CN108339107A - A kind of Chinese medicine composition and the preparation method and application thereof for treating constipation - Google Patents
A kind of Chinese medicine composition and the preparation method and application thereof for treating constipation Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of Chinese medicine composition for treating constipation, the Chinese medicine composition includes the raw material of following parts by weight:80 130 parts of positive lotus, 37 parts of fructus cannabis, 37 parts of coreopsis tinctoria.The present invention compounds positive lotus, fructus cannabis, coreopsis tinctoria by rational proportion, drug effect between each raw material component is mutually promoted, and generates synergistic effect, drug effect is made to be maximized, the effect of clearing away heat and eliminating dampeness can be played, relaxed bowel, the constipation of a variety of symptoms can be solved.The used raw material of the present invention is " integration of drinking and medicinal herbs " class food medicinal material, is not added with any additive in the production process, safety is good, takes no toxic side effect for a long time.Preparation method technology degree of the present invention is high, at low cost, is easy to mass produce.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating constipation and preparation method thereof with
Using.
Background technology
Constipation (constipation) is primarily referred to as stool interval reduction, and times of defecation is less than 2-3 times in one week, or
2-3 talent defecates 1 time, referred to as constipation when excrement amount is few and dry and hard.Constipation medically is clinical common complicated symptom, without
It is a kind of disease, is primarily referred to as defecation frequency is reduced, excrement amount is reduced, excrement is dry and hard, defecation is laborious etc..
Currently, most of constipation patients mainly alleviate symptom using various purgatives, but purgatives generally cause diarrhea in a short time,
The phenomenon that it is big to take side effect for a long time, and purgatives can be caused to rely on, can aggravate constipation after drug withdrawal.Doctor trained in Western medicine mostly use " phenolphthalein piece ",
Drugs such as " Kai Saitong " are treated and are alleviated, palliative, and it is low that there are cure rates, the defect easily recurred.
Existing a variety of Chinese medicine compositions for treating constipation, but there are still deficiencies in terms of curative effect, are mainly shown as
Aperient effects are general, easily recur, there are toxic side effects.
The Chinese invention of Publication No. " CN103006978A ", entitled " a kind of Chinese medicine composition for treating constipation " is special
Profit discloses a kind of with Herba Cistanches, Radix Angelicae Sinensis, cassia seed, Cortex Phellodendri, brush-cherry seed, grapefruit flower, dandelion, rhizoma atractylodis macrocephalae, Radix Codonopsis, stir-fry trifoliate orange
Shell, Radix Polygalae, the root of Dahurain angelica, walnut kernel, wrinkled giant hyssop, japanese snakegourd root, fructus cannabis, stone Radix Notoginseng, hawthorn, Chinese yam, fructus cannabis are raw material for controlling
Treat the Chinese medicine composition of constipation.Above-mentioned medicament there are raw material components defect that more, uncertain therapeutic efficacy cuts.
Invention content
Of the existing technology in order to solve the problems, such as, the present inventor is on the Research foundation of Chinese traditional herbs, by for many years
Experiment, screened and compounded from numerous Chinese herbal medicines, obtained a kind of Chinese medicine composition for treating constipation, the composition
Have the advantages that raw material components are few, significant in efficacy, recurrence rate is low and has no toxic side effect.
To achieve the above object, the first aspect of the present invention provides a kind of Chinese medicine composition for treating constipation, in described
Drug composition includes the raw material of following parts by weight:Positive lotus 80-130 parts, 3-7 parts of fructus cannabis, 3-7 parts of coreopsis tinctoria.
Further, the Chinese medicine composition includes the raw material of following parts by weight:Positive lotus 100-120 parts, fructus cannabis 3-7
Part, 3-7 parts of coreopsis tinctoria.
Further, the Chinese medicine composition includes the raw material of following parts by weight:110 parts of positive lotus, 4 parts of fructus cannabis, elder brother
4 parts of logical sequence snow chrysanthemum.
Further, the Chinese medicine composition is oral drugs.
