CN104971235A - Medicine for treating primary hypertension and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating primary hypertension and a preparation method thereof. The medicine is mainly prepared from the following components according to a certain weight proportion: gastrodia elata, earthworms, scorpions, centipedes, leeches, ground beeltle, pseudo-ginseng, coptis chinensis, scutellaria baicalensis, tree peony bark, ligusticum wallichii, chrysanthemum and uncaria rhynchophylla. The medicine provided by the invention has the functions of clearing heat, calming the liver, calming endogenous wind, relieving convulsion, cooling blood, activating blood, dredging collaterals, and eliminating stagnant blood, and is short in treatment course, takes effects quickly and has no toxic or side effects when being used for treating primary hypertension.

Description

A kind of medicine for the treatment of essential hypertension and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of essential hypertension and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Hypertension can be divided into essential hypertension and the large class of secondary hypertension two.In most patient, hypertensive etiology unknown, is referred to as essential hypertension, accounts for total hyperpietic's more than 95%; Less than in 5% patient, it is a kind of clinical manifestation of some disease that blood pressure raises, and itself has clearly and the independently cause of disease, is called secondary hypertension.Essential hypertension, also known as hypertension, patient is except the symptom that hypertension itself can be caused relevant, and long-term hypertension also can become the important risk factor of multiple cardiovascular and cerebrovascular disease, and affect important organ after one's own heart, the function of brain, kidney, finally can cause the nonfunction of these organs.Because Western medicine cannot effective fast treating essential hypertension, therefore there is great demand in the Chinese medicine of people to effective treatment essential hypertension, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment essential hypertension, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment essential hypertension.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Rhizoma Gastrodiae, Lumbricus, Scorpio, Scolopendra, Hirudo, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Rhizoma Chuanxiong, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the Radix Astragali, Radix Ginseng, Radix Angelicae Sinensis, the Radix Paeoniae Alba carry out combine preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat essential hypertension.Wherein, select Rhizoma Gastrodiae to be because its nature and flavor are sweet, flat, enter Liver Channel, have endogenous wind stopping, the function of arresting convulsion, control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, little Jing Epilepsy wind symptom.Lumbricus is selected to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, have heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control high fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Selects the scorpion because of their sexual taste salty, flat, toxic, with functions, antispasmodic, t2dm, the function of detoxification, epilepsy, epilepsy, stroke, hemiplegia, mouth askew, migraine, rheumatism bi pain, tetanus, lymph node tuberculosis, measles sore swollen.Select Scolopendra to be because its nature and flavor are pungent, temperature, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, counteracting toxic substances, the function of eliminating stagnation, controls apoplexy ， Jing Epilepsy, tetanus, pertussis, Ji scrofula, tuberculosis ， mass in the abdomen tumor block, sore swollen toxin, and tinea corporis is bald in vain, anal fistula, scalds.Select Hirudo to be because the salty hardship of its nature and flavor, flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, control blood-retention ， mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Eupolyphaga Seu Steleophaga is selected to be salty because of its nature and flavor, cold, slightly poisonous.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Rhizoma Coptidis is selected to be because its nature and flavor are bitter, cold, enter the heart, liver, stomach, large intestine channel, have pathogenic fire purging, dampness, removing toxic substances, the function of parasite killing, row pyretic toxicity, typhoid fever when controlling, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, pulmonary tuberculosis, tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Radix Scutellariae is selected to be because its nature and flavor are bitter, cold, enter the heart, lung, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, hemostasis, antiabortive function, controls high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tells, is defeated in battle, collapses, leaks, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.Cortex Moutan is selected to be because its nature and flavor are worked hard, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, and send out speckle ， Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Rhizoma Chuanxiong to be that temperature, enters liver, gallbladder meridian, have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache and revolve dizzy because its nature and flavor are pungent, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor are bitter, cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclampsia.Select Radix Rehmanniae to be that cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the function of promoting the production of body fluid, and controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, and interior-heat is quenched one's thirst because its nature and flavor are sweet, spit blood, epistaxis, sends out speckle dermexanthesis.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating the spleen and replenishing QI, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Radix Ginseng is selected to be that temperature, enters spleen, lung meridian, have strongly invigorating primordial QI because its nature and flavor are sweet micro-sweet, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, return liver spleen channel, useful blood easing the affected liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls breast abdomen hypochondriac pain, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Rhizoma Gastrodiae 10-15 gram, Lumbricus 10-15 gram, Scorpio 6-8 gram, Scolopendra 3-6 gram, Hirudo 2-5 gram, Eupolyphaga Seu Steleophaga 6-9 gram, Radix Notoginseng 10-15 gram, Rhizoma Coptidis 6-10 gram, Radix Scutellariae 8-12 gram, Cortex Moutan 10 grams, Rhizoma Chuanxiong 6-15 gram, Flos Chrysanthemi 10-15 gram, Ramulus Uncariae Cum Uncis 10-15 gram, Radix Rehmanniae 10-15 gram, Radix Astragali 10-20 gram, Radix Ginseng 8-15 gram, Radix Angelicae Sinensis 8-16 gram, Radix Paeoniae Alba 10-15 gram, Mel 60-80 gram.

