CN103623273A - Traditional Chinese medicine for treating henoch-schonlein purpura nephritis - Google Patents
Traditional Chinese medicine for treating henoch-schonlein purpura nephritis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating henoch-schonlein purpura nephritis. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 16 parts of trema cannabina, 14 parts of eurya groffii merr leaves, 14 parts of phyllostachys viridis, 12 parts of urtica laetevirens, 15 parts of syringa velutina, 15 parts of merremia hungaiensis, 10 parts of tripterygium glycosides, 14 parts of lysimachia fortunei maxim, 14 parts of polygonatum punctatum royle, 10 parts of many-nerved bauhinia leaves, 12 parts of trifoliate acanthopanax twig leaves, 10 parts of coriaria sinica maxim, 16 parts of swertia kauitchensis franch, 8 parts of auricled hedyotis herbs, 8 parts of lowdaphne stringbush flower, 14 parts of stizolobium Cochinchinesis, 18 parts of rubiaceae randia depauperata, 12 parts of polymorpha, 10 parts of stegnogramma cyrtomioides, 8 parts of buddleja asiatica, 10 parts of autumn zephyrlily herb and 8 parts of agalloch eaglewood. The traditional Chinese medicine can safely and effectively treat the henoch-schonlein purpura nephritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis.
Background technology
Henoch Schonlein purpura nephritis means that anaphylactoid purpura take the renal damage that systemic disease that gangrenosum acne polyangitis is main pathological change causes.Clinical manifestation except having skin purpura, arthralgia, suffer from abdominal pain, have blood in stool, the kidney main manifestations of getting involved is that hematuria and albuminuria, part patient with severe symptoms can cause impaired renal function.Kidney get involved multiple be born in skin purpura after a couple of days to several weeks.Its cause of disease can be antibacterial, virus and parasite etc. and infects caused allergy, or is the allergy such as some drugs, food, or is that plant pollen, insect bite etc. cause.Erythra is the starting and main clinical manifestation of primary disease, and erythra occurs in distal limbs, buttocks and hypogastric region, and many symmetry distribute, and a little higher than skin surface, can have gargalesthesia.From purpura, to kidney damage, be everlasting 2 weeks in interval time.
For Henoch Schonlein purpura nephritis, still lack at present the effective medicine of generally recognized as safe.
The present Research of the related medical material of Chinese medicine of the present invention is as follows:
Cortex Trematis Cannabinae Radicis [source] is the root bark Herb of Ulmaceae Cortex Trematis Cannabinae Radicis.Summer, autumn gather, using fresh herb or dry.[function cures mainly] diuretic; Removing toxic substances; Blood circulation promoting and blood stasis dispelling.Main watery diarrhea; Influenza; Venom; Injured bone.
Hilllock Eurya plant leaf [source] is the leaf of plant of theaceae hilllock Eurya plant.All can gather the whole year, using fresh herb or dry.[function cures mainly] expelling phlegm for arresting cough; Removing toxic substances and promoting subsidence of swelling.Main pulmonary tuberculosis cough; Innominate toxic swelling; Impetigo; Traumatic injury; Fracture.
The firm firm bamboo Phyllostachys of bamboo [source] grass family bambusoides Sieb. et Zucc., with root, fruit medicine.[function cures mainly] Eradicates wind heat, the meridian dredging, hemostasis.Cure mainly cough due to pathogenic wind-heat, asthma, extremity insensitive impediment, bones and muscles pain, metrorrhagia.
The wide leaf Herba Urticae Cannabinae of wide leaf Herba Urticae Cannabinae [source] Urticaceae Urtica plant Urtica laetevirens Maxim., is used as medicine with herb, root and seed.When summer, stem and leaf was luxuriant, extract herb on the ground, decontamination, cutting, using fresh herb or dry.Root and seed were gathered in the autumn and winter.[function cures mainly] expelling wind for relieving convulsion, relieving constipation helps digestion.For rheumatic arthritis, puerperal convulsion, infantile convulsion, poliomyelitis sequela, hypertension, dyspepsia, constipation; External is controlled urticaria from the beginning of, venom.
Radix Syringae velutinae [source] is the leaf of Oleaceae plants Northeast Syringa pubescens.Summer, autumn gather, and dry or using fresh herb.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing jaundice eliminating.Main acute icterohepatitis.
Ipomoea hungaiensis Lingelsh. Et Borza. [source] Convolvulaceae morning glory Ipomoea hungaiensis Lingelsh. Et Borza. Ipomoea hungaiensis Lingelsh. etBorza, is used as medicine with tuber.Excavate autumn, cleans, and section, dries.[function cures mainly] spleen invigorating removing food stagnancy, dampness removing.For infantile malnutrition, agalactosis, hepatitis, leucorrhea; Burn and scald is controlled in external.