Further, the Chinese medicine composition is oral solution, powder agent, granule, tablet.
Further, the Chinese medicine composition is made of following steps:
1) each raw material after drying is weighed by corresponding parts by weight;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 4-6 times of positive loading amount, is impregnated
It 10-15 minutes, after being boiled by fire, continues boiling by slow fire 10-15 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
3-4 times of loading amount after being boiled by fire, continues boiling by slow fire 10-15 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1-2 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling after
It is continuous to decoct 5-10 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Application of the Chinese medicine composition of the present invention in the drug for preparing treatment constipation.
Application of the Chinese medicine composition of the present invention in the health preserving dietotherapy product for preparing treatment constipation.
The effect of each raw material of the present invention, is as follows:
Positive lotus:It is Zingiber zingiber herbaceos perennial, You Ming Zingiber miogas, asarum, monkey ginger, wild old ginger are that a kind of medicine food is same
The edible wild herbs in source.Positive lotus complete stool has unique fragrance, branches and leaves, rhizome, flowers and fruits can be flat with wind-expelling pain-stopping, clear swollen removing toxic substances, cough-relieving
Asthma, tender shoots, stem fruit delicious flavour are full of nutrition, record according to the study, per 100g sun lotus tender stems and petal 12.4g containing protein,
The anti-2.2g of fat, cellulose 28.1g, vitamin C and vitamin A are total to about 95.85mg, also contain the various trace elements such as iron, zinc, selenium
With aromatic ester etc..Wherein, institute's containing cellulose is a kind of holoside nutrient substance not generating thermal energy, and disperse accumulation stomach invigorating is conducive to keep
Alimentary canal is unobstructed, can treat constipation, has special efficacy to diabetes, often edible, can keep fit and healthy, the moist colour of skin, slow down aging,
With high medical value.
Fructus cannabis:Also known as Chinese pockmarks, cannabis,fructus, fiery fiber crops etc., early in《Zhou Li》In " fiber crops " be one of five cereals,《Herbal guiding principle
Mesh》Then say that fructus cannabis tonifying middle-Jiao and Qi, long term usage be not healthy old.Modern research shows that fructus cannabis is full of nutrition, wherein unsaturated fat
Acid, protein and micro- equal size are very high, and are easy to be absorbed by the body, and are the medical and edible dual purpose plants that health ministry is announced
One of resource.Fructus cannabis is mild-natured, sweet in flavor, has not only been good at moisturizing, but also and qi-restoratives, be clinically used for dry constipation of intestines, quench one's thirst, heat gonorrhea, wandering arthritis,
The signs such as dysentery, irregular menstruation, scabies, epilepsy.
Coreopsis tinctoria:Also known as dichromatism golden wave, it is medicinal and edible plant, chemical composition is abundant, therefrom detaches at present
More than 20 classes are identified, more than 300 kinds of natural component.《Xinhua's book on Chinese herbal medicine outline》It illustrates that it has clearing heat and detoxicating, dampness elimination function, is used for
Acute and chronic dysentery, red eye, swell pain, hygropyretic dysentery, dysentery etc..Modern pharmacology research shows that coreopsis tinctoria has lipid-loweringing, decompression, drop
The physiological activity such as sugared, anti-oxidant.
The invention has the advantages that:
1) present invention compounds positive lotus, fructus cannabis, coreopsis tinctoria by rational proportion, the medicine between each raw material component
Effect is mutually promoted, and synergistic effect is generated, can be with the effect of so that drug effect is maximized, can play clearing away heat and eliminating dampeness, relax bowel
Solve the constipation of a variety of symptoms.
2) the used raw material of the present invention is " integration of drinking and medicinal herbs " class food medicinal material, is not added with any addition in the production process
Agent, safety is good, and long-term use has no toxic side effect.
