CN104258237A - Traditional Chinese medicine composition for treating anaphylactoid purpura as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating anaphylactoid purpura as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating anaphylactoid purpura. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 14 parts of shortstem ardisia root, 12 parts of litsea glutinosa, 15 parts of hedychium coronarium, 11 parts of rabdosia japonica, 12 parts of picris divaricata, 15 parts of calanthe discolor, 13 parts of asian baneberry rhizome, 16 parts of gynura bicolor, 15 parts of root of spinyleaf pricklyash, 12 parts of bodinier caper,15 parts of wild mat grass, 12 parts of cypripedium, 15 parts of anisochilus, 11 parts of hedyotis verticillata, 13 parts of maidenhair spleenwort, 16 parts of incarvillea arguta, 14 parts of drymaria cordata, 11 parts of urtica laetevirens, 12 parts of gnaphalium hypoleucum, 15 parts of lysimachia decurrens and 12 parts of lysimachia candida. The traditional Chinese medicine composition can be used for treating the anaphylactoid purpura.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat anaphylactoid purpura.
Background technology
Anaphylactoid purpura, also known as Henoch-Schonlein purpura, is a kind of allergic angiitis of invading skin and the tiny tremulous pulse of other organs and blood capillary, often accompany stomachache, arthralgia and renal damage, but platelet does not reduce.May be relevant with streptococcal infection, viral infection, medicine, food, insect bite etc., mechanism is due to immune complex deposit or IgE mediated vascular damage.Also there is IgA in report patients serum to increase, in skin lesion and non-skin lesion district skin thin vessels wall and glomerule tissue, have IgA to deposit.Be apt to occur in child and teenager, start to have heating, headache, arthralgia, general malaise etc.Skin lesion shows as syringe needle to Semen Glycines size petechia, ecchymosis or urticaria sample erythra, and vesicle, blood blister can occur severe patient, even ulcer.Be apt to occur in extremity and stretch side, especially two lower limb and buttocks.Skin lesion is symmetrical, occurs in batch, easily recurs.Only have skin lesion person to claim simple purpura, with suffering from abdominal pain, suffering from diarrhoea, have blood in stool, even gastrointestinal hemorrhage person is called gastrointestinal type purpura; Schoenlein purpura is called with arthroncus, pain, even hydrarthrosis person; Companion hematuria, albuminuria, renal damage person is called renal purpura.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat anaphylactoid purpura.
Technical scheme: the object of the invention is by following scheme realize:
A kind of Chinese medicine composition for the treatment of anaphylactoid purpura, it is prepared by the raw material of following parts by weight: Radix ardisiae brevicaulis 14 parts, 12 parts, purling withered tree, Rhizoma Hedychii Coronarii 15 parts, Rabdosia japonica 11 parts, Picris divaricata 12 parts, hard Herba seu Radix Calanthes 15 parts, Rhizoma actaeae asiaticae 13 parts, gynura bicolor 16 parts, Radix Zanthoxyli Spinifolii 15 parts, Cortex capparis Bodinieri radicis 12 parts, wild seat grass 15 parts, yellow capsule lady's slipper 12 parts, Herba lysimachiae capillipedis 15 parts, Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) 11 parts, Herba asplenii trichomanis 13 parts, suona horn spends 16 parts, Drymaria diandra Blume 14 parts, wide leaf Herba Urticae Cannabinae 11 parts, autumn Herba Gnaphalii Affinis 12 parts, scrofula grass 15 parts, pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 12 parts.
The application of Chinese medicine composition in preparation treatment allergy purpura of described treatment anaphylactoid purpura.
In the present invention, Radix ardisiae brevicaulis is Myrsinacea Ardisa plant Radix ardisiae brevicaulis Ardisia brevicaulis Diels, is used as medicine with root.Autumn and winter excavate, and clean and dry.Relieving sore-throat by clearing away heat, promoting blood circulation and detumescence.For laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, venom, Fengshi Guanjie pain, traumatic injury.
