CN105326866A - Method for carrying out superfine wall breaking and smashing on boletus - Google Patents
Method for carrying out superfine wall breaking and smashing on boletus Download PDFInfo
- Publication number
- CN105326866A CN105326866A CN201510830570.8A CN201510830570A CN105326866A CN 105326866 A CN105326866 A CN 105326866A CN 201510830570 A CN201510830570 A CN 201510830570A CN 105326866 A CN105326866 A CN 105326866A
- Authority
- CN
- China
- Prior art keywords
- gamma
- medium chain
- chain triglyceride
- boletus
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a method for carrying out superfine wall breaking and smashing on boletus, and belongs to the field of traditional Chinese medicine. The method for carrying out the superfine wall breaking and smashing on the boletus is characterized by comprising the following steps of (1) smashing the boletus, sieving by a 60 to 80-mesh sieve, and obtaining the boletus powder; (2) uniformly mixing gamma-cyclodextrins with medium chain triglyceride, and obtaining gamma-cyclodextrins-medium chain triglyceride mixed powder, wherein a mass ratio of the gamma-cyclodextrins to the medium chain triglyceride is preferably 8:2; (3) uniformly mixing the boletus powder with the gamma-cyclodextrins-medium chain triglyceride mixed powder, wherein the mass ratio of the boletus powder to the gamma-cyclodextrins-medium chain triglyceride mixed powder is (200-300):1. Compared with a conventional superfine wall breaking and smashing method, the method for carrying out the superfine wall breaking and smashing on the boletus, disclosed by the invention, has the advantages that the processing time is short, the powder extraction rate is high, the retention rate and the dissolution rate of adenosine are high, the average particle diameter of powder is small, and the like.
Description
Technical field
The present invention relates to a kind of Boletus luridus super-micro wall-broken breaking method, belong to medical art.
Background technology
Boletus luridus, the one of mushroom, now extensively eats, have heat clearing away solution be tired of, nourish blood and in, the drug effect such as aid digestion, application is normal in powder form.
After Boletus luridus micronizing, because the specific surface area of particle diameter increases, the dissolution rate of the effective ingredient such as adenosine can be increased considerably, thus improve drug effect.Existing Boletus luridus super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and the problem such as adenosine loss rate is high.
Summary of the invention
The object of this invention is to provide a kind of Boletus luridus super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Boletus luridus super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: pulverized by Boletus luridus, crosses 60 ~ 80 mesh sieves, obtains yellow cattle liver mycopowder;
B: mixed homogeneously with medium chain triglyceride by gamma-cyclodextrin, obtains gamma-cyclodextrin-medium chain triglyceride mixed powder;
C: mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, micronizing is to mean diameter to less than 2 microns.
The mass ratio of gamma-cyclodextrin and medium chain triglyceride is preferably 8:2.
The mass ratio of yellow cattle liver mycopowder and gamma-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Boletus luridus super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, adenosine retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Boletus luridus super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of gamma-cyclodextrin, medium chain triglyceride and Boletus luridus fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 8g gamma-cyclodextrin and 2g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 1.
The Boletus luridus superfine powder related data of table 1 embodiment 1
Embodiment 2
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 12g gamma-cyclodextrin and 3g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 2.
The Boletus luridus superfine powder related data of table 2 embodiment 2
Embodiment 3
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 9.6g gamma-cyclodextrin and 2.4g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 3.
The Boletus luridus superfine powder related data of table 3 embodiment 3
Comparative example 1
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 7g gamma-cyclodextrin and 1.75g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 4.
The Boletus luridus superfine powder related data of table 4 comparative example 1
Comparative example 2
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 13.5g gamma-cyclodextrin and 3.375g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 5.
The Boletus luridus superfine powder related data of table 5 comparative example 2
Comparative example 3
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; Adopted by yellow cattle liver mycopowder SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 6.
The Boletus luridus superfine powder related data of table 6 comparative example 3
Comparative example 4
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; Mixed homogeneously with 10g gamma-cyclodextrin by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 7.
