CN104940848A - Medicine for treating hepatic encephalopathy - Google Patents
Medicine for treating hepatic encephalopathy Download PDFInfo
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- CN104940848A CN104940848A CN201510440882.8A CN201510440882A CN104940848A CN 104940848 A CN104940848 A CN 104940848A CN 201510440882 A CN201510440882 A CN 201510440882A CN 104940848 A CN104940848 A CN 104940848A
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Abstract
The invention relates to a medicine for treating hepatic encephalopathy. The medicine is prepared from the following raw herbal materials in weight proportion: 30 parts of herba lysimachiae, 10 parts of tree-of-heaven ailanthus bark, 5 parts of delphinium grandiflorum, 10 parts of corydalis yanhusuo, 10 parts of curcuma zedoaria, 12 parts of artemisia capillaries, 12 parts of semen vaccariae, 12 parts of root, stem or branch of wrightia pubescens and 12 parts of curcuma aromatic. A clinical experiment result shows that the medicine can effectively treat hepatic encephalopathy.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of hepatic encephalopathy.
Background technology
Hepatic encephalopathy, also known as hepatic coma, is severe liver disease and causes.Central nervous disorders mainly based on disturbance of consciousness, have acute with chronic encephalopathy point, caused by the former many function of detoxification generation serious hindrances because of liver after acute hepatic failure; And the latter is more common in chronic liver failure and door body Doppler flow mapping and is formed or after bypass, from the harmful substance of intestinal, be circulated to brain as ammonia, mercaptan, amine, aromatic amino acid etc. directly enter body and fall ill.Hepatic coma is the final stage of hepatic encephalopathy, and hepatic coma essence is the final clinical manifestation of liver failure.The most elementary tactics for the treatment of hepatic encephalopathy finds, dispels or treat inducement, avoids generation and the development of hepatic encephalopathy.Inducement is clear and definite and easily eliminator's prognosis is better; Liver function is better, makes shunt operation, and the portal-systemic encephalopathy prognosis caused due to feed high protein is better; Have the patient of ascites, jaundice, bleeding tendency to point out liver function very poor, its prognosis is also poor; Hepatic encephalopathy prognosis caused by fulminant hepatic failure is the poorest.
Medical material present Research involved in the present invention is as follows:
Fund grass [another name] Herba Lysimachiae, to seat grass, LUBIANHUANG, everywhere Huang, Hydrocotyle vulgaris L., Yi Chuanqian, CUNGU seven.[source] this product is the dry herb of Ofthe Primulaceae Lysimachia christinae Hance.Summer, Qiu Erji gather, and removing impurity, dries.[nature and flavor] are sweet, salty, are slightly cold.[return through] returns liver, gallbladder, kidney, urinary bladder channel.[function cures mainly] eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, venom; Liver and bile stone, lithangiuria.[usage and dosage] takes orally: decoct soup, 15 ~ 60g.The all poison of [attention] all carbuncle of yin nature, diarrhea due to hypofunction of the spleen person, avoids and smashes the raw clothes of juice.[extracts] " China's book on Chinese herbal medicine ".
Cortex Ailanthi [another name] tree of heaven skin, ailanthus altissima (mill.) swingle skin, bitter Cortex Ailanthi.[source] root for quassia ailanthus altissima (mill.) swingle or the endothelium of cadre.Spring gathers, and takes tree root, scrapes off outside rough bark, beats it gently with wooden stick, make skin zone and woody part loose from, then strip endothelium, face upward and dry; Or strip dried bark.[nature and flavor] are bitter, cold.[return through] GUIXIN, lung, spleen three warp.[function cures mainly] heat extraction, dampness, astringing intestine to stop diarrhea, hemostasis, parasite killing.Control chronic dysentery, chronic diarrhea, discharging fresh blood stool, metrorrhagia, leukorrhagia, seminal emission, nebulousurine, ascarid.[usage and dosage] takes orally: decoct soup, 6 ~ 9g.Person is unavailable for [attention] Deficiency and coldness of spleen and stomach, and metrorrhagia and leukorrhagia belongs to the Kidney-Yin empty person of kidney man and also avoids it, on foot dry therefore also with it.All dysentery pneumatosis are not use up person and also should not hurriedly be used.[extracts] " China's book on Chinese herbal medicine ".
