CN102920762A - High-absorptivity ginseng powder and preparation method thereof - Google Patents
High-absorptivity ginseng powder and preparation method thereof Download PDFInfo
- Publication number
- CN102920762A CN102920762A CN2012104758512A CN201210475851A CN102920762A CN 102920762 A CN102920762 A CN 102920762A CN 2012104758512 A CN2012104758512 A CN 2012104758512A CN 201210475851 A CN201210475851 A CN 201210475851A CN 102920762 A CN102920762 A CN 102920762A
- Authority
- CN
- China
- Prior art keywords
- radix ginseng
- ginseng powder
- powder
- ginseng
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to high-absorptivity ginseng powder and a preparation method thereof. The ginseng powder provided by the invention is prepared from the following ingredients in percentage by total weight: 50-70% of ginseng and 30-50% of beta-cyclodextrin through the steps of cleaning the ginseng, drying over a fire, crushing, homogenizing, drying and packaging a finished product. Compared with the traditional technique, the preparation method provided by the invention has the beneficial effects that the ginseng is higher in absorptivity and better in taste, the bitter taste of the ginseng is reduced, and the natural fragrance of the ginseng is remained.
Description
One. technical field
The present invention relates to a kind of pharmaceutical technology field, especially a kind of high absorption Radix Ginseng powder and preparation method thereof.
Two. background technology
Radix Ginseng mainly contains the materials such as ginsenoside, peptide and aminoacid, vitamin, is fabulous tonic of all times.At present, various processing and eating method are arranged.The Radix Ginseng powder has common Radix Ginseng powder and ultra micro efflorescence Radix Ginseng powder, and common Radix Ginseng powder's absorbance is low, and ultra micro efflorescence Radix Ginseng powder absorbance is higher.But Radix Ginseng main active ginsenoside's water solublity is relatively poor, and absorbance still has much room for improvement; And, these two kinds of Radix Ginseng powder that technique is made, bitter in the mouth, Radix Ginseng natural aromatic composition is lost more, and mouthfeel is not good enough.
(it is the product that starch generates through the acidolysis cyclisation that β-cyclodextrin is called for short β-CD) to cyclodextrin.It can the various compound molecules of envelope, increase by the stability of inclusion complex to photo-thermal, oxygen, change by the physicochemical property of envelope material.Cycloheptaamylose have height selectivity, do not have toxicity, for edibility, non-hygroscopic property, chemical stability is good and be easy to the advantage such as separation.
The application of Benexate Hydrochloride on pharmaceutics: the stability that improves medicine; Make hygroscopy, volatility or liquid medicine powdered; Increase the dissolubility of insoluble drugs; Improve the bioavailability of medicine; Reduce toxic and side effects, the zest of medicine, cover bad smell; Regulate rate of releasing drug.
Test shows, beta-schardinger dextrin-is 353.20g.L-1 to sl. sol. ginsenoside Rg1's dissolubility in water; Ginsenoside Rh2 and β-CD can spontaneous formation clathrates in aqueous solution, make its dissolubility increase nearly 80 times.
Three. summary of the invention
The preparation method that the purpose of this invention is to provide a kind of high absorption Radix Ginseng powder overcomes the problems such as the absorbance that prior art exists is not high, mouthfeel is not good.
The present invention adopts following technical method to realize:
Radix Ginseng powder of the present invention is by the Radix Ginseng of following composition: gross weight 50%-70%, the cycloheptaamylose of 30%-50%.
The best proportioning of Radix Ginseng powder of the present invention is: the Radix Ginseng of gross weight 60%, 40% cycloheptaamylose.
The present invention is prepared from through following steps:
(1) Radix Ginseng is cleaned, is dried: dry to moisture 3-5%;
(2) pulverize: the Radix Ginseng of oven dry, be ground into first 80 purpose fine powders, be ground into 3000-5000 purpose superfine powder with super micron mill again;
(3) homogenate: with Radix Ginseng powder, cycloheptaamylose, add the water of solid-to-liquid ratio 1:15-20 by prescription, stir and carry out homogenate with colloid mill after 10-20 minute;
(4) drying: with the homogenate suspension in 60-85 ℃ of spray drying;
(5) finished product packing.
