CN105213799A - A kind of Chinese medicine preparation and preparation method for the treatment of the hyperthyroidism of phlegm stagnation fire type - Google Patents

Abstract

The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of the hyperthyroidism of phlegm stagnation fire type, Chinese medicine preparation comprises following raw medicinal material: Herba Themedae japonicae Seedling, Cranium Leporis seu Oryctolagi, Herba Chrysosplenii Macrophylli, Herba salviniae natantis, Lobaria pulmonaria (L.) Hoffm., Pseudobulbus Coelogynes corymbosae, Medulla Junci, Herba Melastomatis Dodecandri, Folium Eriobotryae, Herba Spodiopogonis, Radix Castaneae, Fructus Foeniculi, Cortex Annesleae Fragrantis, DAWANHUA and Rhizoma Marantae arundinaceae.Beneficial effect of the present invention: Chinese medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, immunity can be improved by endocrine regulation, recover thyroid normal function, the hyperthyroidism for the treatment of phlegm stagnation fire type has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of the hyperthyroidism of phlegm stagnation fire type

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of the hyperthyroidism of phlegm stagnation fire type.

Background technology

Hyperthyroidism is hyperthyroid abbreviation, be the thyroid hormone secretion that caused by many reasons too much one group of common endocrinopathy extremely.Main clinical manifestation is polyphagia, becomes thin, fears heat, hyperhidrosis, cardiopalmus, exciting contour metabolic syndrome, neural and blood vessel excitement strengthens, and thyromegaly in various degree and eye is prominent, hand tremor, shank vascular murmur etc. be feature, serious occurred hyperthyroidism is endangered phase, even threat to life of going into a coma.

