CN105343161A - Ultramicro wall-breaking grinding method for semen juglandis - Google Patents

Ultramicro wall-breaking grinding method for semen juglandis Download PDF

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Publication number
CN105343161A
CN105343161A CN201510830939.5A CN201510830939A CN105343161A CN 105343161 A CN105343161 A CN 105343161A CN 201510830939 A CN201510830939 A CN 201510830939A CN 105343161 A CN105343161 A CN 105343161A
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powder
glyceryl monostearate
partition
pulullan polysaccharide
attention
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罗瑞雪
张振海
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Suzhou Puluoda Biological Science and Technology Co Ltd
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Suzhou Puluoda Biological Science and Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Jellies, Jams, And Syrups (AREA)

Abstract

The invention belongs to the field of medicines and provides an ultramicro wall-breaking grinding method for semen juglandis. The method is characterized by including steps: (1) grinding the semen juglandis, and filtering through a 60-80-mesh screen to obtain semen juglandis powder; (2) well mixing pulullan with glycerin monostearate to obtain pulullan and glycerin monostearate mixed powder, wherein a mass ratio of the pulullan to the glycerin monostearate is 6:4 preferably; (3) well mixing the semen juglandis powder with the pulullan and glycerin monostearate mixed powder, wherein a mass ratio of the semen juglandis powder to the pulullan and glycerin monostearate mixed powder is 300-200:1 preferably. Compared with a conventional ultramicro wall-breaking grinding method, the ultramicro wall-breaking grinding method for the semen juglandis has the advantages of short processing time, high powder yield, high naringenin retention rate, high dissolution rate, small average particle size of the powder and the like.

