CN104955452A - 含有亚铁氨基酸螯合物的组合物在制备抗癌症的药物中的用途 - Google Patents
含有亚铁氨基酸螯合物的组合物在制备抗癌症的药物中的用途 Download PDFInfo
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- CN104955452A CN104955452A CN201380071525.8A CN201380071525A CN104955452A CN 104955452 A CN104955452 A CN 104955452A CN 201380071525 A CN201380071525 A CN 201380071525A CN 104955452 A CN104955452 A CN 104955452A
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/295—Iron group metal compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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Abstract
本发明公开了一种含有亚铁氨基酸螯合物的组合物及其在制备抗癌症的药物中的用途，其中药物包含有效抗癌症剂量的含有亚铁氨基酸螯合物的组合物以及其药学上可接受的载剂。本发明所述的含有亚铁氨基酸螯合物的组合物中，氨基酸可与亚铁维持螯合状态通过胃，且不影响受体的体重变化；由含有亚铁氨基酸螯合物的组合物制备而得的药物具有抑制或治疗癌症的效果。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/001043 WO2015032011A1 (zh) | 2013-09-05 | 2013-09-05 | 含有亚铁氨基酸螯合物的组合物在制备抗癌症的药物中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104955452A true CN104955452A (zh) | 2015-09-30 |
| CN104955452B CN104955452B (zh) | 2017-06-09 |
Family
ID=52627663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380071525.8A Expired - Fee Related CN104955452B (zh) | 2013-09-05 | 2013-09-05 | 含有亚铁氨基酸螯合物的组合物在制备抗癌症的药物中的用途 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3042652B1 (zh) |
| JP (1) | JP5973684B2 (zh) |
| CN (1) | CN104955452B (zh) |
| AU (1) | AU2013400082B2 (zh) |
| CA (1) | CA2898771C (zh) |
| WO (1) | WO2015032011A1 (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018148922A1 (zh) * | 2017-02-17 | 2018-08-23 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造治疗肝功能异常的医药品的用途 |
| TWI695719B (zh) * | 2018-12-20 | 2020-06-11 | 普惠德生技股份有限公司 | 含有亞鐵胺基酸粒子的組合物及其用於製造治療或改善胰臟相關疾病的醫藥品的用途 |
| TWI710370B (zh) * | 2018-12-20 | 2020-11-21 | 普惠德生技股份有限公司 | 含有亞鐵胺基酸螯合物粒子的組合物用於製備治療或減緩阿茲海默症或帕金森氏症的醫藥品的用途 |
| TWI732164B (zh) * | 2018-03-06 | 2021-07-01 | 普惠德生技股份有限公司 | 經燒結的胺基酸亞鐵粒子及其抗病毒的用途 |
| CN115531369A (zh) * | 2021-06-30 | 2022-12-30 | 采翼生医股份有限公司 | 用于缓解肾脏疾病与器官纤维化的方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017201701A1 (zh) * | 2016-05-26 | 2017-11-30 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造降低乳酸的药物的用途 |
| TWI645848B (zh) * | 2016-12-02 | 2019-01-01 | 普惠德生技股份有限公司 | Use of a composition containing a ferrous amino acid chelate compound for the manufacture of a medicament for preventing cancer metastasis |
| WO2019127295A1 (zh) * | 2017-12-29 | 2019-07-04 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造抑制血管新生的医药品的用途 |
| EP3900719A4 (en) * | 2018-12-20 | 2022-08-03 | Profeat Biotechnology Co. Ltd. | COMPOSITION CONTAINING AN AMINO ACID FERROUS PARTICLE AND ITS USE IN THE PREPARATION OF A PHARMACEUTICAL PRODUCT FOR THE TREATMENT OR IMPROVEMENT OF A PANCREAS-RELATED DISEASE |
| CN112168843A (zh) * | 2019-07-05 | 2021-01-05 | 普惠德生技股份有限公司 | 经烧结的纳米粒子及其抗病毒的用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101102762A (zh) * | 2004-12-22 | 2008-01-09 | 药物技术公司 | 含铁组合物 |
| US20090035385A1 (en) * | 2004-12-22 | 2009-02-05 | Drugtech Corporation | Compositions including iron |