Herba delphinii grandiflori [another name] Radix Delphinii Yunnanensis, opal flower, Rhizoma Coptidis, Herba delphinii grandiflori, Radix Consolidae, pigeon is colored, parrot is careless, Ho Geok Choo color is hollow.The herb that [source] is cohosh Herba delphinii grandiflori or root.7 ~ August gathers, rinsing, and cutting is dried.[nature and flavor] (root) is bitter, cold, nontoxic.[return through] GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.[function cures mainly] pathogenic fire purging pain relieving, parasite killing.[usage and dosage] takes orally: decoct soup, 2 ~ 5g.[attention] this product large bitter Great Cold, cross clothes and take injuring spleen-stomach for a long time, Deficiency and coldness of spleen and stomach person avoids use.Bitter dry impairment of body fluid, deficiency of YIN Tianjin the wounded is cautious use of.[extracts] " China's book on Chinese herbal medicine ".
Rhizoma corydalis [another name] Rhizoma Corydalis element, Rhizoma Corydalis, Rhizoma Corydalis.[source] this product is the dry tuber of papaveraceae plant corydalis.Excavate when early summer stem and leaf is withered, removing fibrous root, cleans, and puts in boiling water and boils to during just without the white heart, take out, dry.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] invigorates blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.[usage and dosage] takes orally: decoct soup, 3-9g.[attention] anemia of pregnant woman is cautious use of.[extracts] " China's book on Chinese herbal medicine ".
Rhizoma Curcumae [another name] Curcuma wenyujin, Rhizoma Curcumae, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung Rhizoma Zingiberis Recens.[source] this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE.The latter practises title " Curcuma wenyujin ".Winter, stem and leaf was excavated after withering, and cleaned, steamed or boil to the saturating heart, dry or remove fibrous root and impurity after cold drying.[nature and flavor] are pungent, bitter, temperature.[return through] returns liver, spleen channel.[function cures mainly] circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.[usage and dosage] takes orally: decoct soup, 6 ~ 12g.[attention] anemia of pregnant woman is forbidden.QI and blood deficiency, weakness of spleen and stomach is without the careful clothes of stagnant person.[extracts] " China's book on Chinese herbal medicine ".
Herba Artemisiae Scopariae [another name] because of dirt, Ma Xian, mattress Gall Artemisia, Herba Artemisiae Scopariae, because of Herba Artemisiae Scopariae, capillary wormwood, floss Artemisia, spire Herba Artemisiae Annuae, smelly Artemisia, An Lvcao, grandmother Artemisia, Radix Rhapontici Artemisia.The young young stem and leaf that [source] is feverfew Herba Artemisiae Scopariae.Gather during seedling height about three cun in spring, removing impurity, removes earth, dries.[nature and flavor] toil, cool.[return through] enters liver, spleen, urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis.Control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Join Fructus Gardeniae, Radix Et Rhizoma Rhei controls YANG jaundice; Join Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis controls YIN jaundice.[attention] heat is very turned to be yellow, without dampness, and the two forbidding.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.[extracts] " China's book on Chinese herbal medicine ".
Semen Vaccariae [another name] SEMEN VACCARIAE, milk rice, king bull, Fructus Hordei Vulgaris cattle.[source] this product is the dry mature seed of pinkwort Vaccaria segetalis.Summer fruit maturation, peel taps plant when not yet ftractureing, dry, lay seed, removing impurity, then dry.[nature and flavor] are bitter, flat.[return through] is bitter, flat.[function cures mainly] promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.[usage and dosage] takes orally: decoct soup, 4.5 ~ 9g.[attention] anemia of pregnant woman is cautious use of.Lose blood disease, metrorrhagia is sick and must avoid it.[extracts] " China's book on Chinese herbal medicine ".