Treatment hyperthyroidism mainly contains operative treatment, radioiodine therapy and Western medicine Drug therapy three kinds of modes.1, operative treatment: by the excision of thyroid major part, radical rate is higher, is also the Therapeutic Method of important hyperthyroidism.But due to thyroid deep, the parathyroid gland containing four very little adjustment Ca,P metabolism, if surgical experience is not enough, has excised parathyroid gland because of carelessness, will cause lifelong tetany because of low calcium, in addition, also may damage vagus nerve and cause celostomia.2, radioiodine therapy: radioiodine is by iodine labeling, make after radioactive substance, be also called 131 iodine, with 131 iodine therapy hyperthyroidisms, the history of existing over half a century, from nineteen forty-two the method, since treatment first case hyperthyroid patient, the whole world accepts the hyperthyroid patient of 131 iodine therapies, reach 2,000,000, so far, also existing more than 20 ten thousand Patients with Hyperthyroidisms, receive 131 iodine therapies in China; But radiation treatment exists certain potential safety hazard, there is the dispute that radioiodine therapy may bring out thyroid nodule, cancer and hereditary complication always, cause psychological burden to a lot of patient.3, Drug therapy: by oral drugs, the state of an illness is controlled, but need Long-term taking medicine, can not drug withdrawal without authorization, and the relapse rate of drug withdrawal is about 30% ~ 50%.And some suffers from the patient of severe liver disease, the treatment of this hyperthyroidism can not be adopted.The patient of oral disposition medicine, one to fortnight, must arrive examination in hospital hemogram, liver function, bother very much.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine preparation and the preparation method that are used for the treatment of the hyperthyroidism of phlegm stagnation fire type, the advantage that this Chinese medicine preparation has determined curative effect, has no side effect and not easily recur.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of the hyperthyroidism of phlegm stagnation fire type, wherein, comprise following raw medicinal material: Herba Themedae japonicae Seedling, Cranium Leporis seu Oryctolagi, Herba Chrysosplenii Macrophylli, Herba salviniae natantis, Lobaria pulmonaria (L.) Hoffm., Pseudobulbus Coelogynes corymbosae, Medulla Junci, Herba Melastomatis Dodecandri, Folium Eriobotryae, Herba Spodiopogonis, Radix Castaneae, Fructus Foeniculi, Cortex Annesleae Fragrantis, DAWANHUA and Rhizoma Marantae arundinaceae.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Herba Themedae japonicae Seedling 5 ~ 15 parts, Cranium Leporis seu Oryctolagi 20 ~ 30 parts, Herba Chrysosplenii Macrophylli 10 ~ 20 parts, Herba salviniae natantis 12 ~ 22 parts, Lobaria pulmonaria (L.) Hoffm. 15 ~ 25 parts, Pseudobulbus Coelogynes corymbosae 10 ~ 20 parts, Medulla Junci 25 ~ 35 parts, Herba Melastomatis Dodecandri 10 ~ 20 parts, Folium Eriobotryae 20 ~ 30 parts, Herba Spodiopogonis 10 ~ 20 parts, Radix Castaneae 10 ~ 20 parts, Fructus Foeniculi 15 ~ 25 parts, Cortex Annesleae Fragrantis 18 ~ 28 parts, DAWANHUA 20 ~ 30 parts and Rhizoma Marantae arundinaceae 15 ~ 25 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Themedae japonicae Seedling 10 ~ 15 parts, Cranium Leporis seu Oryctolagi 22 ~ 27 parts, Herba Chrysosplenii Macrophylli 13 ~ 18 parts, Herba salviniae natantis 15 ~ 20 parts, Lobaria pulmonaria (L.) Hoffm. 18 ~ 23 parts, Pseudobulbus Coelogynes corymbosae 12 ~ 17 parts, Medulla Junci 25 ~ 30 parts, Herba Melastomatis Dodecandri 10 ~ 15 parts, Folium Eriobotryae 25 ~ 30 parts, Herba Spodiopogonis 10 ~ 15 parts, Radix Castaneae 13 ~ 18 parts, Fructus Foeniculi 17 ~ 22 parts, Cortex Annesleae Fragrantis 20 ~ 25 parts, DAWANHUA 25 ~ 30 parts and Rhizoma Marantae arundinaceae 18 ~ 23 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Themedae japonicae Seedling 14 parts, Cranium Leporis seu Oryctolagi 23 parts, Herba Chrysosplenii Macrophylli 16 parts, Herba salviniae natantis 16 parts, Lobaria pulmonaria (L.) Hoffm. 22 parts, Pseudobulbus Coelogynes corymbosae 14 parts, Medulla Junci 30 parts, Herba Melastomatis Dodecandri 12 parts, Folium Eriobotryae 28 parts, Herba Spodiopogonis 12 parts, Radix Castaneae 17 parts, Fructus Foeniculi 18 parts, Cortex Annesleae Fragrantis 24 parts, DAWANHUA 26 parts and Rhizoma Marantae arundinaceae 22 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Themedae japonicae Seedling 12 parts, Cranium Leporis seu Oryctolagi 26 parts, Herba Chrysosplenii Macrophylli 14 parts, Herba salviniae natantis 20 parts, Lobaria pulmonaria (L.) Hoffm. 19 parts, Pseudobulbus Coelogynes corymbosae 16 parts, Medulla Junci 26 parts, Herba Melastomatis Dodecandri 15 parts, Folium Eriobotryae 26 parts, Herba Spodiopogonis 14 parts, Radix Castaneae 15 parts, Fructus Foeniculi 20 parts, Cortex Annesleae Fragrantis 20 parts, DAWANHUA 28 parts and Rhizoma Marantae arundinaceae 20 parts.

Wherein, when the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Wherein, when the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Beneficial effect of the present invention: Chinese medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, immunity can be improved by endocrine regulation, the advantage recover thyroid normal function, pointed strong, rapid-action, the determined curative effect for the treatment of phlegm stagnation fire type hyperthyroidism, safety be high, having no side effect and not easily recur.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of the hyperthyroidism of phlegm stagnation fire type, wherein, comprise following raw medicinal material: Herba Themedae japonicae Seedling, Cranium Leporis seu Oryctolagi, Herba Chrysosplenii Macrophylli, Herba salviniae natantis, Lobaria pulmonaria (L.) Hoffm., Pseudobulbus Coelogynes corymbosae, Medulla Junci, Herba Melastomatis Dodecandri, Folium Eriobotryae, Herba Spodiopogonis, Radix Castaneae, Fructus Foeniculi, Cortex Annesleae Fragrantis, DAWANHUA and Rhizoma Marantae arundinaceae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Themedae japonicae Seedling: [source] medical material Ji Yuan: be the seedling of grass Herba Themedae japonicae.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] suppressing the hyperactive liver.Main hypertension.[extracts] " China's book on Chinese herbal medicine "