Compare with traditional process, the invention has the beneficial effects as follows:
1, by the enclose solubilization of cycloheptaamylose to Radix Ginseng active substance ginsenoside, absorbance is higher.
2, reduced the bitterness of Radix Ginseng, kept the natural aromatic of Radix Ginseng, mouthfeel is better.
Four. the specific embodiment
Below in conjunction with specific embodiment the present invention is elaborated.
(1) with 6 kilograms of Radix Ginsengs, clean, 55 ℃ of dryings are 4 hours in the circulation baking oven, to moisture 4%;
(2) use first Universalpulverizer 80 coarse pulverizations, be ground into 3500-4000 purpose superfine powder with super micron mill again, this super micron mill model HMB-701, the great space development in science and technology in BeiJing ZhongKe company limited is produced;
(3) 4 kilograms of cycloheptaamylose powder and ginseng submicron powder are added 17 kg of water, stir after 15 minutes, cross colloid mill 2 times, this colloid mill model JML80, Shanghai section labor plant equipment company limited is produced;
(4) with the homogenate suspension in 60-85 ℃ of spray drying, what use is that model is the high-speed centrifugal sprayer of GZ-25, Wuxi City weather-drying instrument factory is produced;
(5) get 9.7 kilograms of finished products, enter packing, sell supervisor.
Radix Ginseng powder and the common process Radix Ginseng powder absorbance this technique made by following test compare:
1. ginsenoside's blood drug level
Through testing with the dosage mouse stomach, 2 groups of average blood drug level of each time point of the Radix Ginseng powder that common process Radix Ginseng powder and this technique are made after the mouse stomach administration the results are shown in Table 1.
The Radix Ginseng powder ginsenoside measurement result that table 1 common process Radix Ginseng powder and this technique are made
Illustrate: blood drug level means the total concentration in blood plasma after the drug absorption, comprise be combined with plasma protein or at the medicine of plasma free, sometimes also can make a general reference the concentration of medicine in whole blood.Pharmaceutically-active intensity is directly proportional with the concentration of medicine in blood plasma, and medicine concentration in vivo changed along with the time.Two kinds of technique Radix Ginseng powder different intervals samplings after the mouse stomach administration, measure, as can be seen from Table 1: 30min blood drug level reaches maximum after the mouse stomach administration, this technique is respectively 77.34 ± 11.54 and 26.335 ± 5.21 with common process, afterwards As time goes on, in vivo progressively metabolism, the blood drug level of two kinds of techniques is more and more lower.
Show: adopt ginsenoside's good absorbing of this explained hereafter, absorbance is high.
2. pharmacokinetic parameters
Adopt D AS 2.1.1 version pharmacokinetic analysis software that the blood drug level data are processed, show the ginsenoside in vivo through the time process meet two-compartment model (weight be 1/C
2), the results are shown in Table 2.
The Radix Ginseng powder ginsenoside pharmacokinetic parameters in vivo that table 2 common process Radix Ginseng powder ginsenoside and this technique are made
As can be seen from Table 2: 30min reaches maximum plasma concentration Cmax=77.34mgL after the administration of this technique Radix Ginseng powder ginsenoside mouse stomach
-1, the maximum plasma concentration Cmax=26.335mgL that reaches than common Radix Ginseng powder ginsenoside 30min
-1Exceed 2.9 times, area under the drug-time curve (AUC) is respectively 3504.303mgL
-1Min, 1657.283mgL
-1Min, both ratios are: 2.1.Area under the drug-time curve: mean the area that plasma concentration curve surrounds time shaft.This parameter is to estimate the important indicator of extent of drug absorption, reflection medicine exposure characteristic in vivo.
Show: this technique Radix Ginseng powder ginsenoside absorbance in blood is high.
Claims (3)
1. one kind high absorption Radix Ginseng powder is characterized in that it is comprised of the Radix Ginseng of gross weight 50%-70% and the cycloheptaamylose of 30%-50%.
2. the high Radix Ginseng powder that absorbs according to claim 1 is characterized in that it is comprised of the Radix Ginseng of gross weight 60% and 40% cycloheptaamylose.
