CN105025895B - 用于治疗肺动脉高压和肺损伤的1,3-二氢咪唑-2-硫酮衍生物 - Google Patents

用于治疗肺动脉高压和肺损伤的1,3-二氢咪唑-2-硫酮衍生物 Download PDF

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Publication number
CN105025895B
CN105025895B CN201380059547.2A CN201380059547A CN105025895B CN 105025895 B CN105025895 B CN 105025895B CN 201380059547 A CN201380059547 A CN 201380059547A CN 105025895 B CN105025895 B CN 105025895B
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compound
ethyl
base
thioketones
formula
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Expired - Fee Related
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CN201380059547.2A
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Chinese (zh)
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CN105025895A (zh
Inventor
帕特里西奥·曼纽尔·维埃拉·阿尔奥桥·苏亚雷斯·达·席尔瓦
玛丽亚·乔奥·马塞多·达·席尔瓦·博尼法希尔
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Bial Portela and Cia SA
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Bial Portela and Cia SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380059547.2A 2012-11-14 2013-11-14 用于治疗肺动脉高压和肺损伤的1,3-二氢咪唑-2-硫酮衍生物 Expired - Fee Related CN105025895B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261726119P 2012-11-14 2012-11-14
US61/726,119 2012-11-14
PCT/PT2013/000065 WO2014077715A1 (en) 2012-11-14 2013-11-14 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury

Publications (2)

Publication Number Publication Date
CN105025895A CN105025895A (zh) 2015-11-04
CN105025895B true CN105025895B (zh) 2019-02-26

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CN201380059547.2A Expired - Fee Related CN105025895B (zh) 2012-11-14 2013-11-14 用于治疗肺动脉高压和肺损伤的1,3-二氢咪唑-2-硫酮衍生物

Country Status (23)

Country Link
US (3) US9604970B2 (cg-RX-API-DMAC10.html)
EP (1) EP2919780B1 (cg-RX-API-DMAC10.html)
JP (1) JP6373275B2 (cg-RX-API-DMAC10.html)
KR (1) KR102259938B1 (cg-RX-API-DMAC10.html)
CN (1) CN105025895B (cg-RX-API-DMAC10.html)
AU (1) AU2013345494B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015010969B1 (cg-RX-API-DMAC10.html)
CA (1) CA2890920C (cg-RX-API-DMAC10.html)
CY (1) CY1120953T1 (cg-RX-API-DMAC10.html)
DK (1) DK2919780T3 (cg-RX-API-DMAC10.html)
ES (1) ES2693025T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20181651T1 (cg-RX-API-DMAC10.html)
IN (1) IN2015DN04089A (cg-RX-API-DMAC10.html)
LT (1) LT2919780T (cg-RX-API-DMAC10.html)
MX (1) MX355422B (cg-RX-API-DMAC10.html)
PL (1) PL2919780T3 (cg-RX-API-DMAC10.html)
PT (1) PT2919780T (cg-RX-API-DMAC10.html)
RS (1) RS57874B1 (cg-RX-API-DMAC10.html)
RU (1) RU2718055C2 (cg-RX-API-DMAC10.html)
SI (1) SI2919780T1 (cg-RX-API-DMAC10.html)
SM (1) SMT201800560T1 (cg-RX-API-DMAC10.html)
TR (1) TR201815850T4 (cg-RX-API-DMAC10.html)
WO (1) WO2014077715A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2919780T3 (en) 2012-11-14 2018-11-26 Bial Portela & Ca Sa 1,3-Dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury
GB201810395D0 (en) 2018-06-25 2018-08-08 Bial Portela & Ca Sa Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation
WO2021005623A1 (en) * 2019-07-08 2021-01-14 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. A vaccine formulation for protection against enterotoxigenic e. coli (etec) and cholera
CN118598820B (zh) * 2024-02-06 2025-07-08 石家庄四药有限公司 一种二苯基三嗪类化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
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WO2007081232A1 (en) * 2006-01-13 2007-07-19 Bial- Portela & Ca, S.A. Drug combinations
WO2008136695A1 (en) * 2007-05-08 2008-11-13 Portela & Ca, S.A. 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase

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JPH0623107B2 (ja) * 1990-11-16 1994-03-30 帝人株式会社 プロスタサイクリン類を有効成分とする薬学的組成物
ES2201104T3 (es) * 1994-04-26 2004-03-16 Roche Palo Alto Llc Derivados de benzociclohexilimidazoltiona.
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
US20040102361A1 (en) * 2002-11-27 2004-05-27 Frederic Bodin Pharmaceutical composition for the treatment of pulmonary arterial hypertension
GB0610804D0 (en) * 2006-05-31 2006-07-12 Portela & Ca Sa New crystal forms
GB0700635D0 (en) * 2007-01-12 2007-02-21 Portela & Ca Sa Therapy
WO2008137148A2 (en) * 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Methods and compositions for treating pulmonary hypertension
JP2011506315A (ja) * 2007-12-05 2011-03-03 バイアル−ポルテラ アンド シーエー，エス．エー． 新たな塩、及び結晶形
AU2008347005B2 (en) * 2008-01-03 2013-10-03 Biomarin Pharmaceutical Inc. Pterin analog for treating BH4 responsive condition
AR070841A1 (es) * 2008-03-13 2010-05-05 Bial Portela & Ca Sa Proceso de hidrogenacion catalitica asimetrica
AR071632A1 (es) * 2008-05-06 2010-06-30 Bial Portela & Ca Sa Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa"
DE102008054205A1 (de) * 2008-10-31 2010-05-06 Bayer Schering Pharma Aktiengesellschaft Verwendung von Helium-Sauerstoff-Gasgemischen zur Behandlung der pulmonalen arteriellen Hypertonie
PT2655363T (pt) * 2010-12-22 2017-07-13 Bial-Portela & Ca S A Formas cristalinas e processos para a sua preparação
DK2919780T3 (en) 2012-11-14 2018-11-26 Bial Portela & Ca Sa 1,3-Dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081232A1 (en) * 2006-01-13 2007-07-19 Bial- Portela & Ca, S.A. Drug combinations
WO2008136695A1 (en) * 2007-05-08 2008-11-13 Portela & Ca, S.A. 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase

Also Published As

Publication number Publication date
HK1215393A1 (en) 2016-08-26
HRP20181651T1 (hr) 2018-12-14
JP2016504286A (ja) 2016-02-12
AU2013345494B2 (en) 2018-03-22
MX355422B (es) 2018-04-18
RS57874B1 (sr) 2018-12-31
US9604970B2 (en) 2017-03-28
US20170369477A1 (en) 2017-12-28
CA2890920C (en) 2020-12-15
CA2890920A1 (en) 2014-05-22
SI2919780T1 (sl) 2018-12-31
LT2919780T (lt) 2018-11-12
PL2919780T3 (pl) 2019-01-31
CN105025895A (zh) 2015-11-04
JP6373275B2 (ja) 2018-08-15
MX2015005910A (es) 2015-08-10
US20190241545A1 (en) 2019-08-08
KR20150084022A (ko) 2015-07-21
PT2919780T (pt) 2018-11-13
EP2919780B1 (en) 2018-08-01
ES2693025T3 (es) 2018-12-07
TR201815850T4 (tr) 2018-11-21
RU2718055C2 (ru) 2020-03-30
KR102259938B1 (ko) 2021-06-03
DK2919780T3 (en) 2018-11-26
CY1120953T1 (el) 2020-05-29
SMT201800560T1 (it) 2019-01-11
US20150299172A1 (en) 2015-10-22
WO2014077715A1 (en) 2014-05-22
IN2015DN04089A (cg-RX-API-DMAC10.html) 2015-10-09
BR112015010969A2 (pt) 2017-08-22
RU2015120164A (ru) 2017-01-10
AU2013345494A1 (en) 2015-05-14
US10308640B2 (en) 2019-06-04
EP2919780A1 (en) 2015-09-23
BR112015010969B1 (pt) 2020-05-26

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Granted publication date: 20190226