Cranium Leporis seu Oryctolagi: [source] medical material Ji Yuan: for rabbit section animal covers the skull of Northeast Hare, south China rabbit, Mongolian rabbit and Lepus oiostolus etc.[nature and flavor] sweet in the mouth; Acid; Property is put down.[return through] liver; Spleen; Stomach warp.[function cures mainly] calming liver and clearing heat; Detoxification sore treatment.Main headache is dizzy; Insane disease; Lochiostasis; Quench one's thirst; Infantile emaciation; Carbuncle malignant boil.[extracts] " China's book on Chinese herbal medicine "

Herba Chrysosplenii Macrophylli: [another name] pig ear, Rhizoma Chiritae Eburneae, great Ye gold waist, horse ear, imperial Rhizoma et radix valerianae, Herba Otteliae Alismoidis, big foot sheet, great Ye Herba mimuli platyphylli, Herba Saxifragae, hole grass, vexed Cor Gigeriae Galli, hair Chinese cabbage, Chrysosplenium Hydrocotylifolium Levl. Et Van., rock coal dish, Dou Jia, great Ye hair nail-like boil, rock nest chicken.[source] medical material Ji Yuan: be the herb of saxifragaceae plant great Ye gold waist.[nature and flavor] bitter in the mouth, puckery, cold in nature.[function cures mainly] heat-clearing and toxic substances removing, cough-relieving, leukorrhagia stopping, convergence granulation promoting.Main ecthyma; Scald.[extracts] " China's book on Chinese herbal medicine "

Herba salviniae natantis: [another name] numb Piao, limit dustpan duckweed, long foot float Piao, centipede pasture and water, Herba Kyllingae, large fish duckweed, Ma Ping, water centipede, overflow head grass, Chinese scholartree wooden dipper, Herba Pistiae, Bao Tianma, Japanese pagodatree leaf grass.[source] medical material Ji Yuan: be the herb of Salviniaceae plant Japanese pagodatree leaf duckweed.[nature and flavor] are pungent; Bitter; Cold in nature.[function cures mainly] clearing away heat and expelling pathogen in the exterior; Inducing diuresis to remove edema; Removing toxic substances.Main anemopyretic cold; Measles without adequate eruption; Edema, pyretic stranguria, dysuria; Hematodiarrhoea; Hemorrhoid, carbuncle treats skin ulcer; Erysipelas; Parotitis, eczema; Burn and scald.[extracts] " China's book on Chinese herbal medicine "