3. height according to claim 1 and 2 absorbs Radix Ginseng powder's preparation method, it is characterized in that it may further comprise the steps:
(1) Radix Ginseng is cleaned, is dried: dry to moisture 3-5%;
(2) pulverize: the Radix Ginseng of oven dry, be ground into first 80 purpose fine powders, be ground into 3000-5000 purpose superfine powder with super micron mill again;
(3) homogenate: with Radix Ginseng powder, cycloheptaamylose, add the water of solid-to-liquid ratio 1:15-20 by prescription, stir and carry out homogenate with colloid mill after 10-20 minute;
(4) drying: with the homogenate suspension in 60-85 ℃ of spray drying;
(5) finished product packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104758512A CN102920762A (en) | 2012-11-21 | 2012-11-21 | High-absorptivity ginseng powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104758512A CN102920762A (en) | 2012-11-21 | 2012-11-21 | High-absorptivity ginseng powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102920762A true CN102920762A (en) | 2013-02-13 |
Family
ID=47635787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104758512A Pending CN102920762A (en) | 2012-11-21 | 2012-11-21 | High-absorptivity ginseng powder and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102920762A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103637347A (en) * | 2013-12-02 | 2014-03-19 | 东北林业大学 | Preparation method of water-soluble peony seed powder |
| CN103749750A (en) * | 2014-01-20 | 2014-04-30 | 熊以焯 | Farm product submicron powder processing technology |
| CN105106260A (en) * | 2015-08-18 | 2015-12-02 | 郑红芹 | Superfine wall-breaking pulverization method of ginseng |
| CN107822125A (en) * | 2017-12-15 | 2018-03-23 | 程美路 | A kind of nutrient and healthcare products and preparation method thereof |
| CN109527316A (en) * | 2018-12-25 | 2019-03-29 | 南京悠维有机食品有限公司 | A kind of berry enzyme nutrient solution |
| CN114558043A (en) * | 2022-03-11 | 2022-05-31 | 江南大学 | A method for preparing Ginseng radix composition with high ginsenoside availability |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1493298A (en) * | 2003-09-06 | 2004-05-05 | 南昌弘益科技有限公司 | Ginseng stem leaf total saponin drip pill and its preparation method |
| CN101543518A (en) * | 2008-03-24 | 2009-09-30 | 北京凯瑞创新医药科技有限公司 | Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof |
| CN101623311A (en) * | 2009-07-03 | 2010-01-13 | 青岛格瑞药业有限公司 | Micronization vitamin ginseng zinc and medicine composition thereof |
| CN101828619A (en) * | 2010-05-12 | 2010-09-15 | 吉林农业大学 | Ginseng instant tea |
-
2012
- 2012-11-21 CN CN2012104758512A patent/CN102920762A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1493298A (en) * | 2003-09-06 | 2004-05-05 | 南昌弘益科技有限公司 | Ginseng stem leaf total saponin drip pill and its preparation method |
| CN101543518A (en) * | 2008-03-24 | 2009-09-30 | 北京凯瑞创新医药科技有限公司 | Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof |
| CN101623311A (en) * | 2009-07-03 | 2010-01-13 | 青岛格瑞药业有限公司 | Micronization vitamin ginseng zinc and medicine composition thereof |
| CN101828619A (en) * | 2010-05-12 | 2010-09-15 | 吉林农业大学 | Ginseng instant tea |
Non-Patent Citations (5)
| Title |
|---|
| 《中国中医药信息杂志》 20090531 龚敏阳 beta-环糊精及其衍生物在中药制剂中的研究进展 第16卷, * |
| 何煜等: "中药细胞级微粉碎对体内吸收的影响", 《中成药》 * |
| 张晶等: "超微粉碎对人参中皂苷测定量的影响", 《食品科学》 * |
| 赵伯涛等: "超微冻干人参的粉体特征、皂苷测定及功效研究", 《中草药》 * |
| 龚敏阳: "β-环糊精及其衍生物在中药制剂中的研究进展", 《中国中医药信息杂志》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103637347A (en) * | 2013-12-02 | 2014-03-19 | 东北林业大学 | Preparation method of water-soluble peony seed powder |
| CN103749750A (en) * | 2014-01-20 | 2014-04-30 | 熊以焯 | Farm product submicron powder processing technology |
| CN103749750B (en) * | 2014-01-20 | 2016-03-16 | 熊以焯 | A kind of farm product submicron powder processing technology |
| CN105106260A (en) * | 2015-08-18 | 2015-12-02 | 郑红芹 | Superfine wall-breaking pulverization method of ginseng |