| EP2306187A1 (en) * | 2001-11-13 | 2011-04-06 | Signe BioPharma Inc. | Cancer eradication program |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2041M (fr) * | 1962-04-17 | 1963-09-30 | Andre Anselme Marie | Composition thérapeutique a propriétés cytotoxiques a base d'acide ascorbique et d'ions métalliques. |
| US5578637A (en) * | 1995-05-03 | 1996-11-26 | University Of Washington | Methods of inhibition or killing cancer cells using an endoperoxide |
| EP1658844A1 (en) * | 2004-10-19 | 2006-05-24 | Gerold Schuler | Use of artemisinin derivatives in the manufacture of a medicament for the treatment of melanoma |
| KR20090064400A (ko) * | 2006-09-28 | 2009-06-18 | 머크 앤드 캄파니 인코포레이티드 | Ｈｄａｃ 억제제 및 킬레이트화 가능한 금속 화합물 및 금속-ｈｄａｃ 억제제 킬레이트 착물의 약제학적 조성물 |
| JP5611548B2 (ja) * | 2009-07-08 | 2014-10-22 | Ｓｂｉファーマ株式会社 | ５−アミノレブリン酸若しくはその誘導体、又はそれらの塩を有効成分とするがんの予防・改善剤 |
-
2013
- 2013-09-05 CA CA2898771A patent/CA2898771C/en not_active Expired - Fee Related
- 2013-09-05 EP EP13893164.7A patent/EP3042652B1/en not_active Not-in-force
- 2013-09-05 AU AU2013400082A patent/AU2013400082B2/en not_active Ceased
- 2013-09-05 WO PCT/CN2013/001043 patent/WO2015032011A1/zh active Application Filing
- 2013-09-05 JP JP2015559400A patent/JP5973684B2/ja not_active Expired - Fee Related
- 2013-09-05 CN CN201380071525.8A patent/CN104955452B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2306187A1 (en) * | 2001-11-13 | 2011-04-06 | Signe BioPharma Inc. | Cancer eradication program |
| CN101102762A (zh) * | 2004-12-22 | 2008-01-09 | 药物技术公司 | 含铁组合物 |
| US20090035385A1 (en) * | 2004-12-22 | 2009-02-05 | Drugtech Corporation | Compositions including iron |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018148922A1 (zh) * | 2017-02-17 | 2018-08-23 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造治疗肝功能异常的医药品的用途 |
| CN110198709A (zh) * | 2017-02-17 | 2019-09-03 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造治疗肝功能异常的医药品的用途 |
| TWI732164B (zh) * | 2018-03-06 | 2021-07-01 | 普惠德生技股份有限公司 | 經燒結的胺基酸亞鐵粒子及其抗病毒的用途 |
| TWI695719B (zh) * | 2018-12-20 | 2020-06-11 | 普惠德生技股份有限公司 | 含有亞鐵胺基酸粒子的組合物及其用於製造治療或改善胰臟相關疾病的醫藥品的用途 |
| TWI710370B (zh) * | 2018-12-20 | 2020-11-21 | 普惠德生技股份有限公司 | 含有亞鐵胺基酸螯合物粒子的組合物用於製備治療或減緩阿茲海默症或帕金森氏症的醫藥品的用途 |
| CN113260358A (zh) * | 2018-12-20 | 2021-08-13 | 普惠德生技股份有限公司 | 含有亚铁胺基酸螯合物粒子的组合物用于制备治疗或减缓神经受损相关疾病的医药品的用途 |
| CN115531369A (zh) * | 2021-06-30 | 2022-12-30 | 采翼生医股份有限公司 | 用于缓解肾脏疾病与器官纤维化的方法 |
| CN115531369B (zh) * | 2021-06-30 | 2024-03-08 | 采翼生医股份有限公司 | 用于缓解肾脏疾病与器官纤维化的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104955452B (zh) | 2017-06-09 |
| JP5973684B2 (ja) | 2016-08-23 |
| EP3042652B1 (en) | 2018-08-29 |
| EP3042652A4 (en) | 2017-04-12 |
| CA2898771A1 (en) | 2015-03-12 |
| CA2898771C (en) | 2017-01-03 |
| AU2013400082A1 (en) | 2015-08-06 |
| AU2013400082B2 (en) | 2016-01-28 |
| WO2015032011A1 (zh) | 2015-03-12 |
| EP3042652A1 (en) | 2016-07-13 |
| JP2016510006A (ja) | 2016-04-04 |
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