Description

A kind of Partition in Fructus Juglandis super-micro wall-broken breaking method
Technical field
The present invention relates to a kind of Partition in Fructus Juglandis super-micro wall-broken breaking method, belong to medical art.
Background technology
Partition in Fructus Juglandis, another name estrangement wood is Semen Juglandis kind inner septum.Have the effects such as reinforcing the kindey to control nocturnal emission, application is normal in powder form.
After Partition in Fructus Juglandis micronizing, because the specific surface area of particle diameter increases, the dissolution rate of the effective ingredient such as naringenin can be increased considerably, thus improve drug effect.Existing Partition in Fructus Juglandis super-micro wall-broken breaking method exists that grinding time is long, flour extraction is low and the problem such as the loss of effective components rate such as naringenin is high.
Summary of the invention
The object of this invention is to provide a kind of Partition in Fructus Juglandis super-micro wall-broken breaking method, to solve the problems of the technologies described above.
For foregoing invention object, the invention provides following technical scheme:
Partition in Fructus Juglandis super-micro wall-broken breaking method of the present invention, it is characterized in that, concrete steps are as follows:
A: pulverized by Partition in Fructus Juglandis, crosses 60 ~ 80 mesh sieves, obtains wood powder of diverting one's attention;
B: mixed homogeneously with glyceryl monostearate by pulullan polysaccharide, obtains pulullan polysaccharide-glyceryl monostearate mixed powder;
C: wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and micronizing is to mean diameter to less than 2 microns.
The mass ratio of pulullan polysaccharide and glyceryl monostearate is preferably 6:4.
The divert one's attention mass ratio of wood powder and pulullan polysaccharide-glyceryl monostearate mixed powder is preferably 300 ~ 200:1.
Beneficial effect of the present invention is mainly:
Partition in Fructus Juglandis super-micro wall-broken breaking method of the present invention has that process time is short, flour extraction is high, naringenin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Partition in Fructus Juglandis super-micro wall-broken breaking method of the present invention is unique, and be that the accident in great many of experiments finds, order by merging and the ratio of pulullan polysaccharide, glyceryl monostearate and Partition in Fructus Juglandis fine powder all can not adjust.Therefore the present invention adopt composition, ratio and order of addition, be innovative point of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should note scope of the present invention not by any restriction of these examples.
Embodiment 1
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 6g pulullan polysaccharide and 4g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 1.
The Partition in Fructus Juglandis superfine powder related data of table 1 embodiment 1
Embodiment 2
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 9g pulullan polysaccharide and 6g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 2.
The Partition in Fructus Juglandis superfine powder related data of table 2 embodiment 2
Embodiment 3
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 7.2g pulullan polysaccharide and 4.8g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 3.
The Partition in Fructus Juglandis superfine powder related data of table 3 embodiment 3
Comparative example 1
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 5.7g pulullan polysaccharide and 3.8g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 4.
The Partition in Fructus Juglandis superfine powder related data of table 4 comparative example 1
Comparative example 2
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 9.3g pulullan polysaccharide and 6.2g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 5.
The Partition in Fructus Juglandis superfine powder related data of table 5 comparative example 2
Comparative example 3
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; Wood powder employing SWFJ micronizing of diverting one's attention unit pulverizes 1 hour, and gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 6.
The Partition in Fructus Juglandis superfine powder related data of table 6 comparative example 3
Comparative example 4
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; Wood powder of diverting one's attention is mixed homogeneously with 10g pulullan polysaccharide, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 7.
The Partition in Fructus Juglandis superfine powder related data of table 7 comparative example 4
Comparative example 5
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; Wood powder of diverting one's attention is mixed homogeneously with 10g glyceryl monostearate, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 8.
The Partition in Fructus Juglandis superfine powder related data of table 8 comparative example 5
Comparative example 6
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; Wood powder of diverting one's attention is mixed homogeneously with 15g pulullan polysaccharide, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 9.
The Partition in Fructus Juglandis superfine powder related data of table 9 comparative example 6
Comparative example 7
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; Wood powder of diverting one's attention is mixed homogeneously with 15g glyceryl monostearate, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 10.
The Partition in Fructus Juglandis superfine powder related data of table 10 comparative example 7
Comparative example 8
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 7g pulullan polysaccharide and 3g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 11.
The Partition in Fructus Juglandis superfine powder related data of table 11 comparative example 8
Comparative example 9
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 5g pulullan polysaccharide and 5g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 12.
The Partition in Fructus Juglandis superfine powder related data of table 12 comparative example 9
Comparative example 10
3kg Partition in Fructus Juglandis is pulverized, crosses 60 ~ 80 mesh sieves, obtain wood powder of diverting one's attention; By 4g pulullan polysaccharide and 6g glyceryl monostearate mix homogeneously, obtain pulullan polysaccharide-glyceryl monostearate mixed powder; Wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and adopt SWFJ micronizing unit to pulverize 1 hour, gained powder measures mean diameter, flour extraction, naringenin retention rate and dissolution rate, the results are shown in Table 13.
The Partition in Fructus Juglandis superfine powder related data of table 13 comparative example 10
The present invention has screened a large amount of prescriptions; find: only in scope; namely the mass ratio of pulullan polysaccharide and glyceryl monostearate is preferably 6:4; and the mass ratio of divert one's attention wood powder and pulullan polysaccharide-glyceryl monostearate mixed powder is preferably 300 ~ 200:1; can realize the pulverizing of less than 2 microns, simultaneously flour extraction or naringenin retention rate or dissolution rate are all higher than 95%.And not according to ratio of the present invention, even if the mass ratio as pulullan polysaccharide and glyceryl monostearate is 6:4, but the mass ratio of divert one's attention wood powder and pulullan polysaccharide-glyceryl monostearate mixed powder is not 300 ~ 200:1, as shown in comparative example 1 and 2, its result particle diameter is greater than 2 microns, and simultaneously flour extraction or naringenin retention rate or dissolution rate are all lower than 95%.And comparative example 3-10, the non-6:4 of mass ratio of pulullan polysaccharide and glyceryl monostearate, even do not add pulullan polysaccharide and glyceryl monostearate, its result shows, add pulullan polysaccharide-glyceryl monostearate mixed powder particle diameter to be diminished, do not add rear particle diameter about more than 5 microns, its indices is not up to standard.
Therefore: as can be seen from the above embodiments, in Partition in Fructus Juglandis super-micro wall-broken crushing process, application pulullan polysaccharide and glyceryl monostearate are as assisted comminution material, significantly can improve crush efficiency, and have that flour extraction is high, naringenin retention rate and the advantage such as dissolution rate is high and powder average particle size is little.Wherein when the mass ratio of pulullan polysaccharide and glyceryl monostearate is 6:4, divert one's attention the mass ratio of wood powder and pulullan polysaccharide-glyceryl monostearate mixed powder when being 300 ~ 200:1, be key factor, it has best crushing effect, has very large market popularization value.

Claims (3)

1. a Partition in Fructus Juglandis super-micro wall-broken breaking method, is characterized in that, concrete steps are as follows:
A: pulverized by Partition in Fructus Juglandis, crosses 60 ~ 80 mesh sieves, obtains wood powder of diverting one's attention;
B: mixed homogeneously with glyceryl monostearate by pulullan polysaccharide, obtains pulullan polysaccharide-glyceryl monostearate mixed powder;
C: wood powder of diverting one's attention is mixed homogeneously with pulullan polysaccharide-glyceryl monostearate mixed powder, and micronizing is to mean diameter to less than 2 microns.
2. Partition in Fructus Juglandis super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of pulullan polysaccharide and glyceryl monostearate is 6:4.
3. Partition in Fructus Juglandis super-micro wall-broken breaking method according to claim 1, is characterized in that, the mass ratio of divert one's attention wood powder and pulullan polysaccharide-glyceryl monostearate mixed powder is preferably 300 ~ 200:1.
CN201510830939.5A 2015-11-25 2015-11-25 Ultramicro wall-breaking grinding method for semen juglandis Pending CN105343161A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030896A (en) * 2015-08-18 2015-11-11 郑红芹 Ultrafine wall-breaking grinding method for salviae miltiorrhizae

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030896A (en) * 2015-08-18 2015-11-11 郑红芹 Ultrafine wall-breaking grinding method for salviae miltiorrhizae

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
孙文格等: "中药超微粉碎技术及粉体特征的研究进展", 《中国药业》 *

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Application publication date: 20160224