Radix seu caulis wrightiae pubescentis [another name] Mo Zhuguo, chapter table, Chang Zi, nine dense wood, branch Lignum paulowniae, pig Masson Pine, angle's wax candle, handle of a knife, bitter normal, thin aunt's wood, Ma Ling, pig dish mother, bitter poplar.[source] hangs upside down root or the stem branch of pen for apocynaceae plant.Gather and store: the whole year all can adopt, cleaning, section, dries.[nature and flavor] are sweet; Light; Property is put down.[return through] returns liver, kidney, lung, small intestine meridian.[function cures mainly] dispelling wind and removing obstruction in the collateral; Dissipating phlegm and resolving masses; Dampness removing.Main air pain of dampness syndrome; Lumbocrural pain; Traumatic injury; Scrofula; Chronic bronchitis; Icterohepatitis, cirrhotic ascites.[usage and dosage] takes orally: decoct soup, 9 ~ 30g.[extracts] " China's book on Chinese herbal medicine "
Radix Curcumae [another name] radix curcumae, white silk Radix Curcumae.[source] this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and all the other are practised by character difference and claim " osmanthus Radix Curcumae " or " green filament Radix Curcumae ".Winter, stem and leaf was excavated after withering, and removing silt and radicula, steam or boil to the saturating heart, dry.[nature and flavor] are pungent, bitter, cold.[return through] returns liver, the heart, lung meridian.[function cures mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.[attention] deficiency of YIN is lost blood and avoids clothes without qi depression to blood stasis person, the careful clothes of anemia of pregnant woman.[extracts] " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of hepatic encephalopathy, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing hepatic encephalopathy.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine being used for the treatment of hepatic encephalopathy, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: fund grass 30 parts, Cortex Ailanthi 10 parts, Herba delphinii grandiflori 5 parts, rhizoma corydalis 10 parts, Rhizoma Curcumae 10 parts, Herba Artemisiae Scopariae 12 parts, Semen Vaccariae 12 parts, Radix seu caulis wrightiae pubescentis 12 parts, Radix Curcumae 12 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Outpatient service is collected and hepatic encephalopathy 50 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 30 example and matched group 20 example at random, treatment group man 22 example, female 8 example, 38.7 years old mean age; Matched group man 16 example, female 4 example, 39 years old mean age.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria
Diagnostic criteria according to the meeting of national hepatic encephalopathy clinical speciality: (1) Patients with Subclinical: the hepatic encephalopathy caused by 60%-70% liver cirrhosis has Patients with Subclinical.Patient generally acts normally, and clinical health check-up can not find neuropsychiatric abnormalities.Electroencephalogram is still normal.Special examined need be made could find; (2) prodromal period: have slight personality and dystropy, glad or indifferent, bradyphrasia is unclear.Electroencephalogram is still normal; (3) precoma stage: asterixis, appears in entanglement consciously, sleep disorder, manner abnormality.Electroencephalogram is abnormal; (4) lethargic stage: based on lethargy and severe psychiatric entanglement, various neurosigns sustainable existence.Still can wake up during lethargy; (5) coma stage: mind completely loses, can not wake up.
2, test method
2.1 Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.14 days courses for the treatment of, took for 2 courses for the treatment of.
The oral zinc sulfate of matched group, every day 3 times, each 0.2g, totally 7 days; Du Mike initial dose 30-45 mL/ day, maintenance dose 15-25 mL/ day; Lactulose oral solution, 30mL ~ 45mL/ days, 14 days is a course for the treatment of, takes for 2 courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Clinic control: mind is clear, flapping wing sample chatter disappears, and personality behavior recovers normal more than 1 month, electroencephalogram Non Apparent Abnormality;
Effective: in 1 month, 2 phases or 2 phases following encephalopathy occur less than 2 times;
Invalid: not reach above-mentioned standard person.
3.2 therapeutic outcomes are in table 1.
