CN104800588A - Traditional Chinese medicine composition for treating chronic atrophic gastritis - Google Patents
Traditional Chinese medicine composition for treating chronic atrophic gastritis Download PDFInfo
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- CN104800588A CN104800588A CN201510255984.2A CN201510255984A CN104800588A CN 104800588 A CN104800588 A CN 104800588A CN 201510255984 A CN201510255984 A CN 201510255984A CN 104800588 A CN104800588 A CN 104800588A
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and belongs to the field of traditional Chinese medicine agentia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: galium bungei, cryptolepis sinensis, codonopsis pilosula, Chinese yam and the like. The traditional Chinese medicine composition can treat the chronic atrophic gastritis.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat chronic atrophic gastritis.
Background technology
Chronic atrophic gastritis is with gastric epithelial and body of gland atrophy, and decreased number, gastric mucosa is thinning, and mucosa basic unit thickens, or companion's gland metaplasia and intestinal gland metaplasia, or has atypical hyperplasia to be the chronic digestive system disease of feature.Often show as epigastrium dull pain, distension, belch, inappetence, or become thin, anemia etc., without specificity.A kind of many paathogenic factors disease and precancerous lesion.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat chronic atrophic gastritis.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for chronic atrophic gastritis, it is prepared by the raw material of following parts by weight: four leaf humulus 14 parts, Radix Cryptolepis sinensis 12 parts, Radix Codonopsis 12 parts, Rhizoma Dioscoreae 15 parts, Semen Platycladi 12 parts, Pericarpium Citri tangerinae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Ophiopogonis 15 parts, Radix Polygalae 12 parts, Pericarpium Citri 10 parts, the Radix Paeoniae Alba 12 parts, Poria cum Radix Pini 15 parts, Semen Ziziphi Spinosae 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts.
The application of Chinese medicine composition in preparation treatment chronic atrophic gastritis medicine of described treatment chronic atrophic gastritis.
Four leaf humulus in the present invention, Latin is called Galium bungei Steud., is Rubiaceae, galium.Perennial herb, grows thickly, high 30 ~ 50 centimetres.Root is red.Heat-clearing and toxic substances removing, diuresis, hemostasis, helps digestion.For dysentery, urinary tract infection, infantile malnutrition, leucorrhea, hemoptysis; The present invention adopts all herbal medicine.
Radix Cryptolepis sinensis, Latin is called Cryptolepis sinensis (Lour.) Merr., weak woody climber, tool milk; The usual bronzing of sprig, diameter about 1 millimeter, without hair.Leaf Long Circle.Seed Long Circle, is about 1 centimetre, wide 2 millimeters, brown, top tool white thin,tough silk matter kind hair.Heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasis.For hemoptysis of pulmonary tuberculosis, lung-heat is spat blood, gastrorrhagia, venom, sore ulcer, scabies, traumatic injury knife injury.Summer, autumn gather, using fresh herb or dry.The present invention adopts all herbal medicine.All the other are pharmacopeia kind.
Beneficial effect:
The present invention four leaf humulus, Radix Cryptolepis sinensis heat-clearing and toxic substances removing are monarch drug, Radix Codonopsis, Rhizoma Dioscoreae, Semen Platycladi, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Radix Polygalae, Pericarpium Citri, the Radix Paeoniae Alba, Poria cum Radix Pini, Semen Ziziphi Spinosae, Pseudobulbus Bletillae (Rhizoma Bletillae) blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, supplementing QI for promoting the production of body fluid, astringing to arrest bleeding is ministerial drug, and Fructus Setariae Germinatus, Fructus Hordei Germinatus, Pericarpium Citri tangerinae are adjuvant, cooperatively interact, be prepared into medicament, obtained medicine can safe and effective treatment chronic atrophic gastritis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: claim four leaf humulus 14g, Radix Cryptolepis sinensis 12g, Radix Codonopsis 12g, Rhizoma Dioscoreae 15g, Semen Platycladi 12g, Pericarpium Citri tangerinae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Ophiopogonis 15g, Radix Polygalae 12g, Pericarpium Citri 10g, Radix Paeoniae Alba 12g, Poria cum Radix Pini 15g, Semen Ziziphi Spinosae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch 50g, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take four leaf humulus 14g, Radix Cryptolepis sinensis 12g, Radix Codonopsis 12g, Rhizoma Dioscoreae 15g, Semen Platycladi 12g, Pericarpium Citri tangerinae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Ophiopogonis 15g, Radix Polygalae 12g, Pericarpium Citri 10g, Radix Paeoniae Alba 12g, Poria cum Radix Pini 15g, Semen Ziziphi Spinosae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch 50g, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take four leaf humulus 14g, Radix Cryptolepis sinensis 12g, Radix Codonopsis 12g, Rhizoma Dioscoreae 15g, Semen Platycladi 12g, Pericarpium Citri tangerinae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Ophiopogonis 15g, Radix Polygalae 12g, Pericarpium Citri 10g, Radix Paeoniae Alba 12g, Poria cum Radix Pini 15g, Semen Ziziphi Spinosae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch 50g, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of chronic atrophic gastritis.Oral, every bu is taken for twice sooner or later.
