CN1493298A - Ginseng stem leaf total saponin drip pill and its preparation method - Google Patents
Ginseng stem leaf total saponin drip pill and its preparation method Download PDFInfo
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- CN1493298A CN1493298A CNA031576648A CN03157664A CN1493298A CN 1493298 A CN1493298 A CN 1493298A CN A031576648 A CNA031576648 A CN A031576648A CN 03157664 A CN03157664 A CN 03157664A CN 1493298 A CN1493298 A CN 1493298A
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- leaf
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- stem
- radix ginseng
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Abstract
A dripping pill of ginseng stem and leaf's common saponin and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its effect, high stability and low cost.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically drop pills of total saponin of gen-seng haulms and preparation method thereof.
Background technology
Stem and leaf of Radix Ginseng total saponins is the extract of Stem and leaf of Radix Ginseng, has the enhancing body stress ability, adjust endocrine and autonomic nervous dysfunction, resisting fatigue also has the enhancing myocardial contraction, improve the function of heart blood discharge amount, be used for coronary heart disease clinically, climacteric syndrome, the adjuvant drug of latent diabetes and tumor.List marketing at present stem and leaf of Radix Ginseng total saponins capsule and coated tablet arranged.
The stem and leaf of Radix Ginseng total saponins bitter in the mouth has and draws moistly, influence the stability of capsule or coated tablet, and disintegrate is slow, and dissolution and dissolution rate are lower, and child, old people, bed patient or dysphagia patients are taken inconvenience, and compliance is poor.
The drop pills of total saponin of gen-seng haulms that the present invention makes by using ultramicro communication technique and dropping pill formulation Technology has overcome stem and leaf of Radix Ginseng total saponins sheet or capsular above defective, and the effect of stem and leaf of Radix Ginseng total saponins is not fully exerted.
Summary of the invention
The drop pills of total saponin of gen-seng haulms of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, dissolution and dissolution rate improve, steady quality, the pill volume is little, both can swallow also can buccal, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the child, the old people, the characteristics that bed patient and dysphagia patients are taken, but also have working condition and production equipment is simple, production cost is low, compare the advantage that supplementary product consumption reduces with tablet or capsule, demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the stem and leaf of Radix Ginseng total saponins fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
1. disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
2. dissolution rate: sample thief, according to dissolution method (two appendix XC of Chinese Pharmacopoeia version in 2000), 600ml is a solvent with hydrochloric acid solution (dilute hydrochloric acid 24ml adds water to 1000ml), Revolution Per Minute 100 changes, operation in accordance with the law, through 5,10,20, in the time of 30 and 45 minutes, get solution 10ml and put tool plug graduated cylinder (putting in the ice-water bath in advance), precision adds 1% vanillin perchloric acid solution of new preparation, mixing, heating is 15 minutes in 60 ℃ of water-baths, take out, put into water-bath below 10 ℃ immediately and cooled off 1～2 minute, precision adds sulfuric acid solution (adding 77ml sulphuric acid in the 23ml water), shake up, place.After treating bubble collapse, slowly in the impouring cuvette.Other gets the stem and leaf of Radix Ginseng total saponins reference substance, with above-mentioned dissolve with hydrochloric acid solution and quantitatively dilution, with the method operation, makes the stem and leaf of Radix Ginseng total saponins reference substance solution.Get above-mentioned two kinds of solution,, measure trap, calculate stripping quantity at 540nm wavelength place according to spectrophotography (two appendix IV of Chinese Pharmacopoeia version in 2000 A).
Two, commercially available stem and leaf of Radix Ginseng total saponins sheet testing result
1. disintegration time: 45 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 26.3 35.2 51.4 70.5 82.3
Three, example 1 sample detection result
1. the molten diffusing time: 3 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 81.4 90.2 99.3 101.2 99.5
Four, example 2 sample detection results
1. the molten diffusing time: 4 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 79.6 88.3 99.7 99.6 100.2
Five, example 3 sample detection results
1. the molten diffusing time: 6 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 78.5 83.4 99.8 99.8 100.0
Six, example 4 sample detection results
1. the molten diffusing time: 9 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 82.3 89.5 99.2 99.6 99.3
Seven, example 5 sample detection results
1. the molten diffusing time: 5 minutes
2. dissolution rate:
Time (minute) 5 10 20 30 45
Dissolution (%) 78.1 86.2 98.5 98.3 99.2
Eight, example 6 sample detection results
1. the molten diffusing time: 8 minutes
2. dissolution rate
Time (minute) 5 10 20 30 45
Dissolution (%) 76.3 85.4 96.5 98.6 99.1
The specific embodiment
One, example 1
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the stem and leaf of Radix Ginseng total saponins fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Macrogol 4000 15g
Make 1000
Method for making: the stem and leaf of Radix Ginseng total saponins fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Polyethylene glycol 6000 5g
Macrogol 4000 10g
Make 1000
Method for making: the stem and leaf of Radix Ginseng total saponins fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the stem and leaf of Radix Ginseng total saponins fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the stem and leaf of Radix Ginseng total saponins fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Stem and leaf of Radix Ginseng total saponins 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that stem and leaf of Radix Ginseng total saponins and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (3)
1. drop pills of total saponin of gen-seng haulms and preparation method thereof is characterized in that: the stem and leaf of Radix Ginseng total saponins fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
3. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031576648A CN1493298A (en) | 2003-09-06 | 2003-09-06 | Ginseng stem leaf total saponin drip pill and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031576648A CN1493298A (en) | 2003-09-06 | 2003-09-06 | Ginseng stem leaf total saponin drip pill and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1493298A true CN1493298A (en) | 2004-05-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031576648A Pending CN1493298A (en) | 2003-09-06 | 2003-09-06 | Ginseng stem leaf total saponin drip pill and its preparation method |
Country Status (1)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435809C (en) * | 2005-01-18 | 2008-11-26 | 北京科信必成医药科技发展有限公司 | Ginseng bupleurum drop pill for treating liver disease and its preparation method |
| CN1872112B (en) * | 2005-06-01 | 2010-08-25 | 天津天士力制药股份有限公司 | Drop pills of total saponin of gen-seng haulms, and preparation method |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
| CN106377556A (en) * | 2015-07-22 | 2017-02-08 | 王水生 | Ginseng total saponins dropping pills and preparation method thereof |
| CN116617175A (en) * | 2023-07-20 | 2023-08-22 | 吉林省香辰有机农业有限责任公司 | A Chinese medicinal dripping pill with antiaging and intelligence improving effects, and its preparation method and application |
-
2003
- 2003-09-06 CN CNA031576648A patent/CN1493298A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100435809C (en) * | 2005-01-18 | 2008-11-26 | 北京科信必成医药科技发展有限公司 | Ginseng bupleurum drop pill for treating liver disease and its preparation method |
| CN1872112B (en) * | 2005-06-01 | 2010-08-25 | 天津天士力制药股份有限公司 | Drop pills of total saponin of gen-seng haulms, and preparation method |
| CN102920762A (en) * | 2012-11-21 | 2013-02-13 | 福建圣祥药业有限公司 | High-absorptivity ginseng powder and preparation method thereof |
| CN106377556A (en) * | 2015-07-22 | 2017-02-08 | 王水生 | Ginseng total saponins dropping pills and preparation method thereof |
| CN116617175A (en) * | 2023-07-20 | 2023-08-22 | 吉林省香辰有机农业有限责任公司 | A Chinese medicinal dripping pill with antiaging and intelligence improving effects, and its preparation method and application |
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| WD01 | Invention patent application deemed withdrawn after publication |