CN104998213A - Traditional Chinese medicine composition for treating chronic atrophic gastritis - Google Patents
Traditional Chinese medicine composition for treating chronic atrophic gastritis Download PDFInfo
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- CN104998213A CN104998213A CN201510502757.5A CN201510502757A CN104998213A CN 104998213 A CN104998213 A CN 104998213A CN 201510502757 A CN201510502757 A CN 201510502757A CN 104998213 A CN104998213 A CN 104998213A
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: sinense knotweed rhizome, phyllodium pulchellum, Chinese thorowax root, fructus aurantii and the like. The traditional Chinese medicine composition can be used for treating chronic atrophic gastritis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat chronic atrophic gastritis.
Background technology
Chronic atrophic gastritis is with gastric epithelial and body of gland atrophy, and decreased number, gastric mucosa is thinning, and mucosa basic unit thickens, or companion's gland metaplasia and intestinal gland metaplasia, or has atypical hyperplasia to be the chronic digestive system disease of feature.Often show as epigastrium dull pain, distension, belch, inappetence, or become thin, anemia etc., without specificity.A kind of many paathogenic factors disease and precancerous lesion.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat chronic atrophic gastritis.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for chronic atrophic gastritis, it is prepared by the raw material of following parts by weight: Rhizoma cypripedii macranthi 14 parts, row money set 12 parts, Radix Bupleuri 10 parts, Fructus Aurantii 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Spica Prunellae 20 parts, Fructus Atriplicis Sibiricae 12 parts, Radix Curcumae 10 parts, the Rhizoma Pinelliae 10 parts, Flos Inulae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Scutellariae 10 parts, 10 parts, Poria, Poria cum Radix Pini 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Setariae Germinatus 10 parts, 10 parts, Fructus Hordei Germinatus, 5 parts, Radix Glycyrrhizae.
The application of Chinese medicine composition in preparation treatment chronic atrophic gastritis medicine of described treatment chronic atrophic gastritis.
In the present invention, Rhizoma cypripedii macranthi is the orchid family Cypripedium plant Cypripedium macranthum Cypripedium macranthum Swartz, is used as medicine with root, root stock and flower.Autumn excavates, and cleans and dries.Inducing diuresis to remove edema, blood circulation promoting and blood stasis dispelling, analgesia of dispeling the wind.For anasarca, lower limbs edema, dysuria, leucorrhea, lumbago, skelalgia of rheumatism, traumatic injury.The present invention is used as medicine with root.Row Qian Shuwei pulse family beggar-ticks rows of plants money tree Desmodium pulchellum (L.) Benth., is used as medicine with root and leaf.Xia Qiu gathers, and summer shreds, and dries or using fresh herb.Clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.For cold, fever, malaria, hepatitis, cirrhotic ascites, schistosomicide hepatosplenomegaly, rheumatalgia, traumatic injury.All the other are pharmacopeia kind.
Beneficial effect:
Rhizoma cypripedii macranthi of the present invention, row's money tree heat-clearing and toxic substances removing are monarch drug, Radix Bupleuri, Fructus Aurantii, Bulbus Fritillariae Uninbracteatae, Spica Prunellae, Fructus Atriplicis Sibiricae, Radix Curcumae, the Rhizoma Pinelliae, Flos Inulae, Pericarpium Citri Reticulatae, Radix Scutellariae, Poria, Poria cum Radix Pini, Radix Paeoniae Rubra, Radix Paeoniae Alba blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain are ministerial drug, Fructus Setariae Germinatus, Fructus Hordei Germinatus, Radix Glycyrrhizae are adjuvant, cooperatively interact, be prepared into medicament, obtained medicine can safe and effective treatment chronic atrophic gastritis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: take Rhizoma cypripedii macranthi 14g, row's money tree 12g, Radix Bupleuri 10g, Fructus Aurantii 10g, Bulbus Fritillariae Uninbracteatae 10g, Spica Prunellae 20g, Fructus Atriplicis Sibiricae 12g, Radix Curcumae 10g, Rhizoma Pinelliae 10g, Flos Inulae 10g, Pericarpium Citri Reticulatae 10g, Radix Scutellariae 10g, Poria 10g, Poria cum Radix Pini 10g, Radix Paeoniae Rubra 10g, Radix Paeoniae Alba 10g, Fructus Setariae Germinatus 10g, Fructus Hordei Germinatus 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take Rhizoma cypripedii macranthi 14g, row's money tree 12g, Radix Bupleuri 10g, Fructus Aurantii 10g, Bulbus Fritillariae Uninbracteatae 10g, Spica Prunellae 20g, Fructus Atriplicis Sibiricae 12g, Radix Curcumae 10g, Rhizoma Pinelliae 10g, Flos Inulae 10g, Pericarpium Citri Reticulatae 10g, Radix Scutellariae 10g, Poria 10g, Poria cum Radix Pini 10g, Radix Paeoniae Rubra 10g, Radix Paeoniae Alba 10g, Fructus Setariae Germinatus 10g, Fructus Hordei Germinatus 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take Rhizoma cypripedii macranthi 14g, row's money tree 12g, Radix Bupleuri 10g, Fructus Aurantii 10g, Bulbus Fritillariae Uninbracteatae 10g, Spica Prunellae 20g, Fructus Atriplicis Sibiricae 12g, Radix Curcumae 10g, Rhizoma Pinelliae 10g, Flos Inulae 10g, Pericarpium Citri Reticulatae 10g, Radix Scutellariae 10g, Poria 10g, Poria cum Radix Pini 10g, Radix Paeoniae Rubra 10g, Radix Paeoniae Alba 10g, Fructus Setariae Germinatus 10g, Fructus Hordei Germinatus 10g, Radix Glycyrrhizae 5g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
4, the present invention is to the clinical research of chronic atrophic gastritis
4.1, physical data: inventor collects the out-patient of 80 routine chronic atrophic gastritis altogether between in January ,-2014 in May, 2013, age 35-54 year, course of disease 1-4.Be divided at random: treatment group 40 example, blank group 40 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: the symptom of chronic atrophic gastritis, sign, without specificity, can not, as the foundation of diagnosis, be made a definite diagnosis main by gastroscope and gastric mucosa living tissue pathologic finding.