Lobaria pulmonaria (L.) Hoffm.: [another name] Laolong seven, SHILONG skin, Lobaria retigera (Ach.) Trevis.[source] medical material Ji Yuan: for Corii Bovis seu Bubali leaf section plant oakmoss, split bud oakmoss, the thallus of level and smooth southern oakmoss, oakmoss, Lobaria retigera (Ach.) Trevis etc.[nature and flavor] are light; Micro-hardship; Property is put down.[return through] spleen; Kidney channel.[function cures mainly] digestion-promoting spleen-invigorating; Inducing diuresis to remove edema; Dispelling wind for relieving itching.Main dyspepsia; Infantile malnutrition; Abdominal distention; Edema; Skin pruritus; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Pseudobulbus Coelogynes corymbosae: [another name] Shi Bajiao, to leaf fruit, Herba Bulbophylli Odoratissim, hemostasis fruit, little green splendid achnatherum.[source] medical material Ji Yuan: be pseudobulb or the herb of orchid umbrella room Pseudobulbus Coelogynes corymbosae.[nature and flavor] are pungent; Sweet; Cool.[return through] lung; Kidney channel.[function cures mainly] clearing and antitussive; Hemostasis analgesic therapy.Main bronchus is scorching; Flu; Fracture; Soft tissue contusion; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Medulla Junci: [another name] tiger's whiskers grass, red palpus, lampwick, Medulla Junci, jasper grass, water lampwick, ferrum lampwick, brave wine grass, bent dung grass, seedling are careless.[source] medical material Ji Yuan: be stem pith or the herb of rush family plant Medulla Junci.[nature and flavor] are sweet; Light; Be slightly cold.[return through] heart; Lung; Small intestinal; Urinary bladder channel.[function cures mainly] relieving stranguria by diuresis; Clearing heart fire.Main gonorrhea; Edema; Dysuria; Jaundice due to damp-heat; Dysphoria and insomnia; The nocturnal fretfulness in infants; Sore throat; Aphtha; Wound.[extracts] " China's book on Chinese herbal medicine "

Herba Melastomatis Dodecandri: [another name] mountain region M.-dodecandrum, Herba Melastomatis Candii, Hydrocotyle sibthorpioides, lucky Fructus Persicae, Fructus Vitis viniferae, Flos Carthami, golden head Punica granatum L., Fructus Fici tikouae, floor file M.-dodecandrum, red Herba Melastomatis Candii, land M.-dodecandrum, Herba Melastomatis Dodecandri rattan, short foot and mend that father-in-law, Du eggplant, Chinese sealavender root, small size Pu are light, floor file is glued.[source] medical material Ji Yuan: be the herb of Melastomateae plants Herba Melastomatis Dodecandri.[nature and flavor] sweet in the mouth; Puckery; Cool in nature.[return through] GUIXIN; Liver; Spleen; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis.Main high heat; Lung abscess; Pharyngeal swelling; Toothache; Dysentery; Jaundice; Edema; Dysmenorrhea; Metrorrhagia; Leukorrhagia; Puerperal abdonimal pain; Scrofula; Carbuncle; Furuncle; Hemorrhoid; Venom.[extracts] " China's book on Chinese herbal medicine "

Folium Eriobotryae: [another name] Ba Ye, Folium Eriobotryae, sweet Folium Eriobotryae, Folium Eriobotryae (processed), Lu Juye.[source] medical material Ji Yuan: be the leaf of rosaceous plant Folium Eriobotryae.[nature and flavor] are bitter, pungent; Cold; Nontoxic.[return through] lung; The heart; Stomach warp.[function cures mainly] clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI, quenches the thirst.Main lung-heat phlegmatic cough; Deficiency of YIN chronic cough; Hemoptysis; Epistaxis; Gastric heat is vomitted the sound of vomiting.[extracts] " China's book on Chinese herbal medicine "

Herba Spodiopogonis: [another name] expedites the emergence of grass, Ganoderma lucidum seu Japonicum.[source] medical material Ji Yuan: be the herb of grass spodiopogon sagittifolius.[nature and flavor] are lightly seasoned; Property is put down.[return through] Liver Channel.[function cures mainly] regulating menstruation; Hasten parturition; Circulation of qi promoting.Main menorrhagia; Difficult labour; Breast is vexed; Flatulence.[extracts] " China's book on Chinese herbal medicine "

Radix Castaneae: [source] medical material Ji Yuan: be tree root or the root bark of Fagaceae Semen Castaneae.[nature and flavor] micro-hardship; Property is put down.[function cures mainly] promoting the circulation of QI to relieve pain; Promoting blood flow to regulate menstruation.The main hernia swelling and hanging down of either of the testes; Toothache; Rheumatic arthritis; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