3) preparation method technology degree of the present invention is high, at low cost, is easy to mass produce.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 80 grams of positive lotus, 3 grams of fructus cannabis, 3 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 6 times of positive loading amount, impregnates 10
Minute, it after being boiled by fire, continues boiling by slow fire 10 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
3 times of loading amount after being boiled by fire, continue boiling by slow fire 15 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 2 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling continues
It decocts 8 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 120 grams of positive lotus, 7 grams of fructus cannabis, 7 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 5 times of positive loading amount, impregnates 12
Minute, it after being boiled by fire, continues boiling by slow fire 12 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
4 times of loading amount after being boiled by fire, continue boiling by slow fire 12 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1.5 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling after
It is continuous to decoct 10 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 130 grams of positive lotus, 3 grams of fructus cannabis, 7 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 4.5 times of positive loading amount, is impregnated
It 15 minutes, after being boiled by fire, continues boiling by slow fire 10 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
3 times of loading amount after being boiled by fire, continue boiling by slow fire 12 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 2 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling continues
It decocts 8 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Embodiment 4
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 110 grams of positive lotus, 6 grams of fructus cannabis, 6 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 4 times of positive loading amount, impregnates 10
Minute, it after being boiled by fire, continues boiling by slow fire 15 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
3 times of loading amount after being boiled by fire, continue boiling by slow fire 12 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling continues
It decocts 5 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Embodiment 5
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 100 grams of positive lotus, 7 grams of fructus cannabis, 3 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 5 times of positive loading amount, impregnates 12
Minute, it after being boiled by fire, continues boiling by slow fire 10 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
4 times of loading amount after being boiled by fire, continue boiling by slow fire 15 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1.5 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling after
It is continuous to decoct 10 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Embodiment 6
A kind of Chinese medicine composition for treating constipation, is made of following steps:
1) 110 grams of positive lotus, 4 grams of fructus cannabis, 4 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 6 times of positive loading amount, impregnates 10
Minute, it after being boiled by fire, continues boiling by slow fire 10 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is sun
3 times of loading amount after being boiled by fire, continue boiling by slow fire 12 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling continues
It decocts 8 minutes, filtration;
5) merge:The extracting solution that is obtained in above-mentioned extraction process three times is mixed, is concentrated to get to the treatment constipation
Chinese medicine composition.
Comparative example 1
The Chinese medicine composition of this comparative example, is made of following steps:
1) 80 grams of positive lotus is weighed;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 6 times of positive loading amount, impregnates 15
Minute, it after being boiled by fire, continues boiling by slow fire 15 minutes, filters, obtain filter residue;
3) it extracts for second:Adding water in the filter residue of step 2), the water is 3 times of positive loading amount, after being boiled by fire,
It continues boiling by slow fire 15 minutes, filters;
4) merge:The extracting solution obtained in above-mentioned extraction process twice is mixed, is concentrated to get to Chinese medicine composition.
Comparative example 2
The Chinese medicine composition of this comparative example, is made of following steps:
1) 15 grams of fructus cannabis, 15 grams of coreopsis tinctoria are weighed;
2) it extracts for the first time:Soaked in the fructus cannabis of step 1) and coreopsis tinctoria, the water be fructus cannabis and
6 times of the total weight of coreopsis tinctoria are impregnated 15 minutes, after being boiled by fire, are continued boiling by slow fire 15 minutes, are filtered, are obtained filter residue;
3) it extracts for second:In the filter residue of step 2) plus water, the water are the total weight of fructus cannabis and coreopsis tinctoria
3 times, after being boiled by fire, continue boiling by slow fire 15 minutes, filter;
4) merge:The extracting solution obtained in above-mentioned extraction process twice is mixed, is concentrated to get to Chinese medicine composition.
Test case
In order to illustrate Chinese medicine composition of the invention to the therapeutic effect of constipation, the present invention has carried out following clinical trial.
L, general information
120 patients are selected, 1,2 group, every group each 40 for the treatment of group and control are randomly divided into.Wherein treatment group man 28,
Female 12, age 18-60 Sui, average age be (38.6 ± 8.9) year;Compare 1 group man 16, female 24, age 20-58 Sui,
Average age be (37.4 ± 7.7) year;Compare 2 groups man 20, female 20, age 19-61 Sui, average age for (39.1 ±
8.0) year.Inclusion criteria:Reference《Functional Gastrointestinal Disease Rome III is newly classified and diagnostic criteria》In diagnostic criteria about constipation.
