CN104524168A - Medicine for treating acute mastitis - Google Patents

Medicine for treating acute mastitis Download PDF

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CN104524168A
CN104524168A CN201410800402.XA CN201410800402A CN104524168A CN 104524168 A CN104524168 A CN 104524168A CN 201410800402 A CN201410800402 A CN 201410800402A CN 104524168 A CN104524168 A CN 104524168A
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parts
radix
medicine
acute mastitis
fructus
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李洋
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

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Abstract

The invention provides a medicine for treating acute mastitis, which is prepared from the following raw materials in parts by weight: longfruit speedwell herb, clematis henryi, radix bupleuri, Chinese angelica and the like. The medicine provided by the invention can be used for treating acute mastitis.

Description

A kind of medicine for the treatment of acute mastitis
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of medicine and the preparation method and application that treat acute mastitis.
Background technology
Acute mastitis is many because of cracked nipple, attacks outside ailment said due to cold or exposure, or human milk silt, and newborn network retardance, strongly fragrant heat-transformation of a specified duration forms.With breast portion caking swelling pain, after bursting, pus goes out stiff is feature.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of medicine and the preparation method and application that treat acute mastitis.
Technical scheme: the object of the invention is by following scheme realize:
Treat a medicine for acute mastitis, it is prepared by the raw material of following parts by weight: Herba Veronicae Ciliatae 15 parts, henry clematis 12 parts, Radix Bupleuri 12 parts, Radix Angelicae Sinensis 15 parts, Herba Taraxaci 15 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Trichosanthis 15 parts, Spina Gleditsiae 10 parts, Radix Rehmanniae 15 parts, Cortex Moutan 15 parts, Fructus Forsythiae 15 parts, Fructus Trichosanthis 10 parts, Radix Platycodonis 10 parts, Fructus Liquidambaris 10 parts, Radix Paeoniae Rubra 15 parts, Fructus Gardeniae 10 parts, Flos Lonicerae 10 parts, Radix Ophiopogonis 15 parts, Bulbus Fritillariae Thunbergii 15 parts, 6 parts, Radix Glycyrrhizae.
The application of medicine in the medicine of preparation treatment acute mastitis of described treatment acute mastitis.
In the present invention, Herba Veronicae Ciliatae is Scrophulariaceae brooklime Herba Veronicae ciliatae Veronica ciliata Fisch., with all herbal medicine.Henry clematis, Latin is called Clematis henryi Oliv., and belong to Ranales, Ranunculaceae woody climber, is used as medicine with the root expanded.Spina Gleditsiae is the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..The whole year all can gather, dry, or takes advantage of fresh slices, dry.All the other medicines all meet standards of pharmacopoeia or are documented in Chinese medicine voluminous dictionary.
Beneficial effect: Herba Veronicae Ciliatae of the present invention, henry clematis heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence is monarch drug, Radix Bupleuri, Radix Angelicae Sinensis, Herba Taraxaci, Radix Salviae Miltiorrhizae, Radix Trichosanthis, Spina Gleditsiae, Radix Rehmanniae, Cortex Moutan, Fructus Forsythiae, Fructus Trichosanthis, Radix Platycodonis, Fructus Liquidambaris, Radix Paeoniae Rubra, Fructus Gardeniae, Flos Lonicerae, Radix Ophiopogonis, Bulbus Fritillariae Thunbergii blood circulation promoting and blood stasis dispelling, promoting QI circulation for relieving depression are ministerial drug, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for adjuvant, the medicine that full side obtains can safe and effective treatment acute mastitis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1. prepare embodiment
1.1 take Herba Veronicae Ciliatae 15g, henry clematis 12g, Radix Bupleuri 12g, Radix Angelicae Sinensis 15g, Herba Taraxaci 15g, Radix Salviae Miltiorrhizae 10g, Radix Trichosanthis 15g, Spina Gleditsiae 10g, Radix Rehmanniae 15g, Cortex Moutan 15g, Fructus Forsythiae 15g, Fructus Trichosanthis 10g, Radix Platycodonis 10g, Fructus Liquidambaris 10g, Radix Paeoniae Rubra 15g, Fructus Gardeniae 10g, Flos Lonicerae 10g, Radix Ophiopogonis 15g, Bulbus Fritillariae Thunbergii 15g, Radix Glycyrrhizae 6g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of acute mastitis.Oral, every bu is taken for twice sooner or later.
1.2 take Herba Veronicae Ciliatae 15g, henry clematis 12g, Radix Bupleuri 12g, Radix Angelicae Sinensis 15g, Herba Taraxaci 15g, Radix Salviae Miltiorrhizae 10g, Radix Trichosanthis 15g, Spina Gleditsiae 10g, Radix Rehmanniae 15g, Cortex Moutan 15g, Fructus Forsythiae 15g, Fructus Trichosanthis 10g, Radix Platycodonis 10g, Fructus Liquidambaris 10g, Radix Paeoniae Rubra 15g, Fructus Gardeniae 10g, Flos Lonicerae 10g, Radix Ophiopogonis 15g, Bulbus Fritillariae Thunbergii 15g, Radix Glycyrrhizae 6g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, must meet the granule of adult normal's 1 day consumption.Be used for the treatment of acute mastitis.Oral, every bu is taken for twice sooner or later.
1.3 take Herba Veronicae Ciliatae 15g, henry clematis 12g, Radix Bupleuri 12g, Radix Angelicae Sinensis 15g, Herba Taraxaci 15g, Radix Salviae Miltiorrhizae 10g, Radix Trichosanthis 15g, Spina Gleditsiae 10g, Radix Rehmanniae 15g, Cortex Moutan 15g, Fructus Forsythiae 15g, Fructus Trichosanthis 10g, Radix Platycodonis 10g, Fructus Liquidambaris 10g, Radix Paeoniae Rubra 15g, Fructus Gardeniae 10g, Flos Lonicerae 10g, Radix Ophiopogonis 15g, Bulbus Fritillariae Thunbergii 15g, Radix Glycyrrhizae 6g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, technique is granulated routinely, and tabletting, can obtain the tablet meeting adult normal's 1 day consumption.Be used for the treatment of acute mastitis.Oral, every bu is taken for twice sooner or later.
2. the present invention is to the clinical research of acute mastitis
2.1 physical data: inventor collects the out-patient of 60 routine acute mastitises altogether between in October ,-2013 in May, 2012, women, age 26-37 year, be divided at random: treatment group 30 example, blank group 30 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
2.2 diagnostic criterias:
2.2.1 from the beginning of there being painful lump in breast, skin is not red or micro-red, and milk ejection is smooth, and nipple can be had to break erosion.During suppuration, breast swell and pain increases the weight of, lump deliquescing, has and should refer to sense, after diabrosis or incision and drainage, swells and ache and alleviates.As pus flows out not smooth, swell and ache and do not disappear, the change of " biography capsule " can be had.Do not close up after bursting, seepage flow milk or pus, can form mammary fistula.
2.2.2 have fever with aversion to cold, headache more, and the whole body is uncomfortable waits disease.
2.2.3 Ipsilateral oxter Ke You Xing core enlargement pain.
2.2.4 most patients is nursing women, is common especially with the primipara of non-full moon.
2.2.5 blood leukocytes sum and neutrophilic granulocyte increase.
2.2.6 syndrome-classification
2.2.6.1 stagnation of QI heat is stopped up: human milk silt lumps, and color of the leather is constant or micro-red, swelling pain.With fever with aversion to cold, headache, aching of the whole body, thirsty, constipation.Yellow fur, rapid pulse.
2.2.6.2 excessive noxious heat: high fever, breast swell and pain, skin lifts red scorching hot, lump deliquescing, has and should refer to sense.Or inadequate drainage after incision evacuation of pus, red and swollen heat pain does not disappear, and has " biography capsule " phenomenon.Red tongue, yellow and greasy fur, full and rapid pulse.
2.2.6.3 weakened body resistance poison love: though pus rear udder attachment of bursting swells and ache gently, open sore part pus is continuous, and pus is rare clearly, indolence or formation mammary fistula.Malaise, lustreless complexion, or low grade fever does not move back, and diet reduces.Pale tongue, thin fur, weak pulse is unable.
2.3 test method
2.3.1 the oral the present invention for the treatment of group is according to the obtained capsule of specific embodiment 1.1, sooner or later each once.15 days courses for the treatment of.
2.3.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
2.4 criterions of therapeutical effect and therapeutic outcome
2.4.1 criterion of therapeutical effect
Recovery from illness: General Symptoms disappears, lump dissipates, wound healing.Take a turn for the better: General Symptoms disappears, and partial gall alleviates, or the open sore part not yet heals.Do not heal: " biography capsule " or formation mammary fistula repeatedly.
2.4.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 30 14 8 8 73.3
Blank group 30 1 1 28 6.7
Visible, the medicine that the present invention obtains can safe and effective treatment acute mastitis.
2.5 model case
Wang, female, 38 years old, have painful lump in breast, skin is not red, and nipple breaks erosion.Fever with aversion to cold, headache, the whole body is uncomfortable, and can there be lump pain oxter, left side, yellow fur, rapid pulse.Be diagnosed as the stagnation of QI hot heap soil or fertilizer over and around the roots type acute mastitis, the capsule that oral the present invention obtains according to specific embodiment 1.1, sooner or later each once after 15, General Symptomies disappear, lump dissipation, wound healing.