Purling withered tree is purling withered tree Litsea glutinosa (Lour.) C.B.Rob. of Lauraceae Litsea plant, is used as medicine with root, skin, leaf.Xia Qiu gathers, and root is cleaned section and dried; The many using fresh herbs of leaf, skin.Clearing away damp-heat, detumescence poison, hemostasis, pain relieving.Root: take orally and control diarrhoea, traumatic injury, parotitis, diabetes.Skin, leaf: parotitis is controlled in external, furuncle carbuncle, mastitis from the beginning of, traumatic injury, traumatic hemorrhage.The present invention adopts root to be used as medicine.
Rhizoma Hedychii Coronarii is Zingiberaceae Hedychium Koenig plant Hedychium coronarium Koenig Hedychium coronarium Koen., is used as medicine with root stock, fruit.Winter excavates, and cleans section, dries.Expelling wind and removing dampness, warming spleen and stomach for dispelling cold.Root stock: for flu, headache general pain, rheumatism bones and muscles pain, traumatic injury, cold-damp leucorrhea.Really: for epigastric distension and distress, dyspepsia, cold stagnant disgusting, stomach abdomen hypodynia.The present invention adopts root stock to be used as medicine.
Rabdosia japonica is plant Rabdosia japonica Rabdosia japonica (Burm.f.) Hara var.glaucocalyx (Maxim.) Hara [Plectranthus glaucocalyx Maxim.; Isodon glaucocalyx (Maxim.) Kudo], with ground all herbal medicine.Xia Qiucai, decontamination, dries.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.For flu, laryngopharynx swelling and pain, tonsillitis, gastritis, hepatitis, mastitis, cancer (esophageal carcinoma, carcinoma of gastric cardia, hepatocarcinoma, breast carcinoma) from the beginning of, amenorrhea, traumatic injury, arthralgia, snake bite and insect sting.
Picris divaricata is Compositae sonchus plant Herba Sonchi Oleracei Sonchus oleraceus L., with all herbal medicine.The four seasons can adopt, using fresh herb or dry.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For enteritis, dysentery, acute icteric infectious hepatitis, appendicitis, mastitis, stomatitis, pharyngitis, tonsillitis, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia; Carbuncle pyogenic infections from tumour or sore is controlled in external, otitis media.
Hard Herba seu Radix Calanthes is the orchid family Calanthe plant calanthe Calanthe discolor Lindl., is used as medicine with herb and root stock.The four seasons can adopt, and dry.Blood circulation promoting and blood stasis dispelling, eliminating carbuncle eliminating stagnation.For tuberculous lymphadenitis, carbuncle pyogenic infections from tumour or sore, traumatic injury, rheumatic ostalgia.The present invention adopts all herbal medicine.
Rhizoma actaeae asiaticae is Ranunculaceae baneberry cohosh Actaea asiatica Hara, with root stock and all herbal medicine.Autumn gathers, and dries respectively.Clearing away lung-heat to relieve cough, heat-clearing and toxic substances removing.For headache due to common cold, pertussis.Lyssodexis is controlled in external.The present invention adopts all herbal medicine.
Gynura bicolor, Classification system: Gynura bicolor (Roxb.ex Willd.) DC., for Compositae Radix Gynurae belongs to herbaceos perennial, high 50-100 centimetre, green above blade, purpling color time dry below, two sides without hair, cooling blood for hemostasis, clearing heat for detumescence.For hemoptysis, metrorrhagia, dysmenorrhea, vim and vigour pain, bronchitis, pelvic inflammatory disease, heatstroke, amebic dysentery; Wound hemorrhage is controlled in external, and ulcer does not close up for a long time, furuncle carbuncle, paronychia.The present invention adopts all herbal medicine.
Radix Zanthoxyli Spinifolii, Latin is called Zanthoxylum dimorphophyllumHemsl.Var.spinifolium Rehd.Et Wils., is dicotyledon medicine rutaceae, root: expelling wind and cold.For rheumatic numbness, cough due to wind and cold; Traumatic injury is controlled in external.Root bark: regulating QI to relieve pain.For peratodynia, stomachache.Really: synthetism granulation promoting, alleviating pain and detumescence.For traumatic injury, waist and leg ache.The present invention uses root to be used as medicine.