1) it must include following 2 or 2 or more:1. at least 25% defecation feels laborious;2. at least 25% defecation is dry bulb
Shape excrement or hard shape excrement;Feel not to the utmost 3. at least 25% defecation has;4. have when at least 25% defecation anorectal obstruction feel and
(or) block and feel;5. at least 25% defecation needs gimmick defecation assisting (such as assisting defecation and basin bottom to support with finger);
6. defecation frequency is less than 3 times weekly.2) do not have to loose stools seldom occur when cathartic.3) diagnostic criteria of IBS is not met.Diagnosis
There is at least six moon in preceding symptom, and nearly 3 months symptoms meet the above diagnostic criteria.Two groups of patient's general information compare without significantly
Difference (P > 0.05), is comparable.
2, criterion of therapeutical effect
It cures:I.e. symptom, sign relatively treat preceding disappear or mostly disappear;
It is effective:I.e. symptom, sign are obviously improved before relatively treating;
Effectively:I.e. symptom, sign are improved before relatively treating;
In vain:I.e. symptom, sign are not improved, even it aggravates.
3, therapy
Treatment group:Chinese medicine composition made from oral embodiment 4, daily 1 dose, morning and evening sub-service, 7 days are 1 course for the treatment of.Medication
Period patient does not eat pungent stimulation food, avoids tobacco and wine, takes a good rest.
Compare 1 group:Chinese medicine composition made from oral contrast example 1, daily 1 dose, morning and evening sub-service, 7 days are 1 course for the treatment of.With
Patient does not eat pungent stimulation food during medicine, avoids tobacco and wine, takes a good rest.
Compare 2 groups:Chinese medicine composition made from oral contrast example 2, daily 1 dose, morning and evening sub-service, 7 days are 1 course for the treatment of.With
Patient does not eat pungent stimulation food during medicine, avoids tobacco and wine, takes a good rest.
4, result
By 1 course of therapy, three groups of clinical therapeutic efficacy comparing result is shown in Table 1.
Table 1
Group | It cures | It is effective | Effectively | In vain | Total effective rate/% | Recurrence rate/% |
Treatment group | 15 | 10 | 12 | 3 | 92.5 | 8.1 |
Control group 1 | 8 | 9 | 14 | 9 | 77.5 | 19.3 |
Control group 2 | 6 | 7 | 15 | 12 | 70.0 | 28.6 |
The result shows that:After 1 course for the treatment of of medication, treatment group cures 15, effective 10, effective 12, invalid 3, always has
Efficiency is 92.5%;1 group of healing 8 is compareed, effective 9, effective 14, no effect 9, it is 77.5% to compare 1 group of total effective rate,
2 groups of healings 6 are compareed, effective 7, effective 15, invalid 12, it is 70.0% to compare 2 groups of total effective rates.To cure, it is effective
And after effective follow-up of patients, treatment group's Patients on Recurrence 3, recurrence rate 8.1%, 1 group of recurrence 6 of control, recurrence rate 19.3%,
Compare 2 groups of recurrences 8, recurrence rate 28.6%.
Typical case:
1, Zhang, man, 42 years old, taxi driver, over the past two years, three to four talent stool were primary, and stool is stiff, often for readme
Secondary defecation time about 15 minutes, defecation is very painstaking, belly drum drum, hard, feels that body is heavy.It once ate for a long time big
The charthartics such as Huang, aloe capsule rely on enema defaecation, but can not effect a radical cure.Use Chinese traditional medicine composition made from the embodiment of the present invention 2
Object, after taking 3 days, defecation frequency increases, and a course for the treatment of, defecation is clearly better;Continue to take a course for the treatment of, unimpeded, disease of defecating
Shape disappears;Follow-up 1 year, keeps daily stool 1 time, no relapse.