Claims (2)

1. treat the medicine of acute mastitis for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Herba Veronicae Ciliatae 15 parts, henry clematis 12 parts, Radix Bupleuri 12 parts, Radix Angelicae Sinensis 15 parts, Herba Taraxaci 15 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Trichosanthis 15 parts, Spina Gleditsiae 10 parts, Radix Rehmanniae 15 parts, Cortex Moutan 15 parts, Fructus Forsythiae 15 parts, Fructus Trichosanthis 10 parts, Radix Platycodonis 10 parts, Fructus Liquidambaris 10 parts, Radix Paeoniae Rubra 15 parts, Fructus Gardeniae 10 parts, Flos Lonicerae 10 parts, Radix Ophiopogonis 15 parts, Bulbus Fritillariae Thunbergii 15 parts, 6 parts, Radix Glycyrrhizae.
2. treat the application of medicine in the medicine for the treatment of acute mastitis of acute mastitis as claimed in claim 1.
CN201410800402.XA 2014-12-21 2014-12-21 Medicine for treating acute mastitis Pending CN104524168A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748619A (en) * 2016-03-29 2016-07-13 张晓军 Pharmaceutical composition for treating plasma cell mastitis and preparation method thereof
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Publication number Priority date Publication date Assignee Title
CN105748619A (en) * 2016-03-29 2016-07-13 张晓军 Pharmaceutical composition for treating plasma cell mastitis and preparation method thereof
CN105748619B (en) * 2016-03-29 2020-02-21 中国中医科学院西苑医院 Medicine for treating plasma cell mastitis and preparation method thereof
CN105998323A (en) * 2016-05-27 2016-10-12 青岛绿曼生物工程有限公司 Film-forming pharmaceutical composition for preventing and treating cow mastitis as well as application and preparation method of pharmaceutical composition
CN114699443A (en) * 2022-03-04 2022-07-05 浙江省中医院、浙江中医药大学附属第一医院（浙江省东方医院） Traditional Chinese medicine composition for treating breast inflammatory mass based on gentle cooling therapy and preparation method and application thereof

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