Table 1 liang group comparitive study
| Group | n | Clinic control | Effectively | Invalid | Total effective rate (%) | Serious adverse reaction example |
| Treatment group | 30 | 14 | 12 | 4 | 87% | 0 |
| Matched group | 20 | 5 | 8 | 7 | 65% | 0 |
Visible, the medicine that the present invention obtains can safe and effective treatment hepatic encephalopathy, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: fund grass 30 grams, Cortex Ailanthi 10 grams, Herba delphinii grandiflori 5 grams, rhizoma corydalis 10 grams, Rhizoma Curcumae 10 grams, Herba Artemisiae Scopariae 12 grams, Semen Vaccariae 12 grams, Radix seu caulis wrightiae pubescentis 12 grams, Radix Curcumae 12 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of hepatic encephalopathy.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 2
Take: fund grass 30 grams, Cortex Ailanthi 10 grams, Herba delphinii grandiflori 5 grams, rhizoma corydalis 10 grams, Rhizoma Curcumae 10 grams, Herba Artemisiae Scopariae 12 grams, Semen Vaccariae 12 grams, Radix seu caulis wrightiae pubescentis 12 grams, Radix Curcumae 12 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of hepatic encephalopathy.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 3
Take: fund grass 30 grams, Cortex Ailanthi 10 grams, Herba delphinii grandiflori 5 grams, rhizoma corydalis 10 grams, Rhizoma Curcumae 10 grams, Herba Artemisiae Scopariae 12 grams, Semen Vaccariae 12 grams, Radix seu caulis wrightiae pubescentis 12 grams, Radix Curcumae 12 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of hepatic encephalopathy.Oral, every bu Morning Afternoon Evening is taken for three times.
Claims (1)
1. one kind is used for the treatment of the medicine of hepatic encephalopathy, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: fund grass 30 parts, Cortex Ailanthi 10 parts, Herba delphinii grandiflori 5 parts, rhizoma corydalis 10 parts, Rhizoma Curcumae 10 parts, Herba Artemisiae Scopariae 12 parts, Semen Vaccariae 12 parts, Radix seu caulis wrightiae pubescentis 12 parts, Radix Curcumae 12 parts.
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| CN201510440882.8A CN104940848A (en) | 2015-07-25 | 2015-07-25 | Medicine for treating hepatic encephalopathy |
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| CN201510440882.8A CN104940848A (en) | 2015-07-25 | 2015-07-25 | Medicine for treating hepatic encephalopathy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582393A (en) * | 2016-03-21 | 2016-05-18 | 庄慧勇 | Medicine for treating hepatic encephalopathy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078905A (en) * | 1993-04-02 | 1993-12-01 | 淄博市第一医院 | A kind of medicine for external use for the treatment of hepatopathy |
| CN101745070A (en) * | 2008-12-03 | 2010-06-23 | 袁丽霞 | Medicine for treating hepatopathy |
| CN103830407A (en) * | 2014-03-19 | 2014-06-04 | 成都中医药大学附属医院 | Pharmaceutical composition for treating hepatic encephalopathy |
-
2015
- 2015-07-25 CN CN201510440882.8A patent/CN104940848A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078905A (en) * | 1993-04-02 | 1993-12-01 | 淄博市第一医院 | A kind of medicine for external use for the treatment of hepatopathy |
| CN101745070A (en) * | 2008-12-03 | 2010-06-23 | 袁丽霞 | Medicine for treating hepatopathy |
| CN103830407A (en) * | 2014-03-19 | 2014-06-04 | 成都中医药大学附属医院 | Pharmaceutical composition for treating hepatic encephalopathy |
Non-Patent Citations (2)
| Title |
|---|
| 张学文等: "《中医内科急症学简编》", 28 February 1981, 陕西科学技术出版社 * |
| 毛德文等: ""肝性脑病的中医证治研究"", 《天津中医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582393A (en) * | 2016-03-21 | 2016-05-18 | 庄慧勇 | Medicine for treating hepatic encephalopathy |
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Application publication date: 20150930 |