2, flood certain, female, 28 years old, closely over the past half year, there is constipation symptom since operating pressure is big in company clerk.Two to three days
Stool is primary, often plays acne on the face, long color spot, pachylosis is dark red, lackluster.Once it took cathartic and carries out defaecation, but be discontinued
After defecate it is still obstructed.Chinese medicine composition made from the embodiment of the present invention 6 is taken, after taking 2 days, defecation frequency increases, and defecation is bright
It is aobvious to improve;After one course for the treatment of, stool is unimpeded, and symptom disappears;Follow-up 1 year, keeps daily stool 1-2 times, no relapse.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.
Claims (8)
1. a kind of Chinese medicine composition for treating constipation, which is characterized in that the Chinese medicine composition includes the original of following parts by weight
Material:
Positive lotus 80-130 parts, 3-7 parts of fructus cannabis, 3-7 parts of coreopsis tinctoria.
2. it is according to claim 1 treatment constipation Chinese medicine composition, which is characterized in that the Chinese medicine composition include with
The raw material of lower parts by weight:
Positive lotus 100-120 parts, 3-7 parts of fructus cannabis, 3-7 parts of coreopsis tinctoria.
3. it is according to claim 1 treatment constipation Chinese medicine composition, which is characterized in that the Chinese medicine composition include with
The raw material of lower parts by weight:
110 parts of positive lotus, 4 parts of fructus cannabis, 4 parts of coreopsis tinctoria.
4. the Chinese medicine composition for the treatment of constipation according to claim 1, which is characterized in that the Chinese medicine composition is oral
Drug.
5. the Chinese medicine composition for the treatment of constipation according to claim 4, which is characterized in that the Chinese medicine composition is oral
Liquid, powder agent, granule, tablet.
6. the Chinese medicine composition for the treatment of constipation according to claim 4, which is characterized in that the Chinese medicine composition is by following
Step is made:
1) each raw material after drying is weighed by corresponding parts by weight;
2) it extracts for the first time:It is soaked in the positive lotus of step 1), the water is 4-6 times of positive loading amount, impregnates 10-15
Minute, it after being boiled by fire, continues boiling by slow fire 10-15 minutes, filters, obtain filter residue;
3) it extracts for second:Fructus cannabis and coreopsis tinctoria are added in the filter residue of step 2), and adds water, the water is positive loading
3-4 times of amount after being boiled by fire, continues boiling by slow fire 10-15 minutes, and filtration obtains filter residue;
4) third time is extracted:The water of positive 1-2 times of loading amount is added in the filter residue of step 3), after being boiled by fire, slow boiling continues to decoct
It boils 5-10 minutes, filters;
5) merge:By the extracting solution obtained in above-mentioned extraction process three times mix, concentrate to get to it is described treatment constipation Chinese medicine
Composition.
7. application of the Chinese medicine composition described in claim 1 in the drug for preparing treatment constipation.
8. application of the Chinese medicine composition described in claim 1 in the health preserving dietotherapy product for preparing treatment constipation.
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Citations (4)
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US4328217A (en) * | 1972-12-29 | 1982-05-04 | Mead Johnson & Company | Bran tablet composition and process |
CN102302135A (en) * | 2010-07-16 | 2012-01-04 | 恩施济源药业科技开发有限公司 | Mioga ginger food |
CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
CN103520289A (en) * | 2013-10-28 | 2014-01-22 | 卞佳林 | Chinese medicinal composition for treating constipation, preparation method and application thereof |
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2018
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US4328217A (en) * | 1972-12-29 | 1982-05-04 | Mead Johnson & Company | Bran tablet composition and process |
CN102302135A (en) * | 2010-07-16 | 2012-01-04 | 恩施济源药业科技开发有限公司 | Mioga ginger food |
CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
CN103520289A (en) * | 2013-10-28 | 2014-01-22 | 卞佳林 | Chinese medicinal composition for treating constipation, preparation method and application thereof |
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