Fructus Foeniculi: [another name] Huai perfume, the fragrant son of Huai, aniseed, cumin, wild Fructus Foeniculi, Fructus Anisi Stellati, Fructus Foeniculi perfume, Gu Xiang, fragrant son, Fructus Foeniculi.[source] medical material Ji Yuan: be the fruit of samphire Fructus Foeniculi.[nature and flavor] acrid in the mouth; Warm in nature.[return through] returns liver; Kidney bladder; Stomach warp.[function cures mainly] the kidney warming warms up liver; Promoting the circulation of QI to relieve pain; Stomach function regulating.Main colic of cold type stomachache; The testis swelling and hanging down of either of the testes; Coldness and pain in the epigastrium; Lack of appetite and vomiting; Hypochondriac pain; Lumbago due to renal deficiency; Dysmenorrhea.[extracts] " China's book on Chinese herbal medicine "

Cortex Annesleae Fragrantis: [another name] sets greatly the Cortex Eucommiae, Cortex Seu Folium Linderae.[source] medical material Ji Yuan: be bark or the leaf of plant of theaceae tea pears.[nature and flavor] are puckery; Micro-hardship; Cool.[return through] liver; Stomach; Large intestine channel.[function cures mainly] promoting the circulation of QI to relieve pain; Help digestion antidiarrheal.Main heart peratodynia; Dyspepsia; Dysentery; Hepatitis.[extracts] " China's book on Chinese herbal medicine "

DAWANHUA: [another name] Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), little Flos Calystegiae sepii, dish intestinal ginseng, floor file ginseng.[source] is Convolvulaceae calystegia plant DAWANHUA, is used as medicine with root stock and flower.Autumn digs root stock, cleans and dries or using fresh herb.Xia Qiu picks flowers using fresh herb.[nature and flavor] are sweet, light, flat.[function cures mainly] root stock: invigorating the spleen and benefiting QI, diuresis, regulating menstruation, leukorrhagia stopping; For insufficiency of the spleen dyspepsia, menoxenia, leucorrhea, milk is rare.Flower: pain relieving; Toothache is controlled in external.[extracts] " national Chinese herbal medicine compilation "

Rhizoma Marantae arundinaceae: [source] medical material Ji Yuan: be the rhizome of Marantaceae plant Rhizoma Marantae arundinaceae.[nature and flavor] sweet in the mouth; Light; Cool in nature.[return through] lung; Urinary bladder channel.[function cures mainly] clearing away lung-heat to relieve cough; Clearing away heat and promoting diuresis.Main cough due to lung-heat; Urine burning pain.[extracts] " China's book on Chinese herbal medicine "

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Herba Themedae japonicae Seedling 5 ~ 15 parts, Cranium Leporis seu Oryctolagi 20 ~ 30 parts, Herba Chrysosplenii Macrophylli 10 ~ 20 parts, Herba salviniae natantis 12 ~ 22 parts, Lobaria pulmonaria (L.) Hoffm. 15 ~ 25 parts, Pseudobulbus Coelogynes corymbosae 10 ~ 20 parts, Medulla Junci 25 ~ 35 parts, Herba Melastomatis Dodecandri 10 ~ 20 parts, Folium Eriobotryae 20 ~ 30 parts, Herba Spodiopogonis 10 ~ 20 parts, Radix Castaneae 10 ~ 20 parts, Fructus Foeniculi 15 ~ 25 parts, Cortex Annesleae Fragrantis 18 ~ 28 parts, DAWANHUA 20 ~ 30 parts and Rhizoma Marantae arundinaceae 15 ~ 25 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Themedae japonicae Seedling 10 ~ 15 parts, Cranium Leporis seu Oryctolagi 22 ~ 27 parts, Herba Chrysosplenii Macrophylli 13 ~ 18 parts, Herba salviniae natantis 15 ~ 20 parts, Lobaria pulmonaria (L.) Hoffm. 18 ~ 23 parts, Pseudobulbus Coelogynes corymbosae 12 ~ 17 parts, Medulla Junci 25 ~ 30 parts, Herba Melastomatis Dodecandri 10 ~ 15 parts, Folium Eriobotryae 25 ~ 30 parts, Herba Spodiopogonis 10 ~ 15 parts, Radix Castaneae 13 ~ 18 parts, Fructus Foeniculi 17 ~ 22 parts, Cortex Annesleae Fragrantis 20 ~ 25 parts, DAWANHUA 25 ~ 30 parts and Rhizoma Marantae arundinaceae 18 ~ 23 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Themedae japonicae Seedling 14 parts, Cranium Leporis seu Oryctolagi 23 parts, Herba Chrysosplenii Macrophylli 16 parts, Herba salviniae natantis 16 parts, Lobaria pulmonaria (L.) Hoffm. 22 parts, Pseudobulbus Coelogynes corymbosae 14 parts, Medulla Junci 30 parts, Herba Melastomatis Dodecandri 12 parts, Folium Eriobotryae 28 parts, Herba Spodiopogonis 12 parts, Radix Castaneae 17 parts, Fructus Foeniculi 18 parts, Cortex Annesleae Fragrantis 24 parts, DAWANHUA 26 parts and Rhizoma Marantae arundinaceae 22 parts.

