CN104998146A - Medicinal preparation for treating headaches - Google Patents
Medicinal preparation for treating headaches Download PDFInfo
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- CN104998146A CN104998146A CN201510478130.0A CN201510478130A CN104998146A CN 104998146 A CN104998146 A CN 104998146A CN 201510478130 A CN201510478130 A CN 201510478130A CN 104998146 A CN104998146 A CN 104998146A
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Abstract
The invention belongs to the medical field of medicine and provides a medicinal preparation for treating headaches. The medicinal preparation is prepared from 15 parts of begonia fimbristipula, 18 parts of rootorbarkof tailed spicebush, 5 parts of pinellia ternate, 10 parts of white paeony roots, 30 parts of radix paeoniae alba, 10 parts of astragalus mongholicus, 10 parts of radix pseudostellariae, 10 parts of angelica, 5 parts of liquorice, 10 parts of poria with hostwood, 10 parts of poria cocos, 10 parts of polygala roots, 15 parts of jujube kernels, 15 parts of longan aril, 5 parts of costus roots, 20 parts of flowers of silk trees, 15 parts of malt, 10 parts of lotus leaves, 6 parts of dogwood, 10 parts of roots of kudzu vine, 10 parts of Chinese wolfberries, 5 parts of angelica, 10 parts of radices sileris, 5 parts of leeches, 5 parts of ligusticum wallichii and 10 parts of corydalis tuber. The medicinal preparation can be used for treating headaches.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of headache and its preparation method and application.
Background technology
Headache is by excessive rising of liver-YANG, phlegm and blood stasis and cause clear YANG failing to ascend, or turbid pathogen is violated, YANG-orifices failing to be nourished, take cephalic pain as the disease of main manifestations.For this reason, be bursting to and develop the needs that more medicines for the treatment of headache safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of headache.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of headache, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Begoniae Fimbristipulatae 15 parts, Radix seu Cortex Linderae Caudatae 18 parts, the Rhizoma Pinelliae 5 parts, the Radix Paeoniae Alba 10 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, the Radix Astragali 10 parts, Radix Pseudostellariae 10 parts, Radix Angelicae Sinensis 10 parts, 5 parts, Radix Glycyrrhizae, Poria cum Radix Pini 10 parts, 10 parts, Poria, Radix Polygalae 10 parts, Semen Ziziphi Spinosae 15 parts, Arillus Longan 15 parts, the Radix Aucklandiae 5 parts, Flos Albiziae 20 parts, 15 parts, Fructus Hordei Germinatus, 10 parts, Folium Nelumbinis, Fructus Corni 6 parts, Radix Puerariae 10 parts, Fructus Lycii 10 parts, the Radix Angelicae Dahuricae 5 parts, Radix Saposhnikoviae 10 parts, Hirudo 5 parts, Rhizoma Chuanxiong 5 parts, Rhizoma Corydalis 10 parts.
The described pharmaceutical preparation being used for the treatment of headache, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of headache, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment headache medicine being used for the treatment of headache.
Above-mentioned Rhizoma Begoniae Fimbristipulatae, Latin is called Begonia fimbristipula, is bulb or the Herb of Begoniaceae plant Radix Semiaquilegiae.Clearing away heat and cooling blood, promoting blood circulation and detoxication.Control summer-heat hyperpyrexia, cough due to lung-heat, spitting of blood, osteopatia sprain, blood stasis pain, sore scabies, burn due to hot liquid or fire.The present invention is used as medicine with Herb
Radix seu Cortex Linderae Caudatae is root, leaf, the skin of canella Lindera caudata.Classification system Lindera caudata (Nees) Hook.f. hemostasia and promoting granulation, regulating QI to relieve pain.Control osteopatia sprain, wound congestive edema, hemorrhage, chest pain is coughed.