Fall mao careless [source] Celastraceae tripterygium plant Tripterygium hypoglaucum Tripterygium hypoglaucum (Levl.) Hutch., with root bark or all herbal medicine.Can adopt the whole year, cleans, and dries.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove blood stasis, reunion of fractured tendons and bones.For rheumatic arthritis, traumatic injury, hemiplegia, lumbar muscle strain; Fracture is controlled in external, traumatic hemorrhage.
Large Herba Hyperici Japonici [source] is herb or the root of Ofthe Primulaceae Arisaema balansae Engl. grass.The 4-8 month gathers, using fresh herb or dry.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing heat from blood and promoting blood circulation; Removing toxic substances and promoting subsidence of swelling.Main jaundice; Dysentery; Conjunctival congestion; Spit blood; Stranguria with blood; Leucorrhea; Metrorrhagia; Dysmenorrhea; Amenorrhea; Laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Erysipelas; Scrofula; Traumatic injury; Snake bite and insect sting.
The brightly yellowish smart Polygonatum punctatum Royle exKunth of Rhizoma Polygonati punctati [source] Liliaceae Polygonatum plant point, with root stock or all herbal medicine.Autumn and winter excavate, and clean, and dry.[function cures mainly] removing toxic substances and promoting subsidence of swelling, hemostasis.Traumatic hemorrhage is controlled in external, carbuncle furunculosis, scabies, tinea capitis.
Folium Bauhiniae pernervosae [source] is many arteries and veins of pulse family bauhinia Bauhinia purpurea Bauhinia pernervosa L.Chen, with root and leaf, is used as medicine.Uproot autumn; Picking leaves in summer, cleans and dries.[function cures mainly] tonifying the kidney to consolidate the essence, cough-relieving, hemostasis.Root: seminal emission, the enuresis, cough, metrorrhagia.Leaf: proctoptosis, uterine prolapse.
Folium et Cacumen Acanthopanacis Trifoliati [source] is the browse of the white Jin of Araliaceae.Can adopt the whole year.[function cures mainly] controls carbuncle, treats skin ulcer, mange, wound, stomachache.
Coriaria sinica [source] Coriariaceae Coriaria plant Coriaria sinica Coriaria sinica Maxim., is used as medicine with root, leaf.Root is excavated winter, scrapes off crust, dries; Leaf is adopted summer, dries.[function cures mainly] expelling wind and removing dampness, analgesia, parasite killing.Root: for tuberculous lymphadenitis, traumatic injury, lyssodexis, rheumatic arthritis; Leaf: burn and scald is controlled in external, tinea capitis, eczema, sore swollen toxin.
Swertia kauitchensis Franch [source] is the herb of gentianaceae plant Swertia kauitchensis Franch.Summer, autumn gather, and clean, and dry.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing.Main fever of children; Bitter taste hectic fever; Damp and hot yellow cellulitis; Laryngopharynx swelling and pain; Dyspepsia; Gastritis; Aphtha; Toothache; Acute catarrhal conjunctivitis; Venom.
The herb of Auricled Hedyotis Herb [source] Rubiaceae plants of Hedyotis Auricled Hedyotis Herb Hedyotis auricularia L..Can adopt the whole year, cleans using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood detumescence.For cold, fever, cough due to lung-heat, laryngalgia, acute conjunctivitis, enteritis, dysentery; Venom is controlled in external, traumatic injury, carbuncle pyogenic infections from tumour or sore, mastitis, eczema.
The alabastrum of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis) [source] thymelaeceae Flos Wikstroemiae Dolichanthae platymiscium Wikstroemia chamaedaphne (Bge.) Meisn. Wikstroemia chamaedaphne Meisn., leaf also can be used as medicine.Pick flowers early autumn flower bud and leaf, dry in the shade or dry.[function cures mainly] removing water retention by purgation, relieving constipation.For edema distension, phlegm retention is gathered, cough with dyspnea dyspnea with fullness of the chest, acute and chronic infectious hepatitis, schizophrenia, epilepsy.
Semen Stizolobii Cochinchinensis [source] is seed or the leaf of leguminous plant dragon's paw Semen stizolobii capitati.Gather autumn, lays seed, dries.[function cures mainly] warming middle-JIAO QI invigorating.Control ache of the spinal column.
Cortex berberidis dasystachyae [source] is the peel of stem of the straight fringe Radix Berberidis Amurensis of Berberidaceae plant.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.Control hematodiarrhoea and have blood in stool, jaundice due to damp-heat, lower limb swell and ache, hectic fever night sweat, wind-fire ophthalmalgia, erosion of the oral mucosa, tongue boil, mastitis and carbuncle skin ulcer from the beginning of.