| CN105106260B (en) * | 2015-08-18 | 2018-09-07 | 深圳市盛元堂生物科技有限公司 | A kind of ginseng super-micro wall-broken breaking method |
| CN107822125A (en) * | 2017-12-15 | 2018-03-23 | 程美路 | A kind of nutrient and healthcare products and preparation method thereof |
| CN109527316A (en) * | 2018-12-25 | 2019-03-29 | 南京悠维有机食品有限公司 | A kind of berry enzyme nutrient solution |
| CN114558043A (en) * | 2022-03-11 | 2022-05-31 | 江南大学 | A method for preparing Ginseng radix composition with high ginsenoside availability |
| WO2023169260A1 (en) * | 2022-03-11 | 2023-09-14 | 江南大学 | Preparation method for ginseng composition having high utilization of ginsenoside |
| US20230414643A1 (en) * | 2022-03-11 | 2023-12-28 | Jiangnan University | Preparation Method of Ginseng Composition with High Ginsenoside Bioavailability |
| US11963970B2 (en) * | 2022-03-11 | 2024-04-23 | Jiangnan University | Preparation method of ginseng composition with high ginsenoside bioavailability |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102920762A (en) | High-absorptivity ginseng powder and preparation method thereof | |
| Suo et al. | Lentinan as a natural stabilizer with bioactivities for preparation of drug–drug nanosuspensions | |
| EP3181616A1 (en) | Cellulose micropowder | |
| AU2019365596A1 (en) | Formulation comprising water soluble particles of a non-curcuminoid and a curcuminoid | |
| Tian et al. | Fabrication of nanosuspensions to improve the oral bioavailability of total flavones from Hippophae rhamnoides L. and their comparison with an inclusion complex | |
| CA3124534C (en) | Cellulose powder, use thereof, and tablets | |
| TWI549700B (en) | Panax notoginseng broken wall preparation | |
| CN104800184B (en) | The smooth sustained release agent pieces of butanedioic acid furan Luo Qu | |
| EP3011965B1 (en) | Salvia miltiorrhiza extract, micropellet formulation thereof, methods of preparing same, and uses thereof | |
| CN111419900B (en) | Improved nano suspension freeze-dried preparation based on perhexiline and preparation method thereof | |
| CN108014104A (en) | A kind of Synergistic type dihydromyricetin soluble type compound and preparation method thereof | |
| RO130611A2 (en) | Pharmaceutical composition as oral suspension including a flavonoid fraction and xanthan gum | |
| Zhang et al. | Chitosan and chitosan/β‐cyclodextrin microspheres as sustained‐release drug carriers | |
| Noreen et al. | Polymeric complex nanocarriers of Mangifera indica gum & chitosan for methotrexate delivery: Formulation, characterization, and in vitro toxicological assessment | |
| EP3978026A1 (en) | Use of anthocyanin-anionic polysaccharide complex for preventing or treating influenza virus a infection | |
| TWI508752B (en) | A preparation method of chrysanthemum broken wall preparation | |
| CN108403633A (en) | It is a kind of that there is the high stable type pterostilbene soluble type compound and preparation method thereof for providing faintly acid Micellar Microenvironment | |
| CN104800168A (en) | Stiripentol dry suspension and preparation method thereof | |
| CN1096852C (en) | Resina Draconis preparation as one Chinese medicine and its preparation process | |
| CN108498457A (en) | One kind having high stability Astragaloside IV soluble type compound and preparation method thereof | |
| JP2007063206A (en) | Neutral fat-accumulation inhibitor | |
| CN116850248B (en) | Kekeping capsule and its preparation method | |
| CN105616451A (en) | Cordyceps sinensis micro-powder containing cyclodextrin and preparation method and preparation of cordyceps sinensis micro-powder | |
| CN107714653A (en) | A kind of soluble methotrexate (MTX) granule of stabilization | |
| TWI661841B (en) | Carrier for dispersing hydrophobic botanical extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130213 |