The Boletus luridus superfine powder related data of table 7 comparative example 4
Comparative example 5
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; Mixed homogeneously with 10g medium chain triglyceride by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 8.
The Boletus luridus superfine powder related data of table 8 comparative example 5
Comparative example 6
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; Mixed homogeneously with 15g gamma-cyclodextrin by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 9.
The Boletus luridus superfine powder related data of table 9 comparative example 6
Comparative example 7
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; Mixed homogeneously with 15g medium chain triglyceride by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 10.
The Boletus luridus superfine powder related data of table 10 comparative example 7
Comparative example 8
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 9g gamma-cyclodextrin and 1g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 11.
The Boletus luridus superfine powder related data of table 11 comparative example 8
Comparative example 9
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 7g gamma-cyclodextrin and 3g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 12.
The Boletus luridus superfine powder related data of table 12 comparative example 9
Comparative example 10
3kg Boletus luridus is pulverized, crosses 60 ~ 80 mesh sieves, obtain yellow cattle liver mycopowder; By 5g gamma-cyclodextrin and 5g medium chain triglyceride mix homogeneously, obtain gamma-cyclodextrin-medium chain triglyceride mixed powder; Mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, adenosine retention rate and dissolution rate, the results are shown in Table 13.
The Boletus luridus superfine powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of gamma-cyclodextrin and medium chain triglyceride is preferably 8:2; and the mass ratio of yellow cattle liver mycopowder and gamma-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1; can realize the pulverizing of less than 2 microns, simultaneously flour extraction or adenosine retention rate or dissolution rate are all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as gamma-cyclodextrin and medium chain triglyceride is 8:2, but the mass ratio of yellow cattle liver mycopowder and gamma-cyclodextrin-medium chain triglyceride mixed powder is not 300 ~ 200:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or adenosine retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the non-8:2 of mass ratio of gamma-cyclodextrin and medium chain triglyceride, even do not add gamma-cyclodextrin and medium chain triglyceride, its result shows, add gamma-cyclodextrin-medium chain triglyceride mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Boletus luridus super-micro wall-broken crushing process, application gamma-cyclodextrin and medium chain triglyceride are as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, adenosine retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of gamma-cyclodextrin and medium chain triglyceride is 8:2, when the mass ratio of yellow cattle liver mycopowder and gamma-cyclodextrin-medium chain triglyceride mixed powder is 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.
Claims (3)
1. a Boletus luridus super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: pulverized by Boletus luridus, crosses 60 ~ 80 mesh sieves, obtains yellow cattle liver mycopowder;
B: mixed homogeneously with medium chain triglyceride by gamma-cyclodextrin, obtains gamma-cyclodextrin-medium chain triglyceride mixed powder;
C: mixed homogeneously with gamma-cyclodextrin-medium chain triglyceride mixed powder by yellow cattle liver mycopowder, micronizing is to mean diameter to less than 2 microns.
2. Boletus luridus super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of gamma-cyclodextrin and medium chain triglyceride is 8:2.