Wherein, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Themedae japonicae Seedling 12 parts, Cranium Leporis seu Oryctolagi 26 parts, Herba Chrysosplenii Macrophylli 14 parts, Herba salviniae natantis 20 parts, Lobaria pulmonaria (L.) Hoffm. 19 parts, Pseudobulbus Coelogynes corymbosae 16 parts, Medulla Junci 26 parts, Herba Melastomatis Dodecandri 15 parts, Folium Eriobotryae 26 parts, Herba Spodiopogonis 14 parts, Radix Castaneae 15 parts, Fructus Foeniculi 20 parts, Cortex Annesleae Fragrantis 20 parts, DAWANHUA 28 parts and Rhizoma Marantae arundinaceae 20 parts.

Wherein, when the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Wherein, when the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule

Get Herba Themedae japonicae Seedling 120g, Cranium Leporis seu Oryctolagi 260g, Herba Chrysosplenii Macrophylli 140g, Herba salviniae natantis 200g, Lobaria pulmonaria (L.) Hoffm. 190g, Pseudobulbus Coelogynes corymbosae 160g, Medulla Junci 260g, Herba Melastomatis Dodecandri 150g, Folium Eriobotryae 260g, Herba Spodiopogonis 140g, Radix Castaneae 150g, Fructus Foeniculi 200g, Cortex Annesleae Fragrantis 200g, DAWANHUA 280g and Rhizoma Marantae arundinaceae 200;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Embodiment 2: powder

Get Herba Themedae japonicae Seedling 140g, Cranium Leporis seu Oryctolagi 230g, Herba Chrysosplenii Macrophylli 160g, Herba salviniae natantis 160g, Lobaria pulmonaria (L.) Hoffm. 220g, Pseudobulbus Coelogynes corymbosae 140g, Medulla Junci 300g, Herba Melastomatis Dodecandri 120g, Folium Eriobotryae 280g, Herba Spodiopogonis 120g, Radix Castaneae 170g, Fructus Foeniculi 180g, Cortex Annesleae Fragrantis 240g, DAWANHUA 260g and Rhizoma Marantae arundinaceae 220g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 325 object micropowders;

3rd step, adds the starch relative to its quality 2 times in the micropowders obtained by second step, mixing, obtains powder.

Toxicity test:

Acute toxicity test: the granule prepared with the embodiment of the present invention 1 and the powder of the embodiment of the present invention 2 are dissolved in distilled water respectively, gives 2 groups of white mice feeding dispensings respectively with 240 of clinical consumption per day times and 350 times respectively, observes 14; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.Illustrate that Chinese medicine of the present invention is little to white mice acute use toxicity, application safety.

