CN105025887B - 新颖极低粘度酯化纤维素醚 - Google Patents

新颖极低粘度酯化纤维素醚 Download PDF

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Publication number
CN105025887B
CN105025887B CN201480011014.1A CN201480011014A CN105025887B CN 105025887 B CN105025887 B CN 105025887B CN 201480011014 A CN201480011014 A CN 201480011014A CN 105025887 B CN105025887 B CN 105025887B
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CN
China
Prior art keywords
cellulose ether
esterified cellulose
viscosity
mpa
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201480011014.1A
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English (en)
Chinese (zh)
Other versions
CN105025887A (zh
Inventor
O·彼得曼
R·B·阿佩尔
M·布拉克哈根
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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Publication of CN105025887A publication Critical patent/CN105025887A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480011014.1A 2013-03-07 2014-02-28 新颖极低粘度酯化纤维素醚 Expired - Fee Related CN105025887B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774161P 2013-03-07 2013-03-07
US61/774161 2013-03-07
PCT/US2014/019266 WO2014137778A1 (en) 2013-03-07 2014-02-28 Novel esterified cellulose ethers of very low viscosity

Publications (2)

Publication Number Publication Date
CN105025887A CN105025887A (zh) 2015-11-04
CN105025887B true CN105025887B (zh) 2017-07-28

Family

ID=50439471

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011014.1A Expired - Fee Related CN105025887B (zh) 2013-03-07 2014-02-28 新颖极低粘度酯化纤维素醚

Country Status (7)

Country Link
US (1) US9617351B2 (https=)
EP (1) EP2964204B1 (https=)
JP (1) JP6267239B2 (https=)
KR (1) KR101661952B1 (https=)
CN (1) CN105025887B (https=)
BR (1) BR112015015846A2 (https=)
WO (1) WO2014137778A1 (https=)

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JP6356922B2 (ja) * 2015-03-16 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー 低い中和度を有する水溶性エステル化セルロースエーテル
US20180030157A1 (en) * 2015-03-16 2018-02-01 Dow Global Technologies Llc Process for fractionating an esterified cellulose ether
KR20170128350A (ko) * 2015-03-16 2017-11-22 다우 글로벌 테크놀로지스 엘엘씨 에스테르화된 셀룰로오스 에테르의 수용액
EP3270970B1 (en) 2015-03-16 2019-01-09 Dow Global Technologies LLC Gelling esterified cellulose ethers
BR112017018232A2 (pt) 2015-03-16 2018-04-17 Dow Global Technologies Llc éteres de celulose esterificados solúveis em água
KR20170128349A (ko) * 2015-03-16 2017-11-22 다우 글로벌 테크놀로지스 엘엘씨 지방족 카복실산의 존재하에서의 에스테르화된 셀룰로오스 에테르의 제조 방법
KR20190013815A (ko) * 2016-05-25 2019-02-11 다우 글로벌 테크놀로지스 엘엘씨 셀룰로스 에터 아세테이트의 수용액
KR102490265B1 (ko) * 2016-11-02 2023-01-20 신에쓰 가가꾸 고교 가부시끼가이샤 히프로멜로오스아세트산에스테르숙신산에스테르 및 제조 방법
WO2018170083A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
CN110366566B (zh) 2017-03-17 2021-08-13 陶氏环球技术有限责任公司 用于从反应产物混合物中回收酯化纤维素醚的方法
JP2020511572A (ja) 2017-03-17 2020-04-16 ダウ グローバル テクノロジーズ エルエルシー 反応生成物混合物からのエステル化セルロースエーテルの回収方法

Citations (2)

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US4226981A (en) * 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
EP0219426A2 (en) * 1985-10-07 1987-04-22 Shin-Etsu Chemical Co., Ltd. A method for the preparation of an acidic dicarboxylic acid ester of cellulose ether

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JP3149122B2 (ja) 1994-11-07 2001-03-26 信越化学工業株式会社 固形腸溶製剤のコーティング用基剤
JPH10167959A (ja) * 1996-12-04 1998-06-23 Zensei Yakuhin Kogyo Kk ジクロフェナクナトリウムの徐放性カプセル製剤
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DE10141680B4 (de) * 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
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CN104427979B (zh) 2012-04-11 2018-02-16 陶氏环球技术有限责任公司 具有特定的取代基分布的酯化的纤维素醚
KR102138546B1 (ko) * 2012-08-24 2020-07-28 다우 글로벌 테크놀로지스 엘엘씨 부분적으로 가교결합된 에스테르화된 셀룰로즈 에테르
MX374548B (es) * 2012-08-24 2025-03-06 Dow Global Technologies Llc Eteres de celulosa esterificados novedosos de alto peso molecular y homogeneidad.
MX2015002430A (es) * 2012-08-24 2015-06-22 Dow Global Technologies Llc Acetato-succinatos de hidroxialquilmetilcelulosa.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226981A (en) * 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
EP0219426A2 (en) * 1985-10-07 1987-04-22 Shin-Etsu Chemical Co., Ltd. A method for the preparation of an acidic dicarboxylic acid ester of cellulose ether

Also Published As

Publication number Publication date
JP6267239B2 (ja) 2018-01-24
WO2014137778A1 (en) 2014-09-12
CN105025887A (zh) 2015-11-04
JP2016516835A (ja) 2016-06-09
KR20150119472A (ko) 2015-10-23
US9617351B2 (en) 2017-04-11
EP2964204A1 (en) 2016-01-13
US20150376299A1 (en) 2015-12-31
KR101661952B1 (ko) 2016-10-04
EP2964204B1 (en) 2017-01-04
BR112015015846A2 (pt) 2017-07-11

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Granted publication date: 20170728

Termination date: 20200228