CN105055475B - A kind of Radix Notoginseng super-micro wall-broken breaking method - Google Patents
A kind of Radix Notoginseng super-micro wall-broken breaking method Download PDFInfo
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- CN105055475B CN105055475B CN201510505753.2A CN201510505753A CN105055475B CN 105055475 B CN105055475 B CN 105055475B CN 201510505753 A CN201510505753 A CN 201510505753A CN 105055475 B CN105055475 B CN 105055475B
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Abstract
The present invention provides a kind of Radix Notoginseng super-micro wall-broken breaking methods, belong to the field of Chinese medicines.The Radix Notoginseng super-micro wall-broken breaking method of the present invention, it is characterised in that include the following steps：（1）Radix Notoginseng is routinely crushed, 80 100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；（2）Xylitol is uniformly mixed with methionine, the mass ratio of xylitol and methionine is preferably 1:1, obtain xylitol methionine mixed powder；（3）Radix Notoginseng fine powder is uniformly mixed with xylitol methionine mixed powder, Radix Notoginseng fine powder and the mass ratio of xylitol methionine mixed powder are preferably 200~100:1, average grain diameter is crushed to 2 microns using micronizer hereinafter, up to Radix Notoginseng super-micro wall-broken powder.The Radix Notoginseng super-micro wall-broken breaking method of the present invention, relatively conventional super-micro wall-broken breaking method have the advantages such as process time is short, flour extraction is high, ginsenoside and notoginsenoside retention rate and dissolution rate height and powder average particle size are small.
Description
Technical field
The present invention relates to a kind of Radix Notoginseng super-micro wall-broken breaking methods, belong to pharmaceutical technology field.
Background technology
Radix Notoginseng is the drying root and rhizome of panax araliaceae plant, is common rare medicinal herbs, has dissipate stasis of blood hemostasis and disappears
Swollen analgesic therapy and other effects, principle active component are ginsenoside and notoginsenoside, and clinic is often used as medicine with powder.
After superfine notoginseng powder is broken, since the specific surface area of grain size increases, ginsenoside and Radix Notoginseng soap can be increased considerably
The dissolution rate of glycosides, to improve drug effect.That there are grinding times is long for existing Radix Notoginseng super-micro wall-broken breaking method, flour extraction is low and people
The problems such as joining saponin(e and high notoginsenoside loss late.
Invention content
The object of the present invention is to provide a kind of Radix Notoginseng super-micro wall-broken breaking methods, to solve the above technical problems.
For foregoing invention purpose, the present invention provides following technical scheme：
The Radix Notoginseng super-micro wall-broken breaking method of the present invention, which is characterized in that be as follows：
A：Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；
B：Xylitol is uniformly mixed with methionine, obtains xylitol-methionine mixed powder；
C：Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, ultramicro grinding to average grain diameter to 2 microns with
Under.
The mass ratio of xylitol and methionine is preferably 1:1.
Radix Notoginseng fine powder and the mass ratio of xylitol-methionine mixed powder are preferably 200~100:1.
Beneficial effects of the present invention are mainly：
The Radix Notoginseng super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, ginsenoside and Radix Notoginseng soap
The advantages such as glycosides retention rate and dissolution rate height and powder average particle size are small.The Radix Notoginseng super-micro wall-broken breaking method of the present invention is unique, is
Having been surprisingly found that in many experiments, xylitol, the order by merging of methionine and Radix Notoginseng fine powder and ratio are unable to adjust.Therefore
Ingredient, ratio and the order of addition that the present invention uses are the innovative points of the present invention.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, but should be noted that the scope of the present invention not by this
Any restrictions of a little examples.
Embodiment 1
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；5g xylitols and 5g methionine are mixed
Uniformly, xylitol-methionine mixed powder is obtained；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 1.
The superfine notoginseng powder related data of 1 embodiment 1 of table
Embodiment 2
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；By 2.5g xylitols and 2.5g methionine
It is uniformly mixed, obtains xylitol-methionine mixed powder；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 2.
The superfine notoginseng powder related data of 2 embodiment 2 of table
Embodiment 3
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；4g xylitols and 4g methionine are mixed
Uniformly, xylitol-methionine mixed powder is obtained；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 3.
The superfine notoginseng powder related data of 3 embodiment 3 of table
Comparative example 1
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；10g xylitols and 10g methionine are mixed
It closes uniformly, obtains xylitol-methionine mixed powder；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 4.
The superfine notoginseng powder related data of 4 comparative example 1 of table
Comparative example 2
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；2g xylitols and 2g methionine are mixed
Uniformly, xylitol-methionine mixed powder is obtained；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 5.
The superfine notoginseng powder related data of 5 comparative example 2 of table
Comparative example 3
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；4g xylitols and 6g methionine are mixed
Uniformly, xylitol-methionine mixed powder is obtained；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 6.
The superfine notoginseng powder related data of 6 comparative example 3 of table
Comparative example 4
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；6g xylitols and 4g methionine are mixed
Uniformly, xylitol-methionine mixed powder is obtained；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 7.
The superfine notoginseng powder related data of 7 comparative example 4 of table
Comparative example 5
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；By 1.5g xylitols and 3.5g methionine
It is uniformly mixed, obtains xylitol-methionine mixed powder；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 8.
The superfine notoginseng powder related data of 8 comparative example 5 of table
Comparative example 6
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；By 3.5g xylitols and 1.5g methionine
It is uniformly mixed, obtains xylitol-methionine mixed powder；Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, is used
WZJ12J vibration type ultramicro disintegrators crush 1 hour, and gained powder measures average grain diameter, flour extraction, ginsenoside and Radix Notoginseng soap
The retention rate and dissolution rate of glycosides, the results are shown in Table 9.