Long term toxicity test: the granule embodiment of the present invention 1 prepared is dissolved in water to mice by 15.48g crude drug/kg, the powder of the embodiment of the present invention 2 is dissolved in water to mice by 32.64g crude drug/kg, continuous uses 16 weeks are distinguished to 2 groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of 2 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch the 90 routine hyperthyroid patients coming from the court outpatient, male 46 people, female 44 people; 20 ~ 42 years old age.90 routine patients are divided into treatment by Chinese herbs group and western medicine group at random, treatment by Chinese herbs group 45 people, male 23 people, female 22 people; 20 ~ 41 years old age.Western medicine group 45 people, male 23 people, female 22 people; 22 ~ 42 years old age.

Diagnostic criteria:

Western medicine diagnose standard: according to " internal medicine " the 7th edition teaching material.Have hypermetabolism sings and symptoms, thyromegaly, thyroid function checks serum T T4, FT4, TT3, FT3 increase and TSH lowers.Or have stickiness edema before exophthalmos, shin.

Syndrome Types of TCM standard: phlegm stagnation fire type: thyromegaly, exophthalmos, susceptible to lose temper due to restlessness, does not uncomfortable in chestly relax, excessive phlegm, and larynx has constriction, and finger carefully quivers, red tongue, greasy fur, stringy and rolling pulse.

Therapeutic Method:

Treatment by Chinese herbs group: take granule prepared by the embodiment of the present invention 1, every day 3 times, each 10g 30 days is 1 course for the treatment of.

Western medicine group: oral Propylthiouracil Tablets, every day 3 times, each 2 30 days is 1 course for the treatment of.

The standard of curative effect evaluation: clinical cure: a. transference cure, body weight increases, and pulse frequency is normal, and region thyreoidea trembles and vascular murmur disappears, and goiter and exophthalmos alleviate; B. serum T 3, T4, FT4 level are normally, thyroid tablet or the T3 inhibition test positive (can suppress), and thyroid immunologic test is normal; Effective: a. symptom takes a turn for the better, and pulse frequency slows down, and goiter is reduced, and vascular murmur alleviates; B. serum T 4, T3, FT4 level are normal, and thyroid tablet or T3 inhibition test feminine gender (can not suppress), still need continual cure.Invalid: a. symptom is without improvement, and pulse frequency change is little, goiter is almost without reducing or becoming large, and vascular murmur is without alleviating; B. serum T 4, T3, FT4 level are still abnormal, thyroid tablet or T3 inhibition test feminine gender (can not suppress).

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs hyperthyroidism of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs hyperthyroidism of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

Table 1 liang group treats Clinical efficacy comparison example (%) after 3 courses for the treatment of respectively

Group	Number of cases	Clinical cure	Effective	Invalid	Total effective rate
						Treatment group	45	30	14	1	44(97.8％)
Matched group	45	13	24	8	37(82.2％)

To fully recover after table 2 liang group treats 3 courses for the treatment of respectively number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Treatment group	30	8(17.8％)	19(42.2％)	30(66.7％)
Matched group	13	3(6.7％)	8(17.8％)	13(28.8％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to the 13 routine follow-up of patients 1 year of 30 for the treatment of group clinical cure examples and matched group clinical cure, result is added up, and treatment group 30 example is without recurrence, and relapse rate is 0%.The routine patient of matched group 13, recurs 6 people, relapse rate 46.2%.