Turn celery [source] and turn the root of celery for samphire.Before blooming between summer, autumn, do not excavate, clean, dry.[function cures mainly] delivered and dispeled the wind; Warming spleen and stomach for dispelling cold; Regulating QI to relieve pain.Main exterior syndrome due to wind-cold; Pathogenic wind-warm arthralgia pain; Gastral cavity abdomen; Pain in chest and hypochondrium; Traumatic injury.
Stegnogramma cyrtomioides (C. Chr.) Ching． [source] is the rhizome of Thelypteridaceae plant Stegnogramma cyrtomioides (C. Chr.) Ching．.[function cures mainly] suppressing the hyperactive liver and subsiding YANG.Main dizzy; Vexed insomnia; Night sweat.
Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) [source] is wrapped up in hedge firewood platymiscium for Acanthaceae and is wrapped up in hedge firewood Gendarussa vulgaris Nees [Justicia gendarussa L.F.] and be used as medicine with Herb.Can adopt the whole year, cleans and dry or using fresh herb.[function cures mainly] reunion of fractured tendons and bones, reducing swelling and alleviating pain.For fracture, bruise, rheumatic arthritis.
The herb that Herba Zephyranthis Candidae [source] is amrallid Herba Alii fistulosi lotus all can be adopted the heart whole year, cleans, and mostly is using fresh herb.[function cures mainly] suppressing the hyperactive liver to relieve the wind syndrome.Main infantile convulsion; Epilepsy; Tetanus.
The gal timber that contains volume resin that perfume (or spice) [source] is Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum or the nearly root of Lignum Aquilariae Resinatum of muttering.Choose oiliness in Lignum Aquilariae Resinatum (resin) foot, body constitution is heavy and the glutinous timber stick of property, its oil-containing of pruning is few and part that color is light.[function cures mainly] regulates the flow of vital energy, and pain relieving is sensible.Control and uncomfortable in chestly do not relax, stagnation of QI pain, wind-phlegm is inaccessible.Merit victory Lignum Aquilariae Resinatum.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing Henoch Schonlein purpura nephritis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, it is characterized in that, by the medical material of following weight proportion, be prepared from: 14 parts, Cortex Trematis Cannabinae Radicis 16Fen, hilllock Eurya plant leaf, just 14 parts, bamboo, 12 parts of wide leaf Herba Urticae Cannabinaes, 15 parts of Radix Syringae velutinaes, 15 parts of Ipomoea hungaiensis Lingelsh. Et Borza., fall 10 parts of hair grass, 14 parts of large Herba Hyperici Japonici, 14 parts of Rhizoma Polygonati punctati, 10 parts of Folium Bauhiniae pernervosaes, 12 parts of Folium et Cacumen Acanthopanacis Trifoliati, 10 parts of Coriaria sinicas, 16 parts of Swertia kauitchensis Franchs, 8 parts of Auricled Hedyotis Herbs, 8 parts of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis)s, 14 parts of Semen Stizolobii Cochinchinensiss, 18 parts of Cortex berberidis dasystachyaes, turn 12 parts of celerys, 10 parts of Stegnogramma cyrtomioides (C. Chr.) Ching．s, 8 parts of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)s, 10 parts of Herba Zephyranthis Candidaes, gal mutter fragrant 8 parts.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, physical data
The out-patient that inventor collects 149 routine Henoch Schonlein purpura nephritises between year JIUYUE of November-2012 in 2010 altogether, age 21-45 year, course of disease 1-5.Be divided at random: treatment group 107 examples, blank group 42 examples.The data there was no significant differences such as two groups of ages, the state of an illness, have comparability.
2, test method
The capsule that the oral the present invention of 2.1 treatment group makes according to specific embodiment 1, sooner or later respectively once.30 days courses for the treatment of.
2.2 blank group oral placebo capsules, sooner or later respectively once.30 days courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal, observes more afterwards and has no recurrence for three months.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, and lab testing improves or is normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
3.2 treatment statistical results are in Table 1.
Table 1 liang group curative effect comparison
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) | Untoward reaction example |
| Treatment group | 107 | 33（30.8%） | 58（54.2%) | 16（15%) | 85% | 0 |
| Blank group | 42 | 1（2.4%） | 5（11.9%） | 36（85.7%） | 14.3% | 0 |
Visible, the medicine that the present invention makes can safe and effective treatment Henoch Schonlein purpura nephritis.