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, no matter the gas of the clear sun of six internal organs, or the blood of the five internal organs yin channel, all towards meeting in high mountain peak, therefore claim " all YANG-meridians meeting into the head, the mansion of clear sun ", brain being the marrow sea, six climate exopathogens are invaded outward, internal injury caused by excess of seven emotions, deficient or the meridians Yu Sai of internal organs, the heresies such as capital causes wind and cold damp and hot are outer invades, wind YANG-fire poison is disturbed, phlegm-turbidity and blood stasis blood blocks, cause disorder of meridian-QI, QI and blood is disorderly inverse, headache can be caused, Rhizoma Begoniae Fimbristipulatae of the present invention, Radix seu Cortex Linderae Caudatae, the Rhizoma Pinelliae, the Radix Paeoniae Alba is dispeled the wind and delivers, heat-clearing and toxic substances removing is monarch drug, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Pseudostellariae, Radix Angelicae Sinensis, Poria cum Radix Pini, Poria, Radix Polygalae, Semen Ziziphi Spinosae, Arillus Longan, the Radix Aucklandiae, Flos Albiziae, Fructus Hordei Germinatus, Folium Nelumbinis, Fructus Corni, Radix Puerariae, Fructus Lycii, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Hirudo, Rhizoma Chuanxiong, Rhizoma Corydalis blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain are ministerial drug, Radix Glycyrrhizae is adjuvant, mediation pig medicine, full side's compatibility, dispel the wind and deliver, promoting the circulation of QI to relieve pain, treatment headache successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Rhizoma Begoniae Fimbristipulatae 15g, Radix seu Cortex Linderae Caudatae 18g, Rhizoma Pinelliae 5g, Radix Paeoniae Alba 10g, Rhizoma Atractylodis Macrocephalae 30g, Radix Astragali 10g, Radix Pseudostellariae 10g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 5g, Poria cum Radix Pini 10g, Poria 10g, Radix Polygalae 10g, Semen Ziziphi Spinosae 15g, Arillus Longan 15g, Radix Aucklandiae 5g, Flos Albiziae 20g, Fructus Hordei Germinatus 15g, Folium Nelumbinis 10g, Fructus Corni 6g, Radix Puerariae 10g, Fructus Lycii 10g, Radix Angelicae Dahuricae 5g, Radix Saposhnikoviae 10g, Hirudo 5g, Rhizoma Chuanxiong 5g, Rhizoma Corydalis 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Rhizoma Begoniae Fimbristipulatae 15g, Radix seu Cortex Linderae Caudatae 18g, Rhizoma Pinelliae 5g, Radix Paeoniae Alba 10g, Rhizoma Atractylodis Macrocephalae 30g, Radix Astragali 10g, Radix Pseudostellariae 10g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 5g, Poria cum Radix Pini 10g, Poria 10g, Radix Polygalae 10g, Semen Ziziphi Spinosae 15g, Arillus Longan 15g, Radix Aucklandiae 5g, Flos Albiziae 20g, Fructus Hordei Germinatus 15g, Folium Nelumbinis 10g, Fructus Corni 6g, Radix Puerariae 10g, Fructus Lycii 10g, Radix Angelicae Dahuricae 5g, Radix Saposhnikoviae 10g, Hirudo 5g, Rhizoma Chuanxiong 5g, Rhizoma Corydalis 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Rhizoma Begoniae Fimbristipulatae 15g, Radix seu Cortex Linderae Caudatae 18g, Rhizoma Pinelliae 5g, Radix Paeoniae Alba 10g, Rhizoma Atractylodis Macrocephalae 30g, Radix Astragali 10g, Radix Pseudostellariae 10g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 5g, Poria cum Radix Pini 10g, Poria 10g, Radix Polygalae 10g, Semen Ziziphi Spinosae 15g, Arillus Longan 15g, Radix Aucklandiae 5g, Flos Albiziae 20g, Fructus Hordei Germinatus 15g, Folium Nelumbinis 10g, Fructus Corni 6g, Radix Puerariae 10g, Fructus Lycii 10g, Radix Angelicae Dahuricae 5g, Radix Saposhnikoviae 10g, Hirudo 5g, Rhizoma Chuanxiong 5g, Rhizoma Corydalis 10g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment headache clinical research of the present invention
4.1 general data: this pharmaceutical preparation is applied to clinical observation headache case 60 example, wherein man 25 example, female 35 example, 33 ~ 56 years old age.In the course of disease 4 week of the shortest person, most elder reaches 3 years, average 1.6 years.
4.2 diagnostic criterias:
4.2.1 having a headache, position is many pushes up on head side volume temporo, forehead, top, or left or right tosses about in bed outbreak, or in full headache.The character of headache mostly is jumping pain, twinge, distending pain, confused pain, dull pain, or headache is as split.Sustainable several minutes of each outbreak of headache, a few hours, a couple of days, the person that also has continued for several weeks.
4.2.2 hiddenly attack onset, increase the weight of gradually or recurrent exerbation.
4.2.3 should have a blood test routine, measuring blood pressure, does that waist is worn, bone is worn, electroencephalogram if desired.Do the inspections such as transcranial doppler, CT, magnetic resonance when having ready conditions, with the cause of disease of clearly having a headache, get rid of organic disease.