Be preferably:

12 grams, Rhizoma Gastrodiae, Lumbricus 12 grams, Scorpio 6 grams, Scolopendra 4 grams, Hirudo 4 grams, Eupolyphaga Seu Steleophaga 8 grams, Radix Notoginseng 10 grams, Rhizoma Coptidis 8 grams, Radix Scutellariae 10 grams, Cortex Moutan 10 grams, Rhizoma Chuanxiong 10 grams, Flos Chrysanthemi 12 grams, Ramulus Uncariae Cum Uncis 10 grams, Radix Rehmanniae 12 grams, the Radix Astragali 12 grams, Radix Ginseng 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Alba 10 grams, Mel 70 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Gastrodiae: be laid in by Rhizoma Gastrodiae slice and sprayed on the watch core paper of water, put in pot, burns sallow to paper color with slow fire, is constantly stirred by tablet to the strong yellow of two sides;

2, Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

3, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

4, Scolopendra: wipe clean, removing cephalopodium, cuts off use;

5, Hirudo: clean, vexed soft, cutting, dries;

6, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

7, Radix Notoginseng: pick most impurity, smash to pieces, grinds or runs through section into powder and dry;

8, Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;

9, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

10, Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

11, Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

12, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

13, Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;

14, Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;

15, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

16, Radix Ginseng: except removing LU, cutting;

17, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

18, Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull dry in the sun out, moisten to internal and external temperature even, section, dry.

Two, prepare

1, levigation: by the Rhizoma Gastrodiae after the process of preparing Chinese medicine, Lumbricus, Scorpio, Scolopendra, Hirudo, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Rhizoma Chuanxiong, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the Radix Astragali, Radix Ginseng, Radix Angelicae Sinensis, the Radix Paeoniae Alba grind as fine powder.

2, Mel is refined into the tender honey of 110 DEG C-115 DEG C.

3, stir evenly grinding to pour in Mel for the medicated powder of fine powder, mixing system sticks together, then rubbing pill, 9 grams, every ball.

In prescription, Ramulus Uncariae Cum Uncis has heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the function of controlling slight Hypertension be monarch drug, Rhizoma Gastrodiae endogenous wind stopping, arresting convulsion, Lumbricus heat clearing away, suppressing the hyperactive liver, Zhichuan, dredging collateral, the two is ministerial drug, three taste medicines jointly play heat clearing away, suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., calm the frightened, removing heat from blood and blood, dredging collateral, dissipating blood stasis effect, treatment essential hypertension effect is comprehensive, and can effect a permanent cure for master with heat clearing away, removing heat from blood, dissipating blood stasis; Scorpio have dispel the wind, relieving convulsion, dredging collateral, removing toxic substances function be adjuvant drug, Radix Ginseng has strongly invigorating primordial QI, solid de-promote the production of body fluid, the function of calming the nerves for making medicine, all medicines take stopgap measures with being left.

The present invention have heat clearing away, suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., calm the frightened, removing heat from blood and blood, dredging collateral, dissipating blood stasis function, be used for the treatment of essential hypertension short treating period, instant effect, have no side effect.

Detailed description of the invention:

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 0.2g/kg, and normal amount is 0.1g/kg, and administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept essential hypertension out-patient totally 36 examples for medical treatment.

2, diagnostic criteria

The standard of current domestic hypertensive diagnosis employing Chinese Treatment Guidelines for Hypertension suggestion in 2000:

When systolic pressure as patient adheres to different ranks separately from diastolic pressure, be then as the criterion with higher grade scale.Isolated systolic hypertension also can be divided into 1,2,3 grade according to systolic pressure level.