(1) age: many above middle age, the course of disease is long, often has chronic superficial gastritis medical history.
(2) symptom and sign: long-term ingestion is bad, gastral cavilty portion distension is uncomfortable, poor appetite, weak, become thin, anemia etc.
(3) 1. gastric mucosa color is thin out in gastroscopy; 2. under mucosa, blood vessel is shown in thoroughly; 3. duplicature is tiny even disappears; 4. when atrophic gastritis is with body of gland cervical region hyperplasia or intestinal epithelial metaplasia, the coarse injustice of mucous membrane surface, in graininess or nodositas, visible pseudopolyp is formed sometimes, and under mucosa, the feature of exposed vessel is often covered; 5. atrophy mucosa fragility increases, easily hemorrhage, and can have rotten to the corn stove; 6. atrophic gastritis simultaneously with the performance of chronic superficial gastritis, as congested erythema, can adhere to mucus, and reflective enhancing etc.
(4) the body of gland atrophy that pathologic finding is 1. intrinsic in gastric mucosa; 2. life is changed; 3. hypertrophy; 4. canceration.
(5) the lab testing 1. many anacidities of gastric analysis A type CAG patient or low acid, Type B CAG patient can normal or low acid; 2. pepsinogen measures pepsin reason cell secretes, and during atrophic gastritis, blood and the pepsinogen content in urinating reduce; 3. the G emiocytosis gastrin of serum gastrin determination gastric antrum portion mucosa.A type CAG patient, serum gastrin Chang Mingxian increases; Type B CAG patient Antral atrophy, directly affects G emiocytosis gastrin function, and serum gastrin is lower than normally; 4. immunologic test parietal cell antibody (PCA), intrinsic factor antibody (IFA), gastrin secretion cell antibody (GCA) measure, and can be used as the auxiliary diagnosis of atrophic gastritis and typing thereof.
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 21 | 14 | 5 | 87.5 |
| Blank group | 40 | 0 | 2 | 38 | 5 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic atrophic gastritis.
Claims (2)
1. treat the Chinese medicine composition of chronic atrophic gastritis for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Rhizoma cypripedii macranthi 14 parts, row money set 12 parts, Radix Bupleuri 10 parts, Fructus Aurantii 10 parts, Bulbus Fritillariae Uninbracteatae 10 parts, Spica Prunellae 20 parts, Fructus Atriplicis Sibiricae 12 parts, Radix Curcumae 10 parts, the Rhizoma Pinelliae 10 parts, Flos Inulae 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Scutellariae 10 parts, 10 parts, Poria, Poria cum Radix Pini 10 parts, Radix Paeoniae Rubra 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Setariae Germinatus 10 parts, 10 parts, Fructus Hordei Germinatus, 5 parts, Radix Glycyrrhizae.
2. treat the application of Chinese medicine composition in treatment chronic atrophic gastritis medicine of chronic atrophic gastritis as claimed in claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497777A (en) * | 2015-12-03 | 2016-04-20 | 黄连启 | Traditional Chinese medicine for treating chronic atrophic gastritis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766782A (en) * | 2010-04-08 | 2010-07-07 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicine composite for treating chronic gastritis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 吴凤海: "柴胡疏肝散加味治疗慢性胃炎50例临床观察", 《内蒙古中医药》 * |
| 王广等: "疏肝养胃汤治疗慢性胃炎200例", 《河南中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497777A (en) * | 2015-12-03 | 2016-04-20 | 黄连启 | Traditional Chinese medicine for treating chronic atrophic gastritis |
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Application publication date: 20151028 |