Model case: Cui, male, 37 years old, is diagnosed as hyperthyroidism in other hospitals.Take thiamazole two months, therapeutic effect is not good, after the hyperhidrosis that occurred again that To Be Protected from Heat, the symptoms such as emotion is irritable, come here and go to a doctor, check through thyroid function inspection and other, be diagnosed as hyperthyroidism and have the trend developed gradually.Then according to TCM Syndrome Type: thyromegaly, exophthalmos, susceptible to lose temper due to restlessness, does not uncomfortable in chestly relax, excessive phlegm, and larynx has constriction, and finger carefully quivers, red tongue, greasy fur, stringy and rolling pulse.Typing is the hyperthyroidism of phlegm stagnation fire type.Take Chinese medicine preparation embodiment 1 granule of the present invention, every day 3 times, each 10g, treat and fully recover after 50 days, continue to take drug withdrawal in 10 days, follow up a case by regular visits to and do not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine preparation for phlegm stagnation fire type hyperthyroidism, it is characterized in that, comprise following raw medicinal material: Herba Themedae japonicae Seedling, Cranium Leporis seu Oryctolagi, Herba Chrysosplenii Macrophylli, Herba salviniae natantis, Lobaria pulmonaria (L.) Hoffm., Pseudobulbus Coelogynes corymbosae, Medulla Junci, Herba Melastomatis Dodecandri, Folium Eriobotryae, Herba Spodiopogonis, Radix Castaneae, Fructus Foeniculi, Cortex Annesleae Fragrantis, DAWANHUA and Rhizoma Marantae arundinaceae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: Herba Themedae japonicae Seedling 5 ~ 15 parts, Cranium Leporis seu Oryctolagi 20 ~ 30 parts, Herba Chrysosplenii Macrophylli 10 ~ 20 parts, Herba salviniae natantis 12 ~ 22 parts, Lobaria pulmonaria (L.) Hoffm. 15 ~ 25 parts, Pseudobulbus Coelogynes corymbosae 10 ~ 20 parts, Medulla Junci 25 ~ 35 parts, Herba Melastomatis Dodecandri 10 ~ 20 parts, Folium Eriobotryae 20 ~ 30 parts, Herba Spodiopogonis 10 ~ 20 parts, Radix Castaneae 10 ~ 20 parts, Fructus Foeniculi 15 ~ 25 parts, Cortex Annesleae Fragrantis 18 ~ 28 parts, DAWANHUA 20 ~ 30 parts and Rhizoma Marantae arundinaceae 15 ~ 25 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: Herba Themedae japonicae Seedling 10 ~ 15 parts, Cranium Leporis seu Oryctolagi 22 ~ 27 parts, Herba Chrysosplenii Macrophylli 13 ~ 18 parts, Herba salviniae natantis 15 ~ 20 parts, Lobaria pulmonaria (L.) Hoffm. 18 ~ 23 parts, Pseudobulbus Coelogynes corymbosae 12 ~ 17 parts, Medulla Junci 25 ~ 30 parts, Herba Melastomatis Dodecandri 10 ~ 15 parts, Folium Eriobotryae 25 ~ 30 parts, Herba Spodiopogonis 10 ~ 15 parts, Radix Castaneae 13 ~ 18 parts, Fructus Foeniculi 17 ~ 22 parts, Cortex Annesleae Fragrantis 20 ~ 25 parts, DAWANHUA 25 ~ 30 parts and Rhizoma Marantae arundinaceae 18 ~ 23 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: Herba Themedae japonicae Seedling 14 parts, Cranium Leporis seu Oryctolagi 23 parts, Herba Chrysosplenii Macrophylli 16 parts, Herba salviniae natantis 16 parts, Lobaria pulmonaria (L.) Hoffm. 22 parts, Pseudobulbus Coelogynes corymbosae 14 parts, Medulla Junci 30 parts, Herba Melastomatis Dodecandri 12 parts, Folium Eriobotryae 28 parts, Herba Spodiopogonis 12 parts, Radix Castaneae 17 parts, Fructus Foeniculi 18 parts, Cortex Annesleae Fragrantis 24 parts, DAWANHUA 26 parts and Rhizoma Marantae arundinaceae 22 parts.

5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is: Herba Themedae japonicae Seedling 12 parts, Cranium Leporis seu Oryctolagi 26 parts, Herba Chrysosplenii Macrophylli 14 parts, Herba salviniae natantis 20 parts, Lobaria pulmonaria (L.) Hoffm. 19 parts, Pseudobulbus Coelogynes corymbosae 16 parts, Medulla Junci 26 parts, Herba Melastomatis Dodecandri 15 parts, Folium Eriobotryae 26 parts, Herba Spodiopogonis 14 parts, Radix Castaneae 15 parts, Fructus Foeniculi 20 parts, Cortex Annesleae Fragrantis 20 parts, DAWANHUA 28 parts and Rhizoma Marantae arundinaceae 20 parts.

6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

7. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.