4, the present invention is to the clinical research of chronic atrophic gastritis
4.1, physical data: inventor collects the out-patient of 100 routine chronic atrophic gastritis altogether between in May ,-2014 in August, 2012, age 39-56 year, course of disease 1-5.Be divided at random: treatment group 50 example, blank group 50 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: the symptom of chronic atrophic gastritis, sign, without specificity, can not, as the foundation of diagnosis, be made a definite diagnosis main by gastroscope and gastric mucosa living tissue pathologic finding.
(1) age: many above middle age, the course of disease is long, often has chronic superficial gastritis medical history.
(2) symptom and sign: long-term ingestion is bad, gastral cavilty portion distension is uncomfortable, poor appetite, weak, become thin, anemia etc.
(3) 1. gastric mucosa color is thin out in gastroscopy; 2. under mucosa, blood vessel is shown in thoroughly; 3. duplicature is tiny even disappears; 4. when atrophic gastritis is with body of gland cervical region hyperplasia or intestinal epithelial metaplasia, the coarse injustice of mucous membrane surface, in graininess or nodositas, visible pseudopolyp is formed sometimes, and under mucosa, the feature of exposed vessel is often covered; 5. atrophy mucosa fragility increases, easily hemorrhage, and can have rotten to the corn stove; 6. atrophic gastritis simultaneously with the performance of chronic superficial gastritis, as congested erythema, can adhere to mucus, and reflective enhancing etc.
(4) the body of gland atrophy that pathologic finding is 1. intrinsic in gastric mucosa; 2. life is changed; 3. hypertrophy; 4. canceration.
(5) the lab testing 1. many anacidities of gastric analysis A type CAG patient or low acid, Type B CAG patient can normal or low acid; 2. pepsinogen measures pepsin reason cell secretes, and during atrophic gastritis, blood and the pepsinogen content in urinating reduce; 3. the G emiocytosis gastrin of serum gastrin determination gastric antrum portion mucosa.A type CAG patient, serum gastrin Chang Mingxian increases; Type B CAG patient Antral atrophy, directly affects G emiocytosis gastrin function, and serum gastrin is lower than normally; 4. immunologic test parietal cell antibody (PCA), intrinsic factor antibody (IFA), gastrin secretion cell antibody (GCA) measure, and can be used as the auxiliary diagnosis of atrophic gastritis and typing thereof.
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 50 | 25 | 21 | 4 | 92 |
| Blank group | 50 | 1 | 2 | 47 | 6 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic atrophic gastritis.
Claims (2)
1. treat the Chinese medicine composition of chronic atrophic gastritis for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: four leaf humulus 14 parts, Radix Cryptolepis sinensis 12 parts, Radix Codonopsis 12 parts, Rhizoma Dioscoreae 15 parts, Semen Platycladi 12 parts, Pericarpium Citri tangerinae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Ophiopogonis 15 parts, Radix Polygalae 12 parts, Pericarpium Citri 10 parts, the Radix Paeoniae Alba 12 parts, Poria cum Radix Pini 15 parts, Semen Ziziphi Spinosae 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts.
2. treat the application of Chinese medicine composition in treatment chronic atrophic gastritis medicine of chronic atrophic gastritis as claimed in claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944089A (en) * | 2016-04-27 | 2016-09-21 | 迟彩霞 | Capsule for treating atrophic gastritis and preparation method thereof |
Citations (2)
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| KR20140061112A (en) * | 2012-11-13 | 2014-05-21 | 부산대학교 산학협력단 | Processing method, manufacturing method of taemyungchung for gastritic and colitis, and composition thereof |
| CN104258158A (en) * | 2014-10-15 | 2015-01-07 | 卞毓平 | Traditional Chinese medicine composition for treating chronic atrophic gastritis as well as preparation method and application |
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- 2015-05-19 CN CN201510255984.2A patent/CN104800588A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140061112A (en) * | 2012-11-13 | 2014-05-21 | 부산대학교 산학협력단 | Processing method, manufacturing method of taemyungchung for gastritic and colitis, and composition thereof |
| CN104258158A (en) * | 2014-10-15 | 2015-01-07 | 卞毓平 | Traditional Chinese medicine composition for treating chronic atrophic gastritis as well as preparation method and application |
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| 张声生等: "《名医重脾胃：北京中医院名医脾胃病诊疗经验集》", 31 January 2014, 上海科学技术出版社 * |
| 田明等: "针药并用治疗慢性萎缩性胃炎50例", 《湖北中医杂志》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105944089A (en) * | 2016-04-27 | 2016-09-21 | 迟彩霞 | Capsule for treating atrophic gastritis and preparation method thereof |
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Application publication date: 20150729 |