Cortex capparis Bodinieri radicis is the Herb of osmanthus, Capparidaceae plant Guizhou Province Capparis Spirrosa: relaxing muscles and tendons and activating QI and blood in the collateral, heat-clearing and toxic substances removing.Herb: for rheumatalgia, traumatic injury; Root bark: tonsillitis, toothache.
Wild seat grass is Cyperaceae Cyperus plant cyperus iria Cyperus iria L., with all herbal medicine.Xia Qiu gathers, using fresh herb or dry.Expelling wind and removing dampness, regulating menstruation diuresis.For rheumatism bones and muscles pain, traumatic injury, menoxenia, dysmenorrhea, amenorrhea, lithangiuria.
Yellow capsule lady's slipper is the orchid family Cypripedium plant yellow capsule lady's slipper Cypripedium Sp., is used as medicine with root.8 ~ JIUYUE is uprooted, and cleans, dries.Heart tonifying diuresis, promoting blood flow to regulate menstruation.For heart failure, menoxenia.
Herba lysimachiae capillipedis is the herb that Primulaceae Lysimachia plant carefully obstructs Herba lysimachiae capillipedis Lysimachia capillipes Hemsl..Xia Qiu gathers, and dries in the shade.Dispel the wind, cough-relieving, regulating menstruation.For cold cough, tracheitis, asthma, menoxenia, neurasthenia.
Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) is the herb of Rubiaceae plants of Hedyotis Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) Hedyotis hispida Retz. [Oldenlandia hispida Poir.].The whole year can adopt, using fresh herb or dry.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For poliomyelitis (paralysis), cold, fever throat pain, gastroenteritis; Venom is controlled in external, centipete bite, dog bite.
Herba asplenii trichomanis is fern Aspleniaceae spleen wort Asplenium trchomanes L. Asplenium trichomanes L., with all herbal medicine.The four seasons can adopt, and clean, using fresh herb or dry.Heat-clearing and toxic substances removing, regulating menstruation, hemostasis, convergence leukorrhagia stopping.For infantile hyperpyrexia, leucorrhea, menoxenia; Burn and scald is controlled in external, traumatic hemorrhage, furuncle swelling toxin, venom.
Suona horn flower is Incarvillea AJuss plant Herba Melicae Scabrosae Incarvillea arguta (Royle) Royle, with root stock or all herbal medicine.Autumn gathers, and cleans section, dries.Expelling wind and removing dampness, anti-inflammatory analgetic, promoting blood circulation to remove blood stasis.For rheumatic ostalgia, menoxenia; Furuncle is controlled in external, carbuncle, fracture.The present invention adopts all herbal medicine.
Drymaria diandra Blume is the herb of Drymaria diandra Blume platymiscium Drymaria diandra Blume Drymaria diandra Blume [D.cordata auct.non (L.) Willd.].Xia Qiucai, cleans using fresh herb or dries.Heat-clearing and toxic substances removing, diuresis relieving constipation, promoting blood circulation and detumescence, nebula removing.For acute hepatitis, stomachache, malaria, pterygium, ascites, constipation; Fracture is controlled in external, carbuncle sore, venom.
Wide leaf Herba Urticae Cannabinae, Classification system is Urtica laetevirens Maxim., is perennial herb, and Herb light green is used as medicine with herb, root and seed.Summer receives stem and leaf, receives root and seed winter.Expelling wind for relieving convulsion, help digestion relieving constipation.For rheumatic arthritis, puerperal convulsion, infantile convulsion, poliomyelitis sequela, hypertension, dyspepsia, constipation; External controls urticaria from the beginning of, venom.The present invention adopts all herbal medicine.
Autumn Herba Gnaphalii Affinis is the herb of Compositae cottonweed autumn Herba Gnaphalii Affinis Gnaphalium hypoleucum DC..Xia Qiu gathers, using fresh herb or dry.Dispelling wind stopping cough, clearing away heat-damp and promoting diuresis.For flu, cough due to lung-heat, dysentery, tuberculous lymphadenitis; Ulcer of the lower limb is controlled in external.