The specific embodiment
In order to understand better and to implement the present invention, below in conjunction with specific embodiment, further illustrate the present invention.
specific embodiment 1
Take: 14 grams, Cortex Trematis Cannabinae Radicis 16Ke, hilllock Eurya plant leaf, just 14 grams, bamboo, 12 grams of wide leaf Herba Urticae Cannabinaes, 15 grams of Radix Syringae velutinaes, 15 grams of Ipomoea hungaiensis Lingelsh. Et Borza., fall 10 grams of hair grass, 14 grams of large Herba Hyperici Japonici, 14 grams of Rhizoma Polygonati punctati, 10 grams of Folium Bauhiniae pernervosaes, 12 grams of Folium et Cacumen Acanthopanacis Trifoliati, 10 grams of Coriaria sinicas, 16 grams of Swertia kauitchensis Franchs, 8 grams of Auricled Hedyotis Herbs, 8 grams of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis)s, 14 grams of Semen Stizolobii Cochinchinensiss, 18 grams of Cortex berberidis dasystachyaes, turn 12 grams of celerys, 10 grams of Stegnogramma cyrtomioides (C. Chr.) Ching．s, 8 grams of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)s, 10 grams of Herba Zephyranthis Candidaes, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
specific embodiment 2
Take: 14 grams, Cortex Trematis Cannabinae Radicis 16Ke, hilllock Eurya plant leaf, just 14 grams, bamboo, 12 grams of wide leaf Herba Urticae Cannabinaes, 15 grams of Radix Syringae velutinaes, 15 grams of Ipomoea hungaiensis Lingelsh. Et Borza., fall 10 grams of hair grass, 14 grams of large Herba Hyperici Japonici, 14 grams of Rhizoma Polygonati punctati, 10 grams of Folium Bauhiniae pernervosaes, 12 grams of Folium et Cacumen Acanthopanacis Trifoliati, 10 grams of Coriaria sinicas, 16 grams of Swertia kauitchensis Franchs, 8 grams of Auricled Hedyotis Herbs, 8 grams of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis)s, 14 grams of Semen Stizolobii Cochinchinensiss, 18 grams of Cortex berberidis dasystachyaes, turn 12 grams of celerys, 10 grams of Stegnogramma cyrtomioides (C. Chr.) Ching．s, 8 grams of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)s, 10 grams of Herba Zephyranthis Candidaes, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, pulverize, must meet the powder of 1 day consumption of normal adult.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
specific embodiment 3
Take: 14 grams, Cortex Trematis Cannabinae Radicis 16Ke, hilllock Eurya plant leaf, just 14 grams, bamboo, 12 grams of wide leaf Herba Urticae Cannabinaes, 15 grams of Radix Syringae velutinaes, 15 grams of Ipomoea hungaiensis Lingelsh. Et Borza., fall 10 grams of hair grass, 14 grams of large Herba Hyperici Japonici, 14 grams of Rhizoma Polygonati punctati, 10 grams of Folium Bauhiniae pernervosaes, 12 grams of Folium et Cacumen Acanthopanacis Trifoliati, 10 grams of Coriaria sinicas, 16 grams of Swertia kauitchensis Franchs, 8 grams of Auricled Hedyotis Herbs, 8 grams of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis)s, 14 grams of Semen Stizolobii Cochinchinensiss, 18 grams of Cortex berberidis dasystachyaes, turn 12 grams of celerys, 10 grams of Stegnogramma cyrtomioides (C. Chr.) Ching．s, 8 grams of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)s, 10 grams of Herba Zephyranthis Candidaes, gal mutter fragrant 8 grams, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, then add appropriate dextrin and correctives, and according to this area common process, to granulate, packing, can make the granule that meets 1 day consumption of normal adult.
Be used for the treatment of Henoch Schonlein purpura nephritis.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. a Chinese medicine for the treatment of Henoch Schonlein purpura nephritis, it is characterized in that, by the medical material of following weight proportion, be prepared from: 14 parts, Cortex Trematis Cannabinae Radicis 16Fen, hilllock Eurya plant leaf, just 14 parts, bamboo, 12 parts of wide leaf Herba Urticae Cannabinaes, 15 parts of Radix Syringae velutinaes, 15 parts of Ipomoea hungaiensis Lingelsh. Et Borza., fall 10 parts of hair grass, 14 parts of large Herba Hyperici Japonici, 14 parts of Rhizoma Polygonati punctati, 10 parts of Folium Bauhiniae pernervosaes, 12 parts of Folium et Cacumen Acanthopanacis Trifoliati, 10 parts of Coriaria sinicas, 16 parts of Swertia kauitchensis Franchs, 8 parts of Auricled Hedyotis Herbs, 8 parts of Flos wikstroemiae chamaedaphnes (Flos et follium wikstroemiae chamaedaphnis)s, 14 parts of Semen Stizolobii Cochinchinensiss, 18 parts of Cortex berberidis dasystachyaes, turn 12 parts of celerys, 10 parts of Stegnogramma cyrtomioides (C. Chr.) Ching．s, 8 parts of Herba Gendarussae (Caulis et Folium Gendarussae vulgaris)s, 10 parts of Herba Zephyranthis Candidaes, gal mutter fragrant 8 parts.
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