3, Therapeutic Method

Select above-mentioned pill, take to patient, every day, sooner or later respectively once each ball, warm water delivery service 10 days was a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: essential hypertension shape is controlled, blood pressure recovers normal;

Take a turn for the better: essential hypertension shape is clearly better, headache, dizziness, cardiopalmus symptom alleviate, and the state of an illness is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy essential hypertension of the present invention (1 grade) patient 15 example, effective 13 examples of result, obvious effective rate is 86.66%, and take a turn for the better 1 example, and improvement rate is 6.67%, and invalid 1 example, total effective rate is 93.33%.

By Drug therapy essential hypertension of the present invention (2 grades) patient 15 example, effective 12 examples of result, obvious effective rate is 80%, and take a turn for the better 1 example, and improvement rate is 6.67%, and invalid 2 examples, total effective rate is 86.67%.

By Drug therapy essential hypertension of the present invention (3 grades) patient 15 example, effective 11 examples of result, obvious effective rate is 73.33%, and take a turn for the better 1 example, and improvement rate is 6.67%, and invalid 3 examples, total effective rate is 80%.

Claims (3)

1. treat a medicine for essential hypertension, it is characterized in that: it is made up of the crude drug in following weight range: Rhizoma Gastrodiae 10-15 gram, Lumbricus 10-15 gram, Scorpio 6-8 gram, Scolopendra 3-6 gram, Hirudo 2-5 gram, Eupolyphaga Seu Steleophaga 6-9 gram, Radix Notoginseng 10-15 gram, Rhizoma Coptidis 6-10 gram, Radix Scutellariae 8-12 gram, Cortex Moutan 10 grams, Rhizoma Chuanxiong 6-15 gram, Flos Chrysanthemi 10-15 gram, Ramulus Uncariae Cum Uncis 10-15 gram, Radix Rehmanniae 10-15 gram, Radix Astragali 10-20 gram, Radix Ginseng 8-15 gram, Radix Angelicae Sinensis 8-16 gram, Radix Paeoniae Alba 10-15 gram, Mel 60-80 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is: 12 grams, Rhizoma Gastrodiae, Lumbricus 12 grams, Scorpio 6 grams, Scolopendra 4 grams, Hirudo 4 grams, Eupolyphaga Seu Steleophaga 8 grams, Radix Notoginseng 10 grams, Rhizoma Coptidis 8 grams, Radix Scutellariae 10 grams, Cortex Moutan 10 grams, Rhizoma Chuanxiong 10 grams, Flos Chrysanthemi 12 grams, Ramulus Uncariae Cum Uncis 10 grams, Radix Rehmanniae 12 grams, the Radix Astragali 12 grams, Radix Ginseng 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Alba 10 grams, Mel 70 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Gastrodiae: be laid in by Rhizoma Gastrodiae slice and sprayed on the watch core paper of water, put in pot, burns sallow to paper color with slow fire, is constantly stirred by tablet to the strong yellow of two sides;

(2) Lumbricus: pick decontamination, rinses with water, pulls out in time, dries, cutting;

(3) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;

(4) Scolopendra: wipe clean, removing cephalopodium, cuts off use;

(5) Hirudo: clean, vexed soft, cutting, dries;

(6) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(7) Radix Notoginseng: pick most impurity, smash to pieces, grinds or runs through section into powder and dry;

(8) Rhizoma Coptidis: pick decontamination, cleans silt particle, runs through, and section, dries in the shade;

(9) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

(10) Cortex Moutan: pick decontamination, removing core, cleans, runs through, and section, dries;

(11) Rhizoma Chuanxiong: pick decontamination, separately large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;

(12) Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

(13) Ramulus Uncariae Cum Uncis: pick old stalk, impurity, cleans, dries;

(14) Radix Rehmanniae: get crude drug, removing impurity, cleans, slightly moistens, cut sheet, dry, and sieve removes chip;

(15) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

(16) Radix Ginseng: except removing LU, cutting;

(17) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;

(18) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull dry in the sun out, moisten to internal and external temperature even, section, dry;

(2) prepare

(1) levigation: by the Rhizoma Gastrodiae after the process of preparing Chinese medicine, Lumbricus, Scorpio, Scolopendra, Hirudo, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Rhizoma Chuanxiong, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the Radix Astragali, Radix Ginseng, Radix Angelicae Sinensis, the Radix Paeoniae Alba grind as fine powder;

(2) Mel is refined into the tender honey of 110 DEG C-115 DEG C;

(3) stir evenly grinding to pour in Mel for the medicated powder of fine powder, mixing system sticks together, then rubbing pill, 9 grams, every ball.