technique made by following test compare:
1. ginsenoside's blood drug level
Through testing with the dosage mouse stomach, 2 groups of average blood drug level of each time point of the Radix Ginseng powder that common process Radix Ginseng powder and this technique are made after the mouse stomach administration the results are shown in Table 1.
The Radix Ginseng powder ginsenoside measurement result that table 1 common process Radix Ginseng powder and this technique are made
Figure BDA00002443007700031
Illustrate: blood drug level means the total concentration in blood plasma after the drug absorption, comprise be combined with plasma protein or at the medicine of plasma free, sometimes also can make a general reference the concentration of medicine in whole blood.Pharmaceutically-active intensity is directly proportional with the concentration of medicine in blood plasma, and medicine concentration in vivo changed along with the time.Two kinds of technique Radix Ginseng powder different intervals samplings after the mouse stomach administration, measure, as can be seen from Table 1: 30min blood drug level reaches maximum after the mouse stomach administration, this technique is respectively 77.34 ± 11.54 and 26.335 ± 5.21 with common process, afterwards As time goes on, in vivo progressively metabolism, the blood drug level of two kinds of techniques is more and more lower.
Show: adopt ginsenoside's good absorbing of this explained hereafter, absorbance is high.
2. pharmacokinetic parameters
Adopt D AS 2.1.1 version pharmacokinetic analysis software that the blood drug level data are processed, show the ginsenoside in vivo through the time process meet two-compartment model (weight be 1/C 2), the results are shown in Table 2.
The Radix Ginseng powder ginsenoside pharmacokinetic parameters in vivo that table 2 common process Radix Ginseng powder ginsenoside and this technique are made
Figure BDA00002443007700041
As can be seen from Table 2: 30min reaches maximum plasma concentration Cmax=77.34mgL after the administration of this technique Radix Ginseng powder ginsenoside mouse stomach -1, the maximum plasma concentration Cmax=26.335mgL that reaches than common Radix Ginseng powder ginsenoside 30min -1Exceed 2.9 times, area under the drug-time curve (AUC) is respectively 3504.303mgL -1Min, 1657.283mgL -1Min, both ratios are: 2.1.Area under the drug-time curve: mean the area that plasma concentration curve surrounds time shaft.This parameter is to estimate the important indicator of extent of drug absorption, reflection medicine exposure characteristic in vivo.
Show: this technique Radix Ginseng powder ginsenoside absorbance in blood is high.

Claims (3)

1. one kind high absorption Radix Ginseng powder is characterized in that it is comprised of the Radix Ginseng of gross weight 50%-70% and the cycloheptaamylose of 30%-50%.
2. the high Radix Ginseng powder that absorbs according to claim 1 is characterized in that it is comprised of the Radix Ginseng of gross weight 60% and 40% cycloheptaamylose.
3. height according to claim 1 and 2 absorbs Radix Ginseng powder's preparation method, it is characterized in that it may further comprise the steps:
(1) Radix Ginseng is cleaned, is dried: dry to moisture 3-5%;
(2) pulverize: the Radix Ginseng of oven dry, be ground into first 80 purpose fine powders, be ground into 3000-5000 purpose superfine powder with super micron mill again;
(3) homogenate: with Radix Ginseng powder, cycloheptaamylose, add the water of solid-to-liquid ratio 1:15-20 by prescription, stir and carry out homogenate with colloid mill after 10-20 minute;
(4) drying: with the homogenate suspension in 60-85 ℃ of spray drying;
(5) finished product packing.
CN2012104758512A 2012-11-21 2012-11-21 High-absorptivity ginseng powder and preparation method thereof Pending CN102920762A (en)

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CN103637347A (en) * 2013-12-02 2014-03-19 东北林业大学 Preparation method of water-soluble peony seed powder
CN103749750A (en) * 2014-01-20 2014-04-30 熊以焯 Farm product submicron powder processing technology
CN105106260A (en) * 2015-08-18 2015-12-02 郑红芹 Superfine wall-breaking pulverization method of ginseng
CN107822125A (en) * 2017-12-15 2018-03-23 程美路 A kind of nutrient and healthcare products and preparation method thereof
CN109527316A (en) * 2018-12-25 2019-03-29 南京悠维有机食品有限公司 A kind of berry enzyme nutrient solution
CN114558043A (en) * 2022-03-11 2022-05-31 江南大学 A method for preparing Ginseng radix composition with high ginsenoside availability

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103637347A (en) * 2013-12-02 2014-03-19 东北林业大学 Preparation method of water-soluble peony seed powder
CN103749750A (en) * 2014-01-20 2014-04-30 熊以焯 Farm product submicron powder processing technology
CN103749750B (en) * 2014-01-20 2016-03-16 熊以焯 A kind of farm product submicron powder processing technology
CN105106260A (en) * 2015-08-18 2015-12-02 郑红芹 Superfine wall-breaking pulverization method of ginseng
CN105106260B (en) * 2015-08-18 2018-09-07 深圳市盛元堂生物科技有限公司 A kind of ginseng super-micro wall-broken breaking method
CN107822125A (en) * 2017-12-15 2018-03-23 程美路 A kind of nutrient and healthcare products and preparation method thereof
CN109527316A (en) * 2018-12-25 2019-03-29 南京悠维有机食品有限公司 A kind of berry enzyme nutrient solution
CN114558043A (en) * 2022-03-11 2022-05-31 江南大学 A method for preparing Ginseng radix composition with high ginsenoside availability
WO2023169260A1 (en) * 2022-03-11 2023-09-14 江南大学 Preparation method for ginseng composition having high utilization of ginsenoside
US20230414643A1 (en) * 2022-03-11 2023-12-28 Jiangnan University Preparation Method of Ginseng Composition with High Ginsenoside Bioavailability
US11963970B2 (en) * 2022-03-11 2024-04-23 Jiangnan University Preparation method of ginseng composition with high ginsenoside bioavailability

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Application publication date: 20130213