4.2.4 syndrome-classification
4.2.4.1 excessive rising of liver-YANG: distention and ache in the head, or take out pull and pain.Pain often warm, flushing conjunctival congestion, tinnitus as Cicadae, vexed xerostomia.Red tongue, yellow fur, stringy pulse.
4.2.4.2 expectorant turbid on disturb: have a headache swollen heavy, or hold concurrently dizzy.Gastral cavity uncomfortable in chest is swollen, lack of appetite of feeling sick, and abundant expectoration is sticky white.White and greasy fur, stringy and rolling pulse.
4.2.4.3 blood stagnant in cerebral venation syndrome: headache repeatedly, prolongedly not to be healed, and sore spot is fixed, pain as being stabbed.Purplish tongue is dark or have ecchymosis, white and thin fur, thready and stringy pulse or carefully puckery.
4.2.4.4 deficiency of qi and blood: have a headache continuous.Two order photophobias, in the afternoon more very, spiritlessness and weakness, complexion huang (all of a sudden) is white, and cardiopalmus is slept few.Light red tongue, thin fur, weak pulse.
4.2.4.5 the hepatic and renal YIN deficiency: have a headache dizzy, time light time heavy.Blurred vision, dysphoria with feverish sensation in the chest palms and soles, xerostomia, waist soreness.The few tongue of red tongue, thready and stringy pulse.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: (1) clinical recovery: headache disappears, and every lab testing is normal.Take a turn for the better: headache alleviates, duration of seizure shortens or cycle stretch-out, and lab testing is improved.Invalid: headache syndromes and blood pressure etc. are unchanged.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 30 | 8 | 16 | 6 | 80 |
| Blank group | 30 | 1 | 1 | 28 | 6.7 |
Visible the present invention has good therapeutic effect to headache, and toxic and side effects does not occur treatments period.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of headache, it is characterized in that, active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Rhizoma Begoniae Fimbristipulatae 15 parts, Radix seu Cortex Linderae Caudatae 18 parts, the Rhizoma Pinelliae 5 parts, the Radix Paeoniae Alba 10 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, the Radix Astragali 10 parts, Radix Pseudostellariae 10 parts, Radix Angelicae Sinensis 10 parts, 5 parts, Radix Glycyrrhizae, Poria cum Radix Pini 10 parts, 10 parts, Poria, Radix Polygalae 10 parts, Semen Ziziphi Spinosae 15 parts, Arillus Longan 15 parts, the Radix Aucklandiae 5 parts, Flos Albiziae 20 parts, 15 parts, Fructus Hordei Germinatus, 10 parts, Folium Nelumbinis, Fructus Corni 6 parts, Radix Puerariae 10 parts, Fructus Lycii 10 parts, the Radix Angelicae Dahuricae 5 parts, Radix Saposhnikoviae 10 parts, Hirudo 5 parts, Rhizoma Chuanxiong 5 parts, Rhizoma Corydalis 10 parts.
2. be used for the treatment of the pharmaceutical preparation of headache as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of headache as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment headache medicine of headache according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510478130.0A CN104998146A (en) | 2015-08-07 | 2015-08-07 | Medicinal preparation for treating headaches |
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| CN201510478130.0A CN104998146A (en) | 2015-08-07 | 2015-08-07 | Medicinal preparation for treating headaches |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080044496A1 (en) * | 2006-08-03 | 2008-02-21 | Jose Angel Olalde Rangel | Arthritis phyto-nutraceutical synergistic composition |
| CN104800505A (en) * | 2015-04-24 | 2015-07-29 | 臧孝国 | Traditional Chinese medicine composition for treating irregular menstruation |
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- 2015-08-07 CN CN201510478130.0A patent/CN104998146A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080044496A1 (en) * | 2006-08-03 | 2008-02-21 | Jose Angel Olalde Rangel | Arthritis phyto-nutraceutical synergistic composition |
| CN104800505A (en) * | 2015-04-24 | 2015-07-29 | 臧孝国 | Traditional Chinese medicine composition for treating irregular menstruation |
Non-Patent Citations (2)
| Title |
|---|
| 吴大真等: "《现代名中医精神神经疾病治疗绝技》", 30 November 2003, 科学技术文献出版社 * |
| 汪文良等: "中西医结合治疗血管神经性头痛34例观察", 《实用中医药杂志》 * |
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Application publication date: 20151028 |