CN101623311A - Micronization vitamin ginseng zinc and medicine composition thereof - Google Patents
Micronization vitamin ginseng zinc and medicine composition thereof Download PDFInfo
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- CN101623311A CN101623311A CN200910158796A CN200910158796A CN101623311A CN 101623311 A CN101623311 A CN 101623311A CN 200910158796 A CN200910158796 A CN 200910158796A CN 200910158796 A CN200910158796 A CN 200910158796A CN 101623311 A CN101623311 A CN 101623311A
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Abstract
The invention discloses micronization vitamin ginseng zinc comprising the components of ginseng, vitamin E, pollenin and zinc sulfate, the size of 70-100 percent of grains is less than or equal to 100 micrometers in a solid component mixture except for the vitamin E. The invention also provides a medicine composition containing the micronization vitamin ginseng zinc and a capsule and a tablet prepared by the composition.
Description
Technical field
The invention belongs to pharmaceutical field, be specifically related to micronization vitamin ginseng zinc and pharmaceutical composition thereof.
Background technology
The WEISHENXIN capsule is a kind of compound preparation, it is by Radix Ginseng, vitamin E, pollenin and the zinc sulfate pharmaceutical composition as effective ingredient, is mainly used in deterioration diseases such as old people's male's sexual, VAOU, audition, cardiac function capacity of self-regulation, pulmonary function.This compound preparation is according to its effective ingredient and called after " WEISHENXIN ", and generally " WEISHENXIN " can be regarded as the general name of 4 kinds of effective ingredient.
Existing WEISHENXIN capsule is a hard capsule, and the granularity of capsule 's content is about 80 orders, and main commercially available specification is every and contains Radix Ginseng 0.125g, vitamin E 0.025g, pollenin 0.025g, zinc sulfate 0.85mg.Its major defect is to absorb slowlyer, and bioavailability is lower.
Other dosage form does not appear in this medicine at present, and the problems referred to above are not resolved yet.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of micronization vitamin ginseng zinc is provided, it absorbs rapidly, and onset time is fast, and bioavailability is higher.
Another object of the present invention is to provide a kind of compositions that contains micronization vitamin ginseng zinc.
Micronization vitamin ginseng zinc of the present invention is by the solid effective ingredient being carried out being prepared from after the grinding and processing, by controlling the particle diameter of effective ingredient micronized particle, guaranteeing that this pharmaceutical preparation has higher bioavailability and better therapeutic.Special needs to be pointed out is,, be not included in the micronization processes, therefore it will be understood by those skilled in the art that " micronization " described among the present invention is meant the micronization of Radix Ginseng, pollenin and zinc sulfate in fact because the effective ingredient vitamin E is a grease.
Micronization vitamin ginseng zinc of the present invention comprises Radix Ginseng, vitamin E, pollenin and four kinds of effective ingredient of zinc sulfate, wherein the weight proportion of each component is: Radix Ginseng: vitamin E: pollenin: zinc sulfate=(140-150): (25-40): (25-40): 1, and the solid matter except that vitamin E is after micronization processes, and the grain diameter of about 70-100% is smaller or equal to 100 μ m; Preferably, the grain diameter of 60-90% is smaller or equal to 80 μ m, and more preferably, 70% grain diameter is smaller or equal to 80 μ m.The present invention also provides the pharmaceutical composition that contains micronization vitamin ginseng zinc, and said composition comprises the component of following weight proportion: Radix Ginseng: vitamin E: pollenin: zinc sulfate: diluent: lubricant: fluidizer=(140-150): (25-40): (25-40): 1: (150-200): (25-45): (700-820).
Wherein, diluent of the present invention, lubricant and fluidizer can be the pharmaceutically conventional materials that uses, and described diluent is starch, dextrin, microcrystalline Cellulose, sucrose, lactose etc., preferably uses starch; Described lubricant is a magnesium stearate; Described fluidizer is Pulvis Talci, micropowder silica gel etc., preferably uses Pulvis Talci.
The pharmaceutical composition that contains micronization vitamin ginseng zinc of the present invention can be made into multiple dosage form, especially is fit to make capsule or tablet, preferably makes capsule.It is 150-300mg that the micronization vitamin ginseng zinc capsule of unit formulation or tablet (one or a slice) contain effective composition total amount.
The method for preparing micronization vitamin ginseng zinc of the present invention can be a conventional breaking method known in the art, comprises comminution by gas stream, ball mill pulverizing etc.
The method that preparation contains the pharmaceutical dosage form of micronization vitamin ginseng zinc can be according to conventional formulation method known in the art, and each component is mixed by proportioning, and granulation or tabletting form.
The specific embodiment
Further describe this explanation with example below, help the present invention and effect thereof, advantage are better understood, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
Embodiment 1: the capsular preparation of micronization vitamin ginseng zinc
Prescription: Radix Ginseng 1.25kg
Pollenin 0.25kg
Zinc sulfate 0.0085kg
Vitamin E 0.25kg
Starch 1.35kg
Magnesium stearate 0.2kg
Pulvis Talci 6.8kg
Make 10000 capsules
Preparation method: Radix Ginseng, pollenin, zinc sulfate are mixed the back pulverize with pulverizing mill, obtain the micronization mixture, wherein about 95% grain diameter is less than 100 μ m.Add the starch mixing then in this mixture, mix with vitamin E, 60 ℃ of dryings add magnesium stearate, Pulvis Talci mixing at last, obtain 10000 micronization vitamin ginseng zinc capsules with the fully-automatic capsule filling machine filling.