Scrofula grass is the herb of Primulaceae Lysimachia plant decurrent leaf Herba lysimachiae capillipedis Lysimachia decurrens Forst..Autumn gathers, and cleans, using fresh herb or dry.Promoting blood flow to regulate menstruation, dispersing swelling and dissipating binds.For menoxenia; Lymphoid tuberculosis is controlled in external, injury and bone fracture.
Pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Classification system is Lysimachia candida Lindl., is Primulaceae, Lysimachia; Natural disposition happiness is wet, medicinal detumescence.Annual or perennial vertical herbage, Herb is without hair.Cylinder top, meat, often redly, single or base portion branch cluster gives birth to shape to base portion.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Innominate toxic swelling is controlled in external, and carbuncle furuncle swells, paddy field dermatitis, injury and bone fracture.The present invention adopts all herbal medicine.
Beneficial effect: the medicine that the present invention obtains can safe and effective treatment anaphylactoid purpura.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: take Radix ardisiae brevicaulis 14g, purling withered tree 12g, Rhizoma Hedychii Coronarii 15g, Rabdosia japonica 11g, Picris divaricata 12g, hard Herba seu Radix Calanthes 15g, Rhizoma actaeae asiaticae 13g, gynura bicolor 16g, Radix Zanthoxyli Spinifolii 15g, Cortex capparis Bodinieri radicis 12g, wild seat grass 15g, yellow capsule lady's slipper 12g, Herba lysimachiae capillipedis 15g, Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) 11g, Herba asplenii trichomanis 13g, suona horn flower 16g, Drymaria diandra Blume 14g, wide leaf Herba Urticae Cannabinae 11g, autumn Herba Gnaphalii Affinis 12g, scrofula careless 15g, damp Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 12g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of anaphylactoid purpura.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take Radix ardisiae brevicaulis 14g, purling withered tree 12g, Rhizoma Hedychii Coronarii 15g, Rabdosia japonica 11g, Picris divaricata 12g, hard Herba seu Radix Calanthes 15g, Rhizoma actaeae asiaticae 13g, gynura bicolor 16g, Radix Zanthoxyli Spinifolii 15g, Cortex capparis Bodinieri radicis 12g, wild seat grass 15g, yellow capsule lady's slipper 12g, Herba lysimachiae capillipedis 15g, Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) 11g, Herba asplenii trichomanis 13g, suona horn flower 16g, Drymaria diandra Blume 14g, wide leaf Herba Urticae Cannabinae 11g, autumn Herba Gnaphalii Affinis 12g, scrofula careless 15g, damp Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 12g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of anaphylactoid purpura.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take Radix ardisiae brevicaulis 14g, purling withered tree 12g, Rhizoma Hedychii Coronarii 15g, Rabdosia japonica 11g, Picris divaricata 12g, hard Herba seu Radix Calanthes 15g, Rhizoma actaeae asiaticae 13g, gynura bicolor 16g, Radix Zanthoxyli Spinifolii 15g, Cortex capparis Bodinieri radicis 12g, wild seat grass 15g, yellow capsule lady's slipper 12g, Herba lysimachiae capillipedis 15g, Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) 11g, Herba asplenii trichomanis 13g, suona horn flower 16g, Drymaria diandra Blume 14g, wide leaf Herba Urticae Cannabinae 11g, autumn Herba Gnaphalii Affinis 12g, scrofula careless 15g, damp Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 12g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of anaphylactoid purpura.Oral, every bu is taken for twice sooner or later.