The superfine notoginseng powder related data of 9 comparative example 6 of table
Comparative example 7
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；Using WZJ12J oscillatory type ultramicro grindings
Machine crush 1 hour, gained powder measure average grain diameter, flour extraction, ginsenoside and notoginsenoside retention rate and dissolution rate,
It the results are shown in Table 10.
The superfine notoginseng powder related data of 10 comparative example 7 of table
Comparative example 8
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；Using WZJ12J oscillatory type ultramicro grindings
Machine crush 5 hours, gained powder measure average grain diameter, flour extraction, ginsenoside and notoginsenoside retention rate and dissolution rate,
It the results are shown in Table 11.
The superfine notoginseng powder related data of 11 comparative example 8 of table
Comparative example 9
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；Radix Notoginseng fine powder is mixed with 10g xylitols
Uniformly, it is crushed 1 hour using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter, flour extraction, ginsenoside
With the retention rate and dissolution rate of notoginsenoside, 12 are the results are shown in Table.
The superfine notoginseng powder related data of 12 comparative example 9 of table
Comparative example 10
1kg Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；Radix Notoginseng fine powder is mixed with 10g methionine
Uniformly, it is crushed 1 hour using WZJ12J vibration type ultramicro disintegrators, gained powder measures average grain diameter, flour extraction, ginsenoside
With the retention rate and dissolution rate of notoginsenoside, 13 are the results are shown in Table.
The superfine notoginseng powder related data of 13 comparative example 10 of table
The present invention has screened a large amount of prescription, finds：Only in the scope of the present invention, i.e. xylitol and methionine
Mass ratio is preferably 1:1 and the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder be preferably 200~100:1, Ke Yishi
Existing 2 microns or less micro powder granules, at the same no matter flour extraction or ginsenoside and notoginsenoside retention rate or dissolution rate it is all very high
In 95%.Rather than in ratio of the present invention, even if if the mass ratio of xylitol and methionine is 1:1, but Radix Notoginseng fine powder and xylose
The mass ratio of alcohol-methionine mixed powder is not 200~100:1, as shown in comparative example 1 and 2, result grain size is more than 2 microns, together
When flour extraction or ginsenoside and notoginsenoside retention rate or dissolution rate be below 95%.And comparative example 3-10, xylitol with
The mass ratio non-1 of methionine；1, or even it is not added with xylitol and methionine, the results show that xylitol-methionine mixed powder is added
Grain size can be become smaller, be not added with rear grain size about at 5 microns or more, indices are not up to standard.
Therefore：As can be seen from the above embodiments, in Radix Notoginseng super-micro wall-broken crushing process, using xylitol-methionine
Mixed powder can significantly improve crush efficiency, and high, ginsenoside and Radix Notoginseng soap with flour extraction as assisted comminution material
The advantages such as glycosides retention rate and dissolution rate height and powder average particle size are small.Wherein when the mass ratio of xylitol and methionine is 1:1, three
The mass ratio of seven fine powders and xylitol-methionine mixed powder is 200~100:It is key factor when 1, with best crushing
Effect has prodigious market popularization value.
Claims (1)
1. a kind of Radix Notoginseng super-micro wall-broken breaking method, which is characterized in that be as follows：
A：Radix Notoginseng is routinely crushed, 80-100 mesh sieve is crossed, obtains Radix Notoginseng fine powder；
B：Xylitol is uniformly mixed with methionine, obtains xylitol-methionine mixed powder；
C：Radix Notoginseng fine powder is uniformly mixed with xylitol-methionine mixed powder, ultramicro grinding to average grain diameter is to 2 microns or less；
The mass ratio of xylitol and methionine is 1:1；, the mass ratio of Radix Notoginseng fine powder and xylitol-methionine mixed powder is 200~100:
1。
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| CN105343135A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Superfine wall-breaking pulverization method for ganoderma spore |
| CN105343537A (en) * | 2015-11-25 | 2016-02-24 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae |
| CN105412219A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves |
| CN105326871A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Ultrafine wall-breaking smashing method for moringa seeds |
| CN105412169A (en) * | 2015-11-25 | 2016-03-23 | 苏州普罗达生物科技有限公司 | Ultramicro wall-breaking smashing method for eurycoma longifolia roots |
| CN105327033A (en) * | 2015-11-25 | 2016-02-17 | 苏州普罗达生物科技有限公司 | Saffron superfine wall-breaking grinding method |
| CN108310030A (en) * | 2018-03-19 | 2018-07-24 | 上海健康医学院 | A kind of nanometer of broken wall Radix Notoginseng powder capsule and preparation method thereof |
| CN111358760A (en) * | 2020-05-13 | 2020-07-03 | 扬子江药业集团广州海瑞药业有限公司 | Ticagrelor tablet pharmaceutical composition and preparation method thereof |
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Effective date of registration: 20180814 Address after: 518000 Shenzhen, Guangdong, Luohu District, Guangyuan Road, Luohu District, Shennan East Road, B, block Jinfeng Building, Applicant after: Shenzhen City Hall Sheng Biotechnology Co. Ltd. Address before: 518000 Shenzhen Shennan Road 5015, Guangdong, Luohu District, B 1502-1503, Jinfeng City mansion. Applicant before: Zheng Hongqin |
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