Embodiment 2: the capsular preparation of micronization vitamin ginseng zinc
Prescription: Radix Ginseng 1.08kg
Pollenin 0.30kg
Zinc sulfate 0.008kg
Vitamin E 0.30kg
Lactose 1.50kg
Magnesium stearate 0.35kg
Micropowder silica gel 6.50kg
Make 10000 capsules
Preparation method: Radix Ginseng, pollenin, zinc sulfate are mixed the back pulverize with pulverizing mill, obtain the micronization mixture, wherein about 85% grain diameter is less than 80 μ m.Add the lactose mixing then in this mixture, mix with vitamin E, 60 ℃ of dryings add magnesium stearate, micropowder silica gel mixing at last, obtain 10000 micronization vitamin ginseng zinc capsules with the fully-automatic capsule filling machine filling.
Embodiment 3: the preparation of micronization vitamin ginseng zinc tablet
Prescription: Radix Ginseng 1.20kg
Pollenin 0.30kg
Zinc sulfate 0.009kg
Vitamin E 0.30kg
Starch 1.55kg
Magnesium stearate 0.30kg
Micropowder silica gel 6.40kg
Make 10000
Preparation method: Radix Ginseng, pollenin, zinc sulfate are mixed the back pulverize with pulverizing mill, obtain the micronization mixture, wherein about 90% grain diameter is less than 100 μ m.Add the starch mixing then in this mixture, mix with vitamin E, 60 ℃ of dryings add magnesium stearate, micropowder silica gel mixing at last, and tabletting obtains 10000 micronization vitamin ginseng zinc metal sheets.
Embodiment 4 micronization vitamin ginseng zinc capsules of the present invention and tablet and the comparative test of common WEISHENXIN capsule dissolution
Commercially available common WEISHENXIN capsule: Qingdao Gerui Pharmaceutical Co., Ltd. produces, lot number 20090413.
Table 1: the Radix Ginseng dissolution relatively
Table 2: the pollenin dissolution relatively
Table 3: the zinc sulfate dissolution relatively
As can be seen from the table, the dissolution of each effective ingredient is all than existing commercially available conventional capsule height in capsule that micronization vitamin ginseng zinc of the present invention is made and the tablet, especially micronization vitamin ginseng zinc capsule, its dissolution obviously improves, in human body, can be absorbed quickly, thereby reach purpose rapid-action, that bioavailability improves.
Claims (10)
1, a kind of micronization vitamin ginseng zinc, its component and weight proportion are: Radix Ginseng: vitamin E: pollenin: zinc sulfate=(140-150): (25-40): (25-40): 1, and in the solid constituent mixture except that vitamin E the granule footpath grain of about 70-100% smaller or equal to 100 μ m.
2, micronization vitamin ginseng zinc as claimed in claim 1, wherein in the solid constituent mixture except that vitamin E the grain diameter of about 60-90% smaller or equal to 80 μ m.
3, micronization vitamin ginseng zinc as claimed in claim 1, wherein in the solid constituent mixture except that vitamin E 80% grain diameter smaller or equal to 80 μ m.
4, a kind of pharmaceutical composition that contains the described micronization vitamin ginseng zinc of claim 1, its component and weight proportion are: Radix Ginseng: vitamin E: pollenin: zinc sulfate: diluent: lubricant: fluidizer=(140-150): (25-40): (25-40): 1: (150-200): (25-45): (700-820);
Wherein diluent is starch, dextrin, microcrystalline Cellulose, sucrose or lactose; Lubricant is a magnesium stearate; Fluidizer is Pulvis Talci, micropowder silica gel.
5, pharmaceutical composition as claimed in claim 4, wherein said diluent are starch.
6, pharmaceutical composition as claimed in claim 4, wherein said fluidizer are Pulvis Talci.
7, the micronization vitamin ginseng zinc capsule made of each described pharmaceutical composition of claim 4-6.
8, the micronization vitamin ginseng zinc metal sheet made of each described pharmaceutical composition of claim 4-6.
9, micronization vitamin ginseng zinc capsule as claimed in claim 7, wherein the effective ingredient weight of unit formulation is 150-300mg.
10, micronization vitamin ginseng zinc metal sheet as claimed in claim 8, wherein the effective ingredient weight of unit formulation is 150-300mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910158796A CN101623311A (en) | 2009-07-03 | 2009-07-03 | Micronization vitamin ginseng zinc and medicine composition thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910158796A CN101623311A (en) | 2009-07-03 | 2009-07-03 | Micronization vitamin ginseng zinc and medicine composition thereof |
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| CN101623311A true CN101623311A (en) | 2010-01-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200910158796A Pending CN101623311A (en) | 2009-07-03 | 2009-07-03 | Micronization vitamin ginseng zinc and medicine composition thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342967A (en) * | 2011-09-29 | 2012-02-08 | 青岛国海生物制药有限公司 | Thin film coated tablets containing vitamin, ginseng and zinc sulfate and preparation method thereof |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
| CN115518053A (en) * | 2022-10-27 | 2022-12-27 | 青岛国海生物制药有限公司 | A capsule containing vitamin, ginseng radix and zinc, and its preparation method |
-
2009
- 2009-07-03 CN CN200910158796A patent/CN101623311A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102342967A (en) * | 2011-09-29 | 2012-02-08 | 青岛国海生物制药有限公司 | Thin film coated tablets containing vitamin, ginseng and zinc sulfate and preparation method thereof |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
| CN115518053A (en) * | 2022-10-27 | 2022-12-27 | 青岛国海生物制药有限公司 | A capsule containing vitamin, ginseng radix and zinc, and its preparation method |
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Open date: 20100113 |