3. Boletus luridus super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of yellow cattle liver mycopowder and gamma-cyclodextrin-medium chain triglyceride mixed powder is preferably 300 ~ 200:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510830570.8A CN105326866A (en) | 2015-11-25 | 2015-11-25 | Method for carrying out superfine wall breaking and smashing on boletus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510830570.8A CN105326866A (en) | 2015-11-25 | 2015-11-25 | Method for carrying out superfine wall breaking and smashing on boletus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105326866A true CN105326866A (en) | 2016-02-17 |
Family
ID=55277772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510830570.8A Withdrawn CN105326866A (en) | 2015-11-25 | 2015-11-25 | Method for carrying out superfine wall breaking and smashing on boletus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105326866A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109315758A (en) * | 2018-07-31 | 2019-02-12 | 云南农业大学 | Bolete is adjusting the application in intestinal flora |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101341888A (en) * | 2008-08-19 | 2009-01-14 | 北京市农林科学院 | Bolete extract, preparation and application thereof |
| CN104719874A (en) * | 2015-04-18 | 2015-06-24 | 黑龙江北极杉生物科技有限公司 | Ganoderma lucidum full-ingredient mixed chewable tablets and preparation method thereof |
| CN104886528A (en) * | 2015-05-25 | 2015-09-09 | 昆明理工大学 | Bolete meat-flavored powder and preparation method thereof |
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105030865A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall breaking pulverizing method of American ginsengs |
-
2015
- 2015-11-25 CN CN201510830570.8A patent/CN105326866A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101341888A (en) * | 2008-08-19 | 2009-01-14 | 北京市农林科学院 | Bolete extract, preparation and application thereof |
| CN104719874A (en) * | 2015-04-18 | 2015-06-24 | 黑龙江北极杉生物科技有限公司 | Ganoderma lucidum full-ingredient mixed chewable tablets and preparation method thereof |
| CN104886528A (en) * | 2015-05-25 | 2015-09-09 | 昆明理工大学 | Bolete meat-flavored powder and preparation method thereof |
| CN105030896A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall-breaking grinding method for salviae miltiorrhizae |
| CN105030865A (en) * | 2015-08-18 | 2015-11-11 | 郑红芹 | Ultrafine wall breaking pulverizing method of American ginsengs |
Non-Patent Citations (1)
| Title |
|---|
| 巴晓革等: "微粉中药制剂添加助剂的制备工艺研究", 《齐鲁药事》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109315758A (en) * | 2018-07-31 | 2019-02-12 | 云南农业大学 | Bolete is adjusting the application in intestinal flora |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105030896B (en) | A kind of Radix Salviae Miltiorrhizae super-micro wall-broken breaking method | |
| CN105055475A (en) | Ultramicro wall-breaking smashing method for panax notoginseng | |
| CN104845411A (en) | Superfine ground calcium carbonate powder production method | |
| CN105030865B (en) | A kind of American Ginseng super-micro wall-broken breaking method | |
| CN115068424B (en) | Preparation method and application of nanoscale wall-broken ganoderma lucidum spore powder | |
| CN106582985A (en) | Ultramicro wall breaking and smashing method for rhizomatic traditional Chinese medicine | |
| CN105055902B (en) | A kind of stem of noble dendrobium super-micro wall-broken breaking method | |
| CN112400709A (en) | Preparation process of bentonite cat litter | |
| CN105326866A (en) | Method for carrying out superfine wall breaking and smashing on boletus | |
| CN105362720A (en) | Ultra-micro wall-breaking pulverizing method for rhizoma gastrodiae | |
| CN105412185A (en) | Ultramicro wall-breaking smashing method for angelica keiskei | |
| CN105343181A (en) | Superfine wall-breaking pulverization method for fructus swietenia macrophylla | |
| CN105343135A (en) | Superfine wall-breaking pulverization method for ganoderma spore | |
| CN105343537A (en) | Ultramicro wall-breaking grinding method for rhizoma gymnadeniae | |
| CN105412219A (en) | Ultramicro wall-breaking smashing method for cyclocarya paliurus leaves | |
| CN105343161A (en) | Ultramicro wall-breaking grinding method for semen juglandis | |
| CN105343153A (en) | Superfine wall-breaking pulverization method for radix astragali | |
| CN105343134A (en) | Superfine wall-breaking pulverization method for cordyceps sinensis | |
| CN105343193A (en) | Superfine wall-breaking pulverization method for orobanche coerulescens | |
| CN105362302A (en) | Ultra-micro wall-breaking pulverizing method for cordyceps militaris | |
| CN105434707A (en) | Superfine wall-breaking crushing method for grape seeds | |
| CN105326881A (en) | Maca ultra-micro wall breaking and crushing method | |
| CN105412533A (en) | Fritillaria-praewalskii-maxim-ex-Batal ultramicro wall-breaking smashing method | |
| CN105412199A (en) | Rhodiola-rosea ultramicro wall-breaking smashing method | |
| CN105326909A (en) | Ultra-micro wall-breaking crushing method of cistanche |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160217 |