4, the present invention is to the clinical research of anaphylactoid purpura
4.1, physical data: inventor collects the out-patient of 60 routine anaphylactoid purpura altogether between in August ,-2013 in May, 2012, age 18-32 year, course of disease 1-3.Be divided at random: treatment group 40 example, blank group 20 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: the inspection that (1) blood is often returned: the light moderate of hemocyte increase acidophil normal or increase amount of bleeding can many anemias clotting time and bleeding time platelet count all normal for clot retration time.(2) erythrocyte sedimentation rate: most of patients erythrocyte sedimentation rate speeds.(3) anti-O: can increase.(4) serum immune globulin: serum LGA can increase.(5) routine urinalysis: albumen erythrocyte or cast can be occurred in renal involvement person urine.(6) blood urea nitrogen and base sweet: renal insufficiency person increase.(7) fecal occult blood: male form during digestive tract hemorrhage.(8) capillary fragility test: about half patient is positive.(9) renal tissue pathology: can determine nephritis change nature to treatment and prognosis be determined with directive significance.(10) there is infection, food, medicine or pollen hypersensitivity, insect bite, the medical histories such as vaccination more.(11) typical characteristic skin purpura is had, in conjunction with joint, gastrointestinal or renal symptom and history of repeated attack.(12) whole blood leukocyte and eosinophilic granulocyte increase, hemorrhage serious time, erythrocyte and hemoglobin reduce.(13) erythrocyte sedimentation rate speeds, and CPR can be positive, and serum IgA increases.(14) when having renal damage, visible hematuria and albuminuria.
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 15 | 17 | 8 | 80 |
| Blank group | 20 | 2 | 2 | 16 | 20 |
Visible, the medicine that the present invention obtains can safe and effective treatment anaphylactoid purpura.
Claims (2)
1. treat the Chinese medicine composition of anaphylactoid purpura for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Radix ardisiae brevicaulis 14 parts, 12 parts, purling withered tree, Rhizoma Hedychii Coronarii 15 parts, Rabdosia japonica 11 parts, Picris divaricata 12 parts, hard Herba seu Radix Calanthes 15 parts, Rhizoma actaeae asiaticae 13 parts, gynura bicolor 16 parts, Radix Zanthoxyli Spinifolii 15 parts, Cortex capparis Bodinieri radicis 12 parts, wild seat grass 15 parts, yellow capsule lady's slipper 12 parts, Herba lysimachiae capillipedis 15 parts, Herba hedyotis hispidae (Herba Hedyotidis Auriculariae) 11 parts, Herba asplenii trichomanis 13 parts, suona horn spends 16 parts, Drymaria diandra Blume 14 parts, wide leaf Herba Urticae Cannabinae 11 parts, autumn Herba Gnaphalii Affinis 12 parts, scrofula grass 15 parts, pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 12 parts.
2. treat the application of Chinese medicine composition in treatment allergy purpura of anaphylactoid purpura as claimed in claim 1.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856176A (en) * | 2015-05-30 | 2015-08-26 | 徐艳 | Drink for curing chloasma |
| CN104873626A (en) * | 2015-06-01 | 2015-09-02 | 陈爱华 | Tablet for treating anaphylactoid purpura |
| CN106138078A (en) * | 2016-06-26 | 2016-11-23 | 钟志敏 | For treating the granule of Allergic Purpura in Children symptom of digestive tract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610928A (en) * | 2013-12-04 | 2014-03-05 | 孙振玲 | Traditional Chinese medicine for treating henoch-schonlein purpura nephritis |
| CN103623273A (en) * | 2013-12-11 | 2014-03-12 | 李慧静 | Traditional Chinese medicine for treating henoch-schonlein purpura nephritis |
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- 2014-10-17 CN CN201410552641.8A patent/CN104258237A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610928A (en) * | 2013-12-04 | 2014-03-05 | 孙振玲 | Traditional Chinese medicine for treating henoch-schonlein purpura nephritis |
| CN103623273A (en) * | 2013-12-11 | 2014-03-12 | 李慧静 | Traditional Chinese medicine for treating henoch-schonlein purpura nephritis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856176A (en) * | 2015-05-30 | 2015-08-26 | 徐艳 | Drink for curing chloasma |
| CN104873626A (en) * | 2015-06-01 | 2015-09-02 | 陈爱华 | Tablet for treating anaphylactoid purpura |
| CN106138078A (en) * | 2016-06-26 | 2016-11-23 | 钟志敏 | For treating the granule of Allergic Purpura in Children symptom of digestive tract |